HYDROXYPHOSPHONO ACETIC ACID

HYDROXYPHOSPHONO ACETIC ACID  = 2-HYDROXY PHOSPHONO ACETIC ACID = HPAA

CAS Number: 23783-26-8
EC Number: 405-710-8
Molecular Formula: C2H5O6P

HydroxyPhosphono Acetic Acid is white crystals with a phosphorus content of 19.8% and a melting point of 165-167.5 °c. 
The pH value of 1% aqueous solution is 1, which can be miscible with water in any proportion.
HydroxyPhosphono Acetic Acid, HPAA, is a powerful mild steel corrosion inhibitor for all-organic cooling water formulations. 
HydroxyPhosphono Acetic Acid reduces iron fouling which improves heat transfer efficiency. 

Good biodegradability of HydroxyPhosphono Acetic Acid makes it suitable in areas where the molybdenum discharge rate is regulated at very low levels. 
HydroxyPhosphono Acetic Acid can be easily monitored by a standard organophosphonate test kit.
HydroxyPhosphono Acetic Acid is chemically stable, hard to be hydrolyzed, hard to be destroyed by acid or alkali, safety in use, no toxicity, no pollution.

HydroxyPhosphono Acetic Acid can improve zinc solubility. 
HydroxyPhosphono Acetic Acid's corrosion inhibition ability is 5-8 times better than that of HEDP and EDTMP. 
When built with low molecular polymers, HydroxyPhosphono Acetic Acid's corrosion inhibition effect is even better.
HydroxyPhosphono Acetic Acid is an organic phosphine scale and corrosion inhibitor with low phosphorus content.

HydroxyPhosphono Acetic Acid's molecule contains phosphonic acid group, carboxylic acid group and hydroxyl group. 
HydroxyPhosphono Acetic Acid has excellent performance in scale and corrosion inhibition, especially in soft water and high hardness water. 
In addition, HydroxyPhosphono Acetic Acid has the characteristics of low phosphorus, good thermal stability, low toxicity, etc. 

HydroxyPhosphono Acetic Acid can achieve good compatibility and synergy with some common water stabilizers. 
HydroxyPhosphono Acetic Acid can achieve better corrosion inhibition when used with zinc salt.
HydroxyPhosphono Acetic Acid, the English name is 2-Hydroxyphosphonoacetic Acid, is a chemical substance with the chemical formula C6H15O3P.

HydroxyPhosphono Acetic Acid has good chemical stability, hard to be hydrolyzed, and hard to be damaged by acid or alkali, safe and reliable to use, non-toxic and pollution-free. 
HydroxyPhosphono Acetic Acid can improve the solubility of zinc, with strong inhibition, HydroxyPhosphono Acetic Acid has better inhibition performance than HEDP, EDTMP.

HydroxyPhosphono Acetic Acid is chemically stable, hard to be hydrolyzed, hard to be destroyed by acid or alkali, safety in use, no toxicity, no pollution. 
HydroxyPhosphono Acetic Acid can improve zinc solubility. 
HydroxyPhosphono Acetic Acid's corrosion inhibition ability is 5-8 times better than that of HEDP and EDTMP. 
When built with low molecular polymers, HydroxyPhosphono Acetic Acid's corrosion inhibition effect is even better.

USES and APPLICATIONS of HYDROXYPHOSPHONO ACETIC ACID:
-HydroxyPhosphono Acetic Acid is widely used in steel, petrochemical, electric power, pharmaceutical and other industries of circulating cooling water system scale inhibition, corrosion inhibition, suitable for low hardness water quality in southern China.
-HydroxyPhosphono Acetic Acid is used as corrosion inhibitor.

-HydroxyPhosphono Acetic Acid can be widely used in steel, petrochemical, electric power, the scale inhibition and corrosion inhibition of circulating cooling water system in medicine and other industries are generally compounded with zinc salt to form corrosion inhibitor, which is suitable for low hardness water quality in Southern China and has scale inhibition effect.

-HydroxyPhosphono Acetic Acid has excellent corrosion inhibition performance, especially for low hardness, low alkalinity, strong corrosive water, showing a strong corrosion inhibition.
-HydroxyPhosphono Acetic Acid has a good chelating effect with divalent ions, which can be used as a metal ion stabilizer to effectively stabilize Fe2, Fe3, Mn2 and Al3 plasma in water and reduce corrosion and scaling.

-HydroxyPhosphono Acetic Acid can significantly reduce the deposition of calcium carbonate and silicon dioxide, and has good scale inhibition performance, but the scale inhibition performance of HydroxyPhosphono Acetic Acid on calcium sulfate scale is slightly poor. 
-HydroxyPhosphono Acetic Acid is mainly used as a cathode corrosion inhibitor in the oilfield refill water system in fields such as steel & iron, petrochemical, power plant, and medical industries.

