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Isopropyl myristate

ATAMAN's Fatty Acid Esters: ATAMAN CHEMICALS offers natural emollients and emulsifiers for Cosmetics

Isopropyl myristate= Ester of Isopropyl alcohol + Myristic acid
Chemical Description: Myristic acid isopropylester
Isopropyl myristate (IPM) is the ester of isopropyl alcohol and myristic acid. Isopropyl myristate is a texture enhancer, emollient and emulsifier in cosmetic formulations.

EC / List no.: 203-751-4
CAS no.: 110-27-0

Isopropyl myristate is among the commonly used fatty acid ester and is isopropyl ester of tetradecanoic acid. Isopropyl myristate is categorized mainly employed as synthetic oil and is produced by reaction of isopropyl alcohol and myristic acid. Isopropyl myristate is among the foremost available substitutes for natural oil in the cosmetics industry. Isopropyl myristate is also used as solvent in several trans-dermal pharmaceutical products and pharmaceuticals creams.

Major end user industries for isopropyl myristate include personal care, pharmaceuticals, food and lubricants among several others.
Personal care is the largest application segment for isopropyl myristate and the trend is anticipated to continue for a foreseeable future.
Isopropyl myristate is also used as a pesticide free product for killing lice.
Isopropyl myristate helps in enhancing skin penetration properties of products owing to which, pharmaceutical is anticipated to be the fastest growing application segment for isopropyl myristate.
Other applications of isopropyl myristate include solvents, plasticizer and bio diesel among others.

Isopropyl myristate is an emollient, it helps to strengthen the skin barrier, ensuring that moisture stays locked in. As an emollient, it also helps soften and smooth dry skin, which is why this is a great ingredient for those with dry or flaky skin.

This fabulous ingredient can also acts as a lubricant, thickening agent or a moisturiser in your cosmetic product. It is used to give your product a slicker, smoother feel rather than an oily one.
Isopropyl myristate is an emollient. It nourishes the skin while preserving its hydration. Its main advantage is that it does not leave a greasy finish on the skin.

ISOPROPYL MYRISTATE is classified as :
Binding
Emollient
Skin conditioning
Solvent
Perfuming

CAS Number: 110-27-0
EINECS/ELINCS No: 203-751-4
INN Name: isopropyl myristate
PHARMACEUTICAL EUROPEAN NAME: isopropylis myristas
Chem/IUPAC Name: Tetradecanoic acid, isopropyl ester

Recommendations
Aftershaves, Shampoos, Bath oils, Creams and Lotions.
INCI Name
Isopropyl Myristate

Dosage
1-10%

Isopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption. Isopropyl myristate has been largely studied and impulsed as a skin penetration enhancer. At the moment the primary usage for which isopropyl myristate is formally indicated is as the active ingredient in a non-prescription pediculicide rinse.
Isopropyl Myristate is an ester of isopropyl alcohol and myristic acid (a fatty acid that naturally occurs in coconut and palm oils). It is a very lightweight emollient and can be used like a carrier oil in many applications.

Isopropyl myristate finds many applications in food, cosmetic and pharmaceutical industries as an emollient, thickening agent, or lubricant.
Isopropyl Myristate (IPM) is an emollient ester of low viscosity; light weight oil.
IPM is ester of isopropyl alcohol and myristic acid (vegetable-derived).

Isopropyl myristate is mainly used as a solubilizer, emulsifier and emollient in cosmetic and topical medicines. It is also used as a flavoring agent in the food industry

Isopropyl Myristate is a synthetic oil used as an emollient, thickening agent or lubricant in beauty products. Isopropyl Myristate is a popular cosmetic and pharmaceutical ingredient.
Isopropyl Myristate is most often used as an additive in aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.

Isopropyl myristate IPM is the ester of myristic acid and isopropyl alcohol. It is manufactured from high quality palmkernel or coconut oil. Isopropyl Myristate is a thin fluid with high stability. It is easy to spread onto the skin, is easily absorbed and in addition smoothens the skin. IPM also helps bind certain cosmetic preparations (fine grain and powdery).

IPM is a multifunctional (emollient, solvent, spreading agent, penetrant) synthetically produced ester of vegetal myristic acid and petrochemical isopropyl alcohol

INCI Name: Isopropyl Myristate
IPM is commonly found in formulations to help reduce the greasiness of whipped butters and emulsions.

IPM is not soluble in water, but it is soluble in castor and several other oils.
Suggested Usage Rates: Lotions & Creams: 2-5% - Lipsticks & Lip Balms – 1-5% - Massage Oils 4-10%

INCI: Isopropyl Myristate
Appearance / Product characteristics: Clear, colorless, almost odorless oil
Use: Fast spreading emollient suitable for all cosmetic applications.

Application
After Sun Antiperspirants & Deodorants
Baby Care and Cleansing
Body Care
Color Care
Conditioning Face Care
Face Cleansing
Personal Care Wipes
Self Tanning
Sun Protection
Product Groups: Emollients
Isopropyl myristate (IPM) is used as a substitute for natural oils in cosmetics and a co-solvent with skin penetration enhancement properties of active ingredients in many topical and transdermal preparations. Isopropyl myristate is a novel pediculicide rinse (50%) and a safe and effective therapy for the treatment of head lice in children and adults.
Isopropyl Myristate is a fast spreading emollient suitable for all cosmetic applications.

Isopropyl myristate is the synthetic oil widely used in the cosmetics as a lubricant and emollient.
This emmolient is manufactured by condensing myristic acid with isopropyl alcohol.
Isopropyl myristate is readily absorbed by the skin and lessens the greasy nature of cosmetics while lending them a sheer, slick feel.
Generally Isopropyl myristate is considered to be safe

It is non-occlusive, spreads well and provides an elegant, non-oily skin feel. It may be used as a carrier for cosmetic and pharmaceutical additives, and is also an excellent solubilizer for lanolin. Hence it finds broad application in topically applied cosmetic and pharmaceutical liquid, cream, lotion, powder and spray products.

