IMIDAZOLIDINYL UREA

Imidazolidinyl UREA

Imidazolidinyl urea is an antimicrobial preservative used in cosmetics . Likewise used is chemically related to diazolidinyl urea. Imidazolidinyl urea acts as a formaldehyde release.

CAS Number: 39236-46-9
EC Number: 254-372-6

IUPAC NAMES:
', N' '' - methylenebis {1- [3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] urea}
1,1'-methylenebis {3- [1- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] urea}
1- [3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] -3 - [[[3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] carbamoylamino] methyl] urea
3- [3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] -1 - [({[3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] carbamoyl} amino) methyl] urea
Imidazolidinyl UREA
Imidazolidinyl Urea
Imidazolidinyl urea
N ', N' '' - methylenebis {1- [3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] urea}
N, N '' - Methylenebis [N '- [3- (hydroxymethyl) -2,5-dioxo-4-imidazolidinyl] urea]
N, N '' - Methylenebis [N '- [3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] urea]
N, N '' - methylenebis [N '- [3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] urea]
N, N'-Methylenebis [N '- [3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] urea]

SYNONYMS

Imidazolidinyl urea; IMIDUREA; 39236-46-9; 1,1'-Methylenebis (3- (3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl) urea); Germall 115; Imidurea [NF]; UNII- M629807ATL; 1- [3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] -3 - [[[3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] carbamoylamino] methyl] urea; Metanebis (N, N '- (5-ureido-2,4-diketotetrahydroimidazole) -N, N-dimethylol); MLS002154142; CHEBI: 51805; M629807ATL; Imidurea (NF); NCGC00164388-01; SMR001233448; 1,1'-Metlenis (3- (3- (hydroxymethyl) -2,5-dioxo-4-imidazolidinyl) urea); N ', N "' - methanediylbis {1- [3- (hydroxymethyl) -2,5-dioxoimidazolidin-4- yl] urea}; DSSTox_CID_20151; DSSTox_RID_79449; DSSTox_GSID_40151; Imidurea, 26-28% nitrogen; N, N '' - methylenebis (N '- (3- (hydroxymethyl) -2,5-dioxo-4-imidazolidinyl) urea); Imidazolinidyl urea; EINECS 254-372-6; 1,1'-methylenebis {3- [3- (hydroxymethyl ) -2,5-dioxo-4-imidazolidinyl] urea}; C11H16N8O8; N, N '' - Methylenebis (N '- (1- (hydroxymethyl) -2,5-dioxo-4-imidazolidinyl) urea); CAS- 39236-46-9; MFCD00221482; Prestwick0_001071; Prestwick1_001071; Prestwick 2_001071; Prestwick3_001071, EC 254-372-6, SCHEMBL34461; bspbio_001082; cid_38258; CHEMBL65433; spbio_002991; bpbio1_001192; DTXSID2040151; BDBM66981; CTK8C4780; HMS1571G04; HMS2098G04; HMS2230O16; HMS3369E04; HMS3715G04, HY-B1158; Tox21_112112; Tox21_302325; ANw-73112; s5212; SBB058157; AKOS015895558; N, N '' - Methylenebis (N '- (3- (hydroxymethyl) -2,5-dioxo-4-imidazolidin-yl) urea; N, N '' - Methylenebis (N'- (3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl) urea); N, N'-Methylenebis (N '- (3- (hydroxymethyl) -2,5-dioxo-4-imidazolidinyl) urea); N, N'-Methylenebis [N '- (3-hydroxymethyl-2,5-dioxo-4-imidazolidinyl) urea; Urea, N, N '' - methylenebis (N '- (1- (hydroxymethyl) -2,5-dioxo-4-imidazolidinyl) - CCG-221071; CS-4609; DB14075; MCULE-6258433159; KS-000018Z5; Urea, N, N '' - methylenebis (N '- (3- (hydroxymethyl) -2,5-dioxo-4-imidazolidin-yl) -; NCGC00179313-01; NCGC00179313-03; NCGC00179313-05; NCGC00255574-01; 1- [3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] -3- [[[3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] c; AK106225; AS-1526; O658 ; SC-18639; AB00514030; FT-0658132; I0665; ST50307320; D04513; SR-01000841816; Q2737856; SR-01000841816-2; Imidurea, United States Pharmacopoeia (USP) Reference Standard; Imidurea, Pharmaceutical Secondary Standard; Certified Reference Material N, N "-Methylenebis [N" - [3- (hydroxymethyl) -2,5-dioxo-4-imidazolidinyl] urea]; N, N-methylenebis N'-1- (hydroxymethyl) -2,5-dioxo -4-imidazolidinyl urea; 1- (2,5-diketo-3-methylol-imidazolidin-4-yl) -3 - [[(2,5-diketo-3-methylol-imidazolidin-4-yl) carbamoylamino] methyl ] urea; 1- [3- (hydroxymethyl) -2,5-bis (oxida nylidene) imidazolidin-4-yl] -3 - [[[3- (hydroxymethyl) -2,5-bis (oxidanylidene) imidazolidin -4-yl] carbamoylamino] methyl] urea; 1- [3- (hydroxymethyl) -2,5-dioxo-4-imidazolidinyl] -3 - [[[[3- (hydroxymethyl) -2,5-dioxo-4-imidazolidinyl] amino] -oxomethyl] amino] methyl] urea; 1- [3- (hydroxymethyl) -2,5-dioxo-imidazolidin-4-yl] -3 - [[[3- (hydroxymethyl) -2,5-dioxo-imidazolidin-4-yl] carbamoylamino] methyl] urea ; 3- [3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] -1 - [({[3- (hydroxymethyl) -2,5-dioxoimidazolidin-4-yl] carbamoyl} amino) methyl] urea; N- [3- (hydroxymethyl) -2,5-dioxo (1,3-diazolidin-4-yl)] {[({[3- (hydroxymethyl) -2,5-dioxo (1,3-diazolidin-4) -yl] amino} carbonylamino) methyl] amino} carboxamide; N- [3- (hydroxymethyl) -2,5-dioxo (1,3-diazolidin-4-yl)] {[({N- [3- (hydroxymethyl) -2,5-dioxo (1,3- diazolidin-4-yl)] carbamoyl} amino) methyl] amino} carboxamide; N, N '' - Methylenebis (N '- (3- (hydroxymethyl) -2,5-dioxo-4-imidazolidin-yl) urea; Urea, N, N' '- methylenebis (N' - (3- (hydroxymethyl) ) -2,5-dioxo-4-imidazolidin-yl) -; 1,1'-Methylenebi

