ISETHIONATES

Isethionates is a colorless, syrupy, strongly acidic liquid that can form detergents with oleic acid. 
Isethionates is an organic salt and an important intermediate for pharmaceuticals, cosmetics and daily chemicals.
Isethionates are a class of chemical compounds derived from isethionic acid, which is the sodium salt of 2-hydroxyethanesulfonic acid. 

CAS Number: 1562-00-1
Molecular Formula: C2H5NaO4S
Molecular Weight: 148.11
EINECS Number: 216-343-6

Synonyms: SODIUM ISETHIONATE, 1562-00-1, Sodium 2-hydroxyethanesulfonate, Isethionic acid sodium salt, 2-Hydroxyethanesulfonic acid sodium salt, Sodium hydroxyethylsulfonate, Ethanesulfonic acid, 2-hydroxy-, monosodium salt, MFCD00007534, Ethanesulfonic acid, 2-hydroxy-, sodium salt (1:1), Sodium beta-hydroxyethanesulfonate, 2-Hydroxyethanesulfonic acid, sodium salt, DTXSID7027413, 3R36J71C17, Sodium 1-hydroxy-2-ethanesulfonate, Sodium 2-hydroxy-1-ethanesulfonate, Sodium 2-hydroxyethanesulfonate, Sodium 2-hydroxyethylsulfonate, Sodium 2-hydroxyethanesulphonate, HSDB 5838, NSC-124283, Sodium 1-hydroxy-2-ethanesulfonate, Sodium 2-hydroxy-1-ethanesulfonate, C2H5NaO4S, EINECS 216-343-6, NSC 124283, Isethionic acid, sodium salt, sodium,2-hydroxyethanesulfonate, UNII-3R36J71C17, Ethanesulfonic acid, 2-hydroxy-, sodium salt, EC 216-343-6, 2-Hydroxyethanesulfonic acid sodium salt (SHES), sodium hydroxyethyl sulfonate, SCHEMBL125497, CHEMBL172191, DTXCID007413, ISETHIONATE, SODIUM SALT, Sodium 2-Hydroxy-Ethanesulfonate, SODIUM ISETHIONATE [HSDB], Isethionic acid sodium salt, 98%, HY-Y1173, Tox21_200227, AKOS015912506, NCGC00257781-01, CAS-1562-00-1, SODIUM 2-HYDROXYETHANESULFONIC ACID, CS-0017163, H0241, NS00078178, G74509, J-009283, Q1969744, F1905-7166, sodium2-hydroxyethylsulfonate,sodiumbeta-hydroxyethanesulfonate,Ethanesulfonic acid, 2-hydroxy-, sodium salt (1:1),2-HydroxyethanesuL,phonic acid,Ethanesulfonicacid,2-hydroxy-,monosodiumsalt,sodium2-hydroxy-1-ethanesulfonate,2-Hydroxyethansulfonsure, Na-Salz

Isethionates offers benefits including soft after feel, mildness and biodegradability.
Isethionates are known for their surfactant properties, meaning they can lower the surface tension between two liquids or a liquid and a solid. 
This makes them useful in formulations such as cleansers, shampoos, and body washes.

The most common form is Isethionates, which is widely used in various industrial and consumer products.
Isethionates are obtained on an industrial scale reacting mixtures of carboxylic acids with salts of isethionic acid under acidic catalysis e. g. with methanesulfonic acid.
The mixtures of carboxylic acids are obtained from the hydrolysis of animal fats (tallow) or vegetable oils, preferably coconut oil, but also palm oil, soybean oil or castor oil.

Isethionates are solids which are often mixed with fatty acids (up to 30% by weight) to lower their freezing point.
Despite its low water solubility (100ppm at 25 °C), the lower-priced sodium cocoylisethionate has found more widespread use than its well water-soluble ammonium salt (> 25 wt.% at 25 °C).
To solubilize the sparsely soluble isethionates and taurides, the formation of mixtures with amphoteric surfactants (such as cocamidopropyl betaine) are proposed.

