GLYCYRRHETINIC ACID

Glycyrrhetinic Acid is a bioactive triterpenoid compound obtained from glycyrrhizin, the main constituent of licorice root (Glycyrrhiza glabra).
Glycyrrhetinic Acid is widely used in cosmetics, pharmaceuticals, and personal care formulations due to its anti-inflammatory, antioxidant, and skin-soothing properties.
Glycyrrhetinic Acid exhibits corticosteroid-like activity without the side effects of steroids, making it valuable in treating skin irritation, redness, and allergic reactions.
Glycyrrhetinic Acid is also recognized for its antimicrobial, wound-healing, and anti-aging effects, suitable for both topical and oral formulations.

CAS Number: 471-53-4
EC Number: 207-377-1
Molecular Formula: C30H46O4
Molecular Weight: 470.68 g/mol

Synonyms: Enoxolone, Glycyrrhetic Acid, 18β-Glycyrrhetinic Acid, β-Glycyrrhetinic Acid, Licorice Root Acid, Glycyrrhizin Aglycone, Enoxolone Acid, Licorice Extract Active, Anti-inflammatory Licorice Compound, Glycyrrhetinic Acid Powder, Glycyrrhetinic Acid, Enoxolone, 18β-Glycyrrhetinic Acid, β-Glycyrrhetinic Acid, Glycyrrhetic Acid, Glycyrrhetin, Glycyrrhetic Acid, Glycyrrhizic Acid Aglycone, Glycyrrhizin Hydrolysis Product, Licorice Root Active Compound, Licorice Triterpenoid, Licorice Acid, 3β-Hydroxy-11-oxo-olean-12-en-29-oic Acid, Oleanane Triterpenoid, 18-Beta Glycyrrhetinic Acid, 18α-Glycyrrhetinic Acid, Glycyrrhetinic Acid Compound, Glycyrrhetinic Acid Material, Glycyrrhetinic Acid Product, Glycyrrhetinic Acid Substance, Glycyrrhetinic Acid Chemical, Glycyrrhetinic Acid Technical Grade, Glycyrrhetinic Acid Industrial Grade, Glycyrrhetinic Acid Pharmaceutical Grade, Glycyrrhetinic Acid Food Grade, Glycyrrhetinic Acid Cosmetic Grade, Glycyrrhetinic Acid Laboratory Grade, Glycyrrhetinic Acid Research Grade, Glycyrrhetinic Acid Pure, Glycyrrhetinic Acid Extra Pure, Glycyrrhetinic Acid High Purity, Glycyrrhetinic Acid Refined, Glycyrrhetinic Acid Stabilized, Glycyrrhetinic Acid Certified, Glycyrrhetinic Acid Certified Standard, Glycyrrhetinic Acid Analytical Standard, Glycyrrhetinic Acid Laboratory Standard, Glycyrrhetinic Acid Certified Reagent, Glycyrrhetinic Acid Laboratory Reagent, Glycyrrhetinic Acid Test Reagent, Glycyrrhetinic Acid Assay, Glycyrrhetinic Acid Bulk Chemical, Glycyrrhetinic Acid Commercial Grade, Glycyrrhetinic Acid Raw Material, Glycyrrhetinic Acid Fine Chemical, Glycyrrhetinic Acid Specialty Chemical, Glycyrrhetinic Acid Active Ingredient, Glycyrrhetinic Acid Functional Ingredient, Glycyrrhetinic Acid Specialty Ingredient, Glycyrrhetinic Acid Functional Additive, Glycyrrhetinic Acid Specialty Additive, Glycyrrhetinic Acid Anti-Inflammatory Agent, Glycyrrhetinic Acid Antioxidant, Glycyrrhetinic Acid Antimicrobial Agent, Glycyrrhetinic Acid Skin Soothing Agent, Glycyrrhetinic Acid Skin Conditioning Agent, Glycyrrhetinic Acid Whitening Agent, Glycyrrhetinic Acid Brightening Agent, Glycyrrhetinic Acid Wound Healing Agent, Glycyrrhetinic Acid Antiaging Agent

APPLICATIONS

Glycyrrhetinic Acid is used in skin care formulations for its anti-inflammatory and soothing properties.
Glycyrrhetinic Acid reduces redness, irritation, and inflammation in sensitive skin.
Glycyrrhetinic Acid helps restore skin comfort after UV exposure or cosmetic treatments.

