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Isopropyl Myristate (MASESTER E1140) produced by reacting myristic acid with isopropy alcohol.
Isopropyl Myristate (MASESTER E1140) is fully refined and deodorised.
Isopropyl Myristate (MASESTER E1140) is odorless when pure.
CAS: 110-27-0
MF: C17H34O2
MW: 270.45
EINECS: 203-751-4
Synonyms
Isopropyl Myristate, 96% 25GR;IPM 100;IPM-EX;IPM-R;Radia 7730 (IPM);Isopropyl myristate Vetec(TM) reagent grade, 98%;MYRISTIC ACID ISOPROPYL ESTER MINIMU;ISO-PROPYL N;TETRADECANOATE;ISOPROPYL MYRISTATE;110-27-0;Isopropyl tetradecanoate;Estergel;Tetradecanoic acid, 1-methylethyl ester;Bisomel;Isomyst;Promyr;Deltyl Extra;Kesscomir;Tegester;propan-2-yl tetradecanoate;Sinnoester MIP;Crodamol IPM;Plymoutm IPM;Starfol IPM;Unimate IPM;Kessco IPM;Emcol-IM;Wickenol 101;Stepan D-50;Emerest 2314;1-Methylethyl tetradecanoate;Deltylextra;Myristic acid isopropyl ester;JA-FA IPM;Crodamol I.P.M.;Kessco isopropyl myristate;Tetradecanoic acid, isopropyl;FEMA No. 3556;Myristic acid, isopropyl ester;Tetradecanoic acid, isopropyl ester;Caswell No. 511E;Isopropyl myristate [USAN];1-Tridecanecarboxylic acid, isopropyl ester;HSDB 626;NSC 406280;UNII-0RE8K4LNJS;0RE8K4LNJS;EINECS 203-751-4;MFCD00008982;Estergel (TN);EPA Pesticide Chemical Code 000207;NSC-406280;BRN 1781127;methylethyl tetradecanoate;iso-Propyl N-tetradecanoate;DTXSID0026838;CHEBI:90027;EC 203-751-4;Tetradecanoic acid methyethyl ester;1405-98-7;NCGC00164071-01;WE(2:0(1Me)/14:0);isopropylmyristate;MYRISTIC ACID, ISOPROPYL ALCOHOL ESTER;Isopropyl myristate, 98%;TETRADECONOIC ACID, 1-METHYLETHYL ESTER;DTXCID306838;ISOPROPYL MYRISTATE (II);ISOPROPYL MYRISTATE [II];ISOPROPYL MYRISTATE (MART.);ISOPROPYL MYRISTATE [MART.];ISOPROPYL MYRISTATE (USP-RS);ISOPROPYL MYRISTATE [USP-RS];CAS-110-27-0;ISOPROPYL MYRISTATE (EP MONOGRAPH);ISOPROPYL MYRISTATE [EP MONOGRAPH];IPM-EX;Isopropyl myristate; 1-Methylethyl tetradecanoate;IPM-R;tetradecanoic acid 1-methylethyl ester;Deltyextra;Myristic acid-isopropyl ester;Tegosoft M;Isopropyl myristate [USAN:NF];Liponate IPM;Crodamol 1PM;IPM 100;isopropyl-myristate;Lexol IPM;Isopropyltetradecanoate;Radia 7190;Isopropyl myristate (NF);Isopropyl tetradecanoic acid;SCHEMBL2442;Isopropyl myristate, >=98%;Isopropyl myristate (Standard);CHEMBL207602;ISOPROPYL MYRISTATE [MI];WLN: 13VOY1&1;FEMA 3556;tetradecanoic acid isopropyl ester;ISOPROPYL MYRISTATE [FHFI];ISOPROPYL MYRISTATE [HSDB];ISOPROPYL MYRISTATE [VANDF];Isopropyl myristate, >=90% (GC);Tox21_112080;Tox21_202065;Tox21_303171;ISOPROPYL MYRISTATE [WHO-DD];LMFA07010677;NSC406280;s2428;AKOS015902296;Tox21_112080_1;DB13966;FI32552;HY-124190R;USEPA/OPP Pesticide Code: 000207;NCGC00164071-02;NCGC00164071-03;NCGC00256937-01;NCGC00259614-01;LS-14615;DB-040910;HY-124190;CS-0085813;M0481;NS00006471;Isopropyl Myristate Solution. 500mL, Sterile;D02296;F71211;SBI-0654218.0001;EN300-25299830;Q416222;SR-01000944751;Isopropyl myristate, Vetec(TM) reagent grade, 98%;SR-01000944751-1;BRD-K13409143-001-01-9;Isopropyl myristate, United States Pharmacopeia (USP) Reference Standard;TETRADECANOIC ACID,ISOPROPYL ESTER (MYRISTATE,ISOPROPYL ESTER);Isopropyl myristate, Pharmaceutical Secondary Standard; Certified Reference Material;203-751-4;InChI=1/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H
Isopropyl Myristate (MASESTER E1140) is a nonsteroidal anti-inflammatory drug that is used to treat inflammatory conditions.
