PRODUCTS

ICOSAN-1-OL

Icosan-1-ol helps create smooth, luxurious formulations while reducing moisture loss from the skin.
In pharmaceutical formulations, Icosan-1-ol serves as: Tablet excipient, Topical ointment ingredient, Cream base component, Lubricating agent, Controlled-release formulation ingredient.
Icosan-1-ol is used in numerous industrial sectors.

CAS Number: 629-96-9
EC Number: 211-119-4
Molecular Formula: C₂₀H₄₂O
Molecular Weight: 298.55 g/mol

SYNONYMS:
1-EICOSANOL, Icosan-1-ol, 629-96-9, Arachidyl alcohol, Arachidic alcohol, Arachic alcohol, Eicosyl alcohol, N-Eicosanol, 1-Icosanol, N-1-Eicosanol, Pri-N-eicosyl alcohol, NSC 120887, HSDB 5731, 1QR1QRA9BU, EINECS 211-119-4, AI3-36485, NSC-120887, 1-EICOSANOL [HSDB], DTXSID0027272, CHEBI:75627, EC 211-119-4, ARACHIDYL ALCOHOL [USP-RS], ARACHIDYL ALCOHOL (USP-RS), nEicosanol, arachyl alcohol, n1Eicosanol, Icosan1ol, prinEicosyl alcohol, RefChem:432161, DTXCID007272, ARACHIDYL ALCOHOL [INCI], 211-119-4, InChI=1/C20H42O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21/h21H,2-20H2,1H, EICOSANOL, eicosan-1-ol, icosanol, MFCD00002938, 28679-05-2, Eicosanol-(1), Arachinyl alcohol, UNII-1QR1QRA9BU, a-eicosanol, 1-Ecosanol, 1-Prydroxyeicosane, n-eicosan-1-ol, N-Eicosanol (d41), 1-Eicosanol, 98%, 1-Eicosanol (Standard), A1EQ8, SCHEMBL108302, SCHEMBL158754, SCHEMBL630625, CHEMBL451717, orb1217797, orb1296988, orb3026102, QSPL 202, SCHEMBL1435928, SCHEMBL2069657, SCHEMBL3394049, SCHEMBL5820037, SCHEMBL9871388, 1-icosanol (ACD/Name 4.0), SCHEMBL18315999, SCHEMBL28257054, FOH 20:0, HY-W004263R, ZNA55389, LMFA05000221, NSC120887, SBB060169, TN6760, AKOS015839826, CS-W004263, EBC-389249, FA68034, HY-W004263, MSK159776-100T, 1-Eicosanol, technical, >=90% (GC), 1-Eicosanol, purum, >=97.0% (GC), BP-41333, BS-51501, Eicosanol Solution in Toluene, 100ug/mL, SY049846, DB-250389, E0004, NS00004340, ST51046403, H10676, F241876, Q4783532, ABA1F4B5-39FD-4206-A0A7-70D182257EEE, Arachidyl alcohol, United States Pharmacopeia (USP) Reference Standard, Icosan-1-ol[1], Arachidalcohol, Arachidic alcohol, Hydroxyicosane, Icosalcohol, Icosanol, 1-Icosanol, n-Icosanol, Icosyl alcohol, Icosyl hydrate, Icosylic alcohol, Nonadecylcarbinol, 1-Eicosanol, arachic alcohol, arachidic alcohol, arachidyl alcohol, arachinyl alcohol, eicosan-1-ol, eicosanol, N-eicosanol, N-1-eicosanol, eicosyl alcohol, icosan-1-ol, icosanol, n-Eicosanol, n-1-Eicosanol, Arachic alcohol, Arachidic alcohol, Arachidyl alcohol, Eicosyl alcohol, 1-Icosanol, Eicosanol-(1), Eicosan-1-ol, Eicosanol, NSC 120887, icosan-1-ol, 1-PRYDROXYEICOSANE, 1-icosanol, Arachidyl alcohol, Eicosan-1-ol, Eicosanol-(1), N-EICOSYL ALCOHOL, NSC 120887, arachic alcohol, arachidic alcohol, eicosanol, eicosyl alcohol, icosan-1-ol, n-1-Eicosanol, n-Eicosanol, Icosan-1-ol, Arachidic Alcohol, Arachidyl alcohol,Eicosan-1-ol, N-Eicosanol, Arachinyl Alcohol, Eicosanol (USP), Icosan-1-ol, 1-Eicosanol, Eicosanol, Arachidyl Alcohol, Arachyl Alcohol, Arachic Alcohol, Arachidic Alcohol, Hydroxyicosane, Icosanol, Icosyl Alcohol, n-Eicosanol, n-1-Eicosanol, Eicosanol-(1), Nonadecylcarbinol, NSC 120887

Icosan-1-ol, or 1-Eicosanol, or arachidyl alcohol, is a chemical compound belonging to the group of fatty alcohols .
Icosan-1-ol is a long-chain, saturated , primary fatty alcohol that is soluble in acetone and benzene .

