ISOCETYL PALMITATE

Emollient: Isocetyl Palmitate is widely used in cosmetic and skincare formulations as an emollient that forms a barrier on the skin, aiding in moisture retention and providing a smooth, soft feel.
Isocetyl Palmitate acts to enhance the skin’s texture and hydration, often leaving it feeling soft and supple.
Isocetyl Palmitate is widely used in cosmetics and personal care products as an emollient and thickening agent.

CAS Number: 127770-27-8
Chem/IUPAC Name: Hexadecanoic acid, isohexadecyl ester
Molecular Formula: C32H64O2

SYNONYMS:
dermol ICP, hexadecanoic acid isohexadecyl ester, hexadecanoic acid, isohexadecyl ester, 14-methylpentadecyl hexadecanoate, Isocetyl palmitate, 355356620Z, 127770-27-8, Hexadecanoic acid, isohexadecyl ester, UNII-355356620Z, Hexadecanoic acid, isohexadecyl ester, Isocetyl palmitate, Isohexadecyl palmitate, Nikkol ICP, Nikkol ISP, ISOCETYL PALMITATE, 14-methylpentadecyl hexadecanoate, Hexadecanoic acid, isohexadecyl ester, Hexadecanoic acid, isohexadecyl ester, Cetyl Palmitate, Hexadecanoic Acid Isocetyl Ester, Palmitic Acid Isocetyl Ester, 14-methylpentadecylhexadecanoate, Isocetylpalmitate, 127770-27-8, SCHEMBL5873231, Hexadecanoicacid,isohexadecylester, UNII-355356620Z

Isocetyl Palmitate contains isocetyl alcohol (14-methylpentadecan-1-ol) as alcoholic component.
Palmitates are salts or esters of palmitic acid (hexadecanoic acid).

Isocetyl Palmitate belongs to the following substance groups
Isocetyl Palmitate is present in 0.01% of cosmetics.

USES and APPLICATIONS of ISOCETYL PALMITATE:
Emollient: Isocetyl Palmitate is widely used in cosmetic and skincare formulations as an emollient that forms a barrier on the skin, aiding in moisture retention and providing a smooth, soft feel.
Skin-Conditioning Agent: Isocetyl Palmitate acts to enhance the skin’s texture and hydration, often leaving it feeling soft and supple.

Stabilizer: Isocetyl Palmitate is often used in creams and lotions to improve consistency and stability, ensuring even distribution of ingredients.
Isocetyl Palmitate is a waxy solid at room temperature and is commonly used in cosmetics and personal care products due to its emollient properties .

Isocetyl Palmitate is primarily sourced in personal care products as it serves both functional and aesthetic purposes by maintaining the texture and smoothness of formulations used on skin. 

SCIENTIFIC RESEARCH APPLICATIONS OF ISOCETYL PALMITATE:
Isocetyl palmitate has a wide range of applications in scientific research.
Chemistry: Isocetyl Palmitate is used as a model compound in studies of esterification and hydrolysis reactions.

Biology: Investigated for Isocetyl Palmitate's role in lipid metabolism and as a component of biological membranes.
Medicine: Explored for Isocetyl Palmitate's potential use in drug delivery systems due to its biocompatibility and ability to form stable emulsions.
Industry: Isocetyl Palmitate is widely used in cosmetics and personal care products as an emollient and thickening agent.

MECHANISM OF ACTION OF ISOCETYL PALMITATE:
The mechanism of action of hexadecanoic acid, isohexadecyl ester involves Isocetyl Palmitate's interaction with lipid bilayers in biological membranes. 
Isocetyl Palmitate can integrate into the lipid bilayer, affecting membrane fluidity and permeability . 
This property makes Isocetyl Palmitate useful in drug delivery systems, where it can enhance the absorption of active ingredients through the skin .

COMPARISON WITH SIMILAR COMPOUNDS OF ISOCETYL PALMITATE:
Isocetyl palmitate is similar to other long-chain fatty acid esters, such as:
Hexadecanoic acid, hexadecyl ester (cetyl palmitate) 
Hexadecanoic acid, cyclohexyl ester 

UNIQUENESS OF ISOCETYL PALMITATE:
Isocetyl Palmitate is unique due to its specific combination of hexadecanoic acid and isohexadecanol, which imparts distinct physical and chemical properties. 
Isocetyl Palmitate's ability to form stable emulsions and its biocompatibility make it particularly valuable in cosmetic and pharmaceutical applications .

WHAT DOES ISOCETYL PALMITATE DO IN A FORMULATION?
*Emollient
*Skin conditioning

PREPARATION METHODS OF ISOCETYL PALMITATE:
Synthetic Routes and Reaction Conditions
Isocetyl palmitate can be synthesized through the esterification of hexadecanoic acid with isohexadecanol. 
The reaction typically involves heating the reactants in the presence of an acid catalyst, such as sulfuric acid, to facilitate the esterification process . 
The reaction is carried out under an inert atmosphere to prevent oxidation and other side reactions.

INDUSTRIAL PRODUCTION METHODS OF ISOCETYL PALMITATE:
In industrial settings, the production of hexadecanoic acid, isohexadecyl ester involves mixing hexadecanoic acid and isohexadecanol in a specific molar ratio, heating the mixture to a molten state, and then cooling it to room temperature. 