-In order to avoid the decomposition of HydroxyPhosphono Acetic Acid by the oxidizing bactericide, the protective agent can be used, but the residual chlorine (0.5~1-0 mg/L) is less affected in the intermittent chlorination cooling water system. 
-The combination of HydroxyPhosphono Acetic Acid and zinc salt has obvious synergistic corrosion inhibition effect. 
The recommended concentration is generally 5 to 30mg/L.
-Acid corrosion resistance shall be provided for each medicine.

-When built with zinc salt, the effect is even better. 
As a corrosion inhibitor, HydroxyPhosphono Acetic Acid is mainly applied in the cooling water/industrial water system of oilfield, petrochemical plant and power plant.
-HydroxyPhosphono Acetic Acid is also used for metal surface treatment in steel.
-HydroxyPhosphono Acetic Acid is considered being a mild steel corrosion inhibitor and is mainly used in the water treatment industry. 

-HydroxyPhosphono Acetic Acid shows superior performance in all organic formulations compared to commonly used Phosphonates. 
In certain formulations HydroxyPhosphono Acetic Acid can replace Molybdate or its derivatives.
-Cooling water systems / industrial water treatment
-Metal surface treatment as corrosion inhibitor for steel

-HydroxyPhosphono Acetic Acid- 50% in water (cas# 23783-26-8) is used in preparation method of salt-resistant calcium-magnesium resistant polymer colloid system and HydroxyPhosphono Acetic Acid's application in oil reservoir oil displacement.
-pH regulators and water treatment products.
-HydroxyPhosphono Acetic Acid reduces iron fouling, thus improving heat transfer efficiency and reducing system maintenance costs.

-HydroxyPhosphono Acetic Acid is an environmentally acceptable corrosion inhibitor for carbon steel in cooling water systems. 
HydroxyPhosphono Acetic Acid gives better corrosion protection for carbon steel when used in conjunction with zinc or other phosphonates. 
-HydroxyPhosphono Acetic Acid is biodegradable and especially suitable in applications where the molybdate discharge is regulated OR all organic cooling water treatment is desired. 

-HydroxyPhosphono Acetic Acid is expected to be susceptible to halogen attack.
-HydroxyPhosphono Acetic Acid is mainly used as cathode corrosion inhibitor in oilfield refill water system in fields such as steel & iron, petrochemcal, power plant and medical industries. When built with zinc salt, the effect is even better.
-HydroxyPhosphono Acetic Acid is mainly used as a cathodic corrosion inhibitor for metals.

-HydroxyPhosphono Acetic Acid is widely used as a corrosion and scale inhibitor for recirculating cooling water systems in steel, petrochemical, power, and pharmaceutical industries. 
-HydroxyPhosphono Acetic Acid can also be combined with common organic phosphine, polymer and other monomers to form scale and corrosion inhibitors. 
In combination with zinc salt, the performance of corrosion inhibition will be better.

-The organic corrosion inhibitors of which HydroxyPhosphono Acetic Acid combines with low molecular weight polymer have excellent performance. 
When built with zinc salt, the effect is even better. 
-HydroxyPhosphono Acetic Acid has good chemical stability, hard to be hydrolyzed, and hard to be damaged by acid or alkali, safe and reliable to use, non-toxic and pollution-free.

-HydroxyPhosphono Acetic Acid is mainly used as the cathodic corrosion inhibitor for metals, but also widely used to realize corrosion inhibition and scale inhibition in circulating cooling water system of steel, petrochemical, electric power, pharmaceutical and other industries. 
-HydroxyPhosphono Acetic Acid is specially suitable for low hardness and easy-corrosive water quality.
-HydroxyPhosphono Acetic Acid (HPA or HPAA) is used as antiscalant and corrosion inhibitor in cooling water systems.

-HydroxyPhosphono Acetic Acid is widely used for scale and corrosion inhibition of circulating cooling water systems in steel, petrochemical, electric power, medicine and other industries, and is suitable for low-hardness water quality in southern country; HydroxyPhosphono Acetic Acid can be widely used in circulating cooling water systems in steel, petrochemical, electric power, medicine and other industries. 

-Scale and corrosion inhibition, generally compounded with zinc salt as a corrosion inhibitor, suitable for low-hardness water quality in southern country, and has the effect of scale inhibition.
-HydroxyPhosphono Acetic Acid is mainly used as cathode corrosion inhibitor in oilfield refill water system in fields such as steel & iron, petrochemcal, power plant and medical industries. 
When built with zinc salt, the effect is even better.

THE MAIN HYDROXYPHOSPHONO ACETIC ACID PRODUCTION ROUTE IS AS FOLLOWS:
Phosphorus acid solution reacts with glyoxylic at 100-110°C for 4-10hours. 
And then input water to prepare HydroxyPhosphono Acetic Acid aqueous solution. 
This reaction can be 1-step forward and starts from PCl3 hydrolysis.
Some research is studying to use microwave irradiation to replace the heating process for reducing energy consumption and reaction time.

