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HEPTAETHYLENE GLYCOL

Heptaethylene Glycol = 3,6,9,12,15,18-Hexaoxaicosane-1,20-diol

CAS Number: 5617-32-3
EC Number : 227-040-3
PubChem CID : 79718
Molecular Formula : C14H30O8
Molecular Weight: 326.38

Heptaethylene glycol is a poly(ethylene glycol).
Heptaethylene glycol contains repeating ethylene glycol subunits and two terminal hydroxyl groups.
The hydroxyl groups can react to further derivatize the compound.
The hydrophilic PEG linker increases the water solubility of a compound in aqueous media.
The water solubility properties of the PEG linker are enhanced with longer PEG chains.

Application of Heptaethylene Glycol
O-(2-Azidoethyl)heptaethylene glycol is used to synthesize oligo and poly(ethylene glycol) derivatives that are used as structural units of dendrimers, hydrogels, surface modifiers, self-assembling systems and molecular crosslinkers. This precursor is compatible for acetylene-azide click reactions.

Some of the reported applications include:
-Synthesis of strain-stiffening hydrogels through self-assembly of oligomers fibres derived from Azido-PEG (n=7).
-Synthesis of biodegradable tetra-PEG hydrogels for drug delivery system.
-Synthesis of heterobifunctional oligo(ethylene glycol) linkers for bioconjugation and targeted drug delivery.
-Preparation of synthetic amphiphiles for programmed pH-dependent dispersions of carbon nanotubes (CNTs).
-Selective glycoprotein detection through allosteric click-imprinting by using a self-assembled monolayer developed from the above oligomer.
-Preparation of bioactivated quantum dot micelles containing fluorescent nanocrystals.

Heptaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Use and Manufacturing of Heptaethylene Glycol
Use Classification
EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives

The therapeutic efficacy of Antihemophilic factor (recombinant), PEGylated can be decreased when used in combination with Heptaethylene glycol.
The therapeutic efficacy of Certolizumab pegol can be decreased when used in combination with Heptaethylene glycol.
The therapeutic efficacy of Damoctocog alfa pegol can be decreased when used in combination with Heptaethylene glycol.
The therapeutic efficacy of Elapegademase can be decreased when used in combination with Heptaethylene glycol.
The therapeutic efficacy of Lipegfilgrastim can be decreased when used in combination with Heptaethylene glycol.
The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Heptaethylene glycol.

The therapeutic efficacy of Nonacog beta pegol can be decreased when used in combination with Heptaethylene glycol.
The therapeutic efficacy of Heptaethylene glycol can be decreased when used in combination with Pegademase.
The therapeutic efficacy of Pegaptanib can be decreased when used in combination with Heptaethylene glycol.
The therapeutic efficacy of Heptaethylene glycol can be decreased when used in combination with Pegaspargase.

This compound belongs to the class of organic compounds known as polyethylene glycols.
These are oligomers or polymers of ethylene oxide, with the general formula (C2H4O)n (with n>=3).

Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture.
In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Heptaethylene glycol is a boronic acid that can be used as a label for the detection of cancer.
Heptaethylene glycol is synthesized by the reaction of 2-azidoethanol with 1,4-diethylene glycol.
The compound has been shown to have constant molecular weight and may be detected using surface plasmon resonance (SPR) or resonance spectroscopy.
The compound can be used in assays to detect cancer and other diseases, such as Alzheimer's disease.

Heptaethylene glycol 350 is a polymer similar in structure and nomenclature to polyethylene glycols.
Heptaethylene glycol 350 has been used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.
Heptaethylene glycol has also been used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.

Heptaethylene Glycol - belongs to the category of Fine Chemicals and is used as a reference standard in research.
The CAS Number of Heptaethylene Glycol is 5617-32-3.

Heptaethylene glycol belongs to the class of organic compounds known as polyethylene glycols.
These are oligomers or polymers of ethylene oxide, with the general formula (C2H4O)n (with n>=3).
Heptaethylene glycol is slightly soluble (in water) and a very weakly acidic compound (based on its pKa).
Heptaethylene glycol has been detected in multiple biofluids, such as feces and saliva.
Heptaethylene glycol is a poly(ethylene glycol).

Heptaethylene glycol linkers are used in bioconjugation and pegylation applications.
Lumiprobe offers a range of PEG products with different linker lengths, bearing various reactive groups.
Heptaethylene glycol oligomers derivatives have a very interesting application as tracers and markers in many fields from anticounterfeiting in pharmaceuticals and cosmetics to personalized drugs test signature or identification of oil spillage criminals.
With an oligomer purity over 98%, and less of 1% n-1 present, our defined PEG compounds are easy to detect and give uncompromised identification.
Readily derivatized, they can give endless tracers combinations for many monitoring applications. Thus non-toxic and biocompatible, they are safe and environmentally friendly.
We provide diol, mPEG and Dimethoxy PEG as well as functionalized Diamines, Sulfonates and Phenyl ethers derivatives PEG lengths from n=4 to 12.

SPECIFICATIONS & PROPERTIES of Heptaethylene Glycol
Min. Purity Spec:   98% (GC)
Physical Form (at 20°C):   Liquid
Boiling Point:   244°C
Flash Point:   110°C
Refractive Index:   1.458-1.469
Long-Term Storage:   Store long-term in a cool, dry place.

