IODOPROPYNYL BUTYLCARBAMATE (IPBC)

Iodopropynyl butylcarbamate (IPBC) can also be found in wood processing to prevent fungal wood rot and decay.
Iodopropynyl butylcarbamate (IPBC) can be found in products including baby lotions, diaper rash creams, foundations, concealers, eyeshadow, mascara, shampoo and conditioner.
Iodopropynyl butylcarbamate (IPBC) is used as a preservative in cosmetic formulations.

CAS Number: 55406-53-6
EC No: 259-627-5
Chem/IUPAC Name: 3-Iodo-2-propynyl butylcarbamate
Chemical formula: C8H12INO2
Molar mass: 281.093 g·mol−1

SYNONYMS:
3-Iodoprop-2-yn-1-yl butylcarbamate, 3-Iodo-2-propynyl N-butylcarbamate, 3-Iodo-2-propynyl butylcarbamate, Iodocarb, Iodopropynyl butylcarbamate, Ipbc, Woodlife, Troysan KK-108A, Caswell No. 501A, Butyl-3-iodo-2-propynylcarbamate, 3-Iodo-2-propynyl butyl carbamate, 3-iodoprop-2-yn-1-yl N-butylcarbamate, 3-iodo-2-propyn-1-yl N-butylcarbamate, Carbamic acid, butyl-3-iodo-2-propynyl ester, 3-iodoprop-2-ynyl butylcarbamate, 3-IPBC, 3-iodo-2-propynyl-butylcarbamate, iodopropynyl butyl carbamate, 3-iodoprop-2-yn-1-yl butylcarbamate, Iodocarb, 3-Iodo-2-propynyl N-butylcarbamate, 3-iodoprop-2-ynyl N-butylcarbamate, Carbamic acid, butyl-, 3-iodo-2-propynyl ester, 1-Iodoprop-1-yn-3-yl N-n-butylcarbamate, 3-Iodo-2-propynyl-N-butylcarbamate, MFCD00072438, C8H12INO2, DTXSID0028038, CHEBI:83279, 85045-09-6, DTXCID908038, CAS-55406-53-6, 3-Iodo-2-propynyl N-Butylcarbamate-d9, HSDB 7314, EINECS 259-627-5, EPA Pesticide Chemical Code 107801, BRN 2248232, iodocarbe, UNII-603P14DHEB, 3-iodo-2-propynyl-N-butyl carbamate, 1246815-08-6, Iodocarb 100 microg/mL in Acetonitrile, 3-IODO-2-PROPYNYLBUTYLCARBAMATE, IPBC [MI], SCHEMBL114369, CHEMBL1893913, 3-Iodo-2-propynyl butylcarbamate #, 3-iodoprop-2-yn-1-ylbutylcarbamate, Tox21_201864, Tox21_301117, AKOS015905567, CS-W010051, FI16109, GS-3240, NCGC00164376-01, NCGC00164376-02, NCGC00164376-03, NCGC00164376-04, NCGC00164376-05, NCGC00255017-01, NCGC00259413-01, SY052464, 3-Iodo-2-propynyl N-butylcarbamate, 97%, IODOPROPYNYL BUTYLCARBAMATE [VANDF], 3-IODO-2-PROPYNYL BUTYL CARBBAMATE, DB-262370, I0666, IODOPROPYNYL BUTYL CARBAMATE [MART.], NS00000275, N-Butylcarbamic Acid 3-Iodo-2-propynyl Ester, 3-IODO-2-PROPYNYLBUTYLCARBAMATE [HSDB], Q2928998, Carbamic acid, N-butyl-, 3-iodo-2-propyn-1-yl ester, 3-Iodo-2-propynyl N-butylcarbamate, analytical standard, Butyl-3-iodo-2-propynylcarbamate, Carbamic acid, butyl-3-iodo-2-propynyl ester, 3-Iodopropynylbutylcarbamate, 3-Iodo-2-propynyl butyl carbamate, 3-Iodo-2-propynyl-N-butyl carbamate, IPBC, Carbamic acid, N-butyl-, 3-iodo-2-propyn-1-yl ester, 3-Iodo-2-propynyl butylcarbamate, Iodopropynyl Butyl Carbamate, IPBC, 3‑Iodo‑2‑propynyl N‑butylcarbamate, Iodocarb, 3‑Iodo‑2‑propynyl butylcarbamate

