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HEDP

HEDP
CAS NO :2809-21-4
SYNONYMS :Etidronic acid;etidronate;2809-21-4;HEDP;1-Hydroxyethylidene-1,1-diphosphonic acid;EHDP;Etidronsaeure;Acetodiphosphonic acid;Hydroxyethanediphosphonic acid;Didronel;Turpinal SL;Oxyethylidenediphosphonic acid;Dequest 2015;Dequest Z 010;Acido etidronico;Ferrofos 510;Acide etidronique;1-Hydroxyethane-1,1-diphosphonate;1-Hydroxyethane-1,1-diphosphonic acid;Phosphonic acid, (1-hydroxyethylidene)bis-;Diphosphonate (base);(1-Hydroxyethane-1,1-diyl)diphosphonic acid;1-Hydroxyethanediphosphonic acid;Dequest 2010;Ethane-1-hydroxy-1,1-diphosphonic acid;(Hydroxyethylidene)diphosphonic acid;Ethane-1-hydroxy-1,1-diphosphonate;(1-Hydroxyethylene)diphosphonic acid;Acide etidronique [INN-French];Acido etidronico [INN-Spanish];Acidum etidronicum [INN-Latin];(1-Hydroxyethylidene)diphosphonic acid;1,1,1-Ethanetriol diphosphonate;1-Hydroxyethylidene-1,1-bisphosphonate;1-Hydroxyethane-1,1-bisphosphonic acid;1-HYDROXY-1,1-DIPHOSPHONOETHANE;(1-Hydroxyethylidene)bis(phosphonic acid);Acidum etidronicum;(1-Hydroxyethylidene)bisphosphonic acid;(1-hydroxyethane-1,1-diyl)bis(phosphonic acid);Hydroxyethane-1,1-diphosphonic acid;1000SL;(1-Hydroxyethylidene)diphoshonic acid;Etidronic acid [USAN:INN:BAN];RP 61;UNII-M2F465ROXU;1-Hydroxyethylidene-1,1-biphosphonate;Phosphonic acid, (1-hydroxyethylidene)di-;HSDB 5898;(1-hydroxy-1-phosphonoethyl)phosphonic acid;EINECS 220-552-8;Ethane-1-hydroxy-1,1-bisphosphonate;MFCD00070585;Phosphonic acid, 1-hydroxy-1,1-ethanediyl ester;CHEMBL871;NSC 227995;BRN 1789291;1-hydroxy-1,1-bisphosphonic acid;CHEBI:4907;(1-hydroxy-1-phosphono-ethyl)phosphonic acid;1-hydroxyethane 1,1-diphosphonic acid;NSC-227995;1-HydroxyEthylidene-1,1-DiphosphonicAcid;(1-Hydroxy-1,1-ethanediyl)bis(phosphonic acid);Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-;SMR000038750;NCGC00159352-02;Etidronic acid (USAN/INN);;C2H8O7P2;1-Hydroxyethylidenediphosphonic acid;1-hydroxy ethylidene;HDEPA;OEDFK;Etidronate (Didronel);Prestwick0_000863;Prestwick1_000863;Prestwick2_000863;Prestwick3_000863220-552-8;DSSTox_RID_76837;DSSTox_GSID_23028;SCHEMBL18607;BSPBio_000905;0-02-00-00171 (Beilstein Handbook Reference);MLS002207267;MLS002695948;SPBio_002826;BPBio1_000997;GTPL7184;2809-21-4 (freeacid);DTXSID6023028;CTK5C3439;M05BA01;HMS3604E03;HY-B0302;KS-00000WG2;ZINC3830813;Tox21_200417;ANW-46810;BBL028139;BDBM50115102;DL-390;Etidronic acid 60% aqueous solution;NSC227995;s1857;STK721995;AKOS005524039;Etidronic acid, 60% aqueous solution;CCG-266618;DB01077;MCULE-3037955142;(1-hydroxy-ethylidene)diphosphonic acid;NCGC00159352-04;NCGC00159352-05;NCGC00257971-01;K958;SC-25504;1-hydroxyethane-1,1-diyldiphosphonic acid;CAS-2809-21-4;1-hydroxy ethylidene-1,1-diphosphonic acid;LS-106637;FT-0607934;FT-0668439;NS00006820;(1-Hydroxy-1-phosphono-ethyl)-phosphonic acid;(1-hydroxyethan-1,1-diyl)bis(phosphonic acid);A11684;A23202;C07736;D02373;(1-Hydroxyethylidene)bisphosphonic acid monohydrate;J-504794;Q2758338;1-Hydroxy Ethylidene-1,1-Diphosphonic Acid (Powder);(1-Hydroxyethane-1,1-diyl)diphosphonic acid monohydrate;1-Hydroxyethylidenediphosphonic acid 60% aqueous solution;1-Hydroxyethane-1,1,-diphosphonic acid 60% aqueous solution;(1-hydroxyethylene)diphosphonic acid;(1-hydroxyethylene)diphosphonic acid, Tetrapotassium Salt;1 Hydroxyethane 1,1 Diphosphonate;1 Hydroxyethylidene 1,1 Bisphosphonate;1,1 hydroxyethylenediphosphonate;1,1-hydroxyethylenediphosphonate;1-Hydroxyethane-1,1-Diphosphonate;1-Hydroxyethylene Diphosphonate, Disodium;1-Hydroxyethylidene-1,1-Bisphosphonate;Dicalcium EHDP;Dicalcium Etidronate;Didronel;Diphosphonate, Disodium 1-Hydroxyethylene;Diphosphonic Acid, Hydroxyethylidene;Disodium 1 Hydroxyethylene Diphosphonate;Disodium 1-Hydroxyethylene Diphosphonate;Disodium Etidronate;EHDP;EHDP, Dicalcium;Ethanehydroxydiphosphonate;Ethanehydroxyphosphate;Etidronate;Etidronate Disodium;Etidronate, Dicalcium;Etidronate, Disodium;Etidronate, Sodium;Etidronate, Tetrapotassium Salt;Etidronic Acid;HEDP;HEDSPA;Hydroxyethanediphosphonate;Hydroxyethylidene Diphosphonic Acid;Phosphonic acid, (1-hydroxyethylidene)bis-, disodium salt;Salt Etidronate, Tetrapotassium;Sodium Etidronate;Tetrapotassium Salt Etidronate;Xidifon;Xidiphon;Xydiphone

