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Hydroxypropyl methylcellulose (HPMC) is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.
Hydroxypropyl methylcellulose (HPMC) is white or pale white cellulose powder or particles.
Hydroxypropyl methylcellulose (HPMC) and other water-soluble high weight compounds use mixture, become transparent, higher viscosity.
CAS Number: 9004-65-3
Molecular Formula: C3H7O*
Molecular Weight: 59.08708
EINECS Number: 618-389-6
Synonyms: hypromellose 2208 (100 MPA.S), Hydroxypropyl methylcellulose 100, Hydroxypropyl methylcellulose 2208 (100 cps), Hypromellose 2208 (100 cps), B1QE5P712K, BENECEL HPMC K100, HPMC 2208 (100 CPS), HYDROXYPROPYL METHYLCELLULOSE 100 (II)
HYDROXYPROPYLMETHYLCELLULOSE 2208, 100 CPS, HYPROMELLOSE 90SH-100SR, Hypromellose Ophthalmic Solution, METHOCEL K-100-LV
METHOCEL K-100LV, METHOCEL K100 PREMIUM LV METHOCEL K100-LV, METHOCEL K100LV, METOLOSE 90SH 100SR, Vista Gonio Eye Lubricant
Hydroxypropyl methylcellulose (HPMC) is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.
Hydroxypropyl methylcellulose (HPMC) is white or pale white cellulose powder or particles.
Hydroxypropyl methylcellulose (HPMC) has different types of products, the methoxy and hydroxypropyl content ratio is different.
The characteristics of cold water dissolution and hot water insoluble are similar with methyl cellulose.
Solubility in organic solvents is superior than water soluble, can be dissolved in anhydrous methanol and ethanol solution, also soluble in chlorinated hydrocarbons and ketones in organic solvents.
Soluble in water, its water solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the reversible conversion of sol to gel.
Can be used alone in the cold drink, also can be used with other emulsifier, stabilizer.
The gelation temperature of low viscosity products is higher than high viscosity of products.
Its solution is stable at room temperature.
In recent years, Hydroxypropyl methylcellulose (HPMC) has been widely used in petroleum chemical industry, papermaking, leather, textile printing and dyeing, pharmaceutical, food, cosmetics and other industries, and as the dispersing agent, thickening agent, adhesive, excipient, capsule, oil resistant coating and packing etc.
Hydroxypropyl methylcellulose (HPMC) is white or gray fibrous powder or particles.
Hydroxypropyl methylcellulose (HPMC) is soluble in water and some organic solvents and unsoluble in ethanol.
Aqueous solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the sol to gel reversible transformation.
Hydroxypropyl methylcellulose (HPMC) is a propylene glycol ether of methylcellulose in which both hydroxypropyl and methyl groups are bound to the anhydrous glucose ring of cellulose by ether linkages.
Hydroxypropyl methylcellulose (HPMC) is synthesized from methyl cellulose by the action of alkali and propylene oxide.
The resultant product is a water soluble ether derivative of cellulose containing both methoxy and hydroxypropyl groups.
The degree of substitution is 1.08 to 1.83 with the hydroxypropyl groups as the minor constituent.
White to off-white fibrous powder or granules. Soluble in water and some organic solvents.
Insoluble in ethanol, the aqueous solution has surface activity, forms a thin film after drying, and undergoes a reversible transition from sol to gel in turn by heating and cooling.
Hydroxypropyl methylcellulose (HPMC) is an odorless and tasteless, white or creamy-white fibrous or granular powder.
Hydroxypropyl methylcellulose (HPMC) is soluble in water (10 mg/ml). However, it is very important to thoroughly disperse the particles in water with agitation before they will dissolve.
Otherwise, they will lump and form a gelatinous membrane around the internal particles, preventing them from wetting completely.
There are four dispersion techniques commonly used to prepare solutions of Hydroxypropyl methylcellulose (HPMC): dispersion in hot water, dry blending, dispersion in non-solvent medium, and dispersion of surface-treated powders.
Hydroxypropyl methylcellulose (HPMC) belongs to the group of medicines known as artificial tears.
Hydroxypropyl methylcellulose (HPMC) is used to relieve dryness and irritation caused by reduced tear flow.
Hydroxypropyl methylcellulose (HPMC) helps prevent damage to the eye in certain eye diseases.
Hydroxypropyl methylcellulose (HPMC) may also be used to moisten hard contact lenses and artificial eyes.