Iodopropynyl butylcarbamate (IPBC) is a carbamate-based biocide patented in 1975, widely used as a broad-spectrum fungicide and preservative.
Iodopropynyl butylcarbamate (IPBC) is effective at low levels (e.g., ~0.01–0.1%) in industries such as paints, wood treatments, adhesives, and cosmetics.

Iodopropynyl butylcarbamate (IPBC)'s one of those things that help your cosmetics not to go wrong too soon, aka a preservative.
Iodopropynyl butylcarbamate (IPBC)'s strong point is being effective against yeasts and molds, and as a nice bonus seems to be non-comedogenic as well.

Iodopropynyl butylcarbamate (IPBC) is safe in concentrations of less than 0.1% but is acutely toxic when inhaled, so it's not the proper preservative choice for aerosol formulas like hairsprays.
Iodopropynyl butylcarbamate (IPBC) is a potent fungicide and preservative, which has been used in the paints, coatings, wood preservatives, personal care, and cosmetics industries.

Iodopropynyl butylcarbamate (IPBC) is a white or slightly off-white, crystalline, water-soluble powder containing iodine.
Iodopropynyl butylcarbamate (IPBC) was originally developed as a preservative in the construction industry (paints), where it protected coatings against mold and mildew thanks to its fungicidal effects.

Due to its low cost and sustainability, Iodopropynyl butylcarbamate (IPBC) is still a popular preservative today.
Iodopropynyl butylcarbamate (IPBC) is also used as a preservative in cosmetic products, where it prevents microbial growth and thus extends the shelf life of products.

Iodopropynyl butylcarbamate (IPBC) is found in a wide range of cosmetic and personal care products.
It has been shown to be acutely toxic when inhaled, so Iodopropynyl butylcarbamate (IPBC) should not be used in products that can be inhaled or sprayed.

Iodopropynyl butylcarbamate (IPBC) should also not be used in products that are applied to a large area of the skin (e.g. body lotions) or in oral care products.
At a concentration of 0.5%, Iodopropynyl butylcarbamate (IPBC) can be mildly irritating to the skin, but the maximum permitted amount according to the EU is no more than 0.02% in rinse-off products, 0.01% in leave-in products and even 0.0075% in deodorants.

Iodopropynyl butylcarbamate (IPBC) is prohibited in oral hygiene products, lip products and some products for children under 3 years of age.
Iodopropynyl butylcarbamate (IPBC) is not a mutagenic or carcinogenic substance.
Iodopropynyl butylcarbamate (IPBC) is a light yellow to beige crystalline powder, a highly effective fungicide preservative for cosmetics and personal care products.

Iodopropynyl butylcarbamate (IPBC) has unique properties and is cost-effective.
Even at a low concentration, Iodopropynyl butylcarbamate (IPBC) provides a high level of antimicrobial activity to inhibit the growth of yeasts and molds.

Iodopropynyl butylcarbamate (IPBC) is an off-white solid.
Iodopropynyl butylcarbamate (IPBC) is a carbamate ester that is carbamic acid in which the nitrogen has been substituted by a butyl group and in which the hydrogen of the carboxy group is replaced by a 1-iodoprop-2-yn-3-yl group.

A fungicide, Iodopropynyl butylcarbamate (IPBC) is used as a preservative and sapstain control chemical in wood products and as a preservative in adhesives, paints, latex paper coating, plastic, water-based inks, metal working fluids, textiles, and numerous consumer products.
Iodopropynyl butylcarbamate (IPBC) has a role as a xenobiotic, an environmental contaminant and an antifungal agrochemical.