Isopropyl Myristate is included in formulas to dramatically reduce the greasy/oily feel; it’s brilliant in recipes with large amounts of butters that are famous for a heavier skin feel (like shea).
Isopropyl Myristate is also a great lightweight emollient; you can include it in recipes as an alternative to a liquid carrier oil to make for a lighter, faster-absorbing product.

At higher concentrations IPM can also be used in products like makeup removers.

Isopropyl Myristate should be included in the oil phase of your products; it can be hot or cold processed.

Isopropyl tetradecanoate is a fatty acid ester.

Isopropyl myristate is used as a thickening agent or as a moisturizer in common beauty products. It is a synthetic oil that actually lessens the "greasy" or oily feeling found in some lotions and creams, while aiding in absorption. While it is widely used in health items, isopropyl myristate is also used as a way to treat head lice and in a mouthwash that kills bacteria.

Isopropyl myristate is a synthetic oil widely used in the cosmetics and pharmaceutical industries as a lubricant, emollient, and as a non-toxic alternative for controlling head lice. The oil is manufactured by condensing myristic acid with isopropyl alcohol and is colorless and mild in odor.

Isopropyl Myristate (IPM) in cosmetics has become universal. Its skin feel, its dry emollience, its skin penetration and clear miscibility with vegetable and mineral oils are just some of the sought after formulation properties.

Isopropyl Myristate is an ester of the fatty acid Myristic Acid.

Isopropyl Myristate has a silky feeling that makes skin (and hair) soft, smooth and supple.

It also reduces the greasy feel of other oils in the same product. Rather than an oily mess, the cream is now sleek and light to the touch.

Isopropyl Myristate is a polar emoliant and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired.

Isopropyl Myristate is being studied as a skin enhancer. It is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.

Isopropyl Myristate is used in the same way in flea and tick killing products for pets.

Isopropyl Myristate is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product "Dentyl pH".

Isopropyl Myristate is is also used as a solvent in perfume materials and in the removal process of prosthetic make-up.

Hydrolisis of the ester from Isopropyl Myristate is can liberate the acid and the alcohol. The acid could be responsible for the decreasing of the pH value of formulations

Chemical Formula: C17H3402

Molar Mass: 270.457 g-mol-1

Density: 0.85 g/cm3

Boiling Point: 167'C (333'F)

GENERAL DATA:

CAS Number 110-27-0
EINECS Number 203-751-4

Isopropyl Myristate

Solubility: Oil Soluble
Benefits: Emollient, thickening agent, lubricant or moisturiser in beauty products. in cosmetic manufacturing this ingredient is used to give the finished product a slicker, smoother feel rather than an oily one.
INCI Name: Isopropyl Myristate

Applications: Most often used at between 1-10%. This all-natural ester is used to empart a dry yet moisturising feel to skin creams.
In addition, Isopropyl Myristate is also used to help solubilise actives such as sunscreens, vitamins and perfumes into a base.

Origin: Vegetable - Palm or Coconut.
Solubility: Insoluble in glycerine and water. Soluble in alcohol.
Recommendations: Aftershaves, Shampoos, Bath oils, Anti-perspirants, Various creams and lotions

Isopropyl Myristate is used as an emollient in cosmetic and topical preparations when good absorption through the skin is desired.

Uses:
Skin Care Products / Cosmetics
Aftershaves
Antiperspirants / Deodorants
Bath oil
Hair sprays, gels, tonics and lotions
Soaps / Cleansers
Shampoos / Conditioners
Moisturizers
Make-ups
Nail Polish Remover
Powders / Sprays
Sunscreens
Topical medications, possibly including tar products
Emulsifier and emollient / lubricant in topical OTC and prescription medications
Fragrances

Other names for Isopropyl Myristate:
IPM
Isopropyl Tetradeconoate
Tetradecanoic acid 1- methylethyl ester
Isopropylis Myristas
Isopropyl Myristas
1-Methylethyl Tetradecanoate
Myristic acid Isopropyl ester
1-Methylethyl Ester Tetradecanoic acid
1-Methylethyl Tetradecanoate
Isopropyl Ester Myristic acid
Isopropyl Tetradecanoate
Tetradecanoic acid
1-Methylethyl Ester
Tetradecanoic acid
1Methylethyl Ester
1-Tridecanecarboxylic Acid
Isopropyl Ester
Bisomel
Crodacol IPM

Benefits: Emollient, thickening agent, lubricant or moisturiser in beauty products. in cosmetic manufacturing this ingredient is used to give the finished product a slicker, smoother feel rather than an oily one.

INCI Name: Isopropyl Myristate

Applications: Most often used at between 1-10%. This all-natural ester is used to empart a dry yet moisturising feel to skin creams. In addition, it is also used to help solubilise actives such as sunscreens, vitamins and perfumes into a base.

Origin: Vegetable – Palm or Coconut.

Solubility: Insoluble in glycerine and water. Soluble in alcohol.

Recommendations:

Aftershaves
Shampoos
Bath oils
Anti-perspirants
Various creams and lotions

This multi-purpose oil is an ester of isopropyl alcohol and myristic acid. The isopropyl component is a propane derivative; mirystic acid is a fatty acid common in plant sources such as nutmeg and palm seeds. Isopropyl myristate possesses several unique characteristics which make it a valuable additive in many cosmetics and pharmaceutical products. Certainly one of the most significant of these is the oil's ease of absorption by the skin. Used as an emollient in creams and lotions, isopropyl myristate ensures deep, quick penetration for these preparations.

This deep penetrating characteristic does have a downside however; extensive use of products containing the oil may lead to pore clogging. It still remains a valuable absorption carrier, though, and is common component of moisturizers, bath oils, and lotions. Although itself an oil, isopropyl myristate also reduces greasiness in cosmetics. When added to lip products and creams, it lends the cosmetics a slick, sheer texture without any greasy feel.