Icosan-1-ol is found in olive oil .
Icosan-1-ol is a white solid that is practically insoluble in water.
Icosan-1-ol, more commonly known as 1-Eicosanol or Arachidyl Alcohol, is a long-chain saturated primary fatty alcohol containing twenty carbon atoms.

Icosan-1-ol belongs to the fatty alcohol family and occurs naturally in plant waxes, olive oil, peanut oil derivatives, and other natural lipid sources.
Because of its wax-like texture, excellent emollient properties, and chemical stability, Icosan-1-ol is widely used in cosmetics, pharmaceuticals, lubricants, wax formulations, specialty chemicals, and analytical chemistry.
Unlike short-chain alcohols such as ethanol or methanol, Icosan-1-ol is a solid at room temperature, exhibits extremely low volatility, and is practically insoluble in water.

Its long hydrocarbon chain gives Icosan-1-ol outstanding lubricating, moisturizing, and film-forming characteristics, making it an important ingredient in personal-care products and industrial formulations.
Icosan-1-ol (Arachidyl alcohol) is a waxy substance used as an emollient in cosmetics.
Icosan-1-ol is a straight-chain fatty alcohol with 20 carbon atoms, typically obtained via the hydrogenation of arachidic acid or arachidonic acid, both of which are present in peanut oil.

Icosan-1-ol's name is derived from that of the peanut plant (Latin: arachis).
Icosan-1-ol is a long-chain primary fatty alcohol that is icosane in which one of the terminal methyl hydrogens is replaced by a hydroxy group.
Icosan-1-ol has a role as a volatile oil component, a plant metabolite and a human metabolite.

Icosan-1-ol is an icosanol and a long-chain primary fatty alcohol.
Icosan-1-ol has been reported in Pyracantha angustifolia, Plumeria rubra, and other organisms with data available.
Icosan-1-ol is insoluble in water.

Icosan-1-ol, also known as behenyl alcohol, is a long-chain fatty alcohol with the molecular formula C20H42O.
Icosan-1-ol is characterized by a straight-chain structure consisting of a 20-carbon alkyl chain with a hydroxyl (-OH) functional group at one end.
Icosan-1-ol is typically a white, waxy solid at room temperature, with a melting point that allows it to remain solid in cooler conditions.

Icosan-1-ol is insoluble in water but soluble in organic solvents such as ethanol and ether, which is typical for long-chain alcohols.
Icosan-1-ol, also known as Arachidyl alcohol, 1-eicosanol or eicosyl alcohol, belongs to the class of organic compounds known as long-chain fatty alcohols.
These are fatty alcohols that have an aliphatic tail of 13 to 21 carbon atoms.

Thus, Icosan-1-ol is considered to be a fatty alcohol lipid molecule.
Icosan-1-ol is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.
Icosan-1-ol is a long-chain primary alcohol, belonging to the class of organic compounds known as fatty alcohols.

Icosan-1-ol typically appears as a waxy, white solid at room temperature, exhibiting a mild, characteristic odor.
Due to its high molecular weight and saturated carbon chain, Icosan-1-ol demonstrates low volatility and limited solubility in water, while being more soluble in nonpolar organic solvents such as ether and chloroform.

Icosan-1-ol was first synthesized in the early 20th century during investigations into long-chain alcohols derived from natural fats and oils.
Icosan-1-ol's preparation often involves the reduction of eicosanoic acid (arachidic acid), which can be obtained from plant sources such as peanuts or through synthetic methods using catalytic hydrogenation under high pressure with suitable reducing agents like lithium aluminum hydride or via hydroboration-oxidation processes.
Icosan-1-ol finds applications primarily in the cosmetic and pharmaceutical industries, where it serves as an emollient, thickening agent, or precursor for ester synthesis used in topical formulations.

Additionally, Icosan-1-ol has found utility in industrial lubricants and coatings due to its hydrophobic nature.
Natural sources include certain plant waxes and animal fats, although commercial production typically relies on synthetic routes for purity and consistency.
Industrial preparation of Icosan-1-ol usually starts from long-chain fatty acids or esters, processed under controlled conditions involving catalysts and elevated temperatures.