Polyethylene glycols, such as nonaethylene glycol monomethyl ether, are useful in a number of areas, including for example, as plasticizers, softeners, humectants, ointments, polishes, paper coatings, mold lubricants, bases for cosmetics and pharmaceuticals, solvents, binders, metal and rubber processing, food additives, chemical intermediates, phase transfer catalysts, polymer-bound reagents, reagents for binding assays, processes for protein and cell purification, peptide synthesis and as modifiers for a variety of substrates, including pharmaceutically active agents.

In particular, polyethylene glycols have been used as covalent modifiers of both low molecular weight compounds and biological macromolecules, predominantly to allow for the alteration of one or more of the properties of the substrate.
For example, polyethylene glycol may be used to improve solubility, increase molecular weight or change a substrate's partition properties in a biphasic system.

Heptaethylene glycol is a kind of non-ionic detergent which can be utilized as a source of carbon and energy by an organism isolated from activated sludge.
Heptaethylene glycol is a useful research chemical.
Buy high-quality Heptaethylene glycol di(p-toluenesulfonate) from Biosynth-Carbosynth for a variety of research applications.
We also offer Heptaethylene glycol di(p-toluenesulfonate) in bulk quantities in addition to our standard pack sizes.

First-aid measures of Heptaethylene glycol
Eye Contact
- Do not rub your eyes.
- Immediately flush eyes with plenty of water for at least 15 minutes and call a doctor/physician.
- Get medical attention immediately.

Skin Contact
- Flush skin with plenty of wter for at least 15 minutes while removing contaminated clothing
and shoes.
- Laundering enough contaminated clothing before reuse.
- Get medical attention immediately.

Inhalation
- When exposed to large amounts of steam and mist, move to fresh air.
- Take specific treatment if needed.
- Get medical attention immediately.

Ingestion
- About whether I should induce vomiting Take the advice of a doctor.
- Rinse your mouth with water immediately.
- Get medical attention immediately.

Delayed and immediate effects and also chronic effects from short and long term exposure
- Not available

Notes to Physician
- Notify medical personnel of contaminated situations and have them take appropriate protective
measures.

Suitable (Unsuitable) extinguishing media
- Avoid use of water jet for extinguishing

Specific hazards arising from the chemical
- Not available

Special protective actions for fire-fighters
- Move containers from fire area, if you can do without the risk.
- Keep unauthorized personnel out.
- Withdraw immediately in case of rising sound from venting safety devices or discoloration of
tank.
- Using a unattended and water devices in case of large fire and leave alone to burn if you do
not imperative.
- Do not access if the tank on fire.
- Vapor or gas is burned at distant ignition sources can be spread quickly.
- The extremely low flash point made by fire-fighters may be less effective at digesting weeks.

Accidental release measures of Heptaethylene glycol
Personal Precautions, protective equipment and emergency procedures
- Wear proper personal protective apparatus as indicated in Section 8 and avoid skin contact and
inhalation.
- Must work against the wind, let the upwind people to evacuate.
- Move container to safe area from the leak area.
- Remove all sources of ignition.
- Do not direct water at spill or source of leak.

Environmental precautions
- Prevent runoff and contact with waterways, drains or sewers.
- if large amounts have been spilled, inform the relevant authorities.

Methods and materials for containment and cleaning up
- Large spill : Stay upwind and keep out of low areas. Dike for later disposal.
- Notification to central government, local government. When emissions at least of the standard
amount.
- Dispose of waste in accordance with local regulation.
- Appropriate container for disposal of spilled material collected.
- Small leak: sand or other non-combustible material, please let use absorption.
- Wipe off the solvent.
- Dike for later disposal.
- Do not use plastic containers.

Handling and storage of Heptaethylene glycol
Precautions for safe handling
- Avoid contact with incompatible materials.
- Dealing only with a well-ventilated place.
- Do not handle until all safety precautions have been read and understood.
- Operators should wear antistatic footwear and clothing.
- Do not inhale the steam prolonged or repeated.
- Avoid contact with heat, sparks, flame or other ignition sources.

Substance identity

EC / List no.: 227-040-3
CAS no.: 5617-32-3
Mol. Formula: C14H30O8

Synonyms:
Heptaethylene glycol
5617-32-3
3,6,9,12,15,18-Hexaoxaicosane-1,20-diol
HO-PEG7-OH
3,6,9,12,15,18-Hexaoxaeicosane-1,20-diol
2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
CHEBI:44748
MFCD00002876
124346-03-8
1,4,8,11-TETRAAZACYCLOTETRADECANE, TETRAHYDROCHLORIDE
HEPTAETHYLENE GLYCOL, PEG330
C14H30O8
EINECS 227-040-3
OH-PEG7-OH
Epitope ID:161055
SCHEMBL147226
AMY4468
DTXSID10204698
BCP29445
ZINC5178829
HEPTAETHYLENE GLYCOL; PEG330
AKOS015839804
DB03394
DS-7472
MCULE-1389453612
s10699
BP-22860
SY045925
HY-141231
CS-0115002
FT-0740524
H1045
Y4960
A870001
3,6,9,12,15,18-Hexaoxaicosane-1,20-diol #
J-511382
Q27120576
3,6,9,12,15,18-Hexaoxaeicosane-1,20-diol;HO-PEG7-OH
3,6,9,12,15,18-hexaoxaicosane-1,20-diol
3,6,9,12,15,18-Hexaoxaicosane-1,20-diol
3,6,9,12,15,18-hexaoxaicosane-1,20-diol
Polyethylene glycol 350
2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
3,6,9,12,15,18-hexaoxaicosane-1,20-diol
5617-32-3
3,6,9,12,15,18-hexaoxaicosane-1,20-diol
3,6,9,12,15,18-Hexaoxaicosane-1,20-diol