From such mixtures, Isethionates are possible to prepare liquid, clear and transparent aqueous concentrates which are liquid at room temperature.
Isethionates are characterized by excellent skin compatibility, excellent foaming (even in hard water), good cleansing properties and a pleasant skin feel.
Isethionates are non-toxic and readily biodegradable.

However, in contrast to the taurides, Isethionates are not long-term stable outside a pH range of 5 to 8.
Isethionates are used in solid soaps (so-called syndet bars) and in other personal care products such as lotions, washing and shower gels, shampoos, liquid soaps, shaving creams, and other cosmetic and dermatological preparations.
Isethionates is an anionic surfactant and a good foamer.

Isethionates are environmentally friendly and biodegradable, making them a sustainable option in personal care products.
These compounds are typically non-irritating to the skin and eyes, which is why they are often found in products for sensitive skin.
Isethionates is based upon fatty acids from natural, renewable coconut oil.

Isethionates is used in personal cleansing products like syndet bar, combo bars, foaming facial washes, body washes, shampoos, bath and showers gels and liquid soaps.
Isethionates are considered to be exceptionally mild for skin, hair, and eyes.
Isethionates made from natural, renewable coconut oil.

Isethionates is very mild to skin and eyes.
Isethionates exhibits excellent foam and lather, performs well in hard water.
Isethionates imparts a soft after-feel to skin or hair.

Isethionates is great for solid cleansing bars, thus avoiding SLS and SLeS.
Isethionates creates an opaque and creamy product when used with other surfactants in winter, but in our hot summers this effect can disappear
Soap has been used by humankind since ancient times and was probably already known to the Sumerians.

Isethionates is a fatty acid salt obtained from the reaction of a strong base with a fatty substance of animal (tallow) or plant origin (oil).
Isethionates are esters of long-chain aliphatic carboxylic acids (C8 – C18) with isethionic acid (2-hydroxyethanesulfonic acid) or salts therefore, such as ammonium isethionate or sodium isethionate.
Isethionates are also referred to as acyl isethionates or acyloxyethanesulfonates.

Isethionates are solids which are often mixed with fatty acids (up to 30% by weight) to lower their freezing point.
Isethionates are characterized by excellent skin compatibility, excellent foaming (even in hard water), good cleansing properties and a pleasant skin feel.
Isethionates are non-toxic and readily biodegradable.

Isethionates are used in solid soaps (so-called syndet bars) and in other personal care products such as lotions, washing and shower gels, shampoos, liquid soaps, shaving creams, and other cosmetic and dermatological preparations.
Isethionates is an anionic surfactant and a good foamer
Isethionates offer benefits including soft after feel, mildness and biodegradability.

Isethionates are used in personal cleansing products like syndet bar, combo bars, foaming facial washes, body washes, shampoos, bath and showers gels and liquid soaps.
Isethionates made from natural, renewable coconut oil.

Isethionates is a mild, biodegradable cleansing agent that is also a very good team-player next to other cleaning agents.
Isethionates is known for its good foam-boosing abilities while improving the mildness of the formula.
Isethionates is a fine white powder that's derived from coconut oil.

Isethionates's a sodium salt that's known to be gentle on the skin.
Isethionates are used in shampoos, body washes, cleansers, and bars of soap.
Isethionates is an organosulfur compound containing an alkylsulfonic acid located beta to a hydroxy group. 

Its discovery is generally attributed to Heinrich Gustav Magnus, who prepared it by the action of solid sulfur trioxide on ethanol in 1833.
Isethionates is a white water-soluble solid used in the manufacture of certain surfactants and in the industrial production of taurine. 
It is most commonly available in the form of its sodium salt (sodium isethionate).

Melting point: 191-194 °C(lit.)
Density: 1762.7[at 20℃]
storage temp.: Store below +30°C.
solubility: H2O: 0.1 g/mL, clear, colorless
form: Fine Powder
color: White
PH: 7.0-11.0 (20g/l, H2O, 20℃)
Water Solubility: SOLUBLE
BRN: 3633992
Stability: Stable. Hygroscopic. Incompatible with strong oxidizing agents, strong acids.
LogP: -4.6 at 20℃

Isethionates is a lathering surfactant used in personal care products such as shampoos, soaps, and detergents. 
It has been gaining market share over the past few years on account of its excellent cleaning properties. 
Isethionates also acts as an emulsifier in cosmetics and other industrial applications where it is used with polymers to make them water-soluble for easier processing.