Isopropyl myristate is also a common ingredient in pharmaceutical formulations. It is often used as a non-pesticide alternative for treating head lice infestations. The oil destroys the wax layer which insulates the lice and causes death by dehydration. It is also effective at controlling oral bacteria and is used in several mouthwash products.

The fatty acid esters have a broad range of applications in industries such as cosmetic industry, food industry, the pharmaceutical industry, the coating industry, lubricants, biodiesel etc.
The esters of fatty acids includes methyl esters, isopropyl esters, butyl esters, partial glycerides and wax esters (esters of fatty acids with long-chain fatty alcohols), and ester oils (esters of fatty acids with poly alcohols)
The commonly used fatty acid ester, isopropyl myristate (IPM), is the main focus of present research.

IPM, the isopropyl ester of myristic acid, is used in cosmetics as a substitute for natural oils because it has excellent spreading properties and is absorbed easily into the skin.
In many topical and transdermal preparations, IPM is also used as a co-solvent with skin penetration enhancement properties of active ingredients.

Conventional methods for IPM synthesis involve the use of chemical catalyst at high temperatures.
But this result in undesirable changes in a final product with respect to colour, odour, and stability, hence there is need for post refining steps which increases overall unit processes.
Therefore, nowadays the use of an enzyme catalyzed reaction is in focus to replace the conventional methods.
Recently, many lipase based catalysis for esters have been reported wherein the esterification reaction were enhanced by reaction/enzyme engineering.

In accompanying papers the lipase-catalyzed esterification of myristic acid and isopropyl alcohol to produce isopropyl myristate ester was studied.
They have used organic solvents like heptanes, petroleum ether to carry out esterification reaction.
However, use of such organic solvents creates two phase system, hence has downstream processing problems.
Further theses conditions affect an enzyme activity adversely. Hence, there is need for medium engineering in order to develop the improved esterification reaction system.
Additionally, lower rate of reaction and yield in enzymatic route needed to be addressed for an efficient isopropyl myristate synthesis reaction.

Description: Ester of isopropyl alcohol and myristic acid (vegetable-derived). Low viscosity fluid non-greasy emollient, tolerates wide pH range, compatible with most surfactants. Thanks to its low viscosity and density, it has a high spreadability. Colorless oil-like liquid. No or little odor. Water-insoluble, but soluble with silicones, and hydrocarbons. Specific gravity 0.85 (at 20°C).
CAS: 110-27-0
INCI Name: Isopropyl myristate

Benefits:
Superior emollient for non-greasy bath, body and baby oils
Lubricant and compression aid for pressed powders
Light & non-tacky emollient for creams and lotions. Readily adsorbed by the skin
When used at high concentrations it gently lifts makeup and surface dirt
Gives gloss and shine to hair
Resistant to oxidation (does not become rancid)
Widely used as diluent for fragrance oils.

Use: Can be added to formulas as is, add to oil phase. Typical use level 1-20%. Required HLB: 11.5.

Storage: Stable when kept in a closed container at a cool & dry place. For external use only.

Applications: Creams, lotions, hand creams, shampoo, shower gels, makeup removers, powders and foundations.

Raw material source: Vegetable oils (myristic acid) and isopropanol
Manufacture: Isopropyl myristate is produced by distillation, which is preceded by the esterification of myristic acid and isopropanol, alkali refined to neutralize the catalyst.

IPM is fatty acid ester of isopropyl alcohol and myristic acid.
It is used in personal care products to enhance their moisturising and skin conditioning properties.

Isopropyl Myristate is derived from Myristic Acid and isopropyl alcohol

IUPAC name: Propan-2-yl tetradecanoate
Other names: Tetradecanoic acid, 1-methylethyl ester, Isopropyl tetradecanoate
Myristic acid isopropyl ester

CAS Number: 110-27-0

Properties
Chemical formula: C17H34O2
Molar mass: 270.457 g·mol−1
Density: 0.85 g/cm³
Boiling point: 167 °C (333 °F; 440 K) at 9 mmHg

Uses
Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired.
Isopropyl myristate is being studied as a skin enhancer. It is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.
It is used in the same way in flea and tick killing products for pets.

It is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product "Dentyl pH".

Isopropyl myristate is also used as a solvent in perfume materials, and in the removal process of prosthetic make-up.

Hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol. The acid could be responsible for decreasing of the pH value of formulations.

Isopropyl myristate works as an emollient, helping to maintain the skin’s natural barrier and retain moisture. Isopropyl myristate also helps to increase the penetration of key ingredients in your product.

ISOPROPYL MYRISTATE

TYPE OF INGREDIENT: Emollient, though it also acts as a thickening agent and lubricant in beauty products.

MAIN BENEFITS: Strengthens the skin's natural moisture barrier to lock in hydration, enhances the penetration of other ingredients, thickens formulas, and makes those with a high oil content feel silky rather than greasy.

WHO SHOULD USE IT: Isopropyl myristate is ideal for anyone with normal to dry skin looking for moisturization benefits, according to Palep.

HOW OFTEN CAN YOU USE IT: For the best results, follow the directions on the product it's found in, though daily or twice daily use is generally fine.

WORKS WELL WITH: Isopropyl myristate works well with an assortment of active ingredients, says Solomon, which is why it's found in so many different types of products and formulas.

DON'T USE WITH: Because it does enhance penetration, it’s important to assess the other ingredients in the formula and whether this increased penetration can cause unexpected side effects such as irritation, cautions Palep.

Benefits of Isopropyl Myristate For Skin
Strengthen's the skin barrier: Isopropyl myristate keeps the outermost layer of the skin strong and intact. Think of the skin barrier as being made up of bricks and mortar: the cells are the bricks and all of the lipids (fats) are the mortar. Isopropyl myristate is that mortar, filling in cracks in between the skin cells so that moisture can't escape.

Softens the skin: As an emollient, it also helps soften and smooth dry skin, which is why this is a choice ingredient for those with dry or flaky skin.

