HEXYLRESORCINOL

EC / List no.: 205-257-4
CAS no.: 136-77-6
Mol. formula: C12H18O2

Hexylresorcinol is an organic compound with local anaesthetic, antiseptic, and anthelmintic properties.

Hexylresorcinol is available for use topically on small skin infections, or as an ingredient in throat lozenges. 

Hexylresorcinol is a substituted phenol with bactericidal, antihelminthic and potential antineoplastic activities. 
Hexylresorcinol is used as an antiseptic in mouthwashes and skin wound cleansers. 
Hexylresorcinol may also inhibit oxidative DNA damage by enhancing the activity of antioxidant enzymes, including glutathione peroxidase and glutathione reductase, which facilitate scavenging reactive oxygen molecules by glutathione (GSH).

P-hexylresorcinol appears as pale-yellow viscous liquid (that becomes solid on standing at room temperature) or a peach colored powder.
Pungent faintly fatty odor. 
Sharp astringent taste. 

Hexylresorcinol is a substituted dihydroxybenzene. 
Hexylresorcinol exhibits antiseptic, anthelmintic, and local anesthetic properties. 
Hexylresorcinol can be found in topical applications for minor skin infections and in oral solutions or throat lozenges for pain relief and first aid antiseptic. 
The compound may also be used commonly in various commercial cosmetic anti-aging creams while ongoing studies research the possibility of using hexylresorcinol as an anti-cancer therapy - indications all of which require further study and testing at the current moment.

Hexylresorcinol (C12H18O2) is proposed for use as a processing aid for prevention of melanosis ("black spot") in shrimp and as an alternative to the currently approved sulfites. 
A safety evaluation was conducted to affirm, based upon scientific procedures, the generally recognized as safe ("GRAS") status of 4-hexylresorcinol for proposed use.

Hexylresorcinol is a substituted dihydroxybenzene. 
Hexylresorcinol exhibits antiseptic, anthelmintic, and local anesthetic properties. 
Hexylresorcinol can be found in topical applications for minor skin infections and in oral solutions or throat lozenges for pain relief and first aid antiseptic.

The compound may also be used commonly in various commercial cosmetic anti-aging creams while ongoing studies research the possibility of using hexylresorcinol as an anti-cancer therapy - indications all of which require further study and testing at the current moment.

Hexylresorcinol is an ingredient used to relieve irritation, pain, and prevent infection.

Clinical Uses:    
4-Hexylresorcinol, or “hexylresorcinol,” is a white crystallinesubstance with a faint phenolic odor. When appliedto the tongue it produces a sensation of numbness. 
Hexylresorcinol is freely soluble in alcohol but only slightly soluble in water(1–20,000 parts). 
Hexylresorcinol is an effective antiseptic,possessing both bactericidal and fungicidal properties.
The phenol coefficient of hexylresorcinol against S. aureusis 98. As is typical for alkylated phenols, hexylresorcinolpossesses surfactant properties. 
The compound also has local anesthetic activity. 
Hexylresorcinol is formulatedinto throat lozenges because of its local anesthetic and antisepticproperties. 
These preparations are probably of littlevalue. 
Hexylresorcinol (in the concentration in thelozenge) is probably not antiseptic, and the local anestheticproperty can anesthetize the larynx, causing temporarylaryngitis.

Uses:    
Hexylresorcinol shows antiimnflammatory activity acting on the human 5-LO (5-Lipoxygenase) proinflammatory enzyme.

Chemical Properties
slightly red powder
Uses:
anthelmintic, topical antiseptic

General Description:
Pale-yellow viscous liquid (that becomes solid on standing at room temperature) or a peach colored powder. 
Pungent faintly fatty odor. 
Sharp astringent taste.

Air & Water Reactions    
Insoluble in water.

Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties. 
Hexylresorcinol is available for use topically on small skin infections, or as an ingredient in throat lozenges. 
Hexylresorcinol may be used as a cosmetic biocide. 
Hexylresorcinol was introduced by Leonard as a urinary antiseptic with great possibilities. 
Used in alkaline solution it promised success in experiments in vitro. 
Boots Hexylresorcinol 2.4mg Throat Lozenges, marketed in UK, are used to relieve sore throat pain. 
Hexylresorcinol has being shown to be useful for the topical treatment of hyperpigmentation.

Hexylresorcinol is used as the starting material to synthesize a potent immune suppressor, celastramycin A. 
Hexylresorcinol is a precursor to prepare resorcinol-sn-glycerol derivatives, that exhibit high affinity for cannabinoid type 1 receptor.
Hexylresorcinol can also be incorporated as a linker while building catenanes.

