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EC / List no.: 618-389-6
CAS no.: 9004-65-3
Hydroxypropyl methylcellulose (HPMC) belongs to the group of cellulose ethers in which hydroxyl groups have been substituted with one or more of the three hydroxyl groups present in the cellulose ring .
HPMC is hydrophilic (water soluble), a biodegradable, and biocompatible polymer having a wide range of applications in drug delivery, dyes and paints, cosmetics, adhesives, coatings, agriculture, and textiles [174–176].
HPMC is also soluble in polar organic solvents, making it possible to use both aqueous and nonaqueous solvents.
Hydroxypropyl methylcellulose has unique solubility properties with solubility in both hot and cold organic solvents.
HPMC possesses increased organo-solubility and thermo-plasticity compared to other methyl cellulose counterparts.
Hydroxypropyl methylcellulose forms gel upon heating with gelation temperature of 75–90oC.
What is hydroxypropyl methylcellulose?
Hydroxypropyl methylcellulose is a white, odourless, tasteless powder made chemically through the modification of cellulose.
Cellulose is a natural polymer – long chains or structures made up of many, many molecules strung together.
What is Hydroxypropyl methylcellulose used for?
Hydroxypropyl methylcellulose is used as a vegan alternative to gelatine in medicines and supplements; as a treatment for dry eye syndrome and as a gluten replacement in gluten-free bread.
In gluten-free bread it improves the elasticity, stability, volume and moisture retention.
This makes a loaf more akin to gluten containing bread (source: Study on effects of HPMC and CMC on the properties of gluten-free bread).
Hydroxypropyl Methylcellulose (HPMC) is multifunctional as a lubricant, foam enhancer and stabilizer, thickener, emulsion stabilizer and film former for hair and skin care products.
HPMC is especially useful in surfactant systems for its foam enhancing properties, helping with the formation of bubble structure, leading to richer, longer lasting lather. HPMC has a high tolerance for both salt and alcohol.
Techniques for Dispersion
The preferred method is to begin by heating approximately 1/3 of the total formulation water to 167°F (75°C) or higher. Add the HPMC to the vortex of agitated and heated water.
Mix until fully dispersed.
HMPC will not dissolve at this temperature.
After complete dispersion, add the remaining water at room temperature or colder and continue mixing for 30 minutes after the total solution has cooled to 77°F. (25°C) or less.
Proceed with the formulation.
If heating is impossible, it is preferred to slurry the HPMC in a non-solvating media, such as glycerin or PEG, then add the slurry to the vortex of vigorously agitated water.
Adding HPMC directly to cold water is not preferred, but if necessary, must be done very slowly under vigorous agitation.
Expect longer mixing times for complete dissolution.
Application
Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.
Product features
Hydroxypropyl methylcellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.
Hydroxypropyl methylcellulose is white or pale white cellulose powder or particles.
The characteristics of cold water dissolution and hot water insoluble are similar with methyl cellulose.
Solubility in organic solvents is superior than water soluble, can be dissolved in anhydrous methanol and ethanol solution, also soluble in chlorinated hydrocarbons and ketones in organic solvents.
Soluble in water, its water solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the reversible conversion of sol to gel.
Can be used alone in the cold drink, also can be used with other emulsifier, stabilizer.
To cold drink, the maximum amount is 1%.
Hydroxypropyl methylcellulose and other water-soluble high weight compounds use mixture, become transparent, higher viscosity.
The gelation temperature of low viscosity products is higher than high viscosity of products.
Its solution is stable at room temperature. In recent years, Hydroxypropyl methylcellulose has been widely used in petroleum chemical industry, papermaking, leather, textile printing and dyeing, pharmaceutical, food, cosmetics and other industries, and as the dispersing agent, thickening agent, adhesive, excipient, capsule, oil resistant coating and packing etc.
Chemical Properties
Hydroxypropyl methylcellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.
Hydroxypropyl methylcellulose is white or pale white cellulose powder or particles.
