PRODUCTS

ISONONYL ALCOHOL

CAS: 2430-22-0
European Community (EC) Number: 248-471-3

IUPAC Name: 7-methyloctan-1-ol

Molecular Formula: C9H20O
Molecular Weight: 144.25 g/mol

Isononyl alcohol, Isononanol, 2430-22-0, 7-methyloctan-1-ol, 7-METHYL-1-OCTANOL, 7-Methyloctanol, 27458-94-2, 7-Methyl-octanol, 1-Octanol, 7-methyl-, 68526-84-1, KY36Z95MC2, Alcohols, C8-10-iso-,C9-rich, 7-methyl-octan-1-ol, EINECS 248-471-3, BRN 1733654, UNII-KY36Z95MC2, iso-nonanol, iso-nonylalcohol, (R)-isononyl alcohol, NEOFLEX 9, EXXAL 9S, EXXSOL 9, EXXAL 9, 7-Methyl-1-octyl alcohol, EC 248-471-3, OXOCOL 900, SCHEMBL61074, 4-01-00-01806 (Beilstein Handbook Reference), DTXSID2058675, CHEBI:188348, EINECS 271-233-5, AKOS006272384, DB-265296, DB-307375, NS00002259, D98911, EC 271-233-5, A1-21212, J-015436, W-109201, Q22668724, Q27282495

Isononyl alcohol (INA) is a primary alcohol that is octane which is substituted by a methyl group at position 7 and a hydroxy group at position 1.
Isononyl alcohol (INA) is a fragrance ingredient.
Isononyl alcohol (INA) has a role as a fragrance.

Isononyl alcohol (INA) is a nine carbon primary alcohol.
Isononyl alcohol (INA) is used in small amounts as fragrance in soap, hair spray, face creams, and shampoo.
Isononyl alcohol (INA), along with 3,5,5-Trimethyl-1-hexanol, makes up the mixture sometimes referred to as isononanol.

Nonyl alcohols, including isononyl alcohol, are typically produced by hydroformylation of octenes.
Isomeric octenes are produced by dimerization of butenes.
These alcohol mixtures are used as solvents in paints and as precursors to plasticizers.

Boiling Point (760 mmHg)°C: 198
Melting Point °C: -30 max
Specific Gravity: (20/20°C)0.837
Refractive Index (nD25): 1.435
Vapor Pressure (150°C) kPa: 19.5
Viscosity (20°C) mPa・s: 12.7
Solubility (in Water 20°C) g/100g: 0.02
Flash Point °C: 94
Ignition Point °C: 280
Explosion Limits Vol%: 0.9 - 6.0

C9 oxo alcohol isononanol, also known as isononyl alcohol or INA for short, is an important raw material for the production of plasticizers and surfactants.
As a C4-based alcohol, Isononyl alcohol (INA) is a key component for the production of high-performance plasticizers such as diisononyl phthalate (DINP), diisononyl cyclohexanoate (DINCH), diisononyl adipate (DINA) and triisononyl trimellitate (TINTM), which all can be used in a broad range of applications.
Products manufactured with Isononyl alcohol (INA) are mainly used in the PVC industry.
For example, they can be found in the automotive industry, flooring, wires and cables and in the construction industry.
Given the evolving health and environmental regulations associated with downstream applications, Isononyl alcohol (INA) is well positioned and compliant with these requirements.

WHAT IS INA USED FOR?
Isononyl alcohol (INA) is mainly used as an intermediate for the production of plastics.
Our customers combine this product with other substances to make new products such as plasticizers.
These are then used in commercial applications such as flooring, wires, cables and artificial leather.

A second important application is surfactants:
Isononyl alcohol (INA)-based surfactants offer superior cleaning benefits and enable manufacturers to develop environmentally friendly, biodegradable and sustainable cleaning formulation offerings.
These surfactants are a sustainable choice for producers looking to replace solvents in their cleaning products and seeking multifunctional ingredients to be used in them.
They demonstrate high performance in degreasing and enable the development of efficient cleaning products with fewer ingredients.