Hexylresorcinol is an alkylresorcinol (AR), a type of phenolic lipid, that can be found naturally in whole grain wheat and rye. 
In skincare, hexylresorcinol is known to function as a skin-brightening agent. 
Hexylresorcinol also possesses antioxidant, as well as astringent properties, that can contribute towards a more even tone complexion. By providing antioxidant protection, hexylresorcinol can help neutralize free radicals present in the environment. 
Studies show topical application of hexylresorcinol may play a role in defending against signs of skin aging (i.e, fine lines and wrinkles) and glycation- a non-enzymatic reaction that may negatively impact skin quality. 
In addition to its skin benefits, skincare products utilize hexylresorcinol due to its well-soluble nature. 
This makes hexylresorcinol a desirable ingredient to be implemented into skincare formulas, as well as mixed with other skin brigthening ingredients such as niacinamide. 
Concentrations of hexylresorcinol occur between 0.5%-1.0%, and can most often be found in creams and serums to provide effective skin-lightening results. 

hexylresorcinol is a crystalline phenol C12H18O2 used as an antiseptic and anthelmintic

Hexylresorcinol is an alkylresorcinol, a type of amphiphilic phenolic lipid having an n-hexyl chain attached to the 4 position of the 1,3-dihydroxybenzene ring. 
Alkylresorcinols provide benefits in a wide range of applications (antibacterial, antiparasitic, anesthetic, antiseptic, etc.) due to the interactions of their alkyl chains with phospholipids and/or proteins and to the antioxidant activity of the phenolic hydroxyl group.

Despite hexylresorcinol’s long history of use in foods and pharmaceuticals it is only recently that its benefits in skin care preparations has been realized. 
Its primary use in skin care products is as a skin lightening agent and to control hyperpigmentation.
Its mechanism of action in skin is by modulating multiple sites in the melanogenesis pathway, namely inhibition of tyrosinase and peroxidase enzyme activities, as well as stimulating antioxidant activity (e.g., glutathione, glutathione peroxidase, and glutathione reductase).

Properties
Solubility: >20% solubility in a wide range of hydrophobic emollients and solubilizers, isosorbide dicaprylate, and low molecular weight glycols.4 Also, soluble in ether and acetone; and slightly soluble in water.
Melting point: 64-69 °C6
pKa: 10.035
Boiling point: 333-335 °C5
Log P (exp): 3.885

Traditionally found in mouthwashes and throat lozenges thanks to its antiseptic and anesthetic properties, Hexylresorcinol has also been used to treat minor cuts, scrapes and skin infections. 
Recently, however, its ability to target pathways in the skin that lead to hyperpigmentation has propelled it into the skin lightening ingredient category. 
There is also thought that Hexylresorcinol has more benefits as well, including an ability to reduce the appearance of fine lines and wrinkles, increase protection against UVB and UVA rays, and improve the skin's barrier against pollution and sun exposure.

Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. 
Hexylresorcinol can induce apoptosis in squamous carcinoma cells. 
Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. 
Hexylresorcinol has protective effects against oxidative DNA damage.

Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. 
Hexylresorcinol can induce apoptosis in squamous carcinoma cells. 
Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. 
Hexylresorcinol has protective effects against oxidative DNA damage

HEXYLRESORCINOL is classified as :
Antimicrobial
CAS Number    136-77-6
EINECS/ELINCS No:    205-257-4
COSING REF No:    56442
Chem/IUPAC Name:    4-Hexyl-1,3-benzenediol

Hexylresorcinol is a chemical compound with anaesthetic, antiseptic and antihelmintic properties.
Hexylresorcinol can be used topically on small skin infections, or as an ingredient in throat lozenges. 
In vivo studies conducted on Synovea HR Hexylresorcinol by Sytheon in January 2007 have shown that it has the same lightening effect as 2% hydroquinone over an 8 week period.

Hexylresorcinol Description
Hexylresorcinol is a synthetic ingredient that has been shown to have skin-brightening ability but there is very limited research about it on skin. 
Hexylresorcinol is mostly an antioxidant.

Hexylresorcinol is an alkylresorcinol that has been found in rye.1 4-Hexylresorcinol-containing lozenges are active against S. aureus, S. pyogenes, M. catarrhalis, H. influenzae, and F. necrophorum in an in vitro model of oral transmucosal delivery.
Hexylresorcinol increases the activities of glutathione peroxidase (GPX), glutathione reductase (GR), and catalase in isolated human peripheral blood lymphocytes when used at concentrations of 25, 50, or 100 µM.
Hexylresorcinol (2.5 mg/kg) in combination with cisplatin (Item No. 13119) reduces tumor growth and increases survival in a patient-derived xenograft (PDX) mouse model of oral mucosal melanoma.
Formulations containing 4-hexylresorcinol have been used as food additives to prevent browning in produce and shrimp.

What is Hexylresorcinol?
Hexylresorcinol is a synthetic substance used topically (on the skin) as an antiseptic and orally as an anti-helminthic (worming agent). 
Hexylresorcinol is an effective agent against many microorganisms.