Enhances the penetration of other ingredients: The exact mechanism by which this works isn't fully clear, but it's thought that isopropyl myristate changes the structure of the stratum corneum, the most external layer of the skin, making it easier for active ingredients to absorb

isopropyl myristate
Categories: Texture Enhancer, Emollients
Texture enhancer and emollient as used in cosmetics. There is also research showing it can help enhance the absorption of ingredients in a cosmetic formula.

Isopropyl myristate is often called out as being a particularly bad pore-clogging ingredient; however, this assessment comes from dated research that doesn’t apply to how this ingredient is used in today’s cosmetics.

Isopropyl Myristate is so good at reducing the greasy feel of other ingredients that it is possible to make products that are primarily shea butter that don’t feel greasy.

Alternatives & Substitutions: It is tricky to substitute Isopropyl Myristate well.
One could use a very absorbing carrier oil instead (something like camellia seed oil), but even the lightest carrier oils won’t dramatically reduce the greasy feeling of a heavier formula, meaning the end product will be much heavier/slower absorbing than originally intended.
You could try something like isododecane or cyclomethicone, but ingredients like that are very volatile, meaning they cannot be heated much and will evaporate out of the finished product over time if given the opportunity.

What Is Isopropyl Myristate?
Isopropyl myristate is an ingredient that you may have unknowingly used many times before. Isopropyl myristate is a synthetic oil made from two components. The first component is isopropyl alcohol, the antimicrobial agent used in some hand sanitizers, baby wipes, and antiseptic formulations. The second component is myristic acid, which is a naturally occurring fatty acid often found in coconut oil, nutmeg, and animal fats such as butter—the two elements when they are combined form an exceptional emollient.

Emollients are thick, slightly waxy ingredients that help to maintain the skin’s natural barrier and provide the skin with that desired hydrated look. The skin’s natural barrier is the first few layers of skin and the protective oils that are produced, sebum. Disruption of the skin’s natural barrier has been linked to skin conditions such as eczema, so skin barrier health is vital to clear healthy-looking skin.

Isopropyl myristate has the added benefit of also enhancing the penetration of ingredients into the skin. This means that key ingredients in your skincare can penetrate deeply into the skin, working to improve the appearance of the skin.

What Are The Benefits of Isopropyl Myristate?
Moisture retaining
Working as an emollient isopropyl myristate helps to maintain the integrity of the skin’s natural barrier. Products with isopropyl myristate help to create a protective coating on the surface of the skin. This helps to prevent moisture loss and limit the skin’s exposure to allergens and bacteria.

Absorption
Isopropyl myristate improves the absorption of other products into the skin. It is often used in medicated formulations so that the skin receives the medication effectively. This is an excellent characteristic when it comes to getting the most out of your skincare ingredients; however, it can be irritating to sensitive skin type or clogging to congested skin types.

Texture
Isopropyl myristate can help to improve the texture of the products. It helps to thicken the product, which enhances the feeling of the product on the skin as it is applied. In formulation, it prevents oil-based ingredients from feeling too greasy or heavy but creating an even emulsion.

Isopropyl myristate (IPM) Chemical Properties, Uses and Production

Chemical Properties
It is a colorless and odorless liquid, and miscible with vegetable oil. It is not easy to be either hydrolyzed or become rancid. The refractive index nD20 is 1.435~1.438, and the relative density (20°C) is 0.85~0.86.

Content Analysis
Weight 1.5 g sample. Then it is determined by the method ester assay (OT-18). The equivalent factor (e) in the calculation is 135.2. Or it is determined by a non-polar column method of gas chromatography (GT-10-4).

Applications
It is applied as a dispersant for lipstick, hair cream, lipstick, cleansing cream, fragrance powder and medical ointment and can be also used as perfume fixative.
It is applied as dispersant for cosmetics.
Carrier solvent. Allowed food flavor additive according GB 2760-96.
It is one of the important ingredients of high-end cosmetics, has excellent penetration into the skin, moisture and softening effect and is used as emulsifier and wetting agent for cosmetics.
Used for organic synthesis. As solvent. For the preparation of spices.
Oily raw materials of cosmetics, solvent for pesticide original drugs.
It is widely used as additives for high-end cosmetics, such as ointment, cream, and conditioner.

Production Method
It is a product of esterification of myristic acid derived from re-steamed coconut coil with isopropyl alcohol.
(1) 200 kg myristic acid and 450 kg isopropyl alcohol were added into the reaction vessel in turn. After mixing, 360 kg sulfuric acid (98%) was added. The reaction mixture was heated to reflux for 10 hours. Isopropyl alcohol was then recovered, washed with ice water, and neutralized with Na2CO3 aqueous solution (10%). Under normal pressure, isopropyl alcohol and water were distilled. While under reduced pressure, isopropyl myristate was distilled (185°C/1.0kPa~195°C/2.7kPa).
(2) 90 kg isopropyl alcohol was added into the reaction vessel and then sulfuric acid as catalyst, with 5% of the total amount, was added. During mixing, 228 kg myristic acid was added slowly. The mixture was heated to reflux and water was continuously separated. Until no water was separated, the reaction temperature was reduced and probe was obtained to measure the acid value. When the acid value reached 1.5 mg KOH/g, the reaction was completed. Alkali was then added for neutralization. After the removal of water under reduced pressure, the pressure was further reduced for dealcoholization until the acid value was 0.05~1.0 mg KOH/g. The final product is then isopropyl myristate.

Toxicity
ADI is not regulated (FAO/WHO, 2001).

Description
Isopropyl myristate is odorless when pure. May be synthesized by conventional esterification of isopropanol with myristic acid.

Chemical Properties
Pure isopropyl myristate is virtually odorless, very slightly fatty, but not rancid

Chemical Properties
colourless liquid of low viscosity

Chemical Properties
Isopropyl myristate is a clear, colorless, practically odorless liquid of low viscosity that congeals at about 5°C. It consists of esters of propan-2-ol and saturated high molecular weight fatty acids, principally myristic acid.

