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Hexamethylene Tetramine is a heterocyclic amine compound commonly known as a formaldehyde donor, and Hexamethylene Tetramine is widely used in resin chemistry, rubber processing, pharmaceuticals, and specialty industrial applications.
Hexamethylene Tetramine is valued for controlled release of reactive formaldehyde under specific conditions, strong utility in phenolic and amino resin systems, and reliable performance as a curing agent or crosslinking contributor in selected processes.
Hexamethylene Tetramine is also used in some medical and laboratory contexts, but Hexamethylene Tetramine handling requires appropriate precautions because Hexamethylene Tetramine dust can irritate eyes and airways and Hexamethylene Tetramine can decompose to release formaldehyde under heat or acidic conditions.
CAS Number: 100-97-0
EC Number: 202-905-8
Molecular Formula: C6H12N4
Molecular Weight: 140.19 g/mol
Synonyms: Hexamethylene Tetramine, Hexamethylenetetramine, Hexamine, Methenamine, Urotropine, Hexametilen Tetramin (variant spelling), Hexa (common short name), Methenamine Base, Hexamine Powder, Hexamethylenetetramine Technical, Hexamethylenetetramine Reagent, Hexamethylene Tetramine Formaldehyde Donor, Hexamethylene Tetramine, Hexamethylenetetramine, Hexamine, Methenamine, Methenamine Base, Methenamine (INN), Methenamine (USAN), Urotropine, Urotropin, Urotropinum, Hexamethylenamine, Hexamethyleneamine (common misspelling variant), Hexamethylene-tetramine, Hexamethylenetetramine (HMTA), Hexamethylenetetramine (HMT), Hexamine (HMT), Hexamine Fuel (use context), Hexamine Fuel Tablets (use context), Solid Fuel Hexamine (use context), Formaldehyde-Ammonia Condensate, Ammonia-Formaldehyde Condensation Product, Formaldehyde Condensation Product with Ammonia, 1,3,5,7-Tetraazatricyclo[3.3.1.1^3,7]decane, 1,3,5,7-Tetraazatricyclodecane (variant), Tetraazaadamantane, Tetramine (common short name), Hexamethylenetetramine Reagent, Hexamethylenetetramine Analytical Grade, Hexamethylenetetramine Laboratory Grade, Hexamethylenetetramine Technical Grade, Hexamethylenetetramine Industrial Grade, Hexamethylenetetramine High Purity, Hexamethylenetetramine 99%, Hexamethylenetetramine 98%, Hexamethylenetetramine Powder, Hexamethylenetetramine Crystals, Hexamethylenetetramine Granules, Methenamine Powder, Methenamine Crystals, Urotropine Powder, Urotropine Crystals, Hexamine Powder, Hexamine Crystals, Hexamine Granules, Hexamethylenetetramine (CAS 100-97-0), CAS 100-97-0, Hexamethylene Tetramine (C6H12N4), C6H12N4, Hexamethylene Tetramine (EC 202-905-8), EC 202-905-8, Methenamine (CAS 100-97-0), Urotropine (CAS 100-97-0), Hexamine (CAS 100-97-0), Hexamethylenetetramine USP, Hexamethylenetetramine EP, Hexamethylenetetramine BP, Hexamethylenetetramine FCC, Hexamethylenetetramine ACS, Hexamethylenetetramine AR, Hexamethylenetetramine GR, Hexamethylenetetramine LR, Methenamine Hippurate (related salt), Methenamine Mandelate (related salt), Urotropine (Latin/legacy name), Hexamethylentetramin
APPLICATIONS
Hexamethylene Tetramine is used as a curing agent in phenolic resin systems to promote crosslinking and improve heat resistance.
Hexamethylene Tetramine is incorporated into phenolic molding compounds to support fast curing and strong final mechanical properties.
Hexamethylene Tetramine is used in friction materials such as brake and clutch linings to support phenolic resin cure and performance stability.
Hexamethylene Tetramine is used in rubber compounding as a crosslinking contributor and formaldehyde donor in specific bonding and resin cure systems.
Hexamethylene Tetramine is incorporated into rubber-to-metal bonding formulations where controlled formaldehyde release supports adhesion chemistry.
Hexamethylene Tetramine is used in elastomer composites to improve strength and heat stability in compatible resin-modified systems.
Hexamethylene Tetramine is used in foundry binders and sand core processes where resin curing requires a controlled hardening agent.
