PRODUCTS

HEXYLENE GLYCOL

Hexylene glycol is an organic compound with the formula (CH3)2C(OH)CH2CH(OH)CH3.
This colourless liquid is a chiral diol.
Hexylene glycol is produced industrially from diacetone alcohol by hydrogenation.

CAS No: 107-41-5
EINECS/ELINCS No:203-489-0

Synonyms: Hexylene glycol;2-METHYL-2,4-PENTANEDIOL;107-41-5;2-Methylpentane-2,4-diol;Pinakon;2,4-Pentanediol, 2-methyl-;Diolane;2,4-Dihydroxy-2-methylpentane;Isol;4-Methyl-2,4-pentanediol;1,1,3-Trimethyltrimethylenediol;Caswell No. 574;2-Methyl pentane-2,4-diol;2-Methyl-2,4-pentandiol;HSDB 1126;UNII-KEH0A3F75J;(+-)-2-Methyl-2,4-pentanediol;NSC 8098;NSC-8098;EINECS 203-489-0;KEH0A3F75J;alpha,alpha,alpha'-Trimethyltrimethylene glycol;EPA Pesticide Chemical Code 068601;BRN 1098298;1,3-dimethyl-3-hydroxybutanol;CCRIS 943;DTXSID5021885;CHEBI:62995;AI3-00919;1,3,3-trimethyl-1,3-propanediol;DTXCID101885;EC 203-489-0;1,1,3-trimethyl-1,3-propanediol;4-01-00-02565 (Beilstein Handbook Reference);HEXYLENE GLYCOL (II);HEXYLENE GLYCOL [II];HEXYLENE GLYCOL (MART.);HEXYLENE GLYCOL [MART.];HEXYLENE GLYCOL (USP-RS);HEXYLENE GLYCOL [USP-RS];203-489-0;hexylene glycol (acgih);TRACID RUBINE 5BL;Hexylene glycol [NF];Hexylene glycol (NF);hexyleneglycol;MPD;CAS-107-41-5;2-Methylpentan-2,4-diol;2-Methyl-pentane-2,4-diol;MFCD00004547;Hexylene glycol, 99%;R-(-)-2-METHYL-2,4-PENTANEDIOL;2methyl-2,4-pentanediol;Hexylene glycol (Standard);Hexylene glycol, >=99%;Hexylene glycol, 99.5%;SCHEMBL19379;HEXYLENE GLYCOL [MI];1,3-Trimethyltrimethylenediol;HEXYLENE GLYCOL [HSDB];CHEMBL2104293;HY-B0903R;NSC8098;(?)-2-Methyl-2,4-pentanediol;HMS3264E19;64229-01-2;HYB0903;Hexyleneglycol,analyticalstandard;Tox21_201975;Tox21_302818;s3588;AKOS015901459;CCG-213719;WLN: QY1 & 1XQ1 & 1;NCGC00249143-01;NCGC00256494-01;NCGC00259524-01;AC-13749;AS-58339;DA-64133;Hexylene glycol, BioXtra, >=99% (GC);(+/-)-2-Methyl-2,4-pentanediol, MPD;DB-057767;Hexylene glycol, puriss., >=99.0% (GC);M0384;NS00005763;(S)-(-)-2-METHYL-2,4-PENTANEDIOL;.alpha.,.alpha.'-Trimethyltrimethylene glycol;Hexylene glycol, BioUltra, >=99.0% (GC);D04439;EN300-170052;AB01563179_01;Q2792203;BRD-A14234430-001-01-4;Z1255485267;Hexylene glycol, United States Pharmacopeia (USP) Reference Standard

Total European and USA production was 15000 tonnes in 2000.
Hexylene glycol exists as two enantiomers, (4R)-(−) and (4S)-(+).
In the Protein Data Bank, the 3-letter code "MPD" refers to the (S)-(−) enantiomer, while "MRD" is used to refer to the (R)-(+) version.
Commercial products labeled "MPD" are usually the racemate, also sold as and referred to as "hexylene glycol".
Hexylene glycol is a clear, colorless liquid that is used in many personal care and cosmetic formulations.
Hexylene glycol largely acts as a solvent, humectant, and viscosity agent.
Decades of research have established Hexylene glycol as a safe and effective ingredient.
Hexylene glycol dissolves other ingredients in a product and enhances its stability and texture.
Hexylene glycol also has a low viscosity that makes it easier to incorporate. The chemical formula of Hexylene Glycol is C6H14O2.

