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Imidazolidinyl urea is a chemical compound used primarily as a preservative in cosmetics and personal care products.
Imidazolidinyl urea functions as an antimicrobial agent that helps to prevent the growth of bacteria and fungi in these products.
Imidazolidinyl urea is a member of ureas.
CAS Number:39236-46-9
Molecular Formula: C11H16N8O8
Molecular Weight:388.29
EINECS Number: 254-372-6
Synonyms: Imidazolidinyl urea, IMIDUREA, 39236-46-9, 1,1'-Methylenebis(3-(3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)urea), Germall 115, Imidurea [NF], 1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]carbamoylamino]methyl]urea, Methanebis(N,N'-(5-ureido-2,4-diketotetrahydroimidazole)-N,N-dimethylol), MLS002154142, DTXSID2040151, CHEBI:51805, M629807ATL, Imidurea (NF), NCGC00164388-01, SMR001233448, N',N'''-methanediylbis{1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea}, N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea), DTXCID0020151, Imidazolinidyl urea, 3-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1-[({[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]carbamoyl}amino)methyl]urea, C11H16N8O8, EINECS 254-372-6, UNII-M629807ATL, N,N''-Methylenebis(N'-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea), CAS-39236-46-9, MFCD00221482, IMIDUREA [II], IMIDUREA [MI], IMIDUREA [VANDF], Prestwick0_001071, Prestwick1_001071, Prestwick2_001071, Prestwick3_001071, IMIDUREA [MART.], IMIDUREA [USP-RS], 1,1'-Methylenebis(3-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea), EC 254-372-6, Urea, N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-, SCHEMBL34461, BSPBio_001082, cid_38258, CHEMBL65433, SPBio_002991, BPBio1_001192, BDBM66981, ZCTXEAQXZGPWFG-UHFFFAOYSA-N, HMS1571G04, HMS2098G04, HMS2230O16, HMS3369E04, HMS3715G04, IMIDAZOLIDINYL UREA [VANDF], HY-B1158, Tox21_112112, Tox21_302325, s5212, AKOS015895558, N,N''-Methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidin- yl)urea, N,N''-Methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)urea), N,N'-Methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea), N,N'-Methylenebis[N'-(3-hydroxymethyl-2,5-dioxo-4-imidazolidinyl)urea], N,N'-Methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-urea, Urea, N,N''-methylenebis(N'-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-, CCG-221071, CS-4609, DB14075, s10971, Urea, N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidin- yl)-, NCGC00179313-01, NCGC00179313-03, NCGC00179313-05, NCGC00255574-01, 1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]c, AS-15260, DA-74451, AB00514030, I0665, NS00002748, D04513, EN300-19627076, SR-01000841816, Q2737856, SR-01000841816-2, BRD-A65444648-001-11-4, Imidurea, United States Pharmacopeia (USP) Reference Standard, Imidurea, Pharmaceutical Secondary Standard; Certified Reference Material, N,N"-Methylenebis[N"-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea], 1,1'-METHYLENEBIS(3-(3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL)UREA, 1-(2,5-diketo-3-methylol-imidazolidin-4-yl)-3-[[(2,5-diketo-3-methylol-imidazolidin-4-yl)carbamoylamino]methyl]urea, 1-[3-(hydroxymethyl)-2,5-bis(oxidanylidene)imidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-bis(oxidanylidene)imidazolidin-4-yl]carbamoylamino]methyl]urea, 1-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-3-[[[[[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]amino]-oxomethyl]amino]methyl]urea, 1-[3-(hydroxymethyl)-2,5-dioxo-imidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxo-imidazolidin-4-yl]carbamoylamino]methyl]urea
Imidazolidinyl urea has a role as an antimicrobial agent.
Imidazolidinyl urea is an antimicrobial preservative used in cosmetics.
Imidazolidinyl urea acts as a formaldehyde releaser.
Imidazolidinyl urea is an antimicrobial preservative used in cosmetics.