Isononyl alcohol (INA) is produced from octene via formylation, hydrogenation, distillation, and refinement.
The octene is formed by the dimerization of butene.
Isononyl alcohol (INA) is an odorous, flammable, and colorless liquid.
Isononyl alcohol (INA) is only slightly soluble in water, but soluble in most organic solvents.

Isononyl alcohol is a polycarboxylic acid that has been used in the treatment of skin conditions, such as atopic dermatitis and psoriasis.
Isononyl alcohol (INA) has been shown to penetrate the skin and stimulate the production of sebum.
Isononyl alcohol is also used as a plasticizer for polyvinyl chloride (PVC) and other plastics, which increases their flexibility.
Isononyl alcohol (INA) also has a hydrophobic effect, which may be due to its hydroxyl group.
The unsaturated alkyl chain on this chemical also makes it susceptible to oxidation by ozone in air and water vapor in air.
Isononyl alcohol is metabolized by humans through conjugation with glucuronic acid or sulfate esters.

Usage: Isononyl alcohol (INA) can be used as a solvent for nitrocellulose, rubber, paint, shellac, alkaloids, etc.
Isononyl alcohol (INA) can be used to produce coatings, inks, extraction agents, aerosol agents, etc.
Isononyl alcohol (INA) can also be used as antifreeze, detergent, additive for blending gasoline, dispersant for pigment production, fixative for printing and dyeing industry, anti-fogging agent for glass and transparent plastic, etc.

Isononyl alcohol (INA) is mainly used to produce high molecular weight phthalate plasticizers such as diisononyl phthalate (DINP).
With the gradual recognition of the safety of DINP in the market, DINP is an environmentally friendly substitute for low molecular weight phthalate plasticizers such as dioctyl phthalate (DOP), and its demand is growing rapidly.
Isononyl alcohol (INA) is widely used in industrial fields such as automobiles, cables, floors, and buildings.

Isodecyl alcohol (INA) is mainly used to produce high molecular weight phthalate plasticizers such as diisodecyl phthalate (DINP).
With the market’s gradual recognition of the safety of DINP use, DINP is an environmentally friendly substitute for low molecular weight phthalate plasticizers such as dioctyl phthalate (DOP), and its demand is growing rapidly.
Widely used in automotive, cable, flooring, construction and other industrial fields.

Scientific Research Applications

Solvent:
Isononyl alcohol is a versatile solvent due to its ability to dissolve a wide range of nonpolar and polar compounds.
This makes it valuable for various research applications, including:
Extraction of biomolecules:
Isononyl alcohol can be used to extract lipids, proteins, and other biomolecules from biological samples.
Synthesis of organic compounds:
Isononyl alcohol can be used as a solvent in the synthesis of various organic compounds, including pharmaceuticals, pesticides, and polymers.

Surfactant:
Isononyl alcohol can act as a nonionic surfactant, meaning it can reduce the surface tension of liquids.
This property makes it useful in various research applications, such as:
Stabilizing emulsions and suspensions:
Isononyl alcohol can help prevent the separation of oil and water in emulsions and keep particles suspended in solutions.

Enhancing the solubility of hydrophobic compounds:
Isononyl alcohol can help dissolve compounds that are not readily soluble in water.
This is useful in various studies, such as drug delivery research.

Plasticizer:
Isononyl alcohol can be used as a plasticizer, which is a substance that adds flexibility and elasticity to polymers.
This property makes it useful in various research applications, such as:
Development of new polymer materials:
Isononyl alcohol can be used to modify the properties of polymers, making them more suitable for specific applications.
Studying the behavior of polymers:
Isononyl alcohol can be used to investigate the mechanical properties and other characteristics of polymers.

Synthesis Analysis
The synthesis of isononyl alcohol and related derivatives has been a subject of extensive study.
For instance, a method involving the rhodium-catalyzed oxidative coupling of α,α-disubstituted benzyl and allyl alcohols with alkynes has been developed for the straightforward synthesis of isochromene derivatives, demonstrating a versatile approach to creating complex molecules from simpler alcohol precursors.
Furthermore, the transformation of allylic alcohols to carbonyl compounds through isomerization represents an atom-economical process that has been optimized for efficiency in natural-product synthesis and bulk chemical processes, highlighting the versatility of alcohols in synthetic chemistry.