Glycyrrhetinic Acid is applied in acne treatment products.
Glycyrrhetinic Acid inhibits bacterial growth and sebum oxidation.
Glycyrrhetinic Acid reduces swelling and redness in acne-prone areas.

Glycyrrhetinic Acid is incorporated in eczema and dermatitis formulations.
Glycyrrhetinic Acid relieves itching and inflammation associated with atopic skin.
Glycyrrhetinic Acid strengthens the skin barrier and promotes healing.

Glycyrrhetinic Acid is used in anti-aging creams and serums.
Glycyrrhetinic Acid inhibits elastase and hyaluronidase, preventing collagen degradation.
Glycyrrhetinic Acid promotes smoother, firmer, and more elastic skin.

Glycyrrhetinic Acid is found in whitening and brightening formulations.
Glycyrrhetinic Acid inhibits tyrosinase activity and melanin synthesis.
Glycyrrhetinic Acid helps even skin tone and reduce hyperpigmentation.

Glycyrrhetinic Acid is used in after-sun and after-shave lotions.
Glycyrrhetinic Acid soothes irritation and reduces burning sensations.
Glycyrrhetinic Acid promotes skin regeneration and moisture retention.

Glycyrrhetinic Acid is applied in wound-healing and repair creams.
Glycyrrhetinic Acid stimulates cell renewal and tissue regeneration.
Glycyrrhetinic Acid accelerates the healing process of minor wounds and abrasions.

Glycyrrhetinic Acid is used in lip care products and balms.
Glycyrrhetinic Acid prevents dryness, cracking, and inflammation of lip tissue.
Glycyrrhetinic Acid enhances lip smoothness and elasticity.

Glycyrrhetinic Acid is incorporated in hair care formulations.
Glycyrrhetinic Acid soothes irritated scalp and reduces dandruff formation.
Glycyrrhetinic Acid supports healthy hair growth by improving scalp condition.

Glycyrrhetinic Acid is used in anti-inflammatory pharmaceutical creams.
Glycyrrhetinic Acid acts as a mild corticosteroid alternative for dermatitis.
Glycyrrhetinic Acid provides local relief from inflammation without systemic effects.

Glycyrrhetinic Acid is used in oral care products such as toothpastes and mouthwashes.
Glycyrrhetinic Acid prevents gingivitis and oral bacterial growth.
Glycyrrhetinic Acid provides anti-inflammatory and antimicrobial protection for gums.

Glycyrrhetinic Acid is used in medicated ointments and gels for burns and rashes.
Glycyrrhetinic Acid soothes irritation and promotes epidermal recovery.
Glycyrrhetinic Acid minimizes scarring during healing.

Glycyrrhetinic Acid is applied in eye creams and under-eye treatments.
Glycyrrhetinic Acid reduces puffiness and dark circles by soothing inflammation.
Glycyrrhetinic Acid improves microcirculation and reduces oxidative stress.

Glycyrrhetinic Acid is incorporated in sun care and photoprotection products.
Glycyrrhetinic Acid enhances cellular defense against UV-induced damage.
Glycyrrhetinic Acid reduces erythema and oxidative degradation of skin lipids.

Glycyrrhetinic Acid is used in cosmeceuticals and dermatological formulations.
Glycyrrhetinic Acid provides multifunctional benefits including antioxidation and protection.
Glycyrrhetinic Acid enhances product efficacy in sensitive and stressed skin.

Glycyrrhetinic Acid is used in pharmaceutical preparations for liver and gastric protection.
Glycyrrhetinic Acid exhibits anti-ulcer and hepatoprotective properties in oral dosage forms.
Glycyrrhetinic Acid reduces oxidative stress in gastrointestinal tissues.

Glycyrrhetinic Acid is employed in formulations for psoriasis and rosacea.
Glycyrrhetinic Acid reduces inflammation and calms visible redness.

Glycyrrhetinic Acid restores comfort to irritated and scaly skin.
Glycyrrhetinic Acid is used in foot and hand care creams.

Glycyrrhetinic Acid softens rough areas and reduces cracking.
Glycyrrhetinic Acid provides anti-inflammatory support to dry, chapped skin.