It is chemically related to diazolidinyl urea which is used in the same way.
Imidazolidinyl urea acts as a formaldehyde releaser.
Imidazolidinyl Urea is a non-aromatic, polar, hydrophilic antimicrobial compound.
It is used as a preservative in a variety of applications, most notably in personal care products and cosmetics.
Imidazolidinyl urea is effective against a broad spectrum of bacteria, fungi and yeast.
It is used as a preservative in cosmetics, shampoos, deodorants, body lotions, and in some therapeutic topical ointments and creams.
Imidazolidinyl urea is a broad-spectrum antimicrobial preservative used in cosmetics and topical pharmaceutical formulations; typical concentrations used are 0.03–0.5% w/w.
Imidazolidinyl urea is effective between pH 3–9 and is reported to have synergistic effects when used with parabens.
Imidazolidinyl urea, a formaldehyde releaser related to diazolidinyl urea (see above), is used as an antimicrobial agent very active against Gram-positive and Gram-negative bacteria, used as a synergist in combination with para- bens.
It is used as a preservative in aqueous products, mainly in cosmetics, toiletries, and liquid soaps.
Imidazolidinyl urea was poorly characterized until recently and the single Chemical Abstracts Service structure assigned to it is probably not the major one in the commercial material.
Instead, new data indicate that the hydroxymethyl functional group of each imidazolidine ring is attached to the carbon, rather than on the nitrogen atom.
Imidazolidinyl urea is an antimicrobial preservative that acts as a formaldehyde releaser in cosmetics and personal care products.
Imidazolidinyl urea is an antimicrobial preservative used in cosmetics . Likewise used is chemically related to diazolidinyl urea.
Imidazolidinyl urea acts as a formaldehyde release.
Imidazolidinyl urea is an antimicrobial preservative used in cosmetics.
Imidazolidinyl urea is chemically related to imidazolidinyl urea which is used in the same way.
Imidazolidinyl urea acts as a formaldehyde releaser.
Imidazolidinyl urea is used in many cosmetics, skin care products, shampoos and conditioners, as well as a wide range of products including bubble baths, baby wipes and household detergents.
Imidazolidinyl urea is found in the commercially available preservative Germaben.
Commercial Imidazolidinyl urea is a mixture of different formaldehyde addition products including polymers.
Imidazolidinyl urea is a kind of preservative in cosmetics.
It has broad spectrum antimicrobial activity.
It can inhibit gram negative and positive bacteria.
It has a certain inhibitory effect on yeasts and fungi.
Imidazolidinyl urea is mainly used to inhibit the growth of microorganisms and can be compatible with various ingredients in cosmetics.
The results show that its antimicrobial activity is not affected by surfactants, proteins and other ingredients in cosmetics.
The effect of special additives.
Imidazolidyl urea, cream, shampoo, lotion, conditioner etc.
Imidazolidinyl urea can be used in products.
It can be used alone and can also be used in combination with IPBC and Nabin esters to increase its antiseptic effect.
The pH value range is 3-9, the general addition is 0.2- 0.4%, and the maximum allowable addition is 0.6%. Can be added in a wide temperature range (<90 C).
Imidazolidinyl urea is often used as a cosmetic preservative in combination with imidazolidinyl urea, Nipagin ester or Kaisong CG. Cream, milk, shampoo, etc.
It can be used in products.
Imidazolidinyl urea is suitable for some advanced nourishing cosmetics that can be easily stained with Chaetobacter aeruginosa, especially when the pH is alkaline.
Usually the dosage is 0.1% - 0.5%. However, imidazolidinyl urea may cause irritation on the skin of some people.
Imidazolidinyl urea was poorly characterized until recently and the single Chemical Abstracts Service structure assigned to it is probably not the major one in the commercial material.
Preservatives protect cosmetic products against microbial spoilage and hence make a major contribution to consumer health.
Preservatives are particularly required in cosmetic formulations containing water, because microorganisms can colonise and reproduce in an aqueous (water-containing) environment.