Imidazolidinyl UREA

Synthesis
Imidazolidinyl urea is produced by the chemical reaction of allantoin and formaldehyde in sodium hydroxide solution and in the presence of heat. The reaction mixture is then neutralized with hydrochloric acid and evaporated:
2 Allantoin + 3 H2C = O → Imidazolidinyl urea
Commercial imidazolidinyl urea is a mixture of different formaldehyde addition products including polymers.

What?
Imidazolidinyl Urea is an odorless white powder. In cosmetics and personal care products, Imidazolidinyl Urea can be found in a wide variety of products, including lotions, creams, conditioners, shampoos and deodorants.

Why is it used in cosmetics and personal care products?
Imidazolidinyl Urea kills microorganisms or prevents or inhibits their growth and reproduction. It prevents the growth of microbes and protects cosmetics and personal care products intact.

Scientific facts:
Imidazolidinyl Urea is one of the most commonly used preservatives in cosmetics and personal care products. It acts synergistically with other preservatives resulting in a system that provides a broader range of protection against the microorganism.

Imidazolidinyl urea is a formaldehyde-releasing preservative. It is used in many cosmetic and pharmaceutical preparations.

Makeup supplies
Foundations, powders, concealers
Eye makeup (liners, shadows, mascara)
Face makeup (blushes)
Bronzes and tanning creams
Makeup removers
Cuticle removers
Self-hygiene / pharmaceutical products
Burning remedies
Shampoos
Moisturizing lotions and creams
Body powders
Sun creams
Cleansers and other skin care products
Prescription topical medications.