Occurrence
Reported found in kumquat peel oil, papaya, starfruit, plum brandy, coriander seed and loquat

Uses
Isopropyl myristate is an emollient in cosmetic and pharmaceutical bases.

Uses
In cosmetic and topical medicinal Preparations where good absorption through the skin is desired. A jellied isopropyl myristate was marketed as Estergel (Merck & Co.) .

Uses
isopropyl myristate is an emollient, moisturizer, binder, and skin softener that also assists in product penetration. An ester of myristic acid, it is naturally occurring in coconut oil and nutmeg. Although isopropyl myristate is generally considered comedogenic, some ingredient manufacturers clearly specify non-comedogenicity on their data sheets.

Production Methods
Isopropyl myristate may be prepared either by the esterification of myristic acid with propan-2-ol or by the reaction of myristoyl chloride and propan-2-ol with the aid of a suitable dehydrochlorinating agent. A high-purity material is also commercially available, produced by enzymatic esterification at low temperature.

Preparation
By conventional esterification of isopropanol with myristic acid

USES & APPLICATIONS
Pharmaceuticals: Thickening Agent, Emollient, Moisturizer in Topical Medicinal Preparations
Personal Care & Cosmetics: Emollient, Moisturizer, Thickening Agent in Creams and Lotions
Flavor and Fragrance: Solvent, Binder, Diluent

Isopropyl Myristate: Uses and Characteristics

Isopropyl myristate is notable for promoting the absorption of medicine and other products through the skin. It is commonly found in creams, lotions and topical medicines. It is also used as a thickening agent, emollient and moisturizer, as well as a solvent, binder and diluent in perfumes and food flavorings.

Pharmaceutical Applications
Isopropyl myristate is a nongreasy emollient that is absorbed readily by the skin. It is used as a component of semisolid bases and as a solvent for many substances applied topically. Applications in topical pharmaceutical and cosmetic formulations include bath oils; make-up; hair and nail care products; creams; lotions; lip products; shaving products; skin lubricants; deodorants; otic suspensions; and vaginal creams. For example, isopropyl myristate is a self-emulsifying component of a proposed cold cream formula, which is suitable for use as a vehicle for drugs or dermatological actives; it is also used cosmetically in stable mixtures of water and glycerol.
Isopropyl myristate is used as a penetration enhancer for transdermal formulations, and has been used in conjunction with therapeutic ultrasound and iontophoresis.It has been used in a water-oil gel prolonged-release emulsion and in various microemulsions. Such microemulsions may increase bioavailability in topical and transdermal applications. Isopropyl myristate has also been used in microspheres, and significantly increased the release of drug from etoposide-loaded microspheres.
Isopropyl myristate is used in soft adhesives for pressuresensitive adhesive tapes.

Contact allergens
Despite wide use in cosmetics, perfumes, and topical medicaments, isopropyl myristate is a very weak sen- sitizer and a mild irritant.

Pharmacology
Isopropyl myristate is used in pharmaceutical preparations because it improves solubility and increases absorption through the skin. External uses include a non-irritating iodine preparation for disinfecting the skin (Powers & Rieger, 1963) and aerosol bactericidal preparations for feminine hygiene use without irritation of the skin and mucous membranes (Geistlich, 1970; Watson. 1969). Preparations for internal use include oral steroid formulations (Hirata, 1970) and anaesthetic injection solutions (Davis, Pearce & Connor, 1972).
Veterinary medications containing isopropyl myristate include oral or parenteral compositions for lungworm infections (N. V. Philips' Gloielampenfabrieken, 1964) and a spray formulation for bovine udders to treat mastitis, combat infection and improve the general skin condition (Kraus, 1965). Isopropyl myristate has been found to be an effective repository vehicle for im injection of penicillin in rabbits and for sc administration of oestrogens in ovariectomized rats (Platcow & Voss, 1954).
In assays on human forearms, vasoconstrictor activity of ointment preparations containing 0025% betamethasone 17-benzoate in white soft paraffin was increased by the presence of isopropyl myristate (Pepler, Woodford & Morrison, 1971). Donovan, Ohmart & Stoklosa (1954) noted that the good solvent properties of isopropyl myristate might increase the therapeutic activity of formulations by the apparent alteration in particle size of the active ingredients, so that further evaluation and clinical study would be necessary before its use in extemporaneous compounding could be recommended. Studies in which the antifungal activity of paraben esters solubilized by surfactants was decreased by isopropyl myristate (Matsumoto & Aoki, 1962) indicate that the effectiveness of medicinal substances may be influenced by the presence of surfactants and oily ingredients such as isopropyl myristate.

Safety
Isopropyl myristate is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.
LD50 (mouse, oral): 49.7 g/kg
LD50 (rabbit, skin): 5 g/kg

Metabolism
Higher molecular weight aliphatic esters are thought to be readily hydrolysed to the corresponding alcohols and acids which are then metabolized; isopropyl myristate is undoubtedly hydrolysed to normal metabolic products (Fassett, 1963). When myristic acid (as the ethyl ester) was fed to dogs,

storage
Isopropyl myristate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container in a cool, dry place and protected from light.

Incompatibilities
When isopropyl myristate comes into contact with rubber, there is a drop in viscosity with concomitant swelling and partial dissolution of the rubber; contact with plastics, e.g. nylon and polyethylene, results in swelling. Isopropyl myristate is incompatible with hard paraffin, producing a granular mixture. It is also incompatible with strong oxidizing agents.

Regulatory Status
Included in the FDA Inactive Ingredients Database (otic, topical, transdermal, and vaginal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Isopropyl myristate Preparation Products And Raw materials

Raw materials:
Myristic acid
Coconut oil

Is Isopropyl Myristate Safe?
According to research conducted by the Cosmetic Ingredient Review Expert Panel, it is safe for its indicated use. However, isopropyl myristate can cause some sensitivity issues. In a case study published in the journal, Contact Dermatitis examined the potential for irritation to occur in sensitive skin types using isopropyl myristate products. They were able to identify that there is some sensitivity associated with the ingredient in some people, about 2%.

