ISOCIL PC

Cost-effective Isocil PC is an antimicrobial for your personal care formulations that performs at
low concentrations, providing you with the efficacy you demand at the most affordable price.
Recommended Applications
Isocil is a suitable preservative for the following rinse-off type applications:
• Shampoos
• Hair Conditioners
• Hair and Body Gels
• Bubble Baths
• Personal Care Surfactants
• Hand soaps and other rinse-off products

Chemical Composition
The active ingredients found in Isocil PC are two isothiazolinones identified by the IUPAC system
of nomenclature as 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one.

Active Ingredients (nominal)-%WT/WT
5-Chloro-2-methyl-4-isothiazolin-3-one 1.15%
2-Methyl-4-isothiazolin-3-one 0.35%
Total active ingredients 1.50%

Inert Ingredients-%WT/WT
Magnesium salts (chloride and nitrate) 23.00%
Water 75.50%
98.50%

Typical Properties
Appearance Clear Liquid
Color, APHA 50
Odor Mild
pH (as manufactured) 3.0
(These do not constitute specifications)

Efficacy
Isocil PC was incorporated into shampoo and conditioner formulas, standard media used for
efficacy studies.
Shampoo Formula
Ingredients (All ingredients unpreserved)-% WT/WT Total Weight Percent
CARSONOL
SLES 35.0%
CARSONOL
TLS 25.0%
CARSAMIDE
CA 3.0%
Water (deionized) 36.0%
Polypro 5000 1.0%
Preservative q.s.

Protein Hair Conditioner Formula
Ingredients-% Active-Use-% Active
CARSOSOFT T90-90-3.0-2.7
POLYPRO 5000 2-100-1.0-1.0
SAG-30 3 (Silicone Emulsion)-30-0.05-0.015
Citric Acid q.s. to pH 5.5
Preservative q.s.
Water 4 q.s. to 100%
Total 100.0% 3.7015%
1) Ditallow Diamido Methosolfate
2) Hormel Co.
3) OSI Specialist Inc.
4) Sterile Deionized
Isocil PC vs. Competitive Isothiazolinone –
Shampoo Mixed Inoculum-Bacteria*

Stability
Isocil PC offers improved stability (in a citrate buffered solution) over the competitive
isothiazolinone due to a low level of impurities. Because of its low level of iron (evidenced by its
color clarity) Isocil PC provides greater stability due to the minimization of complexing with
ingredients such as citrate and citric acids.

Purity
So you’ve decided to formulate with isothiazolinones? Good choice. Why not choose the purest
form? Isocil PC. Lowest iron content and other impurities assures product integrity and safety,
potentially reducing the risk of irritation.
Toxicology and Safety
Isothiazolinones have been deemed safe in concentrations up to 15 parts per million; or 0.1%
Isocil PC in rinse-off products. This is based on mixtures containing 0.35% Methylisothiazolinone
and 1.15% Methylchloroisothiazolinone.

Cost
In today’s highly competitive marketplace, cost is one of the primary considerations in the
manufacturing of personal care products. When compared with other leading preservatives, Isocil
PC provides superior cost effectiveness.

Regulatory Status
Isothiazolinones are approved as personal care preservatives in the countries listed below.

MI/MCI Approval for Use
Argentina Hungary Poland
Australia Indonesia Portugal1
Austria1 Ireland1 Spain1
Belgium1 Italy1 Singapore
Bulgaria Japan2 Sweden1
Brazil Korea Switzerland
Canada3 Luxembourg Taiwan
Chile Mexico Thailand
Denmark1 New Zealand United Kingdom1
Finland1 Netherlands1 U.S.A.4
France1 Norway Yugoslavia
Germany1 Peoples Republic
Greece1 of China5
Hong Kong Philippines

1. E.E.C. member country: the MI/MCI components of Isocil PC are on the E.E.C. definitive list for preservatives.
Maximum use level is 15 ppm active ingredient.
2. Rinse-off products containing MI/MCI have been approved.
3. Listed with C.C.T.F.A.
4. Listed with C.T.F.A.
5. No approval required.

In other countries, approal may be pending or not required. Please contact a Lonza representative for more information.