Icosan-1-ol, more commonly known as 1-Eicosanol or Arachidyl Alcohol, is a long-chain saturated primary fatty alcohol containing twenty carbon atoms.
Unlike short-chain alcohols such as ethanol or methanol, Icosan-1-ol is a solid at room temperature, exhibits extremely low volatility, and is practically insoluble in water.
Its long hydrocarbon chain gives Icosan-1-ol outstanding lubricating, moisturizing, and film-forming characteristics, making it an important ingredient in personal-care products and industrial formulations.

USES and APPLICATIONS of ICOSAN-1-OL:
Icosan-1-ol is used in gradient HPLC aerosol detection methods for the detection of various lipids.
Icosan-1-ol also serves as a lubricant and is used in pharmaceuticals and cosmetics.
Icosan-1-ol is widely used because its long hydrocarbon chain provides excellent conditioning, lubricating, and stabilizing properties.

One of its largest commercial applications is in cosmetics and personal-care products, where Icosan-1-ol functions as an emollient, viscosity controller, and emulsion stabilizer.
Major industrial applications of Icosan-1-ol include: Skin-care creams, Lotions, Hair conditioners, Lipsticks, Waxes, Pharmaceutical formulations, Lubricants, Specialty surfactants, Analytical chemistry, Chemical intermediates.
Its wax-like consistency makes Icosan-1-ol especially useful in products requiring a rich, protective texture.

Cosmetics represent one of the most important markets for Icosan-1-ol.
Icosan-1-ol's functions include: Emollient, Skin-conditioning agent, Viscosity-controlling agent, Emulsion stabilizer, Texture enhancer, Film-forming agent.
Icosan-1-ol helps create smooth, luxurious formulations while reducing moisture loss from the skin.

Icosan-1-ol's high molecular weight also reduces greasiness compared with some heavier waxes.
In pharmaceutical formulations, Icosan-1-ol serves as: Tablet excipient, Topical ointment ingredient, Cream base component, Lubricating agent, Controlled-release formulation ingredient.
Its chemical stability makes Icosan-1-ol suitable for long-term pharmaceutical storage.

Beyond cosmetics, Icosan-1-ol is used in numerous industrial sectors.
Applications of Icosan-1-ol include: Lubricant formulations, Wax blends, Surface coatings, Specialty esters, Nonionic surfactant production, Textile processing, Chemical intermediates.
Icosan-1-ol also serves as a reference compound in gradient HPLC methods used for lipid analysis.

Icosan-1-ol has been used in gradient HPLC-charged aerosol detection method for the detection of different lipids, as internal standard during determination of policosanol?s high molecular weight alcohols (policosanol?s fatty alcohols) in fish oil by GC.
Icosan-1-ol is also used as a non-ionic surfactant in cosmetics, used in lubricants, rubber, plastics, textiles and as an emulsion stabilizer and viscosity increasing agent.

Icosan-1-ol has applications in various industries, including cosmetics, where it serves as an emollient and thickening agent, as well as in the production of surfactants and lubricants.
Additionally, Icosan-1-ol can be used in the synthesis of other chemical compounds and as a potential biofuel due to its fatty acid composition.
Its properties make Icosan-1-ol a valuable substance in both industrial and research settings.

EXTRACTION AND PRESENTATION of ICOSAN-1-OL:
Icosan-1-ol can be obtained by Ziegler synthesis (trialkylaluminium process).
Icosan-1-ol can be produced by the reduction of arachidic acid .

NATURAL OCCURRENCE of ICOSAN-1-OL:
Icosan-1-ol occurs naturally in several biological sources.
Icosan-1-ol has been identified in:
*Olive oil

*Peanut-derived materials
*Plant epicuticular waxes
*Natural lipid mixtures
*Various higher-plant wax coatings
Historically, Icosan-1-ol's name "Arachidyl Alcohol" derives from Arachis, the botanical genus of the peanut.

BENEFITS AND ADVANTAGES of ICOSAN-1-OL:
Icosan-1-ol offers numerous technical advantages.
Icosan-1-ol's greatest strengths include:

Excellent emollient performance
Strong lubricating properties
High thermal stability

Very low volatility
Long-lasting skin-conditioning effects

Good chemical stability
Waxy texture enhancement

Film-forming capability
Oxidation resistance

Broad formulation compatibility
These characteristics explain Icosan-1-ol's popularity in premium cosmetic formulations.

