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Guanidine Acetate is a white crystalline compound formed by the reaction of guanidine with acetic acid.
Guanidine Acetate is primarily used in organic synthesis, pharmaceutical intermediates, and protein denaturation studies.
Guanidine Acetate is appreciated for its strong basicity, buffering capabilities, and role as a chaotropic agent in biochemical applications.
CAS Number: 352-97-6
EC Number: 206-529-5
Molecular Formula: C3H9N3O2
Molecular Weight: 119.12 g/mol
Synonyms: Guanidinium Acetate, Acetic Acid Guanidinium Salt, Guanidine Ethanoate, Guanidinium Ethanoate, Guanidinoacetic Acid Salt, Guanidinium Acetate Salt, Acetate de Guanidine, Guanidinoacétate, Guanidine Acetate Monohydrate (when hydrated), Guanidine Acetate Crystalline, Guanidine Acetate for Synthesis, Guanidine Acetate for Biochemical Use
APPLICATIONS
Guanidine Acetate is used as an intermediate in pharmaceutical synthesis for various guanidine-containing drugs.
Guanidine Acetate is employed in the production of creatine and related nutritional supplements.
Guanidine Acetate is used in biochemical research as a denaturant to unfold proteins and study protein structure.
Guanidine Acetate is used in DNA and RNA isolation protocols to disrupt hydrogen bonds in nucleic acids.
Guanidine Acetate is utilized in chromatography buffers to help solubilize hydrophobic or tightly folded biomolecules.
Guanidine Acetate is included in protein refolding procedures to aid in disaggregation and renaturation.
Guanidine Acetate is applied in peptide synthesis and purification protocols as a stabilizing or chaotropic agent.
Guanidine Acetate is used in the preparation of guanidinium derivatives in fine chemical manufacturing.
Guanidine Acetate is employed in electrophoresis buffers and loading dyes for enhanced sample behavior.
Guanidine Acetate is used as a component in enzyme inhibition studies to assess protein binding sites.
Guanidine Acetate is utilized in veterinary pharmaceutical formulations as a synthetic intermediate.
Guanidine Acetate is found in certain agricultural chemical syntheses involving guanidine salts.
Guanidine Acetate is used in the synthesis of heterocyclic compounds in medicinal chemistry.
Guanidine Acetate is applied in nucleic acid extraction kits for molecular biology research.
Guanidine Acetate is employed in structural biology to determine folding pathways of proteins.
Guanidine Acetate is included in gene expression studies where protein structure is a variable.
Guanidine Acetate is used in the industrial production of guanidine-based resins and polymers.
Guanidine Acetate is applied in the synthesis of catalysts where guanidine moieties are involved.
Guanidine Acetate is used as a reagent in analytical chemistry to identify and separate functional groups.
Guanidine Acetate is employed in the preparation of biodegradable surfactants and ionic liquids.
Guanidine Acetate is used in the purification of monoclonal antibodies and therapeutic proteins.
Guanidine Acetate is used as an intermediate in the synthesis of pharmaceuticals.
Guanidine Acetate is employed in the formulation of agrochemicals and pesticides.
Guanidine Acetate is used in the production of antistatic agents and textile auxiliaries.
Guanidine Acetate is applied in dye and pigment manufacturing as a reaction component.
Guanidine Acetate is used as a catalyst or accelerator in various organic reactions.
Guanidine Acetate is employed in laboratory research for protein denaturation studies.
Guanidine Acetate is used in buffer solutions for RNA and DNA extraction protocols.
Guanidine Acetate is applied in the cosmetics industry as a pH modifier and stabilizer.
Guanidine Acetate is used in electroplating solutions for improving conductivity.
Guanidine Acetate is utilized in the manufacture of flame retardants.
Guanidine Acetate is used as a component in fuel cell electrolytes.
Guanidine Acetate is incorporated in corrosion inhibitors for industrial metal treatments.
Guanidine Acetate is used in the preparation of guanidinium-based ionic liquids.
Guanidine Acetate is employed in analytical chemistry for ion-pairing chromatography.
Guanidine Acetate is used in gel electrophoresis procedures for protein separation.
Guanidine Acetate is applied in the purification of membrane proteins.
Guanidine Acetate is used in the production of specialty polymers and resins.
Guanidine Acetate is used as a chaotropic agent in molecular biology.
Guanidine Acetate is employed in veterinary formulations for parasitic control.
Guanidine Acetate is used in the synthesis of biologically active guanidine derivatives.
Guanidine Acetate is utilized in the production of explosives and propellants in controlled formulations.
Guanidine Acetate is used in textile dye fixation processes.