Isopropyl Myristate (MASESTER E1140) can be found in cosmetics, toiletries, and skin care products.
Isopropyl Myristate (MASESTER E1140) has been shown to inhibit the production of water vapor from skin cells and the development of allergic symptoms in vitro.
Isopropyl Myristate (MASESTER E1140) also has a role in preventing water loss from the skin by acting as a barrier to water vapor.
Isopropyl Myristate (MASESTER E1140) is also able to inhibit autoimmune diseases by inhibiting hiv infection in a model system.
Isopropyl Myristate (MASESTER E1140) has been shown to have antifungal properties and antimicrobial activity against Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis, Bacillus cereus, Candida albicans and Aspergillus niger.
Isopropyl Myristate (MASESTER E1140) is a fatty acid ester.
Isopropyl Myristate (MASESTER E1140) is an ester of isopropyl alcohol myristic acid.
Isopropyl Myristate (MASESTER E1140) is mainly used as a solubilizer, emulsifier and emollient in cosmetic and topical medicines.
Isopropyl Myristate (MASESTER E1140) also finds applications as a flavoring agent in the food industry.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Isopropyl Myristate (MASESTER E1140) is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption.
Isopropyl Myristate (MASESTER E1140) has been largely studied and impulsed as a skin penetration enhancer.
At the moment the primary usage for which Isopropyl Myristate (MASESTER E1140) is formally indicated is as the active ingredient in a non-prescription pediculicide rinse.
Isopropyl Myristate (MASESTER E1140) is the ester of isopropyl alcohol and myristic acid.
Isopropyl Myristate (MASESTER E1140) Chemical Properties
Melting point: ~3 °C (lit.)
Boiling point: 193 °C/20 mmHg (lit.)
Density: 0.85 g/mL at 25 °C (lit.)
Vapor pressure: <1 hPa (20 °C)
Refractive index: n20/D 1.434(lit.)
FEMA: 3556 | ISOPROPYL MYRISTATE
Fp: >230 °F
Storage temp.: 2-8°C
Solubility: <0.05mg/l
Form: Liquid
Specific Gravity: 0.855 (20/4℃)
Color: Clear
Odor: odorless
Biological source: synthetic (organic)
Water Solubility: Miscible with alcohol. Immiscible with water and glycerol.
Merck: 14,5215
JECFA Number: 311
BRN: 1781127
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey: AXISYYRBXTVTFY-UHFFFAOYSA-N
LogP: 7.71
CAS DataBase Reference: 110-27-0(CAS DataBase Reference)
NIST Chemistry Reference: Isopropyl Myristate(110-27-0)
EPA Substance Registry System: Isopropyl myristate (110-27-0)
Isopropyl Myristate (MASESTER E1140) is a colorless and odorless liquid with a faint odor, and miscible with vegetable oil.
Isopropyl Myristate (MASESTER E1140) is not easy to be either hydrolyzed or become rancid.
The refractive index nD20 is 1.435~1.438, and the relative density (20°C) is 0.85~0.86.
Isopropyl Myristate (MASESTER E1140) is used in many applications, including pharma, food and personal care product manufacturing.
Isopropyl Myristate (MASESTER E1140) is virtually odorless, very slightly fatty, but not rancid.
Isopropyl Myristate (MASESTER E1140) is a clear, colorless, practically odorless liquid of low viscosity that congeals at about 5°C.
Isopropyl Myristate (MASESTER E1140) consists of esters of propan-2-ol and saturated high molecular weight fatty acids, principally myristic acid.
Content Analysis
Weight 1.5 g sample.
Then Isopropyl Myristate (MASESTER E1140) is determined by the method ester assay (OT-18).
The equivalent factor (e) in the calculation is 135.2.
Or Isopropyl Myristate (MASESTER E1140) is determined by a non-polar column method of gas chromatography (GT-10-4).
Uses
Isopropyl Myristate (MASESTER E1140) is a fatty acid ester which is used as solvent in water-in-oil emulsion, oils and fatty based ointments.
The use of Isopropyl Myristate (MASESTER E1140) is recommended in the Sterility Test chapter of the European, Japanese and United States Pharmacopoeia (EP, 2.6.13, JP, 4.06 and USP, 71) as diluent for oils and oily solutions, as well as for ointments and creams.
Indeed, Isopropyl Myristate (MASESTER E1140)'s solvent properties improve the filterability of these samples.
Isopropyl Myristate (MASESTER E1140) is known as a penetration enhancer for topical preparations.
Isopropyl Myristate (MASESTER E1140) is a waterclear, low viscous oily liquid with a very good spreading capacity on the skin.
Isopropyl Myristate (MASESTER E1140) is mainly used in cosmetics as an oilcomponent for emulsions, bath oils and as a solvent for active substances.
Isopropyl Myristate (MASESTER E1140) is an emollient, moisturizer, binder, and skin softener that also assists in product penetration.
An ester of myristic acid, Isopropyl Myristate (MASESTER E1140) is naturally occurring in coconut oil and nutmeg.
