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Guanidine Acetate is a white crystalline compound composed of guanidine and acetic acid, widely used in chemical synthesis, pharmaceuticals, and as a precursor in the production of guanidine-based derivatives.
Guanidine Acetate is known for its high nitrogen content, strong basicity, and ability to form stable salts, making it valuable in various organic synthesis reactions.
Guanidine Acetate is also used as an intermediate in the preparation of herbicides, explosives, and specialty chemicals.
CAS Number: 352-97-6
EC Number: 206-529-5
Molecular Formula: C3H9N3O2
Molecular Weight: 119.12 g/mol
Synonyms: Acetic Acid Guanidine Salt, Guanidinium Acetate, Guanidine Ethanoate, Guanidinium Ethanoate, Acetate of Guanidine, Guanidine Acetate Salt, Guanidine Acetic Acid, Guanidine Monacetate, Guanidine Acetate Crystals, Guanidine Acetate Powder
APPLICATIONS
Guanidine Acetate is used as an intermediate in the synthesis of pharmaceuticals, especially those involving guanidine moieties.
Guanidine Acetate is involved in the production of drugs targeting cardiovascular, antiviral, and antidiabetic effects.
Guanidine Acetate contributes to the structural modification of active pharmaceutical ingredients.
Guanidine Acetate is applied in the manufacture of agricultural chemicals, including selective herbicides and pesticides.
Guanidine Acetate supports the synthesis of active agrochemical ingredients through nucleophilic substitution or condensation reactions.
Guanidine Acetate provides enhanced efficacy and stability in agrochemical formulations.
Guanidine Acetate is used in the explosives industry as a nitrogen-rich compound in the synthesis of propellants and detonators.
Guanidine Acetate serves as a precursor for energetic materials that require controlled thermal decomposition.
Guanidine Acetate is valued for its contribution to gas-generating compositions.
Guanidine Acetate is employed in organic synthesis for producing guanidine derivatives, including biguanides and substituted guanidines.
Guanidine Acetate participates in condensation and amidation reactions to introduce basic functional groups.
Guanidine Acetate is used in laboratory-scale reactions to modify amines and other heterocyclic systems.
Guanidine Acetate is used in research and development for studying acid–base chemistry, protonation behavior, and salt formation.
Guanidine Acetate serves as a model compound for understanding guanidine ion interactions and protein denaturation studies.
Guanidine Acetate may also be used as a buffering agent in specialized applications.
Guanidine Acetate is used as a protein denaturant in biochemical research.
Guanidine Acetate is applied in the extraction of nucleic acids from cells.
Guanidine Acetate is used in chromatography for protein unfolding studies.
Guanidine Acetate is utilized in the production of pharmaceuticals as an intermediate.
Guanidine Acetate is employed in the synthesis of guanidine-based drugs.
Guanidine Acetate is used in polymer synthesis involving guanidinium functional groups.
Guanidine Acetate is applied in the formulation of hair relaxers in the cosmetics industry.
Guanidine Acetate is used in hair straightening products as a keratin softener.
Guanidine Acetate is included in specialty hair care products for chemically treated hair.
Guanidine Acetate is used in dermatological creams for exfoliation support.
Guanidine Acetate is employed in high-pH cleansing formulations.
Guanidine Acetate is used as a buffering agent in certain biochemical reactions.
Guanidine Acetate is included in formulations designed to disrupt protein-protein interactions.
Guanidine Acetate is used in the formulation of depilatory creams.
Guanidine Acetate is used in laboratory settings for protein folding experiments.
Guanidine Acetate is used as a precursor for guanidinium-based ionic liquids.
Guanidine Acetate is used in organic synthesis for introducing guanidino groups.
Guanidine Acetate is employed in fertilizers in certain controlled environments.
Guanidine Acetate is used in analytical chemistry to solubilize membrane proteins.
Guanidine Acetate is added to enzyme activity buffers for specific inhibition profiles.
Guanidine Acetate is used in amino acid protection and deprotection schemes.
Guanidine Acetate is employed in synthesis protocols for peptide coupling.
Guanidine Acetate is used in denaturing gradient gel electrophoresis.
Guanidine Acetate is applied in the preparation of molecular biology kits.
Guanidine Acetate is used in histology to dissolve tough tissues before staining.
Guanidine Acetate is used in tissue digestion protocols during proteomic analyses.
Guanidine Acetate is utilized in the chemical modification of enzymes.