Glycyrrhetinic Acid is included in formulations for diaper rash and baby care.
Glycyrrhetinic Acid protects delicate skin from irritation and rash.
Glycyrrhetinic Acid provides a natural soothing and healing action.

Glycyrrhetinic Acid is used in anti-pollution skincare to neutralize environmental stressors.
Glycyrrhetinic Acid reduces the effects of oxidative pollutants on skin barrier integrity.

Glycyrrhetinic Acid enhances overall skin resilience and detoxification.
Glycyrrhetinic Acid is used in pharmaceutical formulations.

Glycyrrhetinic Acid exhibits strong anti-inflammatory and antimicrobial properties.
Glycyrrhetinic Acid is incorporated into topical creams and ointments for skin healing.

Glycyrrhetinic Acid is applied in dermatological preparations.
Glycyrrhetinic Acid reduces redness, irritation, and inflammation in sensitive skin.
Glycyrrhetinic Acid supports the treatment of eczema, psoriasis, and dermatitis.

Glycyrrhetinic Acid is used in cosmetic formulations.
Glycyrrhetinic Acid provides skin-soothing and anti-aging benefits.

Glycyrrhetinic Acid helps restore the natural protective barrier of the skin.
Glycyrrhetinic Acid is incorporated in whitening and brightening products.

Glycyrrhetinic Acid inhibits tyrosinase activity to reduce hyperpigmentation.
Glycyrrhetinic Acid promotes a more even and radiant skin tone.

Glycyrrhetinic Acid is used in sunscreen formulations.
Glycyrrhetinic Acid helps protect skin from UV-induced inflammation.
Glycyrrhetinic Acid complements photoprotective ingredients in sun care products.

Glycyrrhetinic Acid is applied in anti-acne treatments.
Glycyrrhetinic Acid regulates sebum production and reduces bacterial growth.
Glycyrrhetinic Acid soothes irritation caused by acne and blemishes.

Glycyrrhetinic Acid is used in hair care formulations.
Glycyrrhetinic Acid supports scalp health and reduces irritation.
Glycyrrhetinic Acid is incorporated in anti-dandruff and soothing shampoos.

Glycyrrhetinic Acid is applied in lip care products.
Glycyrrhetinic Acid provides anti-inflammatory and softening properties.
Glycyrrhetinic Acid helps repair dry or chapped lips.

Glycyrrhetinic Acid is used in wound care and burn treatment creams.
Glycyrrhetinic Acid accelerates tissue regeneration and healing.

Glycyrrhetinic Acid reduces oxidative stress and swelling around injured areas.
Glycyrrhetinic Acid is incorporated in oral care formulations.

Glycyrrhetinic Acid provides antibacterial protection against oral pathogens.
Glycyrrhetinic Acid supports gum health and helps prevent inflammation.

Glycyrrhetinic Acid is used in anti-aging skincare products.
Glycyrrhetinic Acid inhibits the breakdown of collagen and elastin.
Glycyrrhetinic Acid helps maintain firmness and elasticity of the skin.

Glycyrrhetinic Acid is applied in after-sun and soothing gels.
Glycyrrhetinic Acid calms heat-induced redness and burning sensations.
Glycyrrhetinic Acid restores skin comfort after UV exposure.

Glycyrrhetinic Acid is used in depigmenting and anti-spot treatments.
Glycyrrhetinic Acid regulates melanin synthesis.
Glycyrrhetinic Acid helps diminish dark spots and uneven complexion.

Glycyrrhetinic Acid is incorporated in men’s grooming products.
Glycyrrhetinic Acid soothes post-shaving irritation.
Glycyrrhetinic Acid reduces skin redness and micro-inflammation.

Glycyrrhetinic Acid is used in functional foods and nutraceuticals.
Glycyrrhetinic Acid provides antioxidant and hepatoprotective effects.
Glycyrrhetinic Acid supports liver health and immune system balance.

DESCRIPTION

Glycyrrhetinic Acid is a pentacyclic triterpenoid compound derived from licorice root (Glycyrrhiza glabra).
Glycyrrhetinic Acid is obtained through hydrolysis of glycyrrhizin, the principal active component of licorice.
Glycyrrhetinic Acid is widely used in pharmaceuticals, cosmetics, and nutraceuticals for its bioactive properties.

Glycyrrhetinic Acid has the CAS number 471-53-4.
Glycyrrhetinic Acid has the EC number 207-937-1.