Iodopropynyl butylcarbamate (IPBC) is a carbamate ester, an organoiodine compound, an acetylenic compound and a carbamate fungicide.
On the basis of the data presented in this report, the CIR Expert Panel concludes that Iodopropynyl butylcarbamate (IPBC) is safe as a cosmetic ingredient at concentrations ≤ 0.1%.

Iodopropynyl butylcarbamate (IPBC) should not be used in products intended to be aerosolized.
Iodopropynyl butylcarbamate (IPBC), also known as iodocarb, is a water-soluble preservative used globally in the paints & coatings, wood preservatives, personal care, and cosmetics industries.

Iodopropynyl butylcarbamate (IPBC) is a member of the carbamate family of biocides.
Iodopropynyl butylcarbamate (IPBC) was patented in 1975 and has a long history of effective use as an antifungal technology.

USES and APPLICATIONS of IODOPROPYNYL BUTYLCARBAMATE (IPBC):
Cosmetics/Personal Care: Iodopropynyl butylcarbamate (IPBC) is approved as preservative under EU Regulation 1223/2009; max concentrations vary by product type (≤0.01% in leave‑on; ≤0.02% rinse‑off).
Industrial products: Iodopropynyl butylcarbamate (IPBC) is used in wood preservatives, paints, adhesives, inks, textiles, metal cutting fluids, drilling fluids, and plastics as anti-microbial agent.

Used at 0.1%, Iodopropynyl butylcarbamate (IPBC) has an extremely low rate of skin-irritation when applied directly for 24 hours (around 0.1% of 4,883 participants) and after 48 hours that figure was 0.5%, so it counts as mild and safe unless your skin is super-duper sensitive.
Iodopropynyl butylcarbamate (IPBC) is used in a variety of applications, ranging from household items to industrial processes.

Pesticide: Iodopropynyl butylcarbamate (IPBC)  is found in antimicrobial insecticides and pesticides for nonfood uses, including home and garden pest control.
Manufacturing additive: Many manufacturing processes use Iodopropynyl butylcarbamate (IPBC) as a preservative, such as in plastics, paint, textiles, ink and canvas.

Wood preservative: Iodopropynyl butylcarbamate (IPBC) can also be found in wood processing to prevent fungal wood rot and decay.
Personal care product and cosmetics ingredients: When used in concentrations less than 0.1%, Iodopropynyl butylcarbamate (IPBC) is safe to use as a preservative in personal care products and cosmetics, increasing shelf life and combating microbial growth.

Iodopropynyl butylcarbamate (IPBC) can be found in products including baby lotions, diaper rash creams, foundations, concealers, eyeshadow, mascara, shampoo and conditioner.
HVAC fungicide: Apply Iodopropynyl butylcarbamate (IPBC) in heating, ventilation and air conditioning (HVAC) units to prevent fungi and mold growth, enhancing air quality and reducing dangerous health conditions.

Iodopropynyl butylcarbamate (IPBC) is used as a preservative in cosmetic formulations.
Iodopropynyl butylcarbamate (IPBC) is an effective fungicide at very low concentrations in cosmetics, and has shown very low sensitivity in humans tested with this preservative.

Iodopropynyl butylcarbamate (IPBC) controls bacteria including Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus at rates of application of 250–1000 ppm and the common mold Aspergillus niger at 0.6 ppm.
Iodopropynyl butylcarbamate (IPBC) was approved in 1996 for use up to 0.1% concentrations in topical products and cosmetics.

However, this preservative is mostly used at about one-eighth that level.
Iodopropynyl butylcarbamate (IPBC) is also used as a fungicide in paint, in wallpaper adhesives and to protect timber against fungi including Coriolus versicolor and Serpula lacrymans.