History:
Imidazolidinyl Urea was one of the first ingredients reviewed by the CIR Expert Panel, and the last safety review was published in 1980, with the conclusion that it is "safe when incorporated in cosmetic products in quantities similar to those currently marketed". In 2001, after evaluating new studies and updated usage data, the Panel decided not to reopen the security assessment. Minutes from Panel discussions on this review are included. Since at least 15 years have passed since the initial review summary was published, the Panel should re-evaluate whether the safety assessment of Imidazolidinyl Urea should be reopened in accordance with CIR Procedures. Extensive research was conducted in the world literature for 1999 prospective studies. A brief summary of relevant data is attached. It also includes current and past usage data for your review. The frequency of use has decreased since the first review was evaluated. According to VCRP data, it was reported that Imidazolidinyl Urea was used in 2025 formulations in 2001. In 2019, VCRP shows that Imidazolidinyl Urea was used in 1558 formulations. The current maximum use concentration (0.6%) in dropped products is almost the same as that reported in 2001 (0.7%). Maximum use concentrations (eg eye area, nails) decreased in most categories by type of exposure. A data profile is included for the original (1980) report and for data discovered since the first review. If the panel decides that re-examination is necessary, the full draft amended report will be presented at an upcoming meeting.

Formaldehyde Release
The amount of formaldehyde released from imidazolidinyl Urea and seven other formaldehyde-releasing preservatives depended on the matrix, pH, time, and (mainly) temperature.2 The release effect was also cosmetic specific, and was more likely to occur in products such as hand cleaners.

Ormaldehyde released by products such as toothpaste, nail polish and perfume shampoos and bath gels.

Components
About 30-40% of imidazolidinyl Urea, allantoin, urea and -1,3-bis-hydroxymethyl-urea.3 The remaining fraction is believed to be polymers of the condensation products of allantoin-formaldehyde. Another characterization study of Imidazolidinyl Urea from three different sources found that the compound is allantoin.

Cosmetic Use
Recommended concentration limit is> 1%.

Non-Cosmetic Use
Imidazolidinyl Urea and other formaldehyde releases have been investigated for use as therapeutic cornea and scleral tissue.
crosslinking agents.

Imidazolidinyl urea is soluble only in polar solvents. It is decomposed in aqueous solution to release formaldehyde. Formaldehyde release from imidazolidinyl urea in an aqueous solution increases with increasing pH and temperature of the solution and increasing storage time. One imidazolidinyl urea molecule can release 4 molecules of formaldehyde under stringent conditions. The total free formaldehyde content in a product containing 0.6% imidazolidinyl urea would therefore correspond to 0.186%.

Where is imidazolidinyl urea found?
Imidazolidinyl urea is an antimicrobial agent used as a preservative in cosmetics, shampoos, deodorants, body lotions, and some therapeutic ointments and creams.

What are some products that may contain imidazolidinyl urea?

• Baby bath
• Calming lotion
• Makeup supplies
• Concealer
• Eyeliner
• Eyelashes and eyebrows
• Liquid makeup
• Mascara
• Deodorants
• Smell
• Hair care
• Conditioner
• Hair spray
• Hair recovery
• Pomade
• Shampoo
• Lotions and Skin Care
• After shaving and moisturizing
• Anti-fatigue eye cream
• Anti-wrinkle firming moisturizing cream
• Cuticle remover
• Deep pore scrubbing
• Foam acne wash (10% bpo)
• Gel cleanser
• Hand and body lotion
• Moisturising cream
• Pore ​​cleansing pads
• Scrub
• Sunscreens and Sunscreens
• Therapeutic Topical Ointments and Creams

Imidazolidinyl urea (IU) are formaldehyde releasing agents that are used as antimicrobial preservatives in many cosmetics, skin care products, household detergents, and (several) pharmaceutical creams and ointments formulations. As general cosmetic classes, skin care products are the most common cause of allergic contact dermatitis to DU and / or IU, followed by hair care products, facial cleansers, sunscreen products, makeup, body cleansers and special hygiene products. Hairdressers, beauticians, machinists, and production workers can all be exposed to both IU and DU. Although it is an effective germicidal agent, its activity against fungi is limited. DU / IU is therefore often combined with parabens for antifungal activity. DU appears to be a more potent sensitizer than IU. Patients allergic to formaldehyde should avoid IU, DU and other formaldehyde releasing substances such as quaternium-15 and DMDM ​​hydantoin.

Application Notes
Imidazolidinyl urea is useful as a preservative. Topical formulas for use as antioxidants Used in various studies such as biological studies investigating the antibacterial synergistic activity of essential oils and surfactants against P. aeruginosa and S. aureus, pharmacological studies investigating nutrient-sensitive screening of drugs that alter energy metabolism. From mitochondrial respiration to glycolysis, Therapeutic studies involving nanostructured plant-based carriers for topical delivery of active molecules, Investigation of in vitro induction of apoptosis against necrosis in comparative studies of MEKC and microemulsion electrokinetic chromatography for analytical studies of preservatives.