HEDP
CAS NO :2809-21-4
SYNONYMS :Etidronic acid;etidronate;2809-21-4;HEDP;1-Hydroxyethylidene-1,1-diphosphonic acid;EHDP;Etidronsaeure;Acetodiphosphonic acid;Hydroxyethanediphosphonic acid;Didronel;Turpinal SL;Oxyethylidenediphosphonic acid;Dequest 2015;Dequest Z 010;Acido etidronico;Ferrofos 510;Acide etidronique;1-Hydroxyethane-1,1-diphosphonate;1-Hydroxyethane-1,1-diphosphonic acid;Phosphonic acid, (1-hydroxyethylidene)bis-;Diphosphonate (base);(1-Hydroxyethane-1,1-diyl)diphosphonic acid;1-Hydroxyethanediphosphonic acid;Dequest 2010;Ethane-1-hydroxy-1,1-diphosphonic acid;(Hydroxyethylidene)diphosphonic acid;Ethane-1-hydroxy-1,1-diphosphonate;(1-Hydroxyethylene)diphosphonic acid;Acide etidronique [INN-French];Acido etidronico [INN-Spanish];Acidum etidronicum [INN-Latin];(1-Hydroxyethylidene)diphosphonic acid;1,1,1-Ethanetriol diphosphonate;1-Hydroxyethylidene-1,1-bisphosphonate;1-Hydroxyethane-1,1-bisphosphonic acid;1-HYDROXY-1,1-DIPHOSPHONOETHANE;(1-Hydroxyethylidene)bis(phosphonic acid);Acidum etidronicum;(1-Hydroxyethylidene)bisphosphonic acid;(1-hydroxyethane-1,1-diyl)bis(phosphonic acid);Hydroxyethane-1,1-diphosphonic acid;1000SL;(1-Hydroxyethylidene)diphoshonic acid;Etidronic acid [USAN:INN:BAN];RP 61;UNII-M2F465ROXU;1-Hydroxyethylidene-1,1-biphosphonate;Phosphonic acid, (1-hydroxyethylidene)di-;HSDB 5898;(1-hydroxy-1-phosphonoethyl)phosphonic acid;EINECS 220-552-8;Ethane-1-hydroxy-1,1-bisphosphonate;MFCD00070585;Phosphonic acid, 1-hydroxy-1,1-ethanediyl ester;CHEMBL871;NSC 227995;BRN 1789291;1-hydroxy-1,1-bisphosphonic acid;CHEBI:4907;(1-hydroxy-1-phosphono-ethyl)phosphonic acid;1-hydroxyethane 1,1-diphosphonic acid;NSC-227995;1-HydroxyEthylidene-1,1-DiphosphonicAcid;(1-Hydroxy-1,1-ethanediyl)bis(phosphonic acid);Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-;SMR000038750;NCGC00159352-02;Etidronic acid (USAN/INN);;C2H8O7P2;1-Hydroxyethylidenediphosphonic acid;1-hydroxy ethylidene;HDEPA;OEDFK;Etidronate (Didronel);Prestwick0_000863;Prestwick1_000863;Prestwick2_000863;Prestwick3_000863220-552-8;DSSTox_RID_76837;DSSTox_GSID_23028;SCHEMBL18607;BSPBio_000905;0-02-00-00171 (Beilstein Handbook Reference);MLS002207267;MLS002695948;SPBio_002826;BPBio1_000997;GTPL7184;2809-21-4 (freeacid);DTXSID6023028;CTK5C3439;M05BA01;HMS3604E03;HY-B0302;KS-00000WG2;ZINC3830813;Tox21_200417;ANW-46810;BBL028139;BDBM50115102;DL-390;Etidronic acid 60% aqueous solution;NSC227995;s1857;STK721995;AKOS005524039;Etidronic acid, 60% aqueous solution;CCG-266618;DB01077;MCULE-3037955142;(1-hydroxy-ethylidene)diphosphonic acid;NCGC00159352-04;NCGC00159352-05;NCGC00257971-01;K958;SC-25504;1-hydroxyethane-1,1-diyldiphosphonic acid;CAS-2809-21-4;1-hydroxy ethylidene-1,1-diphosphonic acid;LS-106637;FT-0607934;FT-0668439;NS00006820;(1-Hydroxy-1-phosphono-ethyl)-phosphonic acid;(1-hydroxyethan-1,1-diyl)bis(phosphonic acid);A11684;A23202;C07736;D02373;(1-Hydroxyethylidene)bisphosphonic acid monohydrate;J-504794;Q2758338;1-Hydroxy Ethylidene-1,1-Diphosphonic Acid (Powder);(1-Hydroxyethane-1,1-diyl)diphosphonic acid monohydrate;1-Hydroxyethylidenediphosphonic acid 60% aqueous solution;1-Hydroxyethane-1,1,-diphosphonic acid 60% aqueous solution;(1-hydroxyethylene)diphosphonic acid;(1-hydroxyethylene)diphosphonic acid, Tetrapotassium Salt;1 Hydroxyethane 1,1 Diphosphonate;1 Hydroxyethylidene 1,1 Bisphosphonate;1,1 hydroxyethylenediphosphonate;1,1-hydroxyethylenediphosphonate;1-Hydroxyethane-1,1-Diphosphonate;1-Hydroxyethylene Diphosphonate, Disodium;1-Hydroxyethylidene-1,1-Bisphosphonate;Dicalcium EHDP;Dicalcium Etidronate;Didronel;Diphosphonate, Disodium 1-Hydroxyethylene;Diphosphonic Acid, Hydroxyethylidene;Disodium 1 Hydroxyethylene Diphosphonate;Disodium 1-Hydroxyethylene Diphosphonate;Disodium Etidronate;EHDP;EHDP, Dicalcium;Ethanehydroxydiphosphonate;Ethanehydroxyphosphate;Etidronate;Etidronate Disodium;Etidronate, Dicalcium;Etidronate, Disodium;Etidronate, Sodium;Etidronate, Tetrapotassium Salt;Etidronic Acid;HEDP;HEDSPA;Hydroxyethanediphosphonate;Hydroxyethylidene Diphosphonic Acid;Phosphonic acid, (1-hydroxyethylidene)bis-, disodium salt;Salt Etidronate, Tetrapotassium;Sodium Etidronate;Tetrapotassium Salt Etidronate;Xidifon;Xidiphon;Xydiphone