In addition, Hydroxypropyl methylcellulose (HPMC) may be used in certain eye examinations.
Hydroxypropyl methylcellulose (HPMC) are water soluble polymers derived from cellulose.
They are typically used as thickeners, binders, film formers, and water retention agents.
They also function as suspension aids, surfactants, lubricants, protective colloids, and emulsifiers.
In addition, solutions of these polymers thermally gel.
These polymers are prepared by reacting wood or cotton cellulose fibers with propylene oxide and methyl chloride in the presence of caustic soda.
Hydroxypropyl methylcellulose (HPMC) has a methoxyl content of 28-30% and a hydroxypropoxyl content of 7-12%.
Hydroxypropyl methylcellulose (HPMC) belongs to the group of cellulose ethers in which hydroxyl groups have been substituted with one or more of the three hydroxyl groups present in the cellulose ring (Fig. 3.10).
Hydroxypropyl methylcellulose (HPMC) is hydrophilic (water soluble), a biodegradable, and biocompatible polymer having a wide range of applications in drug delivery, dyes and paints, cosmetics, adhesives, coatings, agriculture, and textiles.
Hydroxypropyl methylcellulose (HPMC) is also soluble in polar organic solvents, making it possible to use both aqueous and nonaqueous solvents.
Hypromellose (INN), short for Hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.
As a food additive, Hydroxypropyl methylcellulose (HPMC) is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin.
Its Codex Alimentarius code (E number) is E464.
Hydroxypropyl methylcellulose (HPMC) is a solid, and is a slightly off-white to beige powder in appearance and may be formed into granules.
The compound forms colloids when dissolved in water.
This non-toxic ingredient is combustible and can react vigorously with oxidizing agents.
Hydroxypropyl methylcellulose (HPMC) in an aqueous solution, like methylcellulose, exhibits a thermal gelation property.
That is, when the solution heats up to a critical temperature, the solution congeals into a non-flowable but semi-flexible mass.
Typically, this critical (congealing) temperature is inversely related to both the solution concentration of HPMC and the concentration of the methoxy group within the Hydroxypropyl methylcellulose (HPMC) molecule (which in turn depends on both the degree of substitution of the methoxy group and the molar substitution).
That is, the higher the concentration of the methoxy group, the lower the critical temperature.
The inflexibility/viscosity of the resulting mass, however, is directly related to the concentration of the methoxy group (the higher the concentration is, the more viscous or less flexible the resulting mass is)
Hydroxypropyl methylcellulose (HPMC) is a synthetic polymer that is quite popular in cosmetics and personal care products.
Hydroxypropyl methylcellulose (HPMC) is a highly versatile ingredient that serves as a thickener, emulsifier, and stabilizer in formulations.
Hydroxypropyl methylcellulose (HPMC) can help in improving the texture and flow properties of products like lotions, creams and gels.
Hydroxypropyl methylcellulose (HPMC) also controls the release of active ingredients and acts as a film-forming agent, protecting the skin from environmental stressors.
In its raw form, Hydroxypropyl methylcellulose (HPMC) appears as a white to off-white odorless powder or granule that is soluble in cold water but insoluble in organic solvents.
The chemical formula of Hydroxypropyl methylcellulose (HPMC) is C56H108O30.
Hydroxypropyl methylcellulose (HPMC) is a water-soluble polymer derived from cellulose.
This polysaccharide forms colloids when dissolved in water.
Hydroxypropyl methylcellulose (HPMC) is a hydrocolloid produced artificially from natural substances.
Hydroxypropyl methylcellulose (HPMC) consists of 28-30% methoxyl content and 7-12% of hydroxypropoxyl content.
Hydroxypropyl Methylcellulose (HPMC) is multifunctional as a lubricant, foam enhancer and stabilizer, thickener, emulsion stabilizer and film former for hair and skin care products.
Hydroxypropyl methylcellulose (HPMC) is especially useful in surfactant systems for its foam enhancing properties, helping with the formation of bubble structure, leading to richer, longer lasting lather.
Hydroxypropyl methylcellulose (HPMC) has a high tolerance for both salt and alcohol.
Hydroxypropyl methylcellulose (HPMC) are cellulose ethers that have had hydroxyl groups on the cellulose chain substituted for a methoxy or hydroxypropyl group.
Hydroxypropyl methylcellulose (HPMC) is used as a thickener, binder, and film former in agrochemicals, coatings, ceramics, adhesives, inks, and various other applications. Aqueous solutions of Hydroxypropyl methylcellulose (HPMC) will reversibly gel when exposed to heat allowing for a controllable boost is green strength of green ceramic bodies. HPMC falls under the METHOCEL line of products from IFF.