How can I avoid Hexylresorcinol?
Products that contain Hexylresorcinol must be avoided. 
wasThis can be accomplished by reading labels, package inserts, and Material Safety Data Sheets (MSDS).

Uses:
Anti-helminthic (treatment of parasitic worms)
Contraceptives
Mouthwash
Throat lozenges
Topical antiseptic
Manufacturer of leather dyes
Manufacturer of adhesives
Pharmaceutical creams and lotions typically used as antiseptics

Other names for Hexylresorcinol:
Resorcin
1,3-Benzenediol, 4-Hexyl-
1,3-Dihyodroxy-4-Hexylbenzene
4-Hexylresorcine
4-Hexylresorcinol
4-Hexylbenzene-1,3-diol

Application    
Hexylresorcinol for synthesis. CAS 136-77-6, chemical formula 4-CH₃(CH₂)₅C₆H₃-1,3-(OH)₂.

Use: Hexylresorcinol, a phenol derivative, could be commonly used as antioxidant, vermifuge and food additives. 
Hexylresorcinol could be commonly used as antioxidant, vermifuge and food additives.
Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties.

What is Hexylresorcinol?
Substituted dihydroxybenzene traditionally found in mouthwashes and throat lozenges.

What are other names for Hexylresorcinol?
1,3-BENZENEDIOL, 4-HEXYL-, 1,3-DIHYDROXY-4-HEXYLBENZENE, 1,3BENZENEDIOL, 4HEXYL, 4-HEXYL- 1,3-BENZENEDIOL, 4-HEXYLRESORCINE, 4-HEXYLRESORCINOL, and HEXYLRESORCINOL

What is Hexylresorcinol used for?
In skincare, hexylresorcinol is known to function as a skin-brightening agent. 
Hexylresorcinol also possesses antioxidant, as well as astringent properties, that can contribute towards a more even tone complexion. By providing antioxidant protection, hexylresorcinol can help neutralize free radicals present in the environment.

How Hexylresorcinol is classified
Antioxidants

INCI name: HEXYLRESORCINOL
EINECS / ELINCS number: 205-257-4
Its functions (INCI)
Antimicrobial: Helps slow the growth of micro-organisms on the skin and counteracts the development of microbes

Hexylresorcinol is an inhibitor of TGase2 (transglutaminase-2) in KB cells. 
Studies indicate that Hexylresorcinol reduces DNA oxidative damage in human lymphocytes. 
The combination of Hexylresorcinol and Cisplatin (sc-200896) has been shown to inhibit tumor growth, cell growth, and KB cell viability. 
Alternate studies suggest that 4-Hexylresorcinol is a potent irreversible inhibitor of polyphenol oxidase (PPO) activity. 
Furthermore, 4-Hexylresorcinol is a mixed-type inhibitor which influences the apparent V(max) and K(m) values of the inhibitor by binding preferentially to the oxy form of PPO.

Hexylresorcinol, Powder, also known simply as Hexylresorcinol, is an organic compound often used as an antiseptic and local anesthetic.
Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.

Hexylresorcinol is an organic compound with anaesthetic, antiseptic and anthelmintic properties. 
Hexylresorcinol is available for use topically on small skin infections, or as an ingredient in throat lozenges. 
An ingredient in Strepsils Extra and, as a 0.1% solution, it is the active ingredient in S.T.37, Topical Antiseptic/Oral Pain Reliever.
A study published in Chemical Research in Toxicology shows that hexylresorcinol used as a food additive exhibits some estrogenic activity, i.e. resembles action of the female sex hormone estrogen.

About Hexylresorcinol
Helpful information
Hexylresorcinol is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 to < 10 tonnes per annum.

Hexylresorcinol is used by consumers, by professional workers (widespread uses) and in formulation or re-packing.

Consumer Uses
Hexylresorcinol is used in the following products: cosmetics and personal care products.
Other release to the environment of Hexylresorcinol is likely to occur from: indoor use as processing aid and outdoor use as processing aid.
Article service life
ECHA has no public registered data on the routes by which Hexylresorcinol is most likely to be released to the environment. ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

Widespread uses by professional workers
Hexylresorcinol is used in the following products: cosmetics and personal care products.
ECHA has no public registered data on the types of manufacture using Hexylresorcinol. Other release to the environment of Hexylresorcinol is likely to occur from: indoor use as processing aid and outdoor use as processing aid.
Formulation or re-packing
Hexylresorcinol is used in the following products: cosmetics and personal care products.
Release to the environment of Hexylresorcinol can occur from industrial use: formulation of mixtures.
Uses at industrial sites
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the types of manufacture using Hexylresorcinol. ECHA has no public registered data on the routes by which Hexylresorcinol is most likely to be released to the environment.

Manufacture
ECHA has no public registered data on the routes by which Hexylresorcinol is most likely to be released to the environment.