They are water treatment chemicals that are very heavily used in many industrial processes such as phosphonates, dispersants, bleaching agents or scale and corrosion inhibitors.
In many of these applications, HEDP (Hydroxyethylidophosphonic acid) can be regenerated with divalent cations such as calcium to form stable divalent cation phosphonate precipitates.
HEDP (Hydroxyethylidene Diphosphonic acid) is an organophosphoric acid inhibitor. It can bind with Zn (Zinc), Cu (Copper) and Fe (Iron) ions to form complex compounds. It can dissolve oxidized materials on these metals. HEDP (Hydroxyethylidophosphonic acid) shows excellent scale and corrosion preventive effects under 250 ° C.
HEDP (Hydroxyethylidene Diphosphonic acid) is difficult to hydrolyze under high pH value. And it has good Chemical stability, difficult to degrade under ordinary light and heat conditions.
Acid / Alkali and Chlorine oxidation tolerance of HEDP (Hydroxyethylidene Diphosphonic acid) is better than other organophosphoric acids (salts). HEDP (Hydroxyethylidene Diphosphonic acid) can form hexa-element chelating complex by reacting with metal ions in the water system, especially with calcium ion. Therefore, HEDP (Hydroxyethylidophosphonic acid) has good antiscale and visible threshold effects. It shows good synergistic effects when done with other water treatment chemicals.
HEDP (Hydroxyethylidene Diphosphonic acid) is suitable in its solid state, ie Crystal powder, in places where winter and room colds are experienced.
HEDP (Hydroxyethyliden Diphosphonic acid) is used as a cleaning agent in the electronics industry and as an additive in chemicals in daily life due to its high purity.
Also known as HEDP, etidronic acid and etidronate; It is a yellow colored, liquid bisphosphonate used in pharmaceutical, detergent, water treatment and cosmetics fields.
It was first patented in 1966 and approved for medical use in 1977.
HEDP is used as a retarder in concrete, lime and corrosion inhibition in the cold water system, oil field and low pressure boilers circulating in fields such as fertilizers in electrical energy, chemical industry, metallurgy and materials field.
In the paint industry, HEDP peroxide is used as a stabilizer and paint stabilizer; In non-cyanide electroplating, HEDP is used as a chelating agent. Dosages of 1–10 mg / L, as scale inhibitors, 10–50 mg / L as corrosion inhibitors, and concentrations of 1000-2000 mg / L are preferred as detergents.
Commonly, HEDP is used together with polycarboxylic acid (superplasticizer), where it acts as the reducing agent.
HEDP is a bisphosphonate used to strengthen bones, treat osteoporosis, and treat Paget's disease of bone.
Bisphosphonates reduce osteoclastic activity, which inhibits bone absorption first, thereby moving the bone absorption-formation balance in the direction of formation, thus making the bone stronger for a long time.
Etidronate is a penetrating agent. It can be discharged as a component of gray wastewater. And potentially contaminating groundwater resources; It can be added against the effects of substances such as calcium, iron or other metal ions or against their effects up to a certain level.
As a phosphonate it has anti-corrosive properties on unalloyed steel. Etidronic acid also delays lipid oxidation of fatty acids.
HEDP and its salts are added to detergents and other hygiene items to prevent the effects of hard water. It is also used in peroxide bleaching to prevent degradation of peroxides by transition metals.
Etidronic acid is among swimming pool chemicals. It is used as an anti-stain agent to prevent metal ions from coming out of solution and staining the edges of swimming pools.