Imidazolidinyl Urea is used as an antimicrobial agent and preservative in cosmetics and toiletries. Very active against gram + and gram bacteria as a synergist in combination with oparabens. The most widely used biocides in cosmetics (antiseptic agents, preservatives, bactericides, slimes, fungicides) are parabens, isothiazolones, formaldehyde and formaldehyde releasing substances.
HOW CAN YOU AVOID IMIDAZOLIDINYL UREA?
• Check all skin care products, toiletries, soaps and detergents (prescription and nonprescription) for imidazolidinyl urea or related ingredients. Do not use products that list these substances on their label or insert. If no information is available, ask your pharmacist or manufacturer.
• Inform your healthcare professionals that you have an imidazolidinyl urea allergy and ask them to use these allergen-free products.
• Avoid cosmetics and other personal care products that contain imidazolidinyl urea or its synonyms, especially in permanent products.
• Check every new purchase; After products are tolerated, reactions may occur due to changes in formulations containing a different preservative.

Imidurea (Imidazolidinyl urea), an antimicrobial agent in cosmetics and toiletries.

Used as an imicrobial agent and preservative. Very active against gram + and gram bacteria as a synergist in combination with parabens. Imidazolidinyl urea is more active against bacteria against fungi and is often combined with parabens to provide a broad spectrum protective system. This protector is one of the most widely used protective systems in the world. The Food and Drug Administration (FDA) recognizes imidazolidinyl urea as one of the most common antimicrobial agents used in cosmetics. Due to its high water solubility, imidazolidinyl urea can be included in almost all water-based cosmetics, toiletries and cold mix formulations. Available in a wide range of liquid and powder products such as baby lotion, skin cream, sunscreens, shampoos, eyeliner, blush, perfumes, deodorants, hair dyes, shaving cream and face masks. Imidazolidinyl urea is allowed for use in personal care products at a maximum concentration of 0.6% in the European Union. In Japan, imidazolidinyl urea is allowed in rinse-off cosmetics such as shampoo, body wash and facial cleanser at a maximum concentration of 0.3%.

Imidazolidinyl Urea is an antimocrobial preservative found in cosmetics. It is often used to protect formulas from deterioration caused by yeast, bacteria or mold. It is often used in combination with other preservatives to cover the widest possible spectrum.

HOW TO USE?
Uses: foundations, powders, concealers. Eye makeup, eye liners, lotions, creams body powders, shadows, mascara, self-tanning lotions, make-up removers, nail products, sunscreen, cleansers and topical medications.

IMIDAZOLIDINYL Urea is an antimocrobial preservative used to protect from deterioration caused by yeast, bacteria or mold found in beauty products and often found in formulas. According to the National Cancer Institute, it is a formaldehyde separator and one of the most used preservatives in the world.

Chemical and Physical Properties
Diazolidinyl Urea is a fine white powder with a mild characteristic odor. It is easily soluble in water and insoluble in oils. Diazolidinyl Urea is 19% to 21% nitrogen, with a maximum loss of 3% upon drying, a residue of 3% maximum upon ignition and a maximum concentration of 10 ppm heavy metals. 

IMIDAZOLIDINYL UREA is an anti-microbial preservative provided as a free flowing hygroscopic powder. It is effective against broad spectrum gram positive and gram negative bacteria, yeast and molds. Imidazolidinyl Urea, which is stable over a wide pH range and compatible with surfactants and protein derivatives, is recommended for liquid and powder type funny products. Also, they are often used with araben as they work well together.

Where is Imidazolidinyl Urea found?
Imidazolidinyl urea is found in cosmetics, shampoos, and skin care products. Examples of cosmetic products and toiletries are lotions, creams, moisturizers, emollients, foundations, powders, concealers, bronzers, bronzers, make-up removers, sunscreens, eyeshadows and mascaras. It is also found in liquid soaps, conditioners, gels, bubble baths, baby wipes, and over-the-counter and prescription topical medications. Other sources of exposure include detergents, dishwashing liquids,
and cleaning agents.