Guanidine Acetate is employed in personal care formulations to stabilize active ingredients.
Guanidine Acetate is used in biochemical research to unfold proteins for structural analysis.
Guanidine Acetate is applied in industrial cleaning formulations requiring strong alkaline action.
Guanidine Acetate is included in specialty adhesives to promote bonding strength.
Guanidine Acetate is used in the development of diagnostic reagents.
Guanidine Acetate is employed in formulation of descaling agents for industrial systems.
Guanidine Acetate is used in detergent formulations for heavy-duty industrial cleaning.
Guanidine Acetate is applied in the production of heat-resistant plastics and elastomers.
Guanidine Acetate acts as a chaotropic agent, disrupting hydrogen bonds in biological molecules.
Guanidine Acetate is commonly used in molecular biology for denaturing proteins and nucleic acids.
Guanidine Acetate is relatively stable under ambient conditions but should be stored in a dry environment.
Guanidine Acetate can be toxic in high concentrations and should be handled with appropriate precautions.
Guanidine Acetate has broad utility in industrial, laboratory, and biochemical applications.
Guanidine Acetate may emit nitrogen-containing gases when decomposed at high temperatures.
Guanidine Acetate serves as a versatile chemical building block in synthesis and formulation work.
DESCRIPTION
Guanidine Acetate is a white to off-white crystalline solid with no significant odor.
Guanidine Acetate is the salt formed between guanidine, a strong organic base, and acetic acid, a weak acid.
Guanidine Acetate is highly soluble in water and hygroscopic in nature.
Guanidine Acetate is considered a chaotropic agent, meaning it disrupts non-covalent bonds in proteins and nucleic acids.
Guanidine Acetate is used in denaturing buffers for biochemical and molecular biology experiments.
Guanidine Acetate is preferred over guanidine hydrochloride in some cases due to lower chloride ion interference.
Guanidine Acetate is chemically stable under normal conditions but should be stored in tightly sealed containers.
Guanidine Acetate has a strong buffering capacity in the physiological pH range.
Guanidine Acetate should be handled with care due to its potential to irritate the skin and eyes.
Guanidine Acetate is biodegradable and does not persist significantly in the environment.
Guanidine Acetate is compatible with a wide range of laboratory reagents and systems.
Guanidine Acetate is a widely used tool compound in structural and protein chemistry.
Guanidine Acetate is a white crystalline solid composed of guanidine and acetic acid.
Guanidine Acetate has the molecular formula CH₆N₃O₂ and is soluble in water and alcohol.
Guanidine Acetate is known for its strong alkalinity and high nucleophilicity.
PROPERTIES
Chemical Formula: C3H9N3O2
Molecular Weight: 119.12 g/mol
Common Name: Guanidine Acetate
Appearance: White crystalline powder
Odor: Odorless
Solubility: Highly soluble in water and alcohol
pH (1% solution): ~6.5–7.5
Melting Point: ~190–195°C (decomposes)
Density: ~1.2 g/cm³
Stability: Stable under recommended storage conditions
Reactivity: Reacts with strong oxidizers; hygroscopic
Storage Conditions: Store in cool, dry, sealed containers at 15–25°C
Shelf Life: Minimum 2 years under proper storage
FIRST AID
Inhalation:
Move the affected person to fresh air.
Seek medical attention if respiratory symptoms persist.
Avoid breathing dust during handling.
Skin Contact:
Wash skin thoroughly with soap and water.
Remove contaminated clothing and wash before reuse.
Seek medical advice if irritation develops.
Eye Contact:
Flush eyes with plenty of water for at least 15 minutes.
Lift eyelids to ensure full rinsing.
Seek medical attention if irritation or redness persists.
Ingestion:
Rinse mouth thoroughly with water.
Do not induce vomiting.
Seek medical attention if symptoms occur.
Note to Physicians:
Treat symptomatically.
No specific antidote known.
Monitor for irritation or metabolic disturbances in large exposures.
HANDLING AND STORAGE
Handling:
Avoid generating dust during handling.
Use protective gloves, lab coat, and safety goggles.
Wash hands thoroughly after handling.
Ventilation:
Ensure good general ventilation in working area.
Use local exhaust in case of powder generation.
Storage:
Keep tightly sealed in original containers.
Store in a cool, dry, and well-ventilated location.
Protect from heat, moisture, and direct sunlight.
Spill and Leak Procedures:
Sweep up and place into labeled containers for disposal.
Avoid contamination of water sources.
Clean spill area with water to remove residues.
Handling Precautions:
Avoid contact with skin and eyes.
Avoid inhaling dust during weighing and mixing.
Use dedicated tools and containers to avoid cross-contamination.