Isethionates works as an amphoteric detergent and can also be used as an intermediate in preparing surfactants derived from fatty acid sulfoalkyl esters (acyloxy ethane sulfonate). 
Isethionates increases the formulation's stability, improves the detergency in hard water, and is smooth to the skin. 
Isethionates is used in cleaning/washing agents, disinfectants, cosmetics, surface-active agents, shampoos, and bubble baths.

Isethionates is a white, granular powder that is insoluble in water. 
It is commonly used as a surfactant, emulsifier, and wetting agent in a variety of personal care and cleaning products. 
Isethionates works by reducing the surface tension of water, which allows it to spread more easily and penetrate surfaces. 

Isethionates is also used to help Suspend soils and oils in water so that they can be removed more easily.
Isethionates is a mild, biodegradable cleansing agent that is also a very good team-player next to other cleaning agents.
Isethionates is known for its good foam-boosing abilities while improving the mildness of the formula.

Isethionates's performance is similar to Isethionates, another group of cleaning agents known for their gentleness.
Isethionates is a fine white powder that's derived from coconut oil.
Isethionates's a sodium salt that's known to be gentle on the skin.

The process of creating Isethionates includes mixing a natural sulfonic acid called isethionic acid with the fatty acids that naturally occur in coconut oil.
Isethionates are used in shampoos, body washes, cleansers, and bars of soap.
Isethionates are used as cleansing agents because they mix well with both oils and water.

The ingredient can mix with oils to lift dirt off the face, helping to rinse away any residue leftover from the day.
Isethionates are used as biodegradable anionic surfactants.
These materials are much milder to skin that other sulfate based surfactants (i.e. sodium lauryl sulfate)[4] making them popular for use in make-up, shampoos and detergent bars including those made by Dove.

Isethionates is also used as a counter ion in certain pharmaceutical formulations, including the antimicrobials hexamidine and pentamidine.
Isethionates is frequently used in "syndet" bars (synthetic detergent bars) for its gentle cleansing properties that don’t strip the skin of natural oils.
It helps create a rich, creamy lather while being mild on the skin and scalp.

Isethionates are used in facial cleansers due to their low irritation profile, making them suitable for sensitive skin.
Isethionates is used in various skin and hair care products as a surfactant and emulsifier, helping to stabilize the formulation and improve texture.
Found in some mild cleaning agents and detergents for delicate fabrics due to its non-aggressive action.

Isethionates surfactants are a class of amphoteric surfactants that contain both sulfonic and carboxylic acid groups. 
They are commonly used as detergents, emulsifiers, and wetting agents in a variety of personal care and cleaning products.  

A surfactant is a molecule that lowers the surface tension of a liquid, allowing it to spread more easily. 
Isethionates are one type of surfactant, derived from isethionic acid. 
They are used in many personal care products such as shampoos, soaps, and toothpaste because they help to remove dirt and oil from the skin or hair.

Uses Of Isethionates:
Isethionates is an amphoteric detergent used in detergent bar soaps. 
Isethionates makes a dense lather in addition to the lather made by the soap. 
It is mild on the skin, and non-drying. 

Isethionates works equally well in soft or hard water. 
Isethionates is also an anti-static agent in shampoos.
Isethionates are widely used in syndet bars, which are synthetic soaps, to provide a rich, creamy lather and effective cleansing without being harsh on the skin. 

They leave the skin feeling soft and moisturized.
Because of their mildness, isethionates are used in facial cleansers for sensitive or dry skin, where harsher surfactants might cause irritation.
Isethionates help in foaming and cleansing the scalp and hair while being gentle enough to avoid stripping natural oils.