ENVIRONMENTAL CHARACTERISTICS of ICOSAN-1-OL:
Icosan-1-ol exhibits environmental behavior typical of long-chain fatty alcohols.
Important characteristics include:

Very low water solubility
Strong adsorption to soils and sediments
High hydrophobicity
Low volatility
Biodegradable under appropriate environmental conditions
Naturally occurring in biological materials
Unlike many chlorinated hydrophobic compounds, long-chain fatty alcohols are generally biodegradable through microbial oxidation pathways.

ALTERNATIVE PARENTS of ICOSAN-1-OL:
Primary alcohols
Hydrocarbon derivatives

SUBSTITUENTS of ICOSAN-1-OL:
Long chain fatty alcohol
Organic oxygen compound
Hydrocarbon derivative
Primary alcohol
Organooxygen compound
Alcohol
Aliphatic acyclic compound

CHEMICAL PROPERTIES of ICOSAN-1-OL:
Icosan-1-ol is chemically stable under normal storage conditions and behaves as a typical saturated primary alcohol.

Important chemical characteristics include:
Long-chain saturated fatty alcohol
Primary hydroxyl group
High hydrophobicity
Excellent lubricity
Low volatility
Good oxidation resistance
High melting point
Waxy crystalline structure
Because Icosan-1-ol contains only one hydroxyl group and no carbon-carbon double bonds, it is considerably more resistant to oxidation than unsaturated fatty alcohols.

MOLECULAR STRUCTURE AND CHARACTERISTICS of ICOSAN-1-OL:
The molecular structure of Icosan-1-ol consists of:
A straight chain of 20 carbon atoms
A terminal primary hydroxyl (-OH) group
A fully saturated hydrocarbon backbone

Icosan-1-ol is essentially linear, allowing efficient crystal packing and giving the compound its wax-like appearance.
Important structural characteristics include:
Straight-chain geometry
Saturated hydrocarbon backbone
Primary alcohol functionality
Strong hydrophobic character
High molecular symmetry
Good crystal-forming ability
This structure contributes directly to Icosan-1-ol's emollient, lubricating, and film-forming behavior.

THERMAL CHARACTERISTICS of ICOSAN-1-OL:
Icosan-1-ol possesses relatively high thermal stability.
Unlike volatile alcohols, Icosan-1-ol:

Melts around 62–65°C.
Icosan-1-ol boils near 370°C.
Icosan-1-ol exhibits very low evaporation.
Icosan-1-ol resists thermal degradation under moderate processing temperatures.

When exposed to excessive heat or fire, decomposition may produce:
Carbon monoxide
Carbon dioxide
Its high flash point makes Icosan-1-ol much less flammable than lower molecular weight alcohols.

SOLUBILITY BEHAVIOR of ICOSAN-1-OL:
One of the defining characteristics of Icosan-1-ol is its strong preference for nonpolar environments.
Icosan-1-ol is:

Practically insoluble in water.
Soluble in acetone.
Soluble in benzene.
Soluble in chloroform.
Slightly soluble in ethanol.
The long hydrocarbon chain dominates its behavior, making Icosan-1-ol behave more like a wax than a conventional alcohol.

CHEMICAL REACTIVITY of ICOSAN-1-OL:
Icosan-1-ol participates in many reactions typical of primary alcohols.
Important reactions include:

Esterification with carboxylic acids.
Oxidation to arachidic aldehyde.
Further oxidation to arachidic acid.
Ether formation.
Sulfation for surfactant production.
Alkoxylation for nonionic surfactants.
These reactions make Icosan-1-ol a valuable intermediate for specialty chemical manufacturing.

NOTES of ICOSAN-1-OL:
Store Icosan-1-ol in cool.
Keep Icosan-1-ol container tightly closed in a dry and well-ventilated place.
Store Icosan-1-ol away from oxidizing agent.

PHYSICAL AND CHEMICAL PROPERTIES of ICOSAN-1-OL:
Icosan-1-ol is a white waxy solid composed of a straight twenty-carbon hydrocarbon chain terminated by a single hydroxyl (-OH) group.
The long hydrocarbon chain dominates its behavior, giving Icosan-1-ol very low water solubility, high hydrophobicity, and excellent lubricating properties.

Unlike short-chain alcohols, Icosan-1-ol behaves more like a wax than a conventional liquid solvent.
Icosan-1-ol melts slightly above room temperature and forms smooth, translucent crystals.