Hexamethylene Tetramine is incorporated into no-bake and hot-box processes to support binder curing and dimensional stability.
Hexamethylene Tetramine is used in casting applications to improve mold strength and reduce defects linked to insufficient binder cure.
Hexamethylene Tetramine is used in wood adhesives and resin systems as a curing promoter in compatible phenolic-based formulations.
Hexamethylene Tetramine is incorporated into laminating resins to support heat-cure performance and bond strength.
Hexamethylene Tetramine is used in insulation and composite manufacturing where phenolic resin curing is required.
Hexamethylene Tetramine is used in industrial coatings and impregnating resins to support crosslinking and improve chemical resistance.
Hexamethylene Tetramine is incorporated into protective coatings where heat-cured phenolic chemistry provides durability.
Hexamethylene Tetramine is used in specialty ink and varnish systems where resin structure and cure behavior are optimized.
Hexamethylene Tetramine is used in chemical synthesis as a nitrogen source, intermediate, or formaldehyde equivalent in selected reactions.
Hexamethylene Tetramine is incorporated into laboratory synthesis pathways where controlled formaldehyde release is beneficial.
Hexamethylene Tetramine is used in research applications to generate or trap reactive intermediates under defined conditions.
Hexamethylene Tetramine is used in pharmaceuticals as methenamine, where Hexamethylene Tetramine can act as a urinary antiseptic under appropriate medical use.
Hexamethylene Tetramine is incorporated into regulated dosage forms where acidic urinary conditions support conversion to active formaldehyde.
Hexamethylene Tetramine is used in medical products only within approved indications, dosing, and regulatory frameworks.
Hexamethylene Tetramine is used in solid fuel tablets for camping and emergency heating, where Hexamethylene Tetramine provides reliable combustion.
Hexamethylene Tetramine is incorporated into compact fuel blocks designed for long shelf life and stable performance.
Hexamethylene Tetramine is used in field and survival products where clean, consistent burning is required.
Hexamethylene Tetramine is used in corrosion inhibition and water-treatment concepts in specialized systems where compatibility is verified.
Hexamethylene Tetramine is incorporated into industrial maintenance formulations where amine chemistry supports performance targets.
Hexamethylene Tetramine is valued because Hexamethylene Tetramine provides versatile curing, bonding, and specialty performance as a stable, easy-to-handle solid.
Hexamethylene Tetramine is used as a curing agent in phenolic resin systems.
Hexamethylene Tetramine supports crosslinking of novolac phenolic resins during molding.
Hexamethylene Tetramine improves final hardness and heat resistance in phenolic molded parts.
Hexamethylene Tetramine is used in phenolic molding compounds for electrical and industrial components.
Hexamethylene Tetramine supports fast cure and good dimensional stability in compression molding.
Hexamethylene Tetramine helps produce heat-resistant parts for switches, terminals, and housings.
Hexamethylene Tetramine is used in friction materials such as brake pads and clutch facings.
Hexamethylene Tetramine supports phenolic binder curing that contributes to strength and wear resistance.
Hexamethylene Tetramine helps improve thermal stability of friction composites under braking heat.
Hexamethylene Tetramine is used in foundry resin systems as a hardener for phenolic and related binders.
Hexamethylene Tetramine supports sand core and mold strength development in casting operations.
Hexamethylene Tetramine helps improve shakeout behavior and reduces defects in properly balanced systems.
Hexamethylene Tetramine is used in rubber compounding as a vulcanization aid in certain systems.
Hexamethylene Tetramine supports curing reactions in chloroprene and some specialty elastomer formulations.
Hexamethylene Tetramine helps improve heat resistance and compression set performance in selected compounds.
Hexamethylene Tetramine is used in adhesive and sealant systems based on phenolic resins.
Hexamethylene Tetramine supports controlled cure to achieve strong, heat-resistant bonds.
Hexamethylene Tetramine helps improve chemical resistance in phenolic adhesive joints.
Hexamethylene Tetramine is used in coating formulations where phenolic resins require crosslinking.
Hexamethylene Tetramine supports bake-cure coatings with improved hardness and solvent resistance.
Hexamethylene Tetramine helps improve film durability in heat-cured industrial coatings.
Hexamethylene Tetramine is used in production of laminated materials using phenolic resins.
Hexamethylene Tetramine supports curing in phenolic-impregnated paper and fabric laminates.
Hexamethylene Tetramine helps improve mechanical strength and heat resistance of laminates.