They provide a luxurious lather and cleansing action that is suitable for everyday use, even on sensitive skin.
The creamy lather produced by isethionates makes them ideal for shaving products, offering skin protection and smooth application.
Isethionates are often included in formulations designed to cleanse the skin while also moisturizing and preserving the skin’s natural oils.

In products that require a balance of exfoliation and cleansing, isethionates help provide effective cleansing without irritation.
Isethionates can be used in detergents for delicate fabrics and baby clothes, where gentler surfactants are preferred.
Isethionates are included in household cleaners designed for surfaces that need a non-aggressive, yet effective, cleaning action.

In pharmaceutical formulations, isethionates can be used as cleansing agents for topical medications or treatments that need to be applied to sensitive skin areas.
Some wound care products contain isethionates for gentle cleansing around sensitive skin areas without causing irritation.
In industrial cleaners that are used on sensitive surfaces, isethionates help in cleaning while preventing damage.

Isethionates can be used in industrial formulations that require controlled foaming, such as in lubricants or other technical products.
Since isethionates are extremely mild and low-irritation, they are often used in baby care products like baby shampoos, bath soaps, and washes.
Isethionates are also used in pet shampoos, providing gentle yet effective cleansing for animals, particularly those with sensitive skin.

Suitable for sensitive skin or frequent use products.
Helps to cleanse while preserving the skin’s natural moisture barrier.
Produces a creamy, rich lather in personal care products.

Environmentally friendly and biodegradable, making it a sustainable choice in formulations.
Isethionates are commonly found in dermatological products specifically formulated for sensitive or reactive skin types. 
They are included in medicated soaps and cleansers for conditions like eczema, psoriasis, and acne because they provide gentle cleansing without exacerbating skin conditions.

Isethionates can be found in both prescription and OTC skin cleansers where a non-irritating, non-comedogenic surfactant is essential.
Isethionates are used in anti-aging products that require a mild surfactant capable of removing dead skin cells without stripping the skin of moisture, which is important for aging skin.
In combination with other active ingredients, isethionates help enhance the texture and performance of cream-based cleansers aimed at mature skin types.

Due to restrictions on liquid products in travel settings, isethionates are commonly used in solid, travel-friendly bar formulations that act as both soap and shampoo. 
These bars maintain mildness and convenience for on-the-go use.
Because isethionates are biodegradable and mild, they are often included in eco-friendly personal care products marketed for their sustainability and minimal environmental impact.

Many hotels and resorts offer soap and shampoo bars containing isethionates as part of their amenity lines. 
These bars offer a luxurious lather that guests enjoy while being gentle on the skin.
Isethionates are used in eco-conscious cleaning products for households where biodegradability is important. 

They provide effective, mild cleaning for surfaces without harsh chemicals that could harm the environment.
Products that contain isethionates may qualify for various green certifications because of their safe, non-toxic, and biodegradable nature.
In addition to their surfactant properties, isethionates act as foam stabilizers in personal care foams, ensuring that products maintain a rich, stable foam over time, enhancing the consumer experience.

Isethionates are used in facial foaming cleansers that provide deep cleansing while being mild enough for daily use.
Isethionates are used in specialized laundry detergents for delicate fabrics such as silk, wool, and baby clothing. 
Their gentle cleansing properties ensure that fabrics are cleaned without being damaged or roughened.

Isethionates are included in some laundry pods and concentrated detergent formulations for high-efficiency washing machines, where low-sudsing, mild, and effective surfactants are required.
Due to their non-irritating nature, isethionates are a key ingredient in baby shampoos, baby bath soaps, and other infant skincare products. 
Isethionates can be included in gentle cleansing formulations for use in diaper rash treatments, ensuring that the affected area is cleaned without further irritation.

Safety Profile Of Isethionates:
While sodium isethionate is mild and suitable for sensitive skin, overuse or prolonged exposure may cause mild irritation or dryness, especially in individuals with very sensitive skin or allergies.
People with pre-existing skin conditions (such as eczema or dermatitis) might experience irritation with frequent or excessive use of products containing isethionates.

If isethionate-containing products come into direct contact with the eyes, they may cause irritation, redness, or discomfort. 
This is typically reversible with rinsing and is not generally severe.