Melting point: 225-230 °C
Density: 1.39
storage temp.: room temp
solubility: H2O: 50 mg/mL, clear to very faintly turbid, faintly yellow
form: powder
color: White to cream
Odor: Odorless
Viscosity: 35.0 - 65.0 cps
Water Solubility: SOLUBLE
Merck: 14,4842
Hydroxypropyl methylcellulose (HPMC) and methyl cellulose are also water-soluble nonionic polymers.
They are compatible with inorganic salts and ionic species up to a certain concentration.
Methyl cellulose can be salted out of solution when the concentration of electrolytes or other dissolved materials exceeds certain limits.
Hydroxypropyl methylcellulose (HPMC) has a higher tolerance for salts in solution than methyl cellulose.
Commercial water-soluble Hydroxypropyl methylcellulose (HPMC) products have a methoxy DS of 1.64 to 1.92.
A DS of lower than 1.64 yields material with lower water solubility.
The methoxy DS in hydroxypropyl methyl cellulose ranges from 1.3 to 2. Thehydroxypropyl MS ranges from 0.13 to 0.82.
Hydroxypropyl methylcellulose (HPMC) polymers have a number of applications and are used as thickeners in latex paints,food products,shampoos,creams and lotions, and cleansing gels.
U.S.Patent 5,565,421 is an example of the use of Hydroxypropyl methylcellulose (HPMC) polymer to gel a light-duty liquid detergent containing anionic surfactants.
Hydroxypropyl methylcellulose (HPMC) is obtained by treatment of fibrous plant material with alkali, methyl chloride and propylene oxide.
The refined cotton cellulose with alkali treatment at 35-40 ℃ for half an hour, press, crushed the cellulose, aging at 35 ℃, so that the average degree of polymerization of alkali cellulose is in a desired range.
The alkali fiber into etherification reactor, followed by adding epoxy propane and methane chloride, etherification at 50-80 ℃ for 5h, the maximum pressure is about 1.8MPa.
The reaction products were produced by postprocessing (hydrochloric acid and oxalic acid, washing and drying).
The consumption of raw material of cotton pulp 1100kg/t, methyl chloride and propylene oxide 4300kg/t, solid alkali 1200kg/t, hydrochloride 30kg/t, oxalic acid 50kg/t.
In the reaction kettle, the chlorinated methane, propylene oxide were added into the reaction kettle.
At 80℃, the pressure was 1.8 MPa, the reaction time is 5 to 8 h, and the amount of Hydroxypropyl methylcellulose (HPMC) and oxalic acid were added to the hot water at 90℃.
Dewatering with centrifuge, washing to neutral, when the water content of the material is below to 60% , 130℃ of hot air flow dried to the moisture content is below 5%.
Finally, the finished Hydroxypropyl methylcellulose (HPMC) sieved by 20 mesh.
Prepared by Hydroxypropyl methylcellulose (HPMC), methyl chloride, and ethylene oxide.
A purified form of cellulose, obtained from cotton linters or wood pulp, is reacted with Hydroxypropyl methylcellulose (HPMC) solution to produce a swollen alkali cellulose that is chemically more reactive than untreated cellulose.
The alkali Hydroxypropyl methylcellulose (HPMC) is then treated with chloromethane and propylene oxide to produce methyl hydroxypropyl ethers of cellulose.
The fibrous reaction Hydroxypropyl methylcellulose (HPMC) is then purified and ground to a fine, uniform powder or granules.
Hydroxypropyl methylcellulose (HPMC) can then be exposed to anhydrous hydrogen chloride to induce depolymerization, thus producing low viscosity grades.
Hydroxypropyl methylcellulose (HPMC) is produced by treating cellulose with sodium hydroxide to form alkali cellulose, which is then reacted with propylene oxide and methyl chloride to substitute hydroxyl groups on the cellulose chain with hydroxypropyl and methyl groups, respectively.
The final Hydroxypropyl methylcellulose (HPMC) is then washed, purified, and dried into a powder or granule form.
Hydroxypropyl methylcellulose (HPMC) one of the key ingredients in drymix mortars due to their ability to influence key dry mix mortars properties such as curing, workability, water retention, rheology and thixothropy.