The cooled mixture is then reheated to around 350°C under an inert atmosphere and maintained at this temperature for 25-35 minutes to complete the esterification process .
This method is advantageous due to Isocetyl Palmitate's simplicity, low cost, and environmental friendliness.

CHEMICAL REACTIONS ANALYSIS OF ISOCETYL PALMITATE:
*Types of Reactions
Isocetyl palmitate undergoes several types of chemical reactions, including:

*Hydrolysis: 
The ester can be hydrolyzed back into hexadecanoic acid and isohexadecanol in the presence of water and an acid or base catalyst.

*Reduction: 
The ester can be reduced to its corresponding alcohols using reducing agents such as lithium aluminum hydride.

*Transesterification: 
The ester can undergo transesterification reactions with other alcohols to form different esters.

COMMON REAGENTS AND CONDITIONS OF ISOCETYL PALMITATE:
*Hydrolysis:
Acidic or basic conditions with water.

*Reduction: 
Lithium aluminum hydride or other strong reducing agents.

*Transesterification: 
Alcohols and an acid or base catalyst.

MAJOR PRODUCTS OF ISOCETYL PALMITATE:
*Hydrolysis: 
Hexadecanoic acid and isohexadecanol.

*Reduction: 
Hexadecanol and isohexadecanol.

*Transesterification: 
Various esters depending on the alcohol used.

FUNCTIOS OF ISOCETYL PALMITATE IN COSMETIC PRODUCTS:
*SKIN CONDITIONING
Isocetyl Palmitate maintains the skin in good condition

*SKIN CONDITIONING - EMOLLIENT
Isocetyl Palmitate softens and smoothens the skin

BENEFITS OF ISOCETYL PALMITATE:
*Moisturizing: 
Isocetyl Palmitate helps prevent water loss, which can make skin feel hydrated and well-conditioned.

*Skin Softening: 
The emollient property of Isocetyl Palmitate makes it an ideal ingredient in products designed for dry or sensitive skin.

*Enhances Product Stability: 
Isocetyl Palmitate contributes to the overall stability of cosmetic products, allowing them to maintain their consistency and effectiveness.

FUNCTIONS OF ISOCETYL PALMITATE:
*Emollient: 
Isocetyl Palmitate softens and smoothes the skin

*Skin care agent : 
Isocetyl Palmitate keeps skin in good condition

FUNCTIONS OF ISOCETYL PALMITATE:
*Skin Conditioning, 
*Emollient

GLOBAL ISOCETYL PALMITATE MARKET SIZE, SCOPE AND FORECAST REPORT:
The market size of the Isocetyl Palmitate Market is categorized based on Type (Natural, Synthetic) and Application (Facial Care, Body Care) and geographical regions (North America, Europe, Asia-Pacific, South America, and Middle-East and Africa).
The provided report presents market size and predictions for the value of Isocetyl Palmitate Market, measured in USD million, across the mentioned segments.

The Isocetyl Palmitate Market has undergone a rapid and substantial growth phase in recent times, with forecasts indicating that this considerable expansion will continue from 2023 to 2031. 
The positive momentum in market dynamics, combined with the expected sustained expansion, indicates the likelihood of robust growth rates throughout the forecasted period. 

In essence, the market is positioned for significant and noteworthy development. 
Recent years have seen a swift and substantial rise in the Isocetyl Palmitate Market, and the projections for sustained significant expansion from 2023 to 2031 highlight a persistent upward trend in market dynamics, pointing towards strong growth rates in the foreseeable future.

PHYSICAL and CHEMICAL PROPERTIES of ISOCETYL PALMITATE:
CAS Number: 127770-27-8
Chem/IUPAC Name: Hexadecanoic acid, isohexadecyl ester
COSING REF No: 34627
CBNumber: CB4961716
Molecular Formula: C32H64O2
Molecular Weight: 480.84936
EWG's Food Scores: 1
FDA UNII: 355356620Z

EPA Substance Registry System: Hexadecanoic acid, isohexadecyl ester (127770-27-8)
CAS Registry Number: 127770-27-8
Molecular Weight: 480.8 g/mol
IUPAC Name: 14-methylpentadecyl hexadecanoate
InChI: InChI=1S/C32H64O2/c1-4-5-6-7-8-9-10-11-14-17-20-23-26-29-32(33)34-30-27-24-21-18-15-12-13-16-19-22-25-28-31(2)3/h31H,4-30H2,1-3H3
InChI Key: OUZOBPPZPCBJAR-UHFFFAOYSA-N
SMILES: CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C
Canonical SMILES: CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C
Synonyms: ISOCETYL PALMITATE

CAS Number: 127770-27-8
EC Number: Unavailable
Molecular Formula: C₃₂H₆₄O₂
Molecular Weight: 480.85 g/mol
Appearance: A white to slightly yellow waxy solid or paste with a faint odor
Solubility: Insoluble in water
Chemical Family: Fatty acid esters
Melting Point: Generally solid at room temperature, but exact melting point data is variable by source

FIRST AID MEASURES of ISOCETYL PALMITATE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of ISOCETYL PALMITATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of ISOCETYL PALMITATE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of ISOCETYL PALMITATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of ISOCETYL PALMITATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of ISOCETYL PALMITATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available