The other issue with isopropyl myristate is that it is considered to be comedogenic, meaning that it can create blockages of the pores. This can increase the visibility of pores and might contribute to the presence of blemishes. For this reason, it may be best to avoid products with high levels of isopropyl myristate if you have congested skin. There is a broad range of concentrations used in products with a range between 0.001-20%. Higher concentrations tend to be present in products such as foundations and heavy moisturizers; other products tend to utilize lower strength.

Other Uses:
Isopropyl myristate is sometimes used as an artificial flavor in food. It is also used in some head lice treatments as the waxy ingredient coats the lice and prevents them from sourcing water or food.

Other Names:
Isopropyl myristate can also be known as 1-methylethyl ester tetradecanoic acid, tetradecanoic acid, IPM, isopropyl ester myristic acid, isopropyl myristate, isopropyl tetradeconoate, myristic acid, isopropyl ester, 1-methylethyl tetradeconoate, 1-methylethyl ester, and tetradecanoic acid.

ISOPROPYL MYRISTATE
110-27-0
Isopropyl tetradecanoate
Tetradecanoic acid, 1-methylethyl ester
Bisomel
Estergel
Isomyst
Promyr
Deltyl Extra
Kesscomir
Tegester
Wickenol 101
Sinnoester MIP
Crodamol IPM
Plymoutm IPM
Starfol IPM
Unimate IPM
Kessco IPM
Emcol-IM
Stepan D-50
Emerest 2314
1-Methylethyl tetradecanoate
Myristic acid isopropyl ester
JA-FA IPM
Kessco isopropyl myristate
Crodamol I.P.M.
Tetradecanoic acid, isopropyl
Myristic acid, isopropyl ester
Tetradecanoic acid, isopropyl ester
UNII-0RE8K4LNJS
1-Tridecanecarboxylic acid, isopropyl ester
MFCD00008982
Estergel (TN)
NSC 406280
methylethyl tetradecanoate
0RE8K4LNJS
iso-Propyl N-tetradecanoate
Isopropyl tetradecanoic acid
CHEBI:90027
tetradecanoic acid isopropyl ester
Tetradecanoic acid methyethyl ester
NCGC00164071-01
Deltylextra
WE(2:0(1Me)/14:0)
DSSTox_CID_6838
Isopropyl myristate, 96%
Isopropyl myristate, 98%
DSSTox_RID_78224
DSSTox_GSID_26838
propan-2-yl tetradecanoate
Caswell No. 511E
Isopropyl myristate [USAN]
CAS-110-27-0
FEMA No. 3556
HSDB 626
IPM-EX
IPM-R
EINECS 203-751-4
EPA Pesticide Chemical Code 000207
BRN 1781127
Tegosoft M
Isopropyl myristate [USAN:NF]
Liponate IPM
Crodamol 1PM
IPM 100
Lexol IPM
myristic acid isopropyl
PubChem19813
ACMC-1BVUK
Radia 7190
Isopropyl myristate (NF)
EC 203-751-4
SCHEMBL2442
component of Sardo Bath Oil
Myristic acid-isopropyl ester
Isopropyl myristate, >=98%
CHEMBL207602
IPM 90
DTXSID0026838
WLN: 13VOY1&1
FEMA 3556
ZINC8214588
Isopropyl myristate, >=90% (GC)
Tox21_112080
Tox21_202065
Tox21_303171
ANW-16142
LMFA07010677
NSC406280
s2428
AKOS015902296
Myristic acid, isopropyl ester (8CI)
Tox21_112080_1
DB13966
NSC-406280
component of Sardo Bath Oil (Salt/Mix)
NCGC00164071-02
NCGC00164071-03
NCGC00256937-01
NCGC00259614-01
R524
SC-19093
DB-040910
FT-0629053
M0481
D02296
Q416222
SR-01000944751
Isopropyl myristate, Vetec(TM) reagent grade, 98%
Q-201418
SR-01000944751-1
TERT-BUTYL[(1R)-1-CYANO-2-PHENYLETHYL]CARBAMATE
UNII-137MVX8C09 component AXISYYRBXTVTFY-UHFFFAOYSA-N
Isopropyl myristate, United States Pharmacopeia (USP) Reference Standard
TETRADECANOIC ACID,ISOPROPYL ESTER (MYRISTATE,ISOPROPYL ESTER)
Isopropyl myristate, Pharmaceutical Secondary Standard; Certified Reference Material

Pharmacodynamics
Isopropyl myristate is an emollient vehicle that is effective at enhancing the penetration of other medical agents that may be incorporated into the vehicle as active agents 7. In one study, a 50:50 isopropanol-isopropyl myristate binary enhancer synergistically increased the transport of estradiol across a two-layer human epidermis in vitro 2.

Mechanism of action
As a pediculicide, isopropyl myristate is capable of physically coating the exoskeleton bodies of lice
This physical coating subsequently immobilizes the lice and works to dissolve the wax covering on the insect exoskeleton and blocks the insects' airways, leading to death by dehydration 8,9,3,4. Although this physical action of isopropyl myristate results in little lice resistance (given the lack of immunologic or chemical activity in this mechanism of action), the substance is also not ovicidal, which means any eggs that may have been laid by lice would not be affected 8,9,3,4. Moreover, isopropyl myristate is capable of eliciting its pediculicide action in a contact time of only 10 minutes per each necessary administration 8,9,3,4.

Absorption
Dermal absorption of isopropyl myristate is predicated to be 0.00020 mg/cm2/event, which is considered a very low absorption rate.
In a study, topically applied isopropyl myristate was largely retained in the stratum corneum. It was not detected in the receptor fluid of flow-through diffusion cells in in-vitro skin permeation experiments using human epidermis (stratum corneum and viable epidermis) and dermis of varying thickness 2.

Volume of distribution
Readily available information regarding the pharmacokinetics of isopropyl myristate is not available.