The thickening effect of Hydroxypropyl methylcellulose (HPMC) can control the mortar to achieve the best consistency, improve the cohesion of the mortar, achieve the anti-dripping effect, improve the operability, and greatly improve the construction efficiency.
The consistency and slip resistance of the mortar is a very important requirement.
For thick layer construction and tile adhesive, the mortar needs to have the proper consistency and slip resistance.
Hydroxypropyl methylcellulose (HPMC) can improve the bonding strength of mortar, even in high temperature environment, it can ensure sufficient moisture of mortar, and make cement fully hydrated, thus ensuring better bonding performance of the mortar and ensuring mortar to various substrates.
Hydroxypropyl methylcellulose (HPMC) is soluble in water and part of solvents such as alcohol-water and propyl alcohol-water solvents in an appropriate proportion.
The aqueous solution owns surface activity, high transparency and stable properties.
Hydroxypropyl methylcellulose (HPMC) of different specifications have different gelation temperatures and the solubility changes with the viscosity.
The lower the viscosity is, the higher the solubility will be.
Hydroxypropyl methylcellulose (HPMC) products with different specifications also have difference in properties and the dissolution of HPMC in water doesn’t get affected by the pH value.
Hydroxypropyl methylcellulose (HPMC) is incompatible with some oxidizing agents. Since it is nonionic, hypromellose will not complex with metallic salts or ionic organics to form insoluble precipitates.
Storage Of Hydroxypropyl methylcellulose (HPMC):
Hypromellose powder is a stable material, although it is hygroscopic after drying.
Hypromellose undergoes a reversible sol–gel transformation upon heating and cooling, respectively.
The gelation temperature is 50–90°C, depending upon the grade and concentration of material.
For temperatures below the gelation temperature, viscosity of the solution decreases as temperature is increased.
Beyond the gelation temperature, viscosity increases as temperature is increased.
Aqueous solutions are comparatively enzyme-resistant, providing good viscosity stability during long-term storage.
However, aqueous solutions are liable to microbial spoilage and should be preserved with an antimicrobial preservative: when hypromellose is used as a viscosity-increasing agent in ophthalmic solutions, benzalkonium chloride is commonly used as the preservative.
Aqueous solutions may also be sterilized by autoclaving; the coagulated polymer must be redispersed on cooling by shaking.
Hydroxypropyl methylcellulose (HPMC) powder should be stored in a well-closed container, in a cool, dry place.
Uses Of Hydroxypropyl methylcellulose (HPMC):
Hydroxypropyl Methyl Cellulose (HPMC) are water soluble polymers derived from cellulose.
They are typically used as thickeners, binders, film formers, and water retention agents.
They also function as suspension aids, surfactants, lubricants, protective colloids, and emulsifiers.
In addition, solutions of these polymers thermally gel.
Hydroxypropyl methylcellulose (HPMC) has many excellent properties.
Stabilizers of emulsions and foams, as a replacement for fat, as a non-caloric bulking agentin foods, as a binder, among others.
As a dispersing and thickening agent, film-coating of tablets, drug preparations,among others.
Hydroxypropyl methylcellulose (HPMC) is used hair shampoo, eye makeup, skin care preparations, among others.
Hydroxypropyl methylcellulose (HPMC) is a gum formed by the reaction of propylene oxide and methyl chloride with alkali cellulose.
Hydroxypropyl methylcellulose (HPMC) will gel as the temperature is increased in heating and upon cooling will liquefy.
The gel temperature ranges from 60°c to 90°c, forming semifirm to mushy gels.
Hydroxypropyl methylcellulose (HPMC) is used in bakery goods, dressings, breaded foods, and salad dressing mix for syneresis control, texture, and to provide hot viscosity.
Hydroxypropyl methylcellulose (HPMC) is used as an ophthalmic lubricant, an emulsifier and a thickening and suspending agent.
Hydroxypropyl methylcellulose (HPMC) is widely used as an excipient in pharmaceutical formulations.
It acts as a food additive.
Its eye drops are known as artificial tears, which are used to relieve eye dryness and soreness.
Hydroxypropyl methylcellulose (HPMC) finds applications in various fields as emulsifier, film former, protective colloid, stabilizer, suspending agent, or thickener in foods.
Pharmaceutic aid (suspending agent; tablet excipient; demulcent; viscosity increasing agent); hydrophilic carrier in drug delivery systems.
In adhesives, asphalt emulsions, caulking compounds, tile mortars, plastic mixes, cements, paints.