Imidazolidinyl urea kills Gram-negative bacteria. It acts synergistically with parabens to provide a broad-spectrum antibiotic effective against mold, yeast and bacteria.

The combination of the two is the most commonly used preservative in cosmetics.

The corresponding preservative works by releasing formaldehyde into the product, such as DMDM ​​hydantoin.

Imidazolidinyl Urea
Imidazolidinyl urea is a kind of preservative in cosmetics. It has broad spectrum antimicrobial activity. It can inhibit gram negative and positive bacteria. It has a certain inhibitory effect on yeasts and fungi. It is mainly used to inhibit the growth of microorganisms and can be compatible with various ingredients in cosmetics. The results show that its antimicrobial activity is not affected by surfactants, proteins and other ingredients in cosmetics. The effect of special additives.
Application: imidazolidyl urea, cream, shampoo, lotion, conditioner etc. It can be used in products. It can be used alone and can also be used in combination with IPBC and Nabin esters to increase its antiseptic effect. The pH value range is 3-9, the general addition is 0.2-0.4%, and the maximum allowable addition is 0.6%. Can be added in a wide temperature range (<90 C).
It is often used as a cosmetic preservative in combination with imidazolidinyl urea, Nipagin ester or Kaisong CG. Cream, milk, shampoo, etc. It can be used in products. It is suitable for some advanced nourishing cosmetics that can be easily stained with Chaetobacter aeruginosa, especially when the pH is alkaline. Usually the dosage is 0.1% - 0.5%. However, imidazolidinyl urea may cause irritation on the skin of some people.

It is not used in some high-end cosmetics because of its penetrating effect and easy to cause allergies.

Use of Imidazolidinyl Urea

1. Used in cream, emulsion, shampoo and wet wipes.
2. dosage: 0.2 ± 0.5%
3.PH range for application: 3 ～ 9
4. Used with surfactant, protein and most cosmetics.

Cosmetic
Diazolidinyl Urea, 1987 FDA computer list,
a total of 95 cosmetic preparations. It is used as a preservative in various fields.
formulations including baby care preparations, eye makeup, face makeup, aftershave and nail, bath, hair and skin care preparations. 90 out of 95 reported uses
At a concentration of 1% 5 when> 1-5%.
Diazolidinyl Urea has been reported to be used in 130 cosmetic preparations.

USAGE AREAS

Items used outside the home (sandboxes, canopies and shelters, garden sculptures, outdoor lighting and seating, outdoor electrical equipment, etc.
Cosmetics, shampoos, perfumes, soaps, lotions, toothpastes, etc. Personal care products including
personal care, cosmetics, perfume-Fragrance
shampoos, perfumes, soaps, lotions, toothpastes, etc. Personal care products including
Products specially designed for use by babies (including diapers with appropriate modifiers, baby toys, baby clothes, baby food, etc.)
General term for eye-related personal care products (eg eye care products)
Personal care products used on the face (includes facial treatments, oil and blemish control, make-up removers, facial cleansers)
Related to body hair removal (shaving products, wax products, trimmers / clippers)
Personal care products including scrub cream, hand creams, shaving cream and tanning cream
Personal care and cosmetics subcategory, lip care products
Subcategory of personal care and cosmetics, lotions and moisturizers for consumer use
Personal care and cosmetics sub-category related to nail products (nail polish, artificial nails)
Used as a personal care product, personal care, cosmetics, perfume-Fragrance
Personal care products for general use on the body (body makeup, body powder, body treatments, body cleansers)
Related to products specially designed for children (eg toys, children's cosmetics, etc.)