Hexylene glycol is a clear liquid surfactant with a mild, sweet odour used as a solvent an key component in adhesives, lubricants, and greases.
Hexylene glycol has a versatility that extends to serving as binder, release agent, and cleaning agent.
Applications for Hexylene glycol reaches from coatings and functional fluids to laboratory reagents, metalworking fluids, rolling oils, and as an additive in agrochemicals.
Hexylene glycol or HG is an oxygenated solvent derived from acetone which has two alcohol functions.
Hexylene glycol has a low evaporation rate and it is completely miscible with water.
Hexylene glycol is mainly used as a solvent or coupling agent.
Hexylene glycol is a potential substitute for glycol ethers.
Hexylene glycol is also an effective shrinkage reduction admixture or SRA for concrete and mortar.
Hexylene glycol can also be used as a building block in chemical synthesis.
Hexylene glycol is a key solvent in many markets such as paints & coatings, metal working fluids, detergency, cosmetics & fragrances, textiles & leather.

Uses
Hexylene glycol exhibits both surfactant and emulsion-stabilizing properties.
Hexylene glycol's relatively high viscosity and low volatility are advantageous in coatings, cleansers, cosmetics, solvents, lubricants, and hydraulic fluids.
Although Hexylene glycol is an irritant at higher concentrations, it is sometimes used in skin care, hair care, soap, and eye cosmetic products at concentrations ranging from 0.1% - 25%.
Hexylene glycol is biodegradable and unlikely to accumulate in the environment.

The single largest user of Hexylene glycol is the industrial coatings industry which uses approximately 45% of the HGL produced world-wide.
Hexylene glycol is a component in lacquers and varnishes, and is a solvent plasticiser in surface coatings.
Hexylene glycol is also a component in both oil and water- based paints, and in paint strippers.
Hexylene glycol is also used as a chemical intermediate, which accounts for approximately 20% of its consumption, and another 10% is used on oil and natural-gas fields where it is both a down hole lubricant, and a grinding and extraction aid.
Hexylene glycol is a clear, colourless liquid with a characteristic odour.
Hexylene glycol is fully miscible in water and has the chemical formula C6H14O2.

Hexylene glycol is also employed as an antifreeze, and as a coupling agent for hydraulic fluids.
Hexylene glycol is a moisturising, and setting, agent in the manufacture of textiles and can also be found in the cosmetics industry where it is a component of fragrances and bath, hair, and soap preparations.
Hexylene glycol also has a role as a wetting agent in pesticide formulations and is a solvent in the preparation of dyes.

Hexylene glycol serves many functional benefits in skin care, hair care, and cosmetic products.
Skin care: Hexylene glycol is primarily used in skin care to improve the sensory feel and texture of the products.
Hexylene glycol also attracts and retains moisture on the surface of the skin, keeping it hydrated and nourished.
Hexylene glycol is often found in products like toners and cleansers.

Hair care: Hexylene glycol is used as a viscosity agent and solvent to improve the texture and stability of formulations.
Hexylene glycol also acts as an emollient in shampoos and conditioners to provide hydration to the shafts
Cosmetic products: Hexylene glycol works to dissolve other ingredients present in a formulation and enhance the texture of the final product.
Since Hexylene glycol has low viscosity, it is a useful ingredient in products like foundations, primers, and concealers

Laboratory uses
In the laboratory Hexylene glycol is a common precipitant and cryoprotectant in protein crystallography.
Since Hexylene glycol is compatible with polar and nonpolar molecules, it competes with the solvent in a crystallography experiment causing the protein to precipitate.
Hexylene glycol is so effective in protein crystallography because its amphiphilic nature and small, flexible structure allows it to bind to many different locations on a protein secondary structure including alpha helices and beta sheets.
When Hexylene glycol binds to these different locations, water is removed and the protein crystals anneal, which prevents ice formation during cryocrystallography techniques.
Incorporation of Hexylene glycol into solution has been known to improve the resolution of X-ray diffraction making protein structures easily identifiable.
Additionally Hexylene glycol is not a strong denaturing agent and thus does not significantly alter the structure of a protein during the crystallography procedure.
Hexylene glycol is also used as a lubricant for polishing specimens in metallography.
Like related diols, it forms borate esters.