Hexamethylene Tetramine is used in abrasive products such as grinding wheels and sanding materials.
Hexamethylene Tetramine supports phenolic binder curing that anchors abrasive grains.
Hexamethylene Tetramine helps improve wheel strength and performance at elevated temperatures.
Hexamethylene Tetramine is used in refractory and insulation composites that use phenolic binders.
Hexamethylene Tetramine supports binder cure for improved shape retention and handling strength.
Hexamethylene Tetramine helps improve heat stability in bonded refractory shapes.
Hexamethylene Tetramine is used as an intermediate in chemical synthesis for specialty chemicals.
Hexamethylene Tetramine supports production routes that require formaldehyde and ammonia-derived building blocks.
Hexamethylene Tetramine helps provide a stable solid source for reactive formaldehyde equivalents in some reactions.
Hexamethylene Tetramine is used in laboratory chemistry as a formaldehyde donor under acidic conditions.
Hexamethylene Tetramine supports controlled release of formaldehyde for selected synthetic procedures.
Hexamethylene Tetramine helps enable reactions where gradual formaldehyde availability is preferred.
Hexamethylene Tetramine is used in pharmaceutical manufacturing as an intermediate for certain APIs and excipients.
Hexamethylene Tetramine supports synthesis steps where regulated formaldehyde input is required.
Hexamethylene Tetramine helps improve handling versus direct formaldehyde solutions in some processes.
Hexamethylene Tetramine is used in medical products as the active component of urinary antiseptic medicines where approved.
Hexamethylene Tetramine supports formaldehyde generation in acidic urine for antimicrobial effect in regulated therapy.
Hexamethylene Tetramine helps manage recurrent urinary tract infection prophylaxis under medical guidance where used.
Hexamethylene Tetramine is used in veterinary urinary antiseptic applications in some approved products.
Hexamethylene Tetramine supports urinary antimicrobial approaches under veterinary supervision.
Hexamethylene Tetramine helps reduce bacterial growth in urinary systems in specific treatment contexts.
Hexamethylene Tetramine is used in corrosion inhibition systems for metal protection in acidic environments.
Hexamethylene Tetramine supports formation of protective films on steel in certain pickling and cleaning processes.
Hexamethylene Tetramine helps reduce acid attack and metal loss when properly formulated.
Hexamethylene Tetramine is used in metal pickling inhibitors to reduce corrosion during acid cleaning.
Hexamethylene Tetramine supports controlled cleaning while minimizing base metal dissolution.
Hexamethylene Tetramine helps improve surface quality before coating or plating operations.
Hexamethylene Tetramine is used in electroplating baths as an additive in some formulations.
Hexamethylene Tetramine supports deposit quality by influencing complexation and bath behavior.
Hexamethylene Tetramine helps reduce defects and improve brightness in certain plating systems.
Hexamethylene Tetramine is used in textile finishing as a crosslinking aid for crease resistance in some treatments.
Hexamethylene Tetramine supports durable press finishes when compatible with the resin system.
Hexamethylene Tetramine helps improve fabric dimensional stability in selected finishing processes.
Hexamethylene Tetramine is used in paper and board wet-strength resin systems in some technologies.
Hexamethylene Tetramine supports crosslinking reactions that improve wet strength of paper products.
Hexamethylene Tetramine helps improve durability of packaging exposed to moisture in selected designs.
Hexamethylene Tetramine is used in specialty concrete and construction admixtures in limited chemistries.
Hexamethylene Tetramine supports controlled formaldehyde release for certain resin-based modifiers.
Hexamethylene Tetramine helps improve performance of resin-modified construction products in niche applications.
Hexamethylene Tetramine is used in pyrotechnic and solid fuel contexts as a fuel component in regulated products.
Hexamethylene Tetramine supports compact fuel tablet manufacturing for camping and emergency use where approved.
Hexamethylene Tetramine helps produce clean-burning solid fuel tablets when formulated correctly.
Hexamethylene Tetramine is used in emergency and outdoor solid fuel tablets for cooking and heating.
Hexamethylene Tetramine supports lightweight, stable fuel sources for field kits.
Hexamethylene Tetramine helps provide predictable burn behavior in standardized tablet formats.
Hexamethylene Tetramine is used in laboratory microbiology as a component in certain fixatives and staining solutions.
Hexamethylene Tetramine supports preparation of buffered formaldehyde-type reagents in specific protocols.
Hexamethylene Tetramine helps provide controlled formaldehyde availability in compatible lab reagents.