Molecular Structure Analysis
Understanding the molecular structure of isononyl alcohol is crucial for exploring its reactivity and properties.
While specific studies detailing the molecular structure analysis of isononyl alcohol through techniques such as X-ray crystallography or NMR spectroscopy are not highlighted here, the general approach to analyzing the molecular structure of organic compounds like isononyl alcohol involves examining its functional groups, stereochemistry, and electronic configuration, which dictate its chemical behavior and interaction with other molecules.

Chemical Reactions and Properties
Isononyl alcohol undergoes various chemical reactions characteristic of primary alcohols.
These include oxidation to produce isononyl aldehyde or isononyl acid, esterification to form isononyl esters, and reactions with phosphorus halides to generate isononyl halides.
The specific reactivity patterns of isononyl alcohol are influenced by its branched alkyl chain, which can impact the steric and electronic environments of the hydroxyl group.

Physical Properties Analysis
The physical properties of isononyl alcohol, such as boiling point, melting point, solubility in water and organic solvents, and viscosity, are important for its application in various industrial processes.
These properties are determined by the molecular structure of isononyl alcohol, particularly its branched alkyl chain, which affects its interactions with solvents and other compounds.

Chemical Properties Analysis
Chemically, isononyl alcohol exhibits properties typical of primary alcohols.
Isononyl alcohol (INA) is a relatively reactive species capable of undergoing nucleophilic substitution reactions, oxidation to form corresponding aldehydes or acids, and serving as a starting material for the synthesis of various esters and ethers.
The branched nature of the isononyl group influences its reactivity and the selectivity of these transformations.

Scientific Research Applications

Fragrance Applications
Isononyl alcohol is prominently used in the fragrance industry.
A detailed toxicological and dermatological review of isononyl alcohol, when used as a fragrance ingredient, revealed that it belongs to the fragrance structural group of branched chain saturated alcohols.
These are characterized by a hydroxyl group per molecule and a C(4)-C(12) carbon chain with one or several methyl side chains.
The review compiled all available papers related to the safety and dermatology of this substance and was not intended as a standalone document.
Instead, it was part of a broader assessment of the safe use of branched chain saturated alcohols in fragrances.

Medical Applications
In the medical field, isononyl alcohol has been implicated in cancer research.
A study identified the expression of the olfactory receptor OR51B5 in chronic myelogenous leukemia (CML) cells and acute myelogenous leukemia (AML) patients.
Isononyl alcohol, recognized as an OR51B5 ligand, was found to increase intracellular Ca2+ levels in both CML cells and AML patient blood cells.
Further, activation of OR51B5 by isononyl alcohol led to reduced cell proliferation in CML cells, suggesting a potential pharmacological target for leukemia treatment.

Environmental Impact
From an environmental perspective, the ecotoxicity and biodegradation behavior of phthalate monoesters, including isononyl alcohol, have been studied.
These compounds, ranging from n-butyl to isononyl monoester, are readily biodegradable with degradation rates of 90% and more.
The study emphasized that the acute aquatic toxicity of these esters is strongly dependent on the carbon chain length of the alcohol moiety, with toxicity values leveling off around 30 mg/l for the isononyl monoester.

Chemical Synthesis
In chemical synthesis, isononyl alcohol has been utilized in the synthesis of 1,2-Cyclohexanedicarboxylic acid diisononyl ester.
The study optimized the synthesis process and explored factors such as reaction temperature, time, raw material molar ratio, and catalyst dosage, concluding that the catalyst used in the process had numerous advantages including high activity, low cost, and environmental friendliness.

Isononyl alcohol (INA) is mainly used to produce high molecular weight phthalate plasticizers such as diisodecyl phthalate (DINP).
With the market’s gradual recognition of the safety of DINP use, DINP is an environmentally friendly substitute for low molecular weight phthalate plasticizers such as dioctyl phthalate (DOP), and its demand is growing rapidly.
Isononyl alcohol (INA) is widely used in automotive, cable, flooring, construction and other industrial fields.

Storage:
Tighten the cap of container and store in a cool , dry , well-ventilated , storage area of cabinet.