HEDP (Hydroxyethyliden Diphosphonic Acid) What Are The Uses?
HEDP (Hydroxyethylidene Diphosphonic acid), Chemical industry, Electric Energy, Metallurgy, Fertilizer etc. It is used as a scale and corrosion inhibitor in circulating cold water systems in areas such as oil field and low pressure boilers.
HEDP (Hydroxyethylidene Diphosphonic acid) to prevent the formation of scales contaminating heat transfer surfaces in industrial water treatment systems such as cooling, boiler water treatment.
HEDP (Hydroxyethylidophosphonic acid), To prevent the precipitation of Fe (Iron) and Mn (Manganese) Oxides in municipal water systems.
HEDP (Hydroxyethylidene Diphosphonic acid), for inhibition on scales for desalination i.e. removal.
HEDP (Hydroxyethylidene Diphosphonic acid), For Stain and Scale control in swimming pools.
HEDP (Hydroxyethylidene Diphosphonic acid) for peroxide bleach stabilization in Industrial and Institutional detergents class cleaners and Personal care products.
HEDP (Hydroxyethylidene Diphosphonic acid) is a Chemical of choice in industrial water treatment versus phosphonates such as SHMP, due to its Hydrolytic stability and ability to be a scale inhibitor.
HEDP (Hydroxyethylidene Diphosphonic acid) is the only phosphonate used in municipal water treatment and Personal care products.
HEDP (Hydroxyethylidene Diphosphonic acid) is technical grade So there is no Food grade.
HEDP (Hydroxyethylidene Diphosphonic acid) is used as a drinking water additive at some rates in some countries.
HEDP (Hydroxyethylidene Diphosphonic acid) is used as metal and nonmetal detergent in light weaving industry.
HEDP (Hydroxyethylidene Diphosphonic acid) is used in the paint industry as a Peroxide stabilizer and dye fixing agent.
HEDP (Hydroxyethylidene Diphosphonic acid) is used as a chelating agent in electroplating without cyanide.

