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ISOBUTYLPARABEN

Isobutylparaben, with the chemical formula of C11H14O3 is an antimicrobial preservative used in many cosmetics, as a food flavoring agent and as a suspending agent for medications.
Isobutylparaben used in industry is synthetically created, but natural parabens also exist in nature.

Isobutylparaben is in the paraben family of preservatives used by the food, pharmaceutical and personal care products to prevent microorganisms such as bacteria, yeast and mold from spoiling and deteriorating the products.

CAS: 4247-02-3
European Community (EC) Number: 224-208-8

IUPAC Name: 2-methylpropyl 4-hydroxybenzoate

Molecular Formula: C11H14O3
Molecular Weight: 194.23 g/mol

Isobutyl 4-hydroxybenzoate, Isobutylparaben, 4247-02-3, isobutyl paraben, Isobutyl p-hydroxybenzoate, 2-Methylpropyl 4-hydroxybenzoate, Isobutyl parahydroxybenzoate, Benzoic acid, 4-hydroxy-, 2-methylpropyl ester, 4-Hydroxybenzoic Acid Isobutyl Ester, BENZOIC ACID, p-HYDROXY-, ISOBUTYL ESTER, p-Oxybenzoesaureisobutylester, 0QQJ25X58G, DTXSID4020749, 4-Hydroxybenzoic acid-isobutyl ester, Isobutyl-4-hydroxybenzoate, 2-Methylpropyl 4-Hydroxybenzoate (Isobutyl Parahydroxybenzoate), 4-Hydroxybenzoic acid-isobutyl ester 1000 microg/mL in Acetonitrile, isobutyl-p-hydroxybenzoate, CCRIS 2463, 2-Methylpropyl 4-Hydroxybenzoate; Butyl Parahydroxybenzoate Imp. E (EP); Isobutyl Parahydroxybenzoate; Butyl Parahydroxybenzoate Impurity E, EINECS 224-208-8, p-Hydroxybenzoic acid isobutyl ester, 4-hydroxybenzoic acid iso-butyl ester, p-Oxybenzoesaureisobutylester [German], BRN 2642305, 4-Hydroxybenzoic acid, 2-methylpropyl ester, ChemDiv2_000057, Isobutyl-4-hydroxy benzoate, UNII-0QQJ25X58G, SCHEMBL34633, Methylpropyl p-hydroybenzoate, BIDD:ER0110, DTXCID20749, ISOBUTYLPARABEN [INCI], CHEMBL3182006, CHEBI:178256, Isobutyl 4-hydroxybenzoate, 97%, HMS1369C13, Butyl parahydroxybenzoate impurity E, Tox21_200501, MFCD00020167, STL067196, ISOBUTYL PARA HYDROXY BENZOATE, p-Hydroxybenzoic acid iso-butyl ester, p-Hydroxybenzoic acid sec-butyl ester, AKOS000319531,CS-W015742, HY-W015026, NCGC00248662-01, NCGC00258055-01, AC-34543, AS-15247, CAS-4247-02-3, DB-070303, EU-0033430, H0493, I0816, NS00007256, C20342, 3-10-00-00308 (Beilstein Handbook Reference), A913460, SR-01000389342, SR-01000389342-1, W-106272, Q2723117, Butyl parahydroxybenzoate impurity E, European Pharmacopoeia (EP) Reference Standard

Isobutylparaben is a 4-hydroxybenzoate ester.
Isobutylparaben is in the parabens family of preservatives used by the food, pharmaceutical, and personal care product industries.

Isobutylparaben prevents the product from spoiling by preventing microorganisms from growing inside the product.

Isobutyl Paraben is an anti-microbial agent and anti-fungal agent. Parabens are effective preservatives in many types of formulas.
Isobutylparaben, also known as 4-hydroxybenzoic acid isobutyl ester, is a synthetic compound extensively utilized in laboratory experiments and research.
Isobutylparaben presents as a white crystalline solid, soluble in organic solvents, and serves as a preservative in food.
Isobutylparabens applications span across organic chemistry, biochemistry, and various scientific research domains.
Isobutylparaben finds widespread use as a preservative in food.
Isobutylparaben contributes to the synthesis of diverse organic compounds like dyes.
Additionally, Isobutylparaben aids in the production of polymers such as polyurethanes and biodegradable plastics.
Isobutylparaben acts as a weak acid, exerting its mechanism of action through the inhibition of carbohydrate and lipid-metabolizing enzymes.
Moreover, Isobutylparaben disrupts the cell membranes of bacteria and fungi, believed to hinder their growth.

Parabens are a group of controversial preservatives that include butylparaben, isobutylparaben, propylparaben, methylparaben, and ethylparaben.
All of these were at one time the most widely used group of preservatives used in cosmetics.
Parabens were so popular because of their gentle, non-sensitizing, and highly effective profile in comparison to other preservatives but also because they were derived naturally from plants, a rare phenomenon for a preservative.
Parabens are found in plants in the form of p-hydroxybenzoic acid (PHBA), a chemical that breaks down to become parabens for a plants own protection.

Isobutyl paraben (C11H14O3) is a nonlinear paraben.
Parabens are a group of alkyl esters of p-hydroxybenzoic acid, and many different parabens exist, e.g. methylparaben, ethylparaben and butylparaben.
Isobutyl parabens is used as preservatives in foods, pharmaceuticals and cosmetics and is used in 0-10 tonnes per annum.