Hexamethylene Tetramine is used in analytical chemistry as a reagent in some derivatization and buffer systems.
Hexamethylene Tetramine supports pH control and reagent stability in selected analytical methods.
Hexamethylene Tetramine helps improve reproducibility in certain assays.
Hexamethylene Tetramine is used in polymer research as a crosslinker model compound for thermoset studies.
Hexamethylene Tetramine supports evaluation of cure kinetics and network formation in phenolic systems.
Hexamethylene Tetramine helps tune cure speed and final properties in experimental resin formulations.
Hexamethylene Tetramine is used in manufacturing of brake linings to improve processing and final strength.
Hexamethylene Tetramine supports consistent cure across thick friction material parts.
Hexamethylene Tetramine helps reduce scrap by improving cure uniformity and dimensional control.
Hexamethylene Tetramine is used in abrasive belt and disc manufacturing using phenolic binders.
Hexamethylene Tetramine supports consistent cure during oven processing.
Hexamethylene Tetramine helps improve bond strength between abrasive grains and backing.
Hexamethylene Tetramine is used in phenolic-based insulation foams and composites in specialized applications.
Hexamethylene Tetramine supports curing and structural development of phenolic matrices.
Hexamethylene Tetramine helps improve heat resistance and smoke performance in phenolic materials.
Hexamethylene Tetramine is used in industrial maintenance to prepare phenolic resin repair compounds.
Hexamethylene Tetramine supports onsite cure of phenolic-based patching systems.
Hexamethylene Tetramine helps achieve durable repairs under heat and chemical exposure.
Hexamethylene Tetramine is used in quality control for phenolic resin systems to measure cure and free formaldehyde behavior.
Hexamethylene Tetramine supports benchmarking of cure speed and final hardness.
Hexamethylene Tetramine helps optimize formulations by adjusting hardener levels.
Hexamethylene Tetramine is used in educational laboratories to demonstrate condensation chemistry of formaldehyde and ammonia.
Hexamethylene Tetramine supports teaching experiments related to aminal formation and decomposition behavior.
Hexamethylene Tetramine helps illustrate controlled release of formaldehyde under acidic conditions.
Hexamethylene Tetramine is used in formulation troubleshooting to address under-cure in phenolic molded parts.
Hexamethylene Tetramine supports cure completion when resin-hardener balance is corrected.
Hexamethylene Tetramine helps restore target mechanical and thermal properties in phenolic applications.
Hexamethylene Tetramine is used in specialty inks and coatings where phenolic crosslinking is desired in niche systems.
Hexamethylene Tetramine supports improved solvent resistance through network formation.
Hexamethylene Tetramine helps improve durability in harsh-environment coatings.
Hexamethylene Tetramine is used in corrosion inhibitor packages for acidizing and cleaning in industrial operations.
Hexamethylene Tetramine supports reduced corrosion rates during acid treatment steps.
Hexamethylene Tetramine helps protect equipment and pipelines under controlled conditions.
Hexamethylene Tetramine is used in research on controlled formaldehyde donors for antimicrobial material development.
Hexamethylene Tetramine supports exploration of slow-release formaldehyde chemistry in polymers.
Hexamethylene Tetramine helps evaluate antimicrobial performance in treated materials under strict safety oversight.
Hexamethylene Tetramine is used in specialty chemical manufacturing as a stable, crystalline intermediate for logistics and dosing.
Hexamethylene Tetramine supports easier transport compared with aqueous formaldehyde solutions.
Hexamethylene Tetramine helps improve handling safety when used within controlled industrial processes.
Hexamethylene Tetramine is used in process chemistry as a reagent for Mannich-type reactions in some systems.
Hexamethylene Tetramine supports controlled introduction of formaldehyde equivalents in multi-component synthesis.
Hexamethylene Tetramine helps improve selectivity and handling in certain reaction setups.
DESCRIPTION
Hexamethylene Tetramine is a heterocyclic aminal compound also known as hexamine or methenamine.
Hexamethylene Tetramine is typically supplied as a white crystalline solid with a mild characteristic odor.
Hexamethylene Tetramine is formed by condensation of formaldehyde and ammonia under controlled conditions.
Hexamethylene Tetramine is soluble in water and many polar solvents, supporting easy dosing in aqueous systems.
Hexamethylene Tetramine can decompose under acidic conditions to release formaldehyde and ammonia.
Hexamethylene Tetramine therefore functions as a formaldehyde donor in chemistry and in some medical uses.