Hydroxypropyl methylcellulose has different types of products, the methoxy and hydroxypropyl content ratio is different.
Hydroxypropyl methylcellulose is white or gray fibrous powder or particles.
Hydroxypropyl methylcellulose is soluble in water and some organic solvents and unsoluble in ethanol.
Aqueous solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the sol to gel reversible transformation.
Applications
Hydroxypropyl methylcellulose (HPMC) are water soluble polymers derived from cellulose.
They are typically used as thickeners, binders, film formers, and water retention agents.
They also function as suspension aids, surfactants, lubricants, protective colloids, and emulsifiers.
In addition, solutions of these polymers thermally gel.
Hydroxypropyl methylcellulose has many excellent properties.
lt is presented below some examples of HPMC applications:
Food industry:
stabilizers of emulsions and foams, as a replacement for fat, as a non-caloric bulking agentin foods, as a binder, among others.
Pharmaceutical industry:
as a dispersing and thickening agent, film-coating of tablets, drug preparations,among others.
Cosmetics industry:
hair shampoo, eye makeup, skin care preparations, among others.
Liquid Detergents
Hydroxypropyl methylcellulose and methyl cellulose are also water-soluble nonionic polymers.
They are compatible with inorganic salts and ionic species up to a certain concentration.
Methyl cellulose can be salted out of solution when the concentration of electrolytes or other dissolved materials exceeds certain limits.
Hydroxypropyl methylcellulose has a higher tolerance for salts in solution than methyl cellulose.
Both are stable over a pH range of 3 to 11.
Commercial water-soluble methyl cellulose products have a methoxy DS of 1.64 to 1.92.
A DS of lower than 1.64 yields material with lower water solubility.
The methoxy DS in Hydroxypropyl methylcellulose ranges from 1.3 to 2.
Thehydroxypropyl MS ranges from 0.13 to 0.82.
Methyl cellulose and Hydroxypropyl methylcellulose polymers have a number of applications and are used as thickeners in latex paints,food products,shampoos,creams and lotions, and cleansing gels. U.S.Patent 5,565,421 is an example of the use of hydroxypropylmethyl cellulose polymer to gel a light-duty liquid detergent containing anionic surfactants.
Methods of production
Hydroxypropyl methylcellulose is obtained by treatment of fibrous plant material with alkali, methyl chloride and propylene oxide.
The refined cotton cellulose with alkali treatment at 35-40 ℃ for half an hour, press, crushed the cellulose, aging at 35 ℃, so that the average degree of polymerization of alkali cellulose is in a desired range.
The alkali fiber into etherification reactor, followed by adding epoxy propane and methane chloride, etherification at 50-80 ℃ for 5h, the maximum pressure is about 1.8MPa.
The reaction products were produced by postprocessing (hydrochloric acid and oxalic acid, washing and drying).
The consumption of raw material of cotton pulp 1100kg/t, methyl chloride and propylene oxide 4300kg/t, solid alkali 1200kg/t, hydrochloride 30kg/t, oxalic acid 50kg/t.
100 kg refined cotton linters immersed in 45% solution, temperature is 35 to 40℃, time is 0.5 to 1 h, and then remove the press.
The pressure to weight is 2.7 times as the weight of lint, stop pressure.
Carry out the crushing.
At 35℃, aging for 16h.
In the reaction kettle, the chlorinated methane, propylene oxide were added into the reaction kettle.
At 80℃, the pressure was 1.8 MPa, the reaction time is 5 to 8 h, and the amount of hydrochloric acid and oxalic acid were added to the hot water at 90℃.
Dewatering with centrifuge, washing to neutral, when the water content of the material is below to 60% , 130℃ of hot air flow dried to the moisture content is below 5%.
Finally, the finished product sieved by 20 mesh.
Prepared by cellulose, methyl chloride, and ethylene oxide.
Description
Cellulose is a natural substance normally present in most diets because it is the major structural carbohydrate of green plants.