Imidazolidinyl urea, a formaldehyde releaser related to diazolidinyl urea (see above), is used as an antimicrobial agent very active against Gram-positive and Gram-negative bacteria, used as a synergist in combination with para- bens. It is used as a preservative in aqueous products, mainly in cosmetics, toiletries, and liquid soaps.
imidazolidinyl urea is one of the most commonly used anti-bacterial preservatives given its low sensitizing potential. In 2010, it was the tenth most frequently used preservative in the united States (parabens ranged from first to sixth place). generally, imidazolidinyl urea is not used alone but as a copreservative with parabens for broad-spectrum activity. Although it may yield low levels of formaldehyde when subjected to destructive methods-such as exposure to high temperatures-under normal use conditions, there is no detection of free formaldehyde release. of all the formaldehydereleasing preservatives, imidazolidinyl urea is the one least likely to cause skin sensitization and allergic reactions.
Imidazilydinyl urea is a wide spectrum preservative, efficient against both gram positive and negative bacteria, including species of pseudomonas.
Imidazilydinyl urea shows a synergic effect with parabens. Biocon IMU is used in a broad range of personal care fomulations.
Imidazolidinyl Urea, also known as Imidurea , is an antimicrobial preservative used as a formaldehyde releaser and in cosmetics. Ungraded products supplied by TCI America are generally suitable for common industrial uses or for research purposes but typically are not suitable for human consumption or therapeutic use.
Chemistry
Imidazolidinyl urea was poorly characterized until recently and the single Chemical Abstracts Service structure assigned to it is probably not the major one in the commercial material. Instead, new data indicate that the hydroxymethyl functional group of each imidazolidine ring is attached to the carbon, rather than on the nitrogen atom:[

Synthesis
Imidazolidinyl urea is produced by the chemical reaction of allantoin and formaldehyde in the presence of sodium hydroxide solution and heat. The reaction mixture is then neutralized with hydrochloric acid and evaporated:
Commercial imidazolidinyl urea is a mixture of different formaldehyde addition products including polymers.

Imidazolidinyl urea is an antimicrobial preservative used in cosmetics, acts as a formaldehyde releaser.
Imidazolidinyl urea is a kind of preservative in cosmetics. It has broad-spectrum antimicrobial activity. It can inhibit Gram-negative and positive bacteria. It has certain inhibitory effect on yeasts and fungi. It is mainly used to inhibit the reproduction of microorganisms and can be compatible with various components in cosmetics. The results show that its antimicrobial activity is not affected by surfactants, proteins and other components in cosmetics. The effect of special additives.
Application: imidazolidyl urea can be used in products such as cream, shampoo, lotion, conditioner and so on. It can be used alone, and can also be used in combination with IPBC and Nabin esters to enhance its antiseptic effect. The range of pH value is 3-9, the general addition is 0.2-0.4%, and the maximum allowable addition is 0.6%. It can be added in a wide temperature range (< 90 C).
Usually imidazolidinyl urea is used as a cosmetic preservative in conjunction with Nipagin ester or Kaisong CG. It can be used in cream, milk, shampoo, etc. It is especially suitable for some advanced nutritional cosmetics which are easily stained with Chaetobacter aeruginosa when the pH value is alkaline. Usually the dosage is 0.1%-0.5%. However, imidazolidinyl urea is not used in some high-end cosmetics because of its irritating effect on some people’s skin and easy to cause allergies.

Imidazolidinyl Urea Usage

1.used in cream, emulsion, shampoo and wet tissure.
2. dosage: 0.2～0.5%
3. PH range for application: 3～9
4. used together with surface active agent, protein and most cosmetics.

Molecular Formula: C11H16N8O8
Molecular Weight: 388.293
It is effective against Gram-negative bacteria, including Pseudomonas aeruginosa. It provides a complete antimicrobial preservative system that is active against bacteria, yeast and mold.

Imidazolidinyl Urea, is permanently listed by the EU at levels up to 0.6% without restrictions. It is one of the most widely used cosmetic preservatives in the world.
It is safe and effective for both leave-on and rinse-off products. The recommended use level is 0.2-0.4%.
Where is imidazolidinyl urea  found?
Imidazolidinyl urea  is an antimicrobial substance used as a preservative in cosmetics, shampoos, deodorants, body lotions, and in some therapeutic topical ointments and creams.
What are some products that may contain imidazolidinyl urea?
• Children’s Products:
– Baby bath
– Calming lotion
• Cosmetics:
– Concealer
– Eye pen
– Lash and brow
– Liquid makeup
– Mascara
• Deodorants
• Fragrance
• Hair Care:
– Conditioner
– Hairspray
– Hair rescue
– Pomade
– Shampoo
• Lotions and Skin Care
– After shave and moisturizer
– Anti-fatigue eye cream
– Anti-wrinkle firming moisture cream
– Cuticle remover
– Deep pore scrub
– Foaming acne wash (10% bpo)
– Gel cleanser
– Hand and body lotion
– Moisture cream
– Pore-cleansing pads
– Scrub
• Sunscreens and Sunblocks
• Therapeutic Topical Ointments and Creams