Iodopropynyl butylcarbamate (IPBC), also known as IPBC or IPBC preservative, is an antimicrobial ingredient commonly used in cosmetics.
Iodopropynyl butylcarbamate (IPBC) appears as a white, crystalline powder.
Iodopropynyl butylcarbamate (IPBC) is not a paraben; it belongs to a different chemical class called carbamates.

Its chemical formula is C9H12IN3O2, and Iodopropynyl butylcarbamate (IPBC) is soluble in both water and oil-based systems.
Iodopropynyl butylcarbamate (IPBC) is added to cosmetic formulations to prevent microbial growth, thus extending the shelf life of products.
Iodopropynyl butylcarbamate (IPBC) is effective against a broad spectrum of microorganisms.

However, Iodopropynyl butylcarbamate (IPBC) is important to note that this ingredient usage should comply with regulatory guidelines to ensure safe levels of exposure in cosmetic applications.
Iodopropynyl butylcarbamate (IPBC) is a carbamate pesticide.

Carbamate pesticides are derived from carbamic acid and kill insects in a similar fashion as organophosphate insecticides.
They are widely used in homes, gardens and agriculture.

The first carbamate, carbaryl, was introduced in 1956 and more of it has been used throughout the world than all other carbamates combined.
Because of carbaryl's relatively low mammalian oral and dermal toxicity and broad control spectrum, it has had wide use in lawn and garden settings.

WHAT IS IODOPROPYNYL BUTYLCARBAMATE (IPBC) USED FOR?
Iodopropynyl butylcarbamate (IPBC) is widely used in the cosmetics industry for its antimicrobial properties and preservative capabilities.
Iodopropynyl butylcarbamate (IPBC) is incorporated into various cosmetic formulations to prevent the growth of bacteria, yeast, and mold, thereby extending the shelf life of the products.

Iodopropynyl butylcarbamate (IPBC) is particularly useful in water-based formulations such as lotions, creams, and liquid cosmetics, where microbial contamination can be a concern.
By inhibiting the growth of microorganisms, Iodopropynyl butylcarbamate (IPBC) helps maintain the safety and integrity of cosmetic products, ensuring that they remain free from spoilage and potential health risks, while maintaining their efficacy over time.

ORIGIN OF IODOPROPYNYL BUTYLCARBAMATE (IPBC):
Iodopropynyl butylcarbamate (IPBC) is typically synthesized through a reaction between iodine, butylamine, and carbamic acid.
The reaction forms the Iodopropynyl butylcarbamate (IPBC), which is then further processed and purified to obtain the final product.
This synthesis method ensures the production of Iodopropynyl butylcarbamate (IPBC) with the desired antimicrobial properties for cosmetic applications.

WHAT DOES IODOPROPYNYL BUTYLCARBAMATE (IPBC) DO IN A FORMULATION?
*ANTIMICROBIAL
*PRESERVATIVE.

Iodopropynyl butylcarbamate (IPBC) is not entirely safe for use and can cause skin irritation or allergic reactions in some individuals.
This necessitates patch testing prior to full usage, especially in the case of sensitive skin.

Additionally, Iodopropynyl butylcarbamate (IPBC) is non-comedogenic and does not cause acne.
Iodopropynyl butylcarbamate (IPBC) is also vegan-friendly since it is not derived from animal sources.

ALTERNATIVES OF IODOPROPYNYL BUTYLCARBAMATE (IPBC):
*PHENOXYETHANOL
*POTASSIUM SORBATE
*SODIUM BENZOATE.

MANUFACTURE OF IODOPROPYNYL BUTYLCARBAMATE (IPBC):
A practical method for the manufacture of Iodopropynyl butylcarbamate (IPBC) was patented by chemists at ICI.
Butyl isocyanate is reacted with propargyl alcohol in toluene to give a carbamate derivative, which is iodinated using sodium iodide in the presence of sodium hydroxide and sodium hypochlorite with ethanol/water as solvent.