Protein binding
Readily available information regarding the pharmacokinetics of isopropyl myristate is not available.

Metabolism
Any isopropyl myristate that is absorbed is likely to be hydrolyzed to its component compounds of isopropylalcohol and myristic acid.

Hover over products below to view reaction partners

Isopropyl myristate
Isopropyl alcohol + Myristic acid

Isopropyl myristate
isopropyl myristate

CAS names: Tetradecanoic acid, 1-methylethyl ester

IUPAC names
IPM
ISOPROPYL MYRISTATE
Isopropyl Myristate
Isopropyl myristate
isopropyl myristate
Isopropyl myristate
isopropyl myristate
Isopropyl Myristate (Tetradecanoic acid, 1-methylethyl ester) CAS 110-27-0
Isopropylmyristate
propan-2-yl tetradecanoate
Tetradecanoic acid, 1-methylethyl ester

Trade names
CHINT: FCE (i-Propyl)E C14
Crodamol IPM
DUB IPM
IPM-S
Isopropyl Palmitate
MMEster E1140
PALMESTER
Palmsurf IPM
Phase I REACH Kandidat
RADIA 7191
RADIA 7727
RADIA 7730
RADIA 7730K
RADIA 7730Q
WAGLINOL 6014
WAGLINOL 6014/95
WAGLINOL 6014/98
WAGLINOL 6014/N

Isopropyl myristate, also commonly known as IPM is a clear, light yellow liquid which is oily in appearance and virtually odourless. It is soluble in most solvents but considered insoluble in water. IPM is manufactured by the esterification of isopropyl alcohol with myristic acid, and increases the absorption of perfumes on the skin. Uses include: reed diffusers, creams, lotions, bath oils, lip balms, and perfumes. IPM is oil soluble and may make surfaces slippery.

APPLICATIONS:
An emollient in skin care cosmetics, preparations where good absorption is desired.
Isopropyl myristate is commonly used as a diluent in room diffusers and oil burners.
Blend with your chosen concentrated fragrance or essential oil (Typically between 10-30% depending on desired strength) to create your own room diffuser and oil burner
Diluent for essential oils, fragrance oil or perfumes

TOXICITY PROFILE FOR ISOPROPYL MYRISTATE (2005)
Isopropyl myristate (IPM) has produced slight irritation of human skin, mild irritation of the rabbit eye and moderate irritation of rabbit skin. Other local effects have included nasal and lung irritation during inhalation of aerosols in monkeys and rats, acne development after application to rabbit skin, and increased permeability of human skin to certain other substances. Skin sensitization reactions have only rarely been reported, and no sensitizing potential has been detected in studies involving a large number of volunteers with normal skin. IPM was of low acute toxicity to laboratory animals by the oral and dermal routes. Repeated administration produced slight effects on the liver and blood in rats treated orally and in rabbits given skin applications

Other names: Tetradecanoic acid, 1-methylethyl ester; Myristic acid, isopropyl ester; Bisomel; Crodamol I.P.M.; Crodamol IPM; Deltyl Extra; Emcol-IM; Isomyst; Isopropyl tetradecanoate; Kessco IPM; Kesscomir; Promyr; Sinnoester MIP; Stepan D-50; Wickenol 101; Emerest 2314; Estergel; Ja-fa IPM; Kessco isopropyl myristate; Plymoutm IPM; Starfol IPM; Tegester; Tetradecanoic acid, isopropyl; Tetradecanoic acid, isopropyl ester; Unimate IPM; 1-Tridecanecarboxylic acid, isopropyl ester; D 50; 1-Methylethyl tetradecanoate; IPM; Lexol IPM; Liponate IPM; Radia 7190; Tegosoft M; iso-Propyl N-tetradecanoate; Methylethyl tetradecanoate; Tetradecanoic acid methyethyl ester; NSC 406280; component of Sardo Bath Oil; 1405-98-7

Isopropyl Myristate is a synthetic oil used as an emollient, thickening agent, or lubricant in beauty products.
Composed of of Isopropyl Alcohol (a propane derivative) and Myristic Acid (a naturally-occurring fatty acid), Isopropyl Myristate is a popular cosmetic and pharmaceutical ingredient.
Isopropyl Myristate is most often used an an additive in aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.

Isopropyl myristate (IPM) is the ester of isopropyl alcohol and myristic acid. Isopropyl myristate (IPM) is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired

Final Report on the Safety Assessment of Myristyl Myristate and Isopropyl Myristate
First Published July 1, 1982 Research Article
https://doi.org/10.3109/10915818209021261
Article information
Free Access
Abstract
Acute oral and dermal toxicity tests indicated that Myristyl Myristate is nontoxic to rats. This cosmetic ingredient produced minimal to mild skin irritation, minimal eye irritation in rabbits, and no sensitization in guinea pigs. Studies with rabbits indicated that undiluted Isopropyl Myristate was a mild irritant after 24 h and moderate to severe when applied for three consecutive days. Isopropyl Myristate was minimally irritating to the rabbits' eye, and was not a skin sensitizer in studies with guinea pigs. In limited studies, Isopropyl Myristate was not carcinogenic on the skin of mice, but a mixture of Isopropyl Myristate and isopropyl alcohol significantly accelerated the carcinogenic activity of benzo(a)pyrene on the skin.

Human studies with Isopropyl Myristate indicated that it was not a human skin irritant or sensitizer when applied in a product formulation containing 15-58% of the ingredient. A product containing 43% Isopropyl Myristate produced no phototoxicity and no photo-contact allergenicity in human studies.

From the available information, it is concluded that Myristyl Myristate and Isopropyl Myristate are safe as cosmetic ingredients in the present practices of use.