PHYSICAL and CHEMICAL PROPERTIES of HYDROXYPHOSPHONO ACETIC ACID:
Molecular Weight: 156.03
Appearance: Liquid
Color: Dark brown
Specific Gravity @ 25°C: 1.32-1.42
pH (1%) solution: < 2
Active Content    Approx. 50%

Solubility: Miscible in water
Density: 2.1±0.1 g/cm3
Appearance: Dark brown liquid
Solid content (%): 48.0 - 52.0
pH (1% solution): 2.0 max.
Density (20 °C, g/cm3):    1.32 - 1.42

Boiling Point: 557.7±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±3.4 mmHg at 25°C
Enthalpy of Vaporization: 96.5±6.0 kJ/mol
Flash Point: 291.1±32.9 °C
Index of Refraction: 1.579
Molar Refractivity: 24.3±0.3 cm3
#H bond acceptors: 6
#H bond donors: 4
#Freely Rotating Bonds:    2
#Rule of 5 Violations: 0

Polar Surface Area: 125 Å2
Polarizability:    9.6±0.5 10-24cm3
Surface Tension: 143.0±3.0 dyne/cm
Molar Volume: 73.2±3.0 cm3
Boling Point: 299.7°C at 760 mmHg
Flash Point: 135°C
Vapor Presure: 0.000278mmHg at 25°C
Physical and Chemical Properties    
Density 1.37 (50% aq.)

Appearance: Liquid
Odor: Slight
Odor threshold: Not available
Color: Dark Brown
pH: 2.5 max (1% solution)
Melting Point: -12 ᵒC
Freezing Point: -5 °C
Boiling Range: 101 - 103 °C @ 760 mm hg
Flash Point: Not data available
Ignition Temp.: Not data available
Thermal Decomposition : >160

Evaporation Rate : Not available
Lower Explosive Limit : Not available
Upper Explosive Limit: Not available
Vapor Pressure: Not available
Vapor Density: Not available
Specific Gravity: 1.30 - 1.50 @ 20ᵒC
Solubility: Soluble
Partition Coefficient
n-octanol/water : <0
Viscosity : max 75 cps @ 25° C
Molecular Weight:156.03

XLogP3-AA: -2    
Hydrogen Bond Donor Count: 3    
Hydrogen Bond Acceptor Count: 6    
Rotatable Bond Count: 3    
Exact Mass: 155.98237487    
Monoisotopic Mass: 155.98237487    
Topological Polar Surface Area: 104 Ų    
Heavy Atom Count: 9    
Formal Charge: 0    
Complexity: 151

FIRST AID MEASURES of HYDROXYPHOSPHONO ACETIC ACID:
-Eyes : 
Remove any contact lenses. 
Get medical aid/attention immediately.

-Skin : 
Remove contaminated clothing. 
Wash skin with plenty of running water and soap. 

-Ingestion : 
Give large amount of water to drink. 

-Inhalation : 
Keep warm and at rest.  
Get medical attention/consult a physician.

-Note to Physician : 
Treat symptomatically.

ACCIDENTAL RELEASE MEASURES of HYDROXYPHOSPHONO ACETIC ACID:
-Protective Gear for Personnel:
--For Small Spill : 
Wear safety glasses.

-Spill Clean-up Procedures:
--For Small Spill : 
Do not let chemical/waste enter the environment.

--For Large Spill : 
Do not let chemical/waste enter the environment.

-Environmental Precaution : 
*Water spill: use appropriate containment to avoid run off or release to sewer or other waterways.
*Land spill: use appropriate containment to avoid run off or release to ground.

EXPOSURE CONTROLS/PERSONAL PROTECTION of HYDROXYPHOSPHONO ACETIC ACID:
-Personal Protective
--Equipment: 
*Eyes and face: 
Wear safety glasses.

HANDLING and STORAGE of HYDROXYPHOSPHONO ACETIC ACID:
-Handling :  
Wash hands thoroughly with soap and water after use. 

-Storage : 
Store in a cool, dry well-ventilated area. 
Keep containers closed when not in use. 
Do not store in Carbon Steel containers.

STABILITY and REACTIVITY of HYDROXYPHOSPHONO ACETIC ACID:
-Stability : 
The product is stable under recommended storage and handling conditions.
-Hazardous Polymerization : 
Polymerization will not occur.

SYNONYMS:
Hydroxyphosphonoacetic acid
hydroxyphosphono acetic acid
SCHEMBL560738
ZINC100443591
DB-029902
2-[hydroperoxy(hydroxy)phosphoryl]acetic acid
Hydroxyphosphono-acetic acid
2-Hydroxy phosphono acetic acid
HPA
HPAA
2-Hydroxy-2-phosphono-acetic acid
2-hydroxy-2-phosphonoacetic acid
2-hydroxy-2-phosphono-ethanoic acid
Acetic acid, hydroxyphosphono-
alpha.-Hydroxyl phosphonoacetic acid
alpha.-Hydroxyphosphonoacetic acid
hpse1
heparanase-1
hpse
snailagglutinin
phosphonoglycolic acid 
heparanase [precursor] 
endo-glucoronidase 
hpa 
belcor 575