Cosmetics often contain more than one preservative substances and these preservative systems act simultaneously against different bacteria, yeasts or moulds.
Each of these substances has been comprehensively tested and assessed for safety (individually and in combination).
Manufacturers always use only the lowest possible effective concentration in a product so that an optimum shelf life and safe application are ensured.
Formaldehyde releasers continuously release a low amount of formaldehyde in the finished cosmetic product and deploy their preservative effect in this way.
As antiseptic, Imidazolidinyl Urea is safe, high-efficency and broad-spectrum antiseptic.
Imidazolidinyl urea is widely added in cream, shampon Specifications As antiseptic, Imidazolidinyl Urea is safe, high-efficency and broad-spectrum antiseptic.
Imidazolidinyl urea is widely added in cream, shampon Being antiseptic it can be used in various cosmetics, usually used with together the Paraben Ester.
It is powdery or liquid, both has wide-range antibacterial ability.
Imidazolidinyl Urea 39236-46-9 is one of the most commonly used anti-bacterial preservatives given its low sensitizing potential.
Imidazolidinyl urea is not used alone but as a copreservative with parabens for broad-spectrum activity.
Although it may yield low levels of formaldehyde when subjected to destructive methods-such as exposure to high temperatures-under normal use conditions,there is no detection of free formaldehyde release.
Imidazolidinyl urea is the one least likely to cause skin sensitization and allergic reactions.
Imidazolidinyl urea can be analyzed by this reverse phase (RP) HPLC method with simple conditions.
The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid.
For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid.
Smaller 3 µm particles columns available for fast UPLC applications.
This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation.
Imidazolidinyl urea also suitable for pharmacokinetics.
Imidazolidinyl Urea is a white, free-flowing hygroscopic powder.
It is very effective against Gram-positive and Gram-negative bacteria, including Pseudomonas species.
Imidazolidinyl urea acts synergistically with other preservatives.
With parabens, it provides a broad spectrum of activity against bacteria, yeast, and mold.
This activity has made the Imidazolidinyl Urea-paraben combination one of the most widely used cosmetic preservative systems in the world.
Imidazolidinyl Urea is a cosmetic preservative that is very active against Gram-negative, including Pseudomonas aeruginosa and positive bacteria.
Imidazolidinyl urea has no activity against fungi and is synergistic with parabens.
Imidazolidinyl Urea is a white granular powder almost odorless and completely soluble in water.
Imidazolidinyl urea is insoluble in oils and has limited solubility in propylene glycol and glycerin.
It breaks down in extended exposure to a pH greater than 9.
Often used in lotions, creams, shampoos, and other personal care products to prolong shelf life by preventing microbial contamination.
Occasionally used in pharmaceutical preparations for similar preservative purposes.
Imidazolidinyl urea releases formaldehyde over time, which acts as a preservative by inhibiting microbial growth.
Imidazolidinyl urea is generally recognized as safe when used in low concentrations in cosmetics and personal care products.
However, its use is regulated, and specific limits are set by regulatory agencies such as the FDA and European Commission.
There have been some concerns about the release of formaldehyde, which is a known irritant and potential carcinogen.
Therefore, products containing imidazolidinyl urea are subject to safety evaluations to ensure they do not pose health risks to consumers.
Can cause irritation in some individuals, particularly those with sensitive skin.
May cause allergic reactions in some people.
The release of formaldehyde can be a concern, especially in high concentrations or prolonged exposure.
Imidazolidinyl urea (IU) are formaldehyde releasing agents that are used as antimicrobial preservatives in many cosmetics, skin care products, household detergents, and (several) pharmaceutical creams and ointments formulations.
As general cosmetic classes, skin care products are the most common cause of allergic contact dermatitis to DU and / or IU, followed by hair care products, facial cleansers, sunscreen products, makeup, body cleansers and special hygiene products.
Hairdressers, beauticians, machinists, and production workers can all be exposed to both IU and DU.