Guanidine Acetate is used in synthetic detergents for protein solubilization.
Guanidine Acetate is employed in the manufacturing of biomedical hydrogels.
Guanidine Acetate is used in capillary electrophoresis for peptide unfolding.
Guanidine Acetate is included in the formulation of anti-dandruff scalp treatments.
Guanidine Acetate is used in anti-lice shampoo formulations for improved scalp penetration.
Guanidine Acetate is used as a solubilizer for insoluble proteins in research.
Guanidine Acetate is employed in cryopreservation solutions.
Guanidine Acetate is used in microfluidic sample preparation kits.
Guanidine Acetate is used in hair perm neutralizers for modifying disulfide bonds.
Guanidine Acetate is used in the study of protein aggregation diseases.
Guanidine Acetate is used in veterinary products for topical application.
Guanidine Acetate is applied in the development of guanidine-based antimicrobial agents.
Guanidine Acetate is used in small-scale chemical etching procedures.
Guanidine Acetate is incorporated into certain bioreactor formulations.
Guanidine Acetate is used in analytical testing kits for protein structure analysis.
Guanidine Acetate is used in lab reagents for breaking hydrogen bonding in proteins.
DESCRIPTION
Guanidine Acetate appears as a white, odorless crystalline solid that is freely soluble in water.
Guanidine Acetate is formed by the reaction of guanidine with acetic acid, resulting in a stable salt.
Guanidine Acetate is hygroscopic and should be stored in a dry environment to avoid clumping or degradation.
Guanidine Acetate possesses strong basicity and can act as a proton acceptor in a variety of chemical reactions.
Guanidine Acetate exhibits both ionic and hydrogen bonding interactions, making it useful in pharmaceutical formulations.
Guanidine Acetate may be recrystallized from ethanol or water to improve purity and stability.
Guanidine Acetate is stable under standard laboratory conditions but should be protected from excessive heat and moisture.
Guanidine Acetate should be handled with care due to potential irritation upon contact with skin, eyes, or respiratory tract.
Guanidine Acetate is non-flammable but may decompose at elevated temperatures, releasing nitrogen-containing gases.
PROPERTIES
Common Name: Guanidine Acetate
Chemical Formula: C3H9N3O2
Molecular Weight: 119.12 g/mol
Appearance: White crystalline solid
Odor: Odorless
Melting Point: ~150°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Density: ~1.4 g/cm³
Solubility: Soluble in water, ethanol; slightly soluble in organic solvents
pH (1% solution): ~7.0–8.5
Stability: Stable under normal storage and handling
Reactivity: Reacts with strong oxidizers and acids
Storage Conditions: Store in a tightly sealed container in a dry, cool place
Shelf Life: Up to 24 months if stored properly
Hazards: Irritating to eyes, skin, and respiratory tract with prolonged exposure
FIRST AID
Inhalation:
Move the affected person to fresh air immediately.
Seek medical attention if symptoms such as coughing, shortness of breath, or irritation persist.
Administer oxygen if breathing is difficult.
Skin Contact:
Wash exposed area thoroughly with soap and water.
Remove contaminated clothing and rinse affected skin.
Seek medical attention if skin irritation continues.
Eye Contact:
Rinse eyes immediately with plenty of water for at least 15 minutes.
Lift eyelids occasionally while rinsing.
Get medical attention if discomfort or redness persists.
Ingestion:
Rinse mouth with water; do not induce vomiting unless directed by medical personnel.
Give water to dilute if the person is conscious.
Seek immediate medical attention.
Note to Physicians:
Provide supportive treatment based on symptoms.
No specific antidote; treat symptomatically.
HANDLING AND STORAGE
Handling:
Wear appropriate PPE including gloves, goggles, and lab coat.
Avoid inhalation of dust and contact with eyes and skin.
Use in a well-ventilated area or fume hood.
Ventilation:
Ensure local exhaust ventilation to minimize exposure to airborne particles.
Storage:
Store in a tightly closed container in a cool, dry, well-ventilated place.
Protect from moisture and direct sunlight.
Keep away from incompatible substances such as strong oxidizers.
Spill and Leak Procedures:
Avoid dispersal of dust.
Sweep up material and place in a suitable container for disposal.
Wash spill site with water and detergent after material removal.
Disposal:
Dispose of in accordance with local, regional, and national regulations.
Do not release into sewers or the environment.