What are the Physical Properties of HEDP (Hydroxyethylidene Diphosphonic Acid)?
HEDP (Hydroxyethylidene Diphosphonic acid) belongs to the class of Chemicals called phosphonates added to water to increase the solubility of certain ions and prevent precipitation of certain mineral compounds. Some phosphonates and polyphosphates as 'Chelating Agents' are used to treat water systems by inactivating metal ions in water.
HEDP (Hydroxyethylidene Diphosphonic acid) has a unique Chemical formula and physical properties. It is water soluble. It is white or pale yellow in color. One of its most important properties has a chloride level of less than 0.1%. It is usually sold in 60% aqueous solution.

How is HEDP (Hydroxyethylidine Diphosphonic Acid) Production?
HEDP (Hydroxyethylidene Diphosphonic acid) is usually produced in glass lined reactors using phosphorous acid or phosphorus trichloride as raw materials. They produce Acetic Acid (CH3COOH) jointly in both processes.

HEDP (Hydroxyethylidene Diphosphonic Acid) How to Use?
1-10 mg / L dosage scale inhibitor, 10-50 mg / L dosage corrosion inhibitor, 1000-2000 mg / L dosage Generally used with HEDP (Hydroxyethylidene Diphosphonic acid) polycarboxylic acid as detergent.
HEDP (Hydroxyethylidene Diphosphonic acid) Liquid; 200 L Plastic drum, IBC (1000 L) may vary according to the customer's request.
HEDP (Hydroxyethylidene Diphosphonic acid) Solid; 25 Kg / Bag, which may vary according to the customer's demand.
It can be stored in a shady room and dry place for 10 months.

Mechanism of Action Help
Bisphosphonates are taken into the bone where they bind to hydroxyapatite. Bone resorption by osteoclasts causes local acidification, releasing the bisphosphonate, which is taken into the osteoclast by fluid-phase endocytosis.[A959] Endocytic vesicles become acidified, releasing bisphosphonates into the cytosol of osteoclasts where they act.[A959] Osteoclasts mediate resorption of bone.[A6366] When osteoclasts bind to bone they form podosomes, ring structures of F-actin.[A6366] Disruption of the podosomes causes osteoclasts to detach from bones, preventing bone resorption.[A6366] First generation bisphosphonates closely mimic the structure of pyrophosphate, which can be incorporated into ATP anologues that cannot be hydrolyzed, disrupting all ATP mediated actions of osteoclasts.[A203360]
Industry Uses Help
Corrosion inhibitors and anti-scaling agents
Finishing agents
Intermediates
Plating agents and surface treating agents
Processing aids, not otherwise listed
Solvents (for cleaning and degreasing)
Surface active agents
used in detergent manufacture

Consumer Uses Help
Automotive care products
Building/construction materials - wood and engineered wood products
Cleaning and furnishing care products
Fabric, textile, and leather products not covered elsewhere
Lubricants and greases
Metal products not covered elsewhere
Water treatment products

Industry Processing Sectors
All other basic inorganic chemical manufacturing
All other basic organic chemical manufacturing
All other chemical product and preparation manufacturing
Fabricated metal product manufacturing
Machinery manufacturing
Miscellaneous manufacturing
Oil and gas drilling, extraction, and support activities
Paper manufacturing
Petroleum lubricating oil and grease manufacturing
Plastics product manufacturing
Rubber product manufacturing
Soap, cleaning compound, and toilet preparation manufacturing
Textiles, apparel, and leather manufacturing
Utilities
Wholesale and retail trade
Wood product manufacturing