Although it is an effective germicidal agent, its activity against fungi is limited.
Imidazolidinyl urea is therefore often combined with parabens for antifungal activity.
Patients allergic to formaldehyde should avoid IU, DU and other formaldehyde releasing substances such as quaternium-15 and DMDM hydantoin.
Melting point: 141-143℃
Boiling point: 514.04°C (rough estimate)
Density: 1.4245 (rough estimate)
vapor pressure: 0Pa at 25℃
refractive inde: 1.6910 (estimate)
storage temp.: 2-8°C
solubility: Soluble in water and in glycerol, but insoluble in almost all organic solvents.
pka: 7.41±0.10(Predicted)
form: Liquid
color: Clear
Water Solubility: soluble
Merck: 14,4916
Stability: Stable.
InChIKey: ZCTXEAQXZGPWFG-UHFFFAOYSA-N
LogP: 0.9 at 20℃
Imidazolidinyl urea is a urea derivative, it comes as a white odorless powder.
It is mainly preventing the growth and reproduction of microbes and also kills microorganism.
Imidazolidinyl urea is stable under normal conditions but can release formaldehyde over time, especially in the presence of moisture and heat.
At high temperatures or in extreme conditions, it can decompose to release formaldehyde, which is a byproduct of its antimicrobial action.
Commonly used in a variety of products including: Skin Care Products: Lotions, creams, and moisturizers.
Imidazolidinyl urea is used in some pharmaceutical formulations as a preservative.
Imidazolidinyl urea is listed in the FDA’s Code of Federal Regulations (CFR) and is generally recognized as safe (GRAS) when used in concentrations up to a certain limit.
Specific concentration limits and usage guidelines are outlined in the Annexes of the regulation.
Listed under the Japanese Ministry of Health, Labour and Welfare (MHLW) regulations for cosmetics.
Prolonged or excessive exposure to formaldehyde can cause respiratory issues, skin irritation, and potentially contribute to cancer risk.
As a result, cosmetic products containing Imidazolidinyl urea are monitored for safe levels of formaldehyde release.
Some individuals may experience allergic reactions, such as skin rashes or irritation, especially if they have sensitive skin or are prone to allergies.
Due to concerns about formaldehyde release, some manufacturers use alternative preservatives such as phenoxyethanol, ethylhexylglycerin, or natural preservatives like rosemary extract.
Store in a cool, dry place, away from direct sunlight and moisture to maintain stability.
Use appropriate personal protective equipment (PPE) to avoid inhalation or skin contact, especially in industrial settings where large quantities are handled.
Imidazolidinyl urea is an antimicrobial preservative used in cosmetics.
Imidazolidinyl urea is chemically related to diazolidinyl urea which is used in the same way.
Imidazolidinyl urea acts as a formaldehyde releaser.
Imidazolidinyl urea is incompatible with strong oxidants.
It is compatible with other preservatives including sorbic acid and quaternary ammonium compounds.
Imidazolidinyl urea is also compatible with other pharmaceutical and cosmetic excipients including proteins, nonionic surfactants, and lecithin.
Imidazolidinyl urea is used as an antimicrobial agent and preservative in cosmetics and toiletries.
is very active against gram+ and gram- bacteria as a synergist in combination with parabens.
Imidazolidinyl urea is more active against bacteria than fungi and is often combined with parabens to provide a broad spectrum preservative system.
This preservative is one of the most widely used preservative systems in the world.
The Food and Drug Administration (FDA) considers imidazolidinyl urea as one of the most common antimicrobial agents used in cosmetics.
Due to its high water solubility, imidazolidinyl urea can be incorporated into almost all waterbased cosmetics, toiletries, and cold mix formulations.
Imidazolidinyl urea is present in a wide range of liquid and powder products such as baby lotion, skin cream, sunscreens, shampoos, eyeliners, blush, perfumes, deodorants, hair dyes, shaving cream, and face masks.