1. It can be used for milk cream, shampoo, dew, conditioner and other products, and can be used separately. It can also be used in conjunction with nipagin esters, IPBC and other products to enhance their anti-corrosion effect. Ph range of 3 ~ 9, general content is 0.2% ~ 0.4%, maximum allowable adding amount was 0.6%, in a wider temperature range (< 90 ºC) to add.
2. It is usually combined with nipagin ester or kesson CG for cosmetic preservatives. It can be used for cream, milk, shampoo, etc., especially for some advanced nutritive cosmetics which are easy to catch cuprous green woollen bacillus when ph value is too alkaline. The usual dosage is 0.1% ~ 0.5%.
3. used in cream, emulsion, shampoo and wet tissure
    dosage: 0.2~0.5%
    PH range for application: 3~9

As antiseptic, Imidazolidinyl Urea is safe, high-efficency and broad-spectrum antiseptic, It is widely added in cream, shampon Specifications As antiseptic, Imidazolidinyl Urea is safe, high-efficency and broad-spectrum antiseptic, It is widely added in cream, shampon Being antiseptic it can be used in various cosmetics, usually used with together the Paraben Ester. It is powdery or liquid, both has wide-range antibacterial ability. Imidazolidinyl Urea 39236-46-9 is one of the most commonly used anti-bacterial preservatives given its low sensitizing potential. imidazolidinyl urea is not used alone but as a copreservative with parabens for broad-spectrum activity. Although it may yield low levels of formaldehyde when subjected to destructive methods-such as exposure to high temperatures-under normal use conditions,there is no detection of free formaldehyde release. of all the formaldehydereleasing preservatives, imidazolidinyl urea is the one least likely to cause skin sensitization and allergic reactions.
Imidazolidinyl urea can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Imidazolidinyl Ureais a white, free-flowing hygroscopic powder. It is very effective against Gram-positive and Gram-negative bacteria, including Pseudomonas species. It acts synergistically with other preservatives. With parabens, it provides a broad spectrum of activity against bacteria, yeast, and mold. This activity has made the Imidazolidinyl Urea-paraben combination one of the most widely used cosmetic preservative systems in the world.
General description

Imidazolidinyl Urea is a cross linking agent that polymerizes with acrylamide and creates cross links within the polyacrylamide gel. It is capable of creating a network rather than linear chains which helps in maintaining the firmness of gel.

Application

Imidazolidinyl Urea has been used in gel preparation.[2] It has also been used as a test compound for studying the biochemical isolation of insoluble Tau in transgenic mouse models of tauopathy by examining the two main isolation methods sarkosyl and formic acid extraction.

Used as a biocide in cosmetics with 0.6% the maximum allowable concentration in the EU; [Kanerva, p. 398, 407] Used as an antimicrobial preservative in cosmetics and topical pharmaceuticals; [Merck Index] One of the most widely used preservative systems (especially in combination with parabens) in the world and often found in cosmetics; 

Imidazolidinyl Urea preservative is one  true classic preservatives.  Known for their ability to deliver efficient antimicrobial power to a wide variety of personal care products, 
Imidazolidinyl Urea preservative, like other classic preservatives, offer balanced and synergistic broad-spectrum protection.  They are compatible with many other cosmetic chemicals are are approved for use in most countries.  Classic preservatives are effective at low doses and can be used to bolster other preservatives.

Imidazolidinyl Urea preservative is sold under the same trade name in EMEA.

Features and Benefits
Effective over broad pH range 3.0–9.0
Very effective against gram-positive and gram-negative bacteria
Acts synergistically with other preservatives 
Global use

Imidazolidinyl Urea preservative is used in formulating leave-on & rinse-off formulas and hair-care products like conditioners, gels, mousses, novel stylers, shampoos and styling lotions/creams. Also used in body-care, color cosmetics, face & body washes, facial care & wipes and sun-care products.