Cellulose is essentially a linear polymer of glucopyranose units connected by (3-1,4-glucoside links. In nature, cellulose is present in plant cell walls as fibers.
The molecular weight of isolated cellulose is approximately 50,000.
The principal sources of cellulose for food related purposes are cotton linters and wood pulp.
Chemical processing converts cellulose into forms or derivatives suitable for incorporation into food products, or for use in food packaging materials.
Hydroxypropylmethyl cellulose is synthesized from methyl cellulose by the action of alkali and propylene oxide.
The resultant product is a water soluble ether derivative of cellulose containing both methoxy and hydroxypropyl groups. The degree of substitution is 1.08 to 1.83 with the hydroxypropyl groups as the minor constituent.
Hydroxypropyl methylcellulose is used as a thickening agent, stabilizer, and emulsifier.
Chemical Properties
white or slightly beige powder or a viscous solution
Hydroxypropyl methylcellulose is an odorless and tasteless, white or creamy-white fibrous or granular powder.
Uses:
Hydroxypropyl methylcellulose is a thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.
As a food additive, Hydroxypropyl methylcellulose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin.
As emulsifier, film former, protective colloid, stabilizer, suspending agent, or thickener in foods.
Pharmaceutic aid (suspending agent, tablet excipient, demulcent, viscosity increasing agent), hydrophilic carrier in drug delivery systems.
In adhesives, asphalt emulsions, caulking compounds, tile mortars, plastic mixes, cements, paints.
Hydroxypropyl Methylcellulose is a gum formed by the reaction of propylene oxide and methyl chloride with alkali cellulose.
Hydroxypropyl methylcellulose will gel as the temperature is increased in heating and upon cooling will liquefy.
the gel temperature ranges from 60°c to 90°c, forming semifirm to mushy gels.
Hydroxypropyl methylcellulose is used in bakery goods, dressings, breaded foods, and salad dressing mix for syneresis control, texture, and to provide hot viscosity.
Usage level ranges from 0.05 to 1.0%.
Production Methods
A purified form of cellulose, obtained from cotton linters or wood pulp, is reacted with sodium hydroxide solution to produce a swollen alkali cellulose that is chemically more reactive than untreated cellulose.
The alkali cellulose is then treated with chloromethane and propylene oxide to produce methyl hydroxypropyl ethers of cellulose.
The fibrous reaction product is then purified and ground to a fine, uniform powder or granules.
Hydroxypropyl methylcellulose can then be exposed to anhydrous hydrogen chloride to induce depolymerization, thus producing low viscosity grades.
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
What is Hydroxypropyl Methylcellulose?
Hydroxypropyl Methylcellulose (HMPC) is a polysaccharide additive used in frosting, coatings, gluten-free baking and dietary supplements.
Hydroxypropyl methylcellulose is also a stabilizer, thickener, fat replacer, bulking and binding agent.
Origin
Hydroxypropyl Methylcellulose is obtained from various natural sources, mainly wood pulp and cotton linters.
Since 1985, HPMC has been used as a gluten replacement for the manufacture of baked goods
Function
HPMC can serve several functions in baked goods such as:
- Stabilizer of emulsions and foams: critical for dough development during baking.
- Thickener: increases viscosity by thickening the aqueous phase.
- Fat-replacer: acts as a lubricant to help maintain creamy mouthfeel.
- Gluten-substitute: most effectively when combined with carboxymethylcellulose (CMC) in baked goods.
- Bulking agent
- Coating agent: film and barrier formation for coating.
- Binder
- Water retention: extends shelf-life.
- Controls water balance during freezing and thawing.
Nutrition
HPMC is considered a non-fermentable soluble dietary fiber, thus providing several health benefits including reduction of total and low density lipoprotein cholesterol, reducing risk factors of type 2 diabetes and aiding intestinal movements.
Using HPMC in gluten-free baked goods helps with diet management for patients with celiac disease.
Commercial production
HPMC is manufactured following this process:
- Alkalinization: wood pulp cellulose is treated with a 50 wt% sodium hydroxide solution in a reactor.
- Etherification: addition of methyl chloride followed by propylene oxide to introduce methoxy and propylene glycol groups, respectively.
- Neutralization: using hydrogen chloride solution.
- Purification: HPMC is washed several times with hot water, and filtered.
- Drying and sizing: the purified product is dried, ground to desirable particle size followed by packaging.
Application
HPMC can be used in the manufacture of several baked products, fillings, foams and coatings.
Hydroxypropyl methylcellulose is a great alternative for gluten substitution in gluten-free baked products in combination with CMC.
Some considerations when adding HPMC to food products include:
- Solubilizing HPMC/CMC before addition for full performance.
- Consider the water activity of the systems, 5-10% of water may be needed in some formulations.
- HPMC should be added after proteins are activated.
- HPMC accommodates high sugar levels, up to 50%.
Methods of incorporating of HPMC/CMC mixtures in food products:
- HPMC/CMC should be dispersed in one third of the required water.
- Add the rest of HPMC/CMC with the dry ingredients to avoid lump formation.
- Disperse the blend in the required oil and then add to the bakery mix.
Hydroxypropyl methylcellulose (HPMC) is a white, odourless, tasteless powder created through the modification of cellulose.
Cellulose is a natural polymer – long chains or structures made up of multiple molecules strung together.
Also known as Hydroxypropyl methylcellulose, it is an emulsifier, thickening and suspending agent with a variety of applications from food to cosmetic uses.
An aqueous product which forms colloids when dissolved in water.
When heated the solution congeals into a non-flowable but semi-flexible mass.
Hydroxypropyl methylcellulose has a multiple use including but not limited to:
Food, Cosmetic, Eye Drops, Contact Lenses, Tile adhesives, Cement Renders, Detergents & Cleaners, Pains & Coatings, Pharmaceutical and Gypsum products.
An ideal vegan alternative to gelatine in medicines and supplements, as a treatment for dry eye syndrome and as a gluten replacement in gluten-free bread (improves the elasticity, stability, volume and moisture retention).
Hydroxypropyl methylcellulose is an EU and FDA-approved food additive and is considered non-toxic to humans.
Chemical and Physical Qualities:
Physical form: Powder
Assay: 90 – 99%
Ash (as NA2SO4): 1.5% Max.
Methoxyl: 19 – 24%
Hydroxypropyl: 4 – 12%
Moisture as packed: 10.0% Max.
Sodium Chloride: 2.0% Max.
pH: 5.0 – 8.0
2% Viscosity, (LVT, 20C): 3000 - 5600 mPas
Typical 2% viscosity, (RVT, 20°C) : 4000 mPas
Gelation Temperature: 70 – 90C
Lead: 2 ppm Max.
Arsenic: 3 ppm Max
Cadmium: 1 ppm Max
Mercury: 1 ppm Max
Particle Size
Retained on 72 Mesh: 10% Max
Total Plate Count: 5000 cfu/g Max
Yeasts & Moulds: 500 cfu/g Max
Coliforms: 100 cfu/g Max
E. coli: Absent /g
Salmonella: Absent /25g
IUPAC NAMES:
(2R,3R,4S,5R,6R)-2,3,4-trimethoxy-6-(methoxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[(2R,3R,4S,5R,6S)-3,4,5-tris(2-hydroxypropoxy)-6-[(2R,3R,4S,5R,6R)-4,5,6-tris(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]propan-2-ol
2-[6-[4,5-bis(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)-6-methoxy-oxan-3-yl]oxy-4,5-dimethoxy-2-(methoxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxy-oxane-3,4-diol
2-[6-[4,5-bis(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dimethoxy-2-(methoxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol
4,5-dimethoxy-2-(methoxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol
Cellulose ether
Cellulose, 2-hydroxypropyl methyl ether
HPMC
Hydroxy propyl methyl cellulose
Hydroxyl propyl methyl cellulose
Hydroxypropyl methylcellulose
Hydroxypropyl methylcellulose
Hydroxypropyl methylcellulose
Hydroxypropyl methylcellulose Ether
HYDROXYPROPYL METHYLCELLULOSE
Hydroxypropyl Methylcellulose
Hydroxypropylmethylcellulose
hydroxypropylmethylcellulose
methylhydroxypropylcellulose
SYNONYMS:
hpmcd
hydroxylpropylmethylcellulose
Hydroxymethylpropylcellulose
isoptoalkaline
isoptoplain
isoptotears
methocele,f,k
HydroxypropylMethylCellulose(Hpmc)
HydroxyPropylMethylCelluloseHpmcE15Lv
HydroxyPropylMethylCelluloseHpmcE5LvPremium
Hydroxypropyl methylcellulose (Mpmc), Cas
Methylcellulose, propylene glycol ether
Hydroxypropyl methylcellulose, M.N. 86,000
viscosity 4,000 cP (2% solution)
HYDROXYPROPYLMETHYLCELLULOSE,100CPS,FCC
HYDROXYPROPYLMETHYLCELLULOSE,4,000CPS,FCC
HYDROXYPROPYLMETHYLCELLULOSE,50CPS,FCC
HYPROMELLOSE,2208,100,000CPS,USP
HYPROMELLOSE,2208,100CPS,USP
HYPROMELLOSE,2208,4,000CPS,USP
HYPROMELLOSE,2910,50CPS,USP
Hydroxyproxyl Cellulose
Hydroxypropyl methylcellulose (HPMC) (13.0-18.0 M
Hydroxypropyl methylcellulose (HPMC) (3.0-7.0 MPA
Hydroxypropyl methylcellulose (HPMC) (40.0-60.0 M
Hydroxypropyl methylcellulose (HPMC) (8.0-12.0 MP
METHYLHYDROXYPROPYLCELLULOSE
PROPYLENEGLYCOLMETHYLCELLULOSE
HYDROXPROPYLMETHYLCELLULOSE
HYDROXYPROPYLMETHYLCELLULOSEGEL
High-Substituted Hydroxyproxyl Cellulose
MHPC
(Hydroxypropyl)Methyl cellulose average Mn ~10,000
(Hydroxypropyl)Methyl cellulose average Mn ~86,000
(Hydroxypropyl)methyl cellulose average Mn ~120,000
(Hydroxypropyl)methyl cellulose average Mn ~90,000
Hydroxypropyl methylcellulose USP
(HYDROXYPROPYL)METHYL CELLULOSE, 15
HYDROXYPROPYLMETHYLCELLULOSE 2910, U
HYDROXYPROPYLMETHYLCELLULOSE APPROX*
Manufacturers Wholesale Hydroxypropyl methylcellulose CAS NO.9004-65-3
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best price white powder HPMC
HPMC Hydroxypropyl methylcellulose cas 9004-65-3
HPMC, High viscosity hydroxypropylmethylcellulose
HPMC, Low viscosity hydroxypropylmethylcellulose
HPMC, Medium viscosity hydroxypropylmethylcellulose
Hydroxypropyl methylcellulose, 28 to 30% methoxyl, 7 to 12% hydroxypropyl, viscosity (2% aq. soln., 20°C) 7500 to 14000mPa.s
Methocel K 15
(Hydroxypropyl)methyl cellulose - Viscocity 40-60 cP, 2 % in H2O (20 °C)
(Hydroxypropyl)methyl cellulose - Viscocity 80-120 cP, 2 % in H2O (20 °C)
Hydroxypropyl methylcellulose(HPMC) K-100
Hypromellose(HPMC)
N-Methyl pyrrole 96-54-8
(Hydroxypropyl)methyl cellulose - Viscocity 3000-5600 cP
Methocel K 15(Hydroxypropyl methylcellulose)
Hydroxy propyl methyl collulose