Isobutylparaben (Isobutyl 4-hydroxybenzoate) is a constitutive androstane receptor (CAR) activator.
Isobutylparaben has a broad-spectrum antimicrobial activity and widely used in personal care products and cosmetics.

Isobutylparaben is a paraben and preservative found in many skincare products, ranging from skin cream to body lotion to deodorant.
Isobutylparaben is a less frequently used paraben and preservative but is most often used to extend the shelf life of beauty products.

Isobutylparaben and other parabens are used in products to help prolong the shelf life of the creams and lotions as well as inhibit the growth of mold and bacteria.

By limiting the growth of bacteria and fungi, preservatives like isobutylparaben help keep us safe from infection and other diseases.
It’s true that skin already acts as a barrier, but if contaminated creams are applied to the skin, an inflammatory response can be elicited, and lead to skin damage in the long term.

In addition, bacteria can easily invade our bodies if contaminated product is applied to broken skin, or if small amounts of contaminated lipstick or lip balm are accidentally ingested through the mouth.

Therefore, it is easy to see how ingredients like isobutylparaben can be very helpful to protecting our health and well being.

Isobutyl 4-hydroxybenzoate is also called isobutyl paraben.
Isobutylparaben is white crystalline with a bit of a unique smell.
Isobutylparaben is freely soluble in alcohol, ether, and chloroform but very slightly soluble in water.
Isobutyl 4-hydroxybenzoate tastes are astringent.

Isobutyl 4-hydroxybenzoate is mainly used as an intermediate of organic synthesis.
However, Isobutylparaben can also be used as antiseptics for medicine, foodstuff, cosmetics, films, etc.

Density: 1.1±0.1 g/cm3
Boiling Point: 302.3±15.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.7 mmHg at 25°C
Enthalpy of Vaporization: 56.4±3.0 kJ/mol
Flash Point: 125.4±13.2 °C
Index of Refraction: 1.524
Molar Refractivity: 53.8±0.3 cm3
#H bond acceptors: 3
#H bond donors:   1
#Freely Rotating Bonds:   4
#Rule of 5 Violations: 0
ACD/LogP: 3.28
ACD/LogD (pH 5.5): 3.12
ACD/BCF (pH 5.5): 139.27
ACD/KOC (pH 5.5): 1191.00
ACD/LogD (pH 7.4): 3.06
ACD/BCF (pH 7.4): 119.49
ACD/KOC (pH 7.4): 1021.89
Polar Surface Area: 47 Å2
Polarizability:   21.3±0.5 10-24cm3
Surface Tension: 40.8±3.0 dyne/cm
Molar Volume: 175.7±3.0 cm3

Usage and Benefits:
Isobutylparaben is mainly used as a preservative that can prevent or delay the growth of bacteria and fungus.
Isobutylparaben increases the stability of any preparation and, to some extent, helps prevent the skin from developing any infection, even if the skin is broken and the product has been used.
Isobutylparaben is used in many skin care and body care preparations.

How Do Parabens Work?
Parabens don’t directly provide benefits to the skin.
They are used to stabilize the formulation and prevent microbial growth.

Antimicrobial
Skincare are highly susceptible to microbial contamination and growth.
The most susceptible products are creams and lotions that are packaged in jars, opened frequently, and applied to the skin with the fingers.

Further, by limiting the growth of bacteria and fungi, preservatives like isobutylparaben help keep us safe from infection and other diseases.
It’s true that skin already acts as a barrier, but if contaminated creams are applied to the skin, an inflammatory response can be elicited, and lead to skin damage in the long term.

Increased shelf-life
Parabens help to stabilize the formulation of a product, increasing its shelf-life.
Without preservatives, most skincare or cosmetic products would only last 2-4 weeks before going rancid.

Inexpensive
In many ways, the inclusion of such preservatives is indispensable in our day and age.
We often take for granted how cheaply some skin care products can be purchased, and the fact that we don’t have to waste money throwing away too many expired products in the trash.
In many ways, this is achieved through the use of parabens and other preservatives.

Isobutyl Paraben is an anti-microbial agent and anti-fungal agent. Parabens are effective preservatives in many types of formulas.
Isobutyl 4-hydroxybenzoate, also known as 4-hydroxybenzoic acid isobutyl ester, is a synthetic compound extensively utilized in laboratory experiments and research.
Isobutylparaben presents as a white crystalline solid, soluble in organic solvents, and serves as a preservative in food.
Isobutylparabens applications span across organic chemistry, biochemistry, and various scientific research domains.
Isobutylparaben finds widespread use as a preservative in food.
Isobutylparaben contributes to the synthesis of diverse organic compounds like dyes.
Additionally, Isobutylparaben aids in the production of polymers such as polyurethanes and biodegradable plastics.
Isobutylparaben acts as a weak acid, exerting its mechanism of action through the inhibition of carbohydrate and lipid-metabolizing enzymes.
Moreover, Isobutylparaben disrupts the cell membranes of bacteria and fungi, believed to hinder their growth.

Isobutylparaben and other parabens are used in products to help prolong the shelf life of the creams and lotions as well as inhibit the growth of mold and bacteria.