Imidazolidinyl urea is permitted for use in personal care products in the European Union at a maximum concentration of 0.6%.
In Japan, imidazolidinyl urea is allowed in rinse-off cosmetics such as shampoo, body wash, and facial cleanser at a maximum concentration of 0.3%.
Imidazolidinyl urea is found in cosmetics, shampoos and skin care products.
Examples of cosmetic products and toiletries are lotions, creams, moisturizers, emollients, foundations, powders, concealers, bronzers, self-tanners, makeup removers, sunscreens, eye shadows, and mascaras.
Imidazolidinyl urea is also found in liquid soaps, hair conditioners, gels, bubble baths, baby wipes, and over-the-counter and prescription topical medicines.
Other sources of exposure include detergents dishwashing liquids, and cleaning agents.
Imidazolidinyl urea in contact with your skin may result in dermatitis.
Avoid cosmetics and other personal care products labeled with imidazolidinyl urea or its synonyms, particularly in stay on products.
Rinse off products should involve less risk.
Imidazolidinyl urea is important to use only ingredient-labeled cosmetics and other skin care products that do not list imidazolidinyl urea or any of its synonyms on the label.
Imidazolidinyl urea for household use are not yet labelled.
Therefore if there is a suspicion that a household product is causing dermatitis, then the manufacturer will have to be contacted for specific advice.
Products that were once tolerated may cause reactions due to change of formulation involving a different preservative.
Therefore each new purchase must be checked.
Imidazolidinyl urea is useful as a preservative.
Topical formulas for use as antioxidants Used in various studies such as biological studies investigating the antibacterial synergistic activity of essential oils and surfactants against P. aeruginosa and S. aureus, pharmacological studies investigating nutrient-sensitive screening of drugs that alter energy metabolism.
From mitochondrial respiration to glycolysis.
Therapeutic studies involving nanostructured plant-based carriers for topical delivery of active molecules, Investigation of in vitro induction of apoptosis against necrosis in comparative studies of MEKC and microemulsion electrokinetic chromatography for analytical studies of preservatives.
Imidazolidinyl Urea is used as an antimicrobial agent and preservative in cosmetics and toiletries.
Very active against gram + and gram bacteria as a synergist in combination with oparabens.
The most widely used biocides in cosmetics (antiseptic agents, preservatives, bactericides, slimes, fungicides) are parabens, isothiazolones, formaldehyde and formaldehyde releasing substances.
Check all skin care products, toiletries, soaps and detergents (prescription and nonprescription) for imidazolidinyl urea or related ingredients.
Do not use products that list these substances on their label or insert.
Inform your healthcare professionals that you have an imidazolidinyl urea allergy and ask them to use these allergen-free products.
Avoid cosmetics and other personal care products that contain imidazolidinyl urea or its synonyms, especially in permanent products.
Check every new purchase; After products are tolerated, reactions may occur due to changes in formulations containing a different preservative.
Used as an Imidazolidinyl urea and preservative.
Very active against gram + and gram bacteria as a synergist in combination with parabens.
Imidazolidinyl urea is more active against bacteria against fungi and is often combined with parabens to provide a broad spectrum protective system.
This protector is one of the most widely used protective systems in the world.
The Food and Drug Administration (FDA) recognizes imidazolidinyl urea as one of the most common antimicrobial agents used in cosmetics.
Due to its high water solubility, imidazolidinyl urea can be included in almost all water-based cosmetics, toiletries and cold mix formulations.
Available in a wide range of liquid and powder products such as baby lotion, skin cream, sunscreens, shampoos, eyeliner, blush, perfumes, deodorants, hair dyes, shaving cream and face masks.
Imidazolidinyl urea is allowed for use in personal care products at a maximum concentration of 0.6% in the European Union.
In Japan, imidazolidinyl urea is allowed in rinse-off cosmetics such as shampoo, body wash and facial cleanser at a maximum concentration of 0.3%.