PHYSICAL and CHEMICAL PROPERTIES of ICOSAN-1-OL:
Molecular Weight: 298.5 g/mol
XLogP3: 9.5
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 18
Exact Mass: 298.323565959 Da
Monoisotopic Mass: 298.323565959 Da
Topological Polar Surface Area: 20.2 Å²
Heavy Atom Count: 21
Formal Charge: 0

Complexity: 167
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Chemical formula: C20H42O
Molar mass: 298.555 g·mol−1
Appearance: White, translucent crystals
Melting point: 64 °C (147 °F; 337 K)

Boiling point: 372 °C (702 °F; 645 K)
Solubility in water: 1.51 × 10−6 g dm−3
log P: 8.99
Vapor pressure: <0.01 kPa (at 20 °C)
Chemical Name: Icosan-1-ol
Common Name: 1-Eicosanol
IUPAC Name: Icosan-1-ol
Other Common Name: Arachidyl Alcohol
CAS Number: 629-96-9
EC Number: 211-119-4
Molecular Formula: C₂₀H₄₂O

Molecular Weight: 298.55 g/mol
PubChem CID: 12404
ChemSpider ID: 11898
Chemical Class: Saturated primary fatty alcohol
Appearance: White waxy solid or translucent crystals
Physical State: Solid
ECHA EINECS - REACH Pre-Reg: 211-119-4
FDA UNII: 1QR1QRA9BU
Nikkaji Web: J11.549E
Beilstein Number: 1705104

MDL: MFCD00002938
XlogP3: 9.50 (est)
Molecular Weight: 298.55394000
Formula: C20 H42 O
Appearance: white solid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 64.00 to 67.00 °C. @ 760.00 mm Hg
Boiling Point: 371.00 to 373.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.000060 mmHg @ 25.00 °C. (est)
Vapor Density: 7.4 (Air = 1)

Flash Point: 383.00 °F. TCC (195.00 °C.)
logP (o/w): 8.990 (est)
Soluble in: alcohol
water, 0.00151 mg/L @ 25 °C (est)
Insoluble in: water
CAS: 629-96-9
IUPAC Name: icosan-1-ol
Molecular Formula: C20H42O
InChI Key: BTFJIXJJCSYFAL-UHFFFAOYSA-N
SMILES: CCCCCCCCCCCCCCCCCCCCO

Molecular Weight (g/mol): 298.56
Synonym: arachidyl alcohol
Appearance (Color): White
Form: Powder or lumps or flakes or pellets
Assay (GC): ≥95.0%
Melting Point (clear melt): 60.0-70.0?C
Physical state: Solid
Appearance: White waxy solid or translucent crystals
Color: White
Odor: Mild or nearly odorless

Molecular formula: C₂₀H₄₂O
Molecular weight: 298.55 g/mol
Melting point: 62–65°C
Boiling point: 370–372°C
Density: 0.84 g/cm³ (20°C)
Vapor density: 7.4 (air = 1)
Vapor pressure: Less than 0.1 mmHg (20°C)
Flash point: 195°C
Autoignition temperature: 245°C

Water solubility: Approximately 0.001 g/L (23°C)
Solubility in acetone: Soluble
Solubility in benzene: Soluble
Solubility in chloroform: Soluble
Solubility in ethanol: Slightly soluble
Refractive index: 1.435
pKa: 15.2 (predicted)
Log P: 8.3–9.0
Henry's Law Constant: 4.7 × 10⁻¹ mol/(m³·Pa)
Chemical Formula: C20H42O
IUPAC name: icosan-1-ol

InChI Identifier: InChI=1S/C20H42O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21/h21H,2-20H2,1H3
InChI Key: BTFJIXJJCSYFAL-UHFFFAOYSA-N
Isomeric SMILES: CCCCCCCCCCCCCCCCCCCCO
Average Molecular Weight: 298.5469
Monoisotopic Molecular Weight: 298.323565966
Solubility: Solubility water: slightly soluble 0.001 g/L at 23 °C; Solubility in hot Methanol very faint turbidity
Sensitivity:
Boiling point: 190°C/1.3mmHg
Melting point: 64-66℃
InChl: InChI=1S/C20H42O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21/h21H, 2-20H2, 1H3

FIRST AID MEASURES of ICOSAN-1-OL:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of ICOSAN-1-OL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of ICOSAN-1-OL:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of ICOSAN-1-OL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of ICOSAN-1-OL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of ICOSAN-1-OL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available

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