Isopropyl Myristate, 96% 25GR
IPM 100
IPM-EX
IPM-R
Radia 7730 (IPM)
Isopropyl myristate Vetec(TM) reagent grade, 98%
MYRISTIC ACID ISOPROPYL ESTER MINIMU
ISO-PROPYL N-TETRADECANOATE
ISOPROPYL TETRADECANOATE
BISOMEL
ISOPROPYL MYRISTATE
ESTERGEL
FEMA 3556
MYRISTIC ACID ISOPROPYL ESTER
TETRADECANOIC ACID 1-METHYLETHYL ESTER
TETRADECANOIC ACID ISOPROPYL ESTER
kesscoipm
kesscoisopropylmyristate
Kesscomir
Lexol IPM-NF
Liponate IPM
Plymoutm IPM
plymoutmipm
Promyr
Propyl myristate
Radia 7190
Revenge
Sinnoester MIP
sinnoestermip
Starfol IPM
starfolipm
Stepan D-50
1-Methylethyl tetradecanoate
1-Methylethyltetradecanoate
1-Tridecanecarboxylic acid, isopropyl ester
ISOPROPYLMYRISTATE,NF
Isopropylmyristat
Myristic acid, isopropyl ester: (Tetradecanoic acid, isopropyl: Isopropyl myristate),
ISOPROPYL MYRISTATE pure
tetraclecyl isopropyl ester
Isoprooyl myristate
Isopropyl tetradecanoate, Myristic acid isopropyl ester
Propan-2-yl tetradecanoat
Isopropyl myristate,96%
Isopropyl Myristate (500 mg)
Isopropy1 myristate
Isopropyl Myristate 98% (IPM)
1-tridecanecarboxylicacid,isopropylester
component of Sardo Bath Oil
crodacolipm
Crodamol 1PM
Crodamol I.P.M.
Crodamol IPM
crodamolipm
D 50
Deltyl Extra
deltylextra
Emcol-IM

Isopropyl myristate (IPM) is used as a substitute for natural oils in cosmetics and a co-solvent with skin penetration enhancement properties of active ingredients in many topical and transdermal preparations. Isopropyl myristate is a novel pediculicide rinse (50%) and a safe and effective therapy for the treatment of head lice in children and adults.

Isopropyl myristate (Resultz) is available in Canada and Europe and received FDA approval for treatment of head lice in 2017, although it is not yet marketed in the United States. It is a non-insecticide–based drug that contains isopropyl myristate, an ingredient commonly used in cosmetics. Its mode of action is a mechanical process that weakens the waxy shell of lice, resulting in internal fluid loss and dehydration. [38] It requires only a 5-minute application time.

Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired.
Isopropyl myristate is being studied as a skin enhancer.
Isopropyl myristate is also used as a solvent in perfume materials.

0RE8K4LNJS
110-27-0 [RN]
13VOY1&1 [WLN]
1-Methylethyl tetradecanoate
203-751-4 [EINECS]
3556
IPM
IPM 100
IPM-EX
IPM-R
Isopropyl myristate [ACD/IUPAC Name] [USAN]
isopropyl tetradecanoate
Isopropylmyristat [German] [ACD/IUPAC Name]
MFCD00008982 [MDL number]
Myristate d'isopropyle [French] [ACD/IUPAC Name]
myristic acid isopropyl ester
Myristic acid, isopropyl ester
Propan-2-yl tetradecanoate
Tetradecanoic acid 1-methylethyl ester
Tetradecanoic acid isopropyl ester
Tetradecanoic acid, 1-methylethyl ester [ACD/Index Name]
Tetradecanoic acid, isopropyl ester
XB8600000
1-Tridecanecarboxylic acid, isopropyl ester
4-02-00-01132 (Beilstein Handbook Reference) [Beilstein]
Bisomel
Crodamol 1PM
Crodamol IPM
DELTYL EXTRA
Deltylextra
EINECS 203-751-4
Emcol-IM
Emerest 2314
Estergel [Trade name]
Estergel (TN)
FEMA 3556
IPM 90
Isomyst
Isopropyl myristate (NF)
isopropyl myristate 96%
isopropyl myristate 98%
isopropyl myristate, ??? 95.0%
isopropyl myristate, 96%
iso-Propyl N-tetradecanoate
isopropyl tetradecanoate, 98%
isopropyl tetradecanoate,98%
Isopropyl tetradecanoic acid
Isopropylmyristate
Isopropylmyristate, Tetradecanoic acid isopropyl ester, Myristic acid isopropyl ester, Sterile IPM
Ja-fa IPM
Jsp000796
Kessco IPM
Kessco isopropyl myristate
Kesscomir
Lexol IPM
Liponate IPM
Methylethyl tetradecanoate
Myristic acid-isopropyl ester
NCGC00164071-01
Promyr
Radia 7190
Sinnoester MIP
Starfol IPM
Stepan D-50
Sterile Isopropyl Myristate (IPM)
Tegester
Tegosoft M
Tetradecanoic acid isopropyl ester, Myristic acid isopropyl ester
Tetradecanoic acid methyethyl ester
Tetradecanoic acid, isopropyl
UNII:0RE8K4LNJS
UNII-0RE8K4LNJS
Unimate IPM
Wickenol 101
WLN: 13VOY1&1

Isopropyl myristate is among the commonly used fatty acid ester and is isopropyl ester of tetradecanoic acid.
Isopropyl myristate is categorized mainly employed as synthetic oil and is produced by reaction of isopropyl alcohol and myristic acid.
Isopropyl myristate is among the foremost available substitutes for natural oil in the cosmetics industry. Isopropyl myristate is also used as solvent in several trans-dermal pharmaceutical products and pharmaceuticals creams.

Major end user industries for isopropyl myristate include personal care, pharmaceuticals, food and lubricants among several others.
Personal care is the largest application segment for isopropyl myristate and the trend is anticipated to continue for a foreseeable future.
Isopropyl myristate is also used as a pesticide free product for killing lice. Isopropyl myristate helps in enhancing skin penetration properties of products owing to which, pharmaceutical is anticipated to be the fastest growing application segment for isopropyl myristate. Other applications of isopropyl myristate include solvents, plasticizer and bio diesