HYDROXYPROPYL STARCH PHOSPHATE

CAS:    113894-92-1
MF:    C10H22O6
MW:    238.27808

Hydroxypropyl distarch phosphate (HDP) is a modified resistant starch. 
Hydroxypropyl Starch Phosphate is currently used as a food additive.
Hydroxypropyl Starch Phosphate is approved for use in the European Union (listed as E1442), the United States, Australia, Taiwan, and New Zealand.

Chemical Properties    
Hydroxypropyl Starch Phosphate occurs as a free-flowing white to off-white coarse powder.

Production Methods    
Hydroxypropyl Starch Phosphate is produced industrially from natural starch, using propylene oxide as the modifying reagent in the presence of alkali, adding hydroxypropyl (CH(OH)CH2CH3) groups at the OH positions by an ether linkage.

Pharmaceutical Applications    
Hydroxypropyl Starch Phosphate is a modified starch and has been used in combination with carrageenan in the production of soft capsules. 
Hydroxypropyl Starch Phosphate has been used experimentally in hydrophilic matrices, where Hydroxypropyl Starch Phosphate was shown to be an effective matrix for tablets designed for controlled-release drug delivery systems.
Hydroxypropyl Starch Phosphate has also been used experimentally in the production of hydrophilic matrices by direct compression.
Hydroxypropyl Starch Phosphate is used in antiseptics and is used widely in cosmetics. 
Hydroxypropyl Starch Phosphate is also used analytically as a bioseparation aqueous-phase-forming polymer.

Safety    
Hydroxypropyl Starch Phosphate is widely used in cosmetics and food products. 
Hydroxypropyl Starch Phosphate is also used in oral pharmaceutical formulations. 
Hydroxypropyl Starch Phosphate has set an acceptable daily intake for hydroxypropyl starch at ‘not limited’ since Hydroxypropyl Starch Phosphate was well tolerated on oral consumption.
LD50 (rat, oral): 0.218 g/kg

Application    
Hydroxypropyl Starch Phosphate, sorbitol, carrageenan and disodium phosphate blend. 
This ready-to-use formulation was developed to replace gelatin in the manufacture of veggie soft capsules. 
Hydroxypropyl Starch Phosphate offers excellent film-forming properties and is used in both pharmaceutical and nutraceutical applications

Synonyms
Pentaethylene glycol
4792-15-8
3,6,9,12-Tetraoxatetradecane-1,14-diol
HO-PEG5-OH
PENTAETHYLENEGLYCOL
2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
Pentaglycol
PEG400
HO[CH2CH2O]5H
Hydroxypropyl starch phosphate
MFCD00002878
113894-92-1
CHEBI:39631
DSSTox_CID_7579
DSSTox_RID_78510
DSSTox_GSID_27579
CAS-4792-15-8
EINECS 225-341-4
OH-PEG5-OH
BRN 1635593
2-(2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol
2-[2-[2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy]-ethoxy]-ethanol
3,6,9,12-Tetraoxatetradocane-1,14-diol
Pentaethylene glycol, 98%
SCHEMBL45272
4-01-00-02405 (Beilstein Handbook Reference)
CHEMBL1229766
DTXSID4027579
AMY4487
ZINC4283769
Tox21_201721
Tox21_303127
AKOS015839786
CS-W007341
DS-4289
HY-W007341
NCGC00164364-01
NCGC00164364-02
NCGC00257199-01
NCGC00259270-01
BP-21065
SY010536
DB-070885
FT-0701756
P1154
Amylopectin, phosphate, 2-hydroxypropyl ether
S10674
A872019
W-106062
Q15656852