Also known as HEDP, etidronic acid and etidronate; It is a yellow colored, liquid bisphosphonate used in pharmaceutical, detergent, water treatment and cosmetics fields.
It was first patented in 1966 and approved for medical use in 1977.
HEDP is used as a retarder in concrete, lime and corrosion inhibition in the cold water system, oil field and low pressure boilers circulating in fields such as fertilizers in electrical energy, chemical industry, metallurgy and materials field.
In the paint industry, HEDP peroxide is used as a stabilizer and paint stabilizer; In non-cyanide electroplating, HEDP is used as a chelating agent. Dosages of 1–10 mg / L, as scale inhibitors, 10–50 mg / L as corrosion inhibitors, and concentrations of 1000-2000 mg / L are preferred as detergents.
Commonly, HEDP is used together with polycarboxylic acid (superplasticizer), where it acts as the reducing agent.
HEDP is a bisphosphonate used to strengthen bones, treat osteoporosis, and treat Paget's disease of bone.
Bisphosphonates reduce osteoclastic activity, which inhibits bone absorption first, thereby moving the bone absorption-formation balance in the direction of formation, thus making the bone stronger for a long time.
Etidronate is a penetrating agent. It can be discharged as a component of gray wastewater. And potentially contaminating groundwater resources; It can be added against the effects of substances such as calcium, iron or other metal ions or against their effects up to a certain level.
As a phosphonate it has anti-corrosive properties on unalloyed steel. Etidronic acid also delays lipid oxidation of fatty acids.
HEDP and its salts are added to detergents and other hygiene items to prevent the effects of hard water. It is also used in peroxide bleaching to prevent degradation of peroxides by transition metals.
Etidronic acid is among swimming pool chemicals. It is used as an anti-stain agent to prevent metal ions from coming out of solution and staining the edges of swimming pools.

Signal Danger
GHS Hazard Statements 
H290 (27.24%): May be corrosive to metals [Warning Corrosive to Metals]
H302 (51.71%): Harmful if swallowed [Warning Acute toxicity, oral]
H314 (26.82%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H318 (91.75%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
H413 (26.64%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statement Codes 
P234, P260, P264, P270, P273, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P363, P390, P404, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)

ECHA C&L Notifications Summary 
Aggregated GHS information provided by 2205 companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Reported as not meeting GHS hazard criteria by 35 of 2205 companies. For more detailed information, please visit ECHA C&L website.
Of the 27 notification(s) provided by 2170 of 2205 companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Etidronic acid is a bisphosphonate used to strengthen bone, treat osteoporosis, and treat Paget's disease of bone.
Bisphosphonates primarily reduce osteoclastic activity, which prevents bone resorption, and thus moves the bone resorption/formation equilibrium toward the formation side and hence makes bone stronger on the long run. Etidronate, unlike other bisphosphonates, also prevents bone calcification. For this reason, other bisphosphonates, such as alendronate, are preferred when fighting osteoporosis. To prevent bone resorption without affecting too much bone calcification, etidronate must be administered only for a short time once in a while, for example for two weeks every 3 months. When given on a continuous basis, say every day, etidronate will altogether prevent bone calcification. This effect may be useful and etidronate is in fact used this way to fight heterotopic ossification. But in the long run, if used on a continuous basis, it will cause osteomalacia.
HEDP is used as a retardant in concrete, scale and corrosion inhibition in circulating cool water system, oil field and low-pressure boilers in fields such as electric power, chemical industry, metallurgy, fertilizer, etc. In light woven industry, HEDP is used as detergent for metal and nonmetal. In dyeing industry, HEDP is used as peroxide stabilizer and dye-fixing agent; In non-cyanide electroplating, HEDP is used as chelating agent. The dosage of 1–10 mg/L is preferred as scale inhibitor, 10–50 mg/L as corrosion inhibitor, and 1000–2000 mg/L as detergent. Usually, HEDP is also used together with polycarboxylic acid (superplasticizer), in which it acts as reducing agent.
Etidronic acid is a chelating agent and may be added to bind or, to some extent, counter the effects of substances, such as calcium, iron or other metal ions, which may be discharged as a component of grey wastewater and could conceivably contaminate groundwater supplies. As a phosphonate it has corrosion inhibiting properties on unalloyed steel. Etidronic acid also acts to retard rancidification and oxidation of fatty acids.
HEDP and its salts are added to detergents and other cleaning agents to prevent the effects of hard water. It is also used in peroxide bleaching to prevent degradation of peroxides by transition metals.
Etidronic acid is listed as an ingredient of several cosmetic formulations where it is used for suppressing radical formation, emulsion stabiliser and viscosity control. While etidronic acid has not been limited from inclusion in cosmetics and does have legitimate uses, it is recommended that, as with most cosmetic products (particularly soaps), the product should be thoroughly rinsed from the skin after use.
Etidronic acid is also included among swimming pool chemicals. It is used as a stain inhibitor to prevent metal ions coming out of solution and staining the sides of swimming pools.

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