Hexamethylene Tetramine is widely used as a curing agent for novolac phenolic resins.
Hexamethylene Tetramine promotes crosslinking that increases hardness, heat resistance, and chemical resistance of phenolic networks.
Hexamethylene Tetramine cure speed depends on temperature, resin type, and hardener concentration.
Hexamethylene Tetramine is typically supplied as a white crystalline powder with high purity and low odor, and Hexamethylene Tetramine is formed from the reaction of formaldehyde and ammonia.
Hexamethylene Tetramine is stable under neutral and alkaline conditions, but Hexamethylene Tetramine can decompose under acidic conditions or high heat to release formaldehyde and ammonia.
Hexamethylene Tetramine is often described as a formaldehyde donor because Hexamethylene Tetramine can generate reactive formaldehyde under controlled process conditions.
Hexamethylene Tetramine is widely used to cure phenolic resins, and Hexamethylene Tetramine helps form crosslinked networks that provide heat resistance, hardness, and chemical durability.
Hexamethylene Tetramine performance depends on temperature, pH, resin type, and formulation additives, so cure schedules and dosage should be optimized for each system.
Hexamethylene Tetramine can be used in powder blends and molding compounds because Hexamethylene Tetramine offers good storage stability and convenient dosing.
Hexamethylene Tetramine should be stored in a cool, dry place in tightly closed containers to prevent moisture pickup and caking.
Hexamethylene Tetramine dust can irritate eyes and respiratory tract, so dust control and appropriate PPE are recommended during handling.
Hexamethylene Tetramine should be used with awareness of potential formaldehyde release under process conditions, and ventilation should be designed accordingly.
PROPERTIES
Chemical Formula: C6H12N4
Molecular Weight: 140.19 g/mol
Common Name: Hexamethylene Tetramine
Other Names: Hexamethylenetetramine, Hexamine, Methenamine, Urotropine
Appearance: White crystalline powder or granules
Odor: Slight to none
Solubility: Soluble in water; soluble in alcohol; limited solubility in nonpolar solvents
Melting / Decomposition: Decomposes on heating; may sublime under certain conditions
pH Behavior: Stable in neutral to alkaline media; decomposes in acidic media with formaldehyde release
Reactivity: Acts as a formaldehyde donor and curing agent in phenolic and related resin systems
Stability: Stable under dry storage; avoid strong acids and high heat in storage
Dust Properties: Fine dust may be irritating and should be controlled
Storage Temperature: 15–25°C, dry, tightly closed
Shelf Life: Typically 24–36 months in original sealed packaging (supplier dependent)
FIRST AID
Inhalation:
Move to fresh air if dust is inhaled.
Seek medical attention if respiratory irritation persists.
Avoid breathing dust during handling and powder transfer.
Skin Contact:
Wash with soap and water after contact.
Remove contaminated clothing and wash before reuse.
Seek medical advice if irritation develops or persists.
Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek medical attention if irritation persists.
Ingestion:
Rinse mouth with water.
Seek medical attention if discomfort occurs or if a significant amount is swallowed.
Never give anything by mouth to an unconscious person.
Note to Physicians:
Treat symptomatically.
Consider formaldehyde exposure potential if decomposition occurred.
Provide supportive care based on exposure route and symptoms.
HANDLING AND STORAGE
Handling:
Use appropriate PPE including gloves and safety glasses, and use dust protection as needed.
Avoid generating dust and avoid inhalation of fine powder.
Wash hands after handling and before eating, drinking, or smoking.
Ventilation:
Use local exhaust or general ventilation where dust may be generated.
Maintain good airflow during weighing, charging, and mixing operations.
Provide adequate ventilation during processes where heating or acidic conditions could release formaldehyde.
Storage:
Store in tightly closed containers in a cool, dry place away from moisture.
Keep away from acids and acidic vapors to prevent decomposition and formaldehyde release.
Keep containers properly labeled and protected from contamination.
Spill and Leak Procedures:
Avoid dust generation and sweep or vacuum using equipment designed for fine powders.
Place collected material into suitable containers for disposal according to local regulations.
Clean the area with wet wiping if needed to remove residues and reduce airborne dust.
Handling Precautions:
Avoid mixing Hexamethylene Tetramine with strong acids in storage or handling areas.
Control process conditions to manage potential formaldehyde release and maintain worker exposure below applicable limits.
Rotate stock using FIFO practices to maintain consistent quality and predictable curing behavior.