Agricultural Research Service scientists are investigating using the plant-derived Hydroxypropyl methylcellulose (HPMC) as a substitute for gluten in making all-oat and other grain breads.
Gluten, which is present in wheat, rye, and barley, is absent (or present only in trace quantities) in oat and other grains.
Like gluten, Hydroxypropyl methylcellulose (HPMC) can trap air bubbles formed by the yeast in bread dough, causing the bread to rise.
Hydroxypropyl methylcellulose (HPMC) is used primarily in construction materials like tile adhesives and renders where it is used as a rheology modifier and water retention agent.
Hydroxypropyl methylcellulose (HPMC) is very similar to HEMC (hydroxy ethyl methyl cellulose) Trade names include Methocel and Walocel.
Hydroxypropyl methylcellulose (HPMC) solutions were patented as a semisynthetic substitute for tear-film.
Its molecular structure is predicated upon a base celluloid compound that is highly water-soluble.
Post-application, celluloid attributes of good water solubility reportedly aid in visual clarity.
When applied, a hypromellose solution acts to swell and absorb water, thereby expanding the thickness of the tear-film.
Hydroxypropyl methylcellulose (HPMC) augmentation therefore results in extended lubricant time presence on the cornea, which theoretically results in decreased eye irritation, especially in dry climates, home, or work environments.
On a molecular level, this polymer contains beta-linked D-glucose units that remain metabolically intact for days to weeks.
On a manufacturing note, since Hydroxypropyl methylcellulose (HPMC) is a vegetarian substitute for gelatin, it is slightly more expensive to produce due to semisynthetic manufacturing processes.
Aside from its widespread commercial and retail availability over the counter in a variety of products, hypromellose 2% solution has been documented to be used during surgery to aid in corneal protection and during orbital surgery.
In addition to its use in ophthalmic liquids, Hydroxypropyl methylcellulose (HPMC) has been used as an excipient in oral tablet and capsule formulations, where, depending on the grade, it functions as controlled release agent to delay the release of a medicinal compound into the digestive tract.
Hydroxypropyl methylcellulose (HPMC) is also used as a binder[12] and as a component of tablet coatings.
Hydroxypropyl methylcellulose (HPMC) is often used in skin care products such as moisturizers, sunscreens, and anti-aging creams due to its moisturizing properties.
Hydroxypropyl methylcellulose (HPMC) can form a protective barrier on the skin, helping to prevent moisture loss and maintaining skin hydration.
Hydroxypropyl methylcellulose (HPMC) can also help to enhance the texture of the skin and provide a smooth and silky feel
Hydroxypropyl methylcellulose (HPMC) is used in hair care products to improve the texture of the shafts and add volume.
Hydroxypropyl methylcellulose (HPMC) can be found in products such as shampoos, conditioners, and styling products.
Further, Hydroxypropyl methylcellulose (HPMC) also helps in controlling frizz and providing a glossy shine.
Hydroxypropyl methylcellulose (HPMC) is often used as a thickener, emulsifier, and stabilizer.
Hydroxypropyl methylcellulose (HPMC) enhances the texture and consistency of products such as lip balms and foundations.
Hydroxypropyl methylcellulose (HPMC) can also help to prevent products from separating or settling over time, ensuring a longer shelf life
Safety profile Of Hydroxypropyl methylcellulose (HPMC):
Hydroxypropyl methylcellulose (HPMC) is considered safe for use in cosmetics and is not toxic or harmful for the skin or hair.
Hydroxypropyl methylcellulose (HPMC) is also not comedogenic, so it does not cause acne breakouts.
However, Hydroxypropyl methylcellulose (HPMC) is essential to note that excessive exposure to this ingredient may cause dryness and irritation.
Conducting a patch test is recommended. Lastly, Hydroxypropyl methylcellulose (HPMC) is a vegan and halal ingredient.
Hydroxypropyl methylcellulose (HPMC) is widely used as an excipient in oral, opthalmic, nasal, and topical pharmaceutical formulations.
Hydroxypropyl methylcellulose (HPMC) is also used extensively in cosmetics and food products.
Hydroxypropyl methylcellulose (HPMC) is generally regarded as a nontoxic and nonirritating material, although excessive oral consumption may have a laxative effect.
The WHO has not specified an acceptable daily intake for Hydroxypropyl methylcellulose (HPMC) since the levels consumed were not considered to represent a hazard to health.
In fact, high dosages of Hydroxypropyl methylcellulose (HPMC) are being investigated for treating various metabolic syndromes.