Glycyrrhetinic Acid has the molecular formula C30H46O4.
Glycyrrhetinic Acid has a molecular weight of 470.69 g/mol.

Glycyrrhetinic Acid appears as a white to off-white crystalline powder.
Glycyrrhetinic Acid is odorless and tasteless.

Glycyrrhetinic Acid is practically insoluble in water but soluble in ethanol, chloroform, and acetone.
Glycyrrhetinic Acid exhibits strong anti-inflammatory, antimicrobial, and antioxidant activity.
Glycyrrhetinic Acid has a melting point in the range of 290–295°C.

Glycyrrhetinic Acid stabilizes membranes and inhibits 11β-hydroxysteroid dehydrogenase activity.
Glycyrrhetinic Acid enhances the bioavailability of other active ingredients in formulations.

Glycyrrhetinic Acid should be stored in tightly sealed containers, protected from moisture and light.
Glycyrrhetinic Acid is a white to off-white crystalline powder with a faint characteristic odor.

Glycyrrhetinic Acid is practically insoluble in water but soluble in ethanol, methanol, chloroform, and DMSO.
Glycyrrhetinic Acid has a melting point of approximately 290°C and exhibits excellent chemical stability.

Glycyrrhetinic Acid is derived from the hydrolysis of glycyrrhizin, a saponin glycoside present in licorice root.
Glycyrrhetinic Acid belongs to the pentacyclic triterpene class with strong anti-inflammatory and antioxidant activity.

Glycyrrhetinic Acid mimics the action of glucocorticoids by inhibiting 11β-hydroxysteroid dehydrogenase.
Glycyrrhetinic Acid demonstrates antibacterial, antiviral, and antifungal properties, making it effective in personal care and medical formulations.

Glycyrrhetinic Acid promotes tissue regeneration and accelerates wound healing.
Glycyrrhetinic Acid prevents collagen degradation and improves extracellular matrix stability.

Glycyrrhetinic Acid is biocompatible and non-sensitizing, suitable for long-term topical use.
Glycyrrhetinic Acid stabilizes emulsions and enhances the performance of other actives such as allantoin and panthenol.
Glycyrrhetinic Acid is effective in both emulsions and anhydrous formulations.

Glycyrrhetinic Acid is considered safe for cosmetic use under international regulations.
Glycyrrhetinic Acid is commonly incorporated at concentrations between 0.05% and 1.0% in cosmetic formulations.
Glycyrrhetinic Acid is stable under normal storage conditions and retains bioactivity for extended periods.

PROPERTIES

Appearance: White to off-white crystalline powder
Odor: Faint characteristic odor
Melting Point: 285–290°C
Boiling Point: >400°C (decomposes)
Density: 1.05 g/cm³ (approx.)
Solubility: Insoluble in water; soluble in ethanol, methanol, and DMSO
pH (1% in ethanol): 6.0–7.5
Stability: Stable under normal storage and processing conditions
Partition Coefficient (log P): ~6.4 (lipophilic)
Purity: ≥98% (HPLC)
Storage Temperature: Store below 25°C, protected from light and moisture

FIRST AID

Inhalation:
Move person to fresh air.
Seek medical attention if irritation or respiratory discomfort occurs.

Skin Contact:
Wash affected area with soap and water.
Seek medical advice if irritation or redness persists.

Eye Contact:
Rinse thoroughly with water for at least 15 minutes.
Seek immediate medical attention if discomfort continues.

Ingestion:
Rinse mouth with water and seek medical attention.
Do not induce vomiting unless advised by a physician.

Note to Physicians:
Treat symptomatically.
No specific antidote known.

HANDLING AND STORAGE

Handling:
Avoid inhalation of dust or direct contact with eyes and skin.
Use in well-ventilated areas and wear protective gloves and goggles.

Ventilation:
Provide local exhaust ventilation in production areas.

Avoidance:
Avoid exposure to strong oxidizing agents and direct sunlight.
Prevent contamination with incompatible materials.

Spill and Leak Procedures:
Collect spills mechanically and dispose of waste in accordance with local regulations.
Clean contaminated surfaces thoroughly.

Storage:
Store in tightly sealed containers in a cool, dry, and well-ventilated area.
Protect from heat, humidity, and light to maintain stability.
Keep container closed when not in use.