Imidurea (Imidazolidinyl urea) is used as an antimicrobial agent and preservative in cosmetics and toiletries. It is very active against gram+ and gram- bacteria as a synergist in combination with parabens. Imidazolidinyl urea is more active against bacteria than fungi and is often combined with parabens to provide a broad spectrum preservative system. This preservative is one of the most widely used preservative systems in the world. The Food and Drug Administration (FDA) considers imidazolidinyl urea as one of the most common antimicrobial agents used in cosmetics. Due to its high water solubility, imidazolidinyl urea can be incorporated into almost all water-based cosmetics, toiletries, and cold mix formulations. It is present in a wide range of liquid and powder products such as baby lotion, skin cream, sunscreens, shampoos, eyeliners, blush, perfumes, deodorants, hair dyes, shaving cream, and face masks. Imidazolidinyl urea is permitted for use in personal care products in the European Union at a maximum concentration of 0.6%. In Japan, imidazolidinyl urea is allowed in rinse-off cosmetics such as shampoo, body wash, and facial cleanser at a maximum concentration of 0.3%. 
Where is Imidazolidinyl urea found?  Imidazolidinyl urea is found in cosmetics, shampoos and skin care products. Examples of cosmetic products and toiletries are lotions, creams, moisturizers, emollients, foundations, powders, concealers, bronzers, self-tanners, makeup removers, sunscreens, eye shadows, and mascaras. It is also found in liquid soaps, hair conditioners, gels, bubble baths, baby wipes, and over-the-counter and prescription topical medicines. Other sources of exposure include detergents dishwashing liquids,
and cleaning agents.
Imidazolidinyl urea in contact with your skin may result in dermatitis.
How to avoid Imidazolidinyl urea. Avoid cosmetics and other personal care products labeled with imidazolidinyl urea or its synonyms, particularly in stay on products. Rinse off products should involve less risk. It is important to use only ingredient-labeled cosmetics and other skin care products that do not list imidazolidinyl urea or any of its synonyms on the label.  Products for household use are not yet labelled. Therefore if there is a suspicion that a household product is causing dermatitis, then the manufacturer will have to be contacted for specific advice. Products that were once tolerated may cause reactions due to change of formulation involving a different preservative. Therefore each new purchase must be checked.
Cosmetics
Foundations, powders, concealers
Eye makeup (liners, shadows, mascara)
Facial makeup (blushes)
Bronzes and tanning creams
Makeup removers
Cuticle removers
Imidazolidinyl urea is a preservative used commonly in cosmetics. Although there have been few reports of contact sensitivity, it does seem to be an important contact allergen. Sensitivity should be considered in any woman with dermatitis of the face.

Imidazolidinyl Urea a white, free-flowing hygroscopic powder, is very effective against Gram-positive and Gram-negative bacteria, including Pseudomonas species. It acts synergistically with other preservatives. With parabens, it provides a broad spectrum of activity against bacteria, yeast, and mold.

Imidazolidinyl urea is soluble only in polar solvents. In aqueous solution, it is decomposed  to release formaldehyde. The formaldehyde release from imidazolidinyl urea in an aqueous solution increases with the increase in pH and temperature of the solution as well as with the increase in storage period (2). One molecule of imidazolidinyl urea can release 4 molecules of formaldehyde under rigorous conditions. The total free formaldehyde content in a product containing 0.6% imidazolidinyl urea will thus correspond to 0.186%. A method for analysis imidazolidinyl urea in cosmetic products was published in 1994 (3). This method employs determination of the compound by micellar electrokinetic chromatography (MEKC). However, it was not established that the chromatographic peak obtained by the analysis of imidazolidinyl urea was in fact the intact compound. Furthermore, this method could not be reproduced in another laboratory (4). The research in the later laboratory also indicated that it would not be possible by the MEKC to discriminate between imidazolidinyl urea and diazolidinyl urea, even if this method worked properly. It is possible that a common decomposition product (an allantoin derivative) of both imidazolidinyl urea and diazolidinyl urea is seen as a single peak in MEKC. Further attempts to develop a method for the analysis of imidazolidinyl urea failed (4), because it was not possible to verify the identity of the parent compound under experimental conditions (as the compound degrades spontaneously in the solution). It has been shown by high performance liquid chromatography (HPLC), capillary zone electrophoresis (CZE) and nuclear magnetic resonance spectrometry (NMR) that the solution of imidazolidinyl urea contains several entities (2,4). It has not been established whether all molecules present in a solution of imidazolidinyl urea are decomposition products of the parent compound or the parent compound itself is a mixture of isomers. In any case, several of these molecules will contain formaldehyde. It is also expected that such molecules exist in the aqueous phase of water-containing cosmetics such as shampoos as well as in emulsion type cosmetics.