Uses Of Imidazolidinyl urea:
imidazolidinyl urea is one of the most commonly used anti-bacterial preservatives given its low sensitizing potential.
In 2010, it was the tenth most frequently used preservative in the united States (parabens ranged from first to sixth place).
Imidazolidinyl urea is not used alone but as a copreservative with parabens for broad-spectrum activity.
Although it may yield low levels of formaldehyde when subjected to destructive methods-such as exposure to high temperatures-under normal use conditions, there is no detection of free formaldehyde release.
Imidazolidinyl urea is the one least likely to cause skin sensitization and allergic reactions.
Imidazolidinyl urea is used to preserve many cosmetics and personal care products, including lotions, creams, hair conditioners, shampoos and deodorants.
Imidazolidinyl urea protects these products by killing, preventing or inhibiting the growth of microorganisms.
Prevents microbial contamination and extends the shelf life of these products.
Keeps the formulations free from bacterial and fungal growth.
Ensures the longevity of products like foundations, powders, and mascaras.
Imidazolidinyl urea is used in some oral and topical pharmaceutical products to inhibit microbial growth and ensure product stability.
Occasionally used in textile processing to prevent microbial growth on fabrics.
Imidazolidinyl urea is used to extend the shelf life and prevent microbial contamination in certain formulations.
Found in some household cleaning products to prevent microbial growth and spoilage.
Occasionally used in some pesticide formulations to enhance stability and efficacy.
Imidazolidinyl urea is effective against a broad spectrum of bacteria and fungi, making it a versatile preservative.
Extends the shelf life of products by preventing microbial contamination and spoilage.
As Imidazolidinyl urea releases formaldehyde over time, its use is regulated to ensure safety in consumer products.
Adhering to specific concentration limits set by regulatory agencies ensures that products remain safe for consumers.
Helps maintain the stability of active ingredients in anti-aging formulations.
Prevents microbial contamination in sunscreens, which can be sensitive to bacterial and fungal growth due to their complex compositions.
Imidazolidinyl urea is used to prevent microbial growth that can cause odor.
Added to ointments and creams to maintain product integrity and prevent contamination during storage.
Occasionally used in oral pharmaceutical products, such as lozenges or tablets, to ensure product safety and longevity.
Imidazolidinyl urea is used in the production of certain paper products to prevent microbial growth that could affect quality and durability.
Helps in preserving the adhesive properties of industrial glues and pastes by preventing microbial contamination.
Imidazolidinyl urea is used in some inks and dyes to extend shelf life and maintain product quality.
Imidazolidinyl urea is used in household surface cleaners to inhibit microbial growth and maintain product efficacy.
Included in some disinfectant formulations to ensure they remain effective over time.
Sometimes used in veterinary products to maintain product stability and prevent microbial growth.
Applied in some agricultural pesticides to improve the shelf life and effectiveness of the product.
Occasionally used in food packaging materials to prevent microbial contamination and spoilage.
Effective against a wide range of bacteria, yeasts, and molds, making it a versatile preservative.
Provides a cost-efficient solution for maintaining product stability and safety.
Regulatory agencies such as the FDA and the European Commission set limits on the concentration of Imidazolidinyl urea in products to ensure safety.
Products containing Imidazolidinyl urea must comply with regulations regarding formaldehyde content to minimize health risks.
The industry is increasingly exploring natural preservatives and alternatives due to concerns about formaldehyde release and consumer preference for natural ingredients.
New technologies and preservation methods are being developed to reduce the need for synthetic preservatives while maintaining product safety and efficacy.
Safety Profile Of Imidazolidinyl urea:
Imidazolidinyl urea is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.
However, there have been some reports of contact dermatitis associated with imidurea, although these are relatively few considering its widespread use in cosmetics.
Although imidurea releases formaldehyde, it does not appear to be associated with cross-sensitization with formaldehyde or other formaldehyde-releasing compounds.
Some people have a contact allergy to imidazolidinyl urea causing dermatitis.
Such people are often also allergic to Imidazolidinyl urea.