IUPAC NAMES:
4-hexyl-1,3-dihydroxy-benzene
4-hexylbenzene-1,3-diol
4-Hexylresorcin
4-Hexylresorcinol
4-hexylresorcinol

SYNONYMS:
hexylresorcinol
4-Hexylresorcinol
136-77-6
4-hexylbenzene-1,3-dio
4-Hexyl-1,3-benzenediol
4-n-Hexylresorcinol
Antascarin
Ascaricid
Ascarinol
Oxana
p-Hexylresorcinol
Adrover
Caprokol
Hidesol
Crystoids
1,3-Benzenediol, 4-hexyl-
Prensol
4-Hexylresorcine
Sucrets
Gelovermin
Hexylresorcin
4-Hexyl-1,3-dihydroxybenzene
Ascaryl
4-(1-Hexyl)resorcinol
Cystoids anthelmintic
1,3-Dihydroxy-4-hexylbenzene
Worm-agen
Resorcinol, 4-hexyl-
Mycoderm
1,3-Dihydroxy-4-n-hexylbenzene
UNII-R9QTB5E82
NSC 1570
4-Hexylresorcinol, 98%
1-n-Hexyl-2,4-dihydroxybenzene
1-(2',4'-Dihydroxyphenyl)hexane
Hexylresorzin
Hexylresorcinolum
Hexylresorcin [German]
EverFresh
4-hexyl resorcinol
CAS-136-77-6
EINECS 205-257-4
BRN 2048312
4-hexylresorcin
AI3-08055
Hexylresorcinol [USP:INN:BAN]
zlchem 16
4-Hexyl-benzenediol
Hexylresorcinol (USP)
Spectrum_000869
1, 4-hexyl-
4-Hexylresorcinol, 8CI
WLN: QR CQ D6
Hexylresorcinol, BAN, USAN
4-06-00-06048 (Beilstein Handbook Reference)
1-(2,4-Dihydroxyphenyl)hexane
4-Hexyl-1,3-dihydroxy benzene
1, 3-Dihydroxy-4-n-hexylbenzene
benzene, 4-hexyl-1,3-dihydroxy-
4-Hexylresorcinol, analytical standard
BENZENE,1,3-DIHYDROXY,4-HEXYL
Hexylresorcinol, European Pharmacopoeia (EP) Reference Standard
Hexylresorcinol, United States Pharmacopeia (USP) Reference Standard
1-(2',4'-Dihydroxyphenyl)hexane;Hexylresorcinol;4-Hexyl-1,3-benzenediol
Hexylresorcinol for system suitability, EuropePharmacopoeia (EP) Reference Standard
1-(2',4'-Dihydroxyphenyl)hexane
1-(2,4-Dihydroxyphenyl)hexane
1,3-Benzenediol, 4-hexyl-
1,3-Benzenediol,4-Hexyl-1,3-benzenediol
1,3-Dihydroxy-4-Hexylbenzene
1,3-Dihydroxy-4-n-hexylbenzene
4-hexylresourcinol
Adrover
Antascarin
Ascaricid
Ascarinol
Ascaryl
benzene,4-hexyl-1,3-dihydroxy-
Caprokol
Crystoids
Cystoids Anthelmintic
cystoidsanthelmintic
Gelovermin
Hexyl-2,4-dihydroxy-benzene
Hexylresorcin
Hidesol
Mycoderm
NCI-C55787
Oxana
p-Hexylresorcinol
Prensol
Resorcinol, 4-hexyl-
S.T. 37
s.t.37
ST-37
Sucrets
Worm-agen
4-hexyl-1，3-benzendiol
4-hexylresorcinol(4HR)
EverFresh
Hexyl Resorcinol , (4-Hexyl-1,3-benzenediol)
4-Hexylresorcinol,98%
4-Hexylresorcinol,4-Hexyl-1,3-dihydroxybenzene
Hexylresorcinol (200 mg)
4-Hexyl Resorcinol, (4-Hexyl-1,3-benzenediol)
Nano Liposomal 4-Hexylresorcinol
5-hexyl-2,6-dihydroxycyclohexa-2,4-dienone
Hexylresorcinol for system suitability
PARA-HEXYLRESORCINOL
4-HEXYLRESORCINOL 99+%
4-Hydroxylresorcinol
4-Hexylresorcin
Bupivacaine Impurity 17
1-n-Hexyl-2,4-dihydroxybenzene
4-N-Hexylresorcinol99%
Hexylcaine
HEXYLRESORCINOL
4-HEXYLRESORCINOL,POWDER
1,4-Dihydroxy-4-hexylbenzene
3-Benzenediol,4-hexyl-1
4-(1-Hexyl)resorcinol
4-hexyl-3-benzenediol
4-hexylbenzene,1,3-dihydroxy-