Although Isopropyl Myristate (MASESTER E1140) is generally considered comedogenic, some ingredient manufacturers clearly specify non-comedogenicity on their data sheets.
Isopropyl Myristate (MASESTER E1140) is an emollient in cosmetic and pharmaceutical bases.
In cosmetic and topical medicinal Preparations where good absorption through the skin is desired.
A jellied Isopropyl Myristate (MASESTER E1140) was marketed as Estergel.
Isopropyl Myristate (MASESTER E1140) is a polar emollient and is used in cosmetic and topical pharmaceutical preparations where skin absorption is desired.
Isopropyl Myristate (MASESTER E1140) is also used as a treatment for head lice.
Isopropyl Myristate (MASESTER E1140) is also in flea and tick killing products for pets.
Isopropyl Myristate (MASESTER E1140) is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product "Dentyl pH".
Isopropyl Myristate (MASESTER E1140) is also used as a solvent in perfume materials, and in the removal process of prosthetic make-up.
Hydrolysis of the ester from Isopropyl Myristate (MASESTER E1140) can liberate the acid and the alcohol.
The acid is theorized to be responsible for decreasing of the pH value of formulations.
As a cosmetics deep agent and skin moisturizer, penetrant.
Isopropyl Myristate (MASESTER E1140) has excellent penetration, moisturizing, and softening effects on the skin, and is used for emulsifiers and moisturizers for cosmetics.
Isopropyl Myristate (MASESTER E1140) can be used in cosmetics such as sol products, hair conditioners, skin creams, sunscreen, and shaving cream.
Pharmaceutical Applications
Isopropyl Myristate (MASESTER E1140) is a nongreasy emollient that is absorbed readily by the skin.
Isopropyl Myristate (MASESTER E1140) is used as a component of semisolid bases and as a solvent for many substances applied topically.
Applications in topical pharmaceutical and cosmetic formulations include bath oils; make-up; hair and nail care products; creams; lotions; lip products; shaving products; skin lubricants; deodorants; otic suspensions; and vaginal creams.
For example, Isopropyl Myristate (MASESTER E1140) is a self-emulsifying component of a proposed cold cream formula, which is suitable for use as a vehicle for drugs or dermatological actives; it is also used cosmetically in stable mixtures of water and glycerol.
Isopropyl Myristate (MASESTER E1140) is used as a penetration enhancer for transdermal formulations, and has been used in conjunction with therapeutic ultrasound and iontophoresis.
Isopropyl Myristate (MASESTER E1140) has been used in a water-oil gel prolonged-release emulsion and in various microemulsions.
Such microemulsions may increase bioavailability in topical and transdermal applications.
Isopropyl Myristate (MASESTER E1140) has also been used in microspheres, and significantly increased the release of drug from etoposide-loaded microspheres.
Isopropyl Myristate (MASESTER E1140) is used in soft adhesives for pressuresensitive adhesive tapes.
Production Method
Isopropyl Myristate (MASESTER E1140) is a product of esterification of myristic acid derived from re-steamed coconut coil with isopropyl alcohol.
(1) 200 kg myristic acid and 450 kg isopropyl alcohol were added into the reaction vessel in turn.
After mixing, 360 kg sulfuric acid (98%) was added.
The reaction mixture was heated to reflux for 10 hours.
Isopropyl alcohol was then recovered, washed with ice water, and neutralized with Na2CO3 aqueous solution (10%).
Under normal pressure, isopropyl alcohol and water were distilled.
While under reduced pressure, isopropyl myristate was distilled (185°C/1.0kPa~195°C/2.7kPa).
(2) 90 kg isopropyl alcohol was added into the reaction vessel and then sulfuric acid as catalyst, with 5% of the total amount, was added.
During mixing, 228 kg myristic acid was added slowly.
The mixture was heated to reflux and water was continuously separated.
Until no water was separated, the reaction temperature was reduced and probe was obtained to measure the acid value.
When the acid value reached 1.5 mg KOH/g, the reaction was completed.
Alkali was then added for neutralization.
After the removal of water under reduced pressure, the pressure was further reduced for dealcoholization until the acid value was 0.05~1.0 mg KOH/g.
The final product is then Isopropyl Myristate (MASESTER E1140).
Production Methods
Isopropyl Myristate (MASESTER E1140) may be prepared either by the esterification of myristic acid with propan-2-ol or by the reaction of myristoyl chloride and propan-2-ol with the aid of a suitable dehydrochlorinating agent.
A high-purity material is also commercially available, produced by enzymatic esterification at low temperature.
Contact allergens
Despite wide use in cosmetics, perfumes, and topical medicaments, Isopropyl Myristate (MASESTER E1140) is a very weak sen- sitizer and a mild irritant.
Biochem/physiol Actions
Isopropyl Myristate (MASESTER E1140) is used to change the physicochemical characteristics of microsheres such as poly(lactic-co-glycolic acid) (PLGA) microspheres.
Isopropyl Myristate (MASESTER E1140) is used as a oil phase component in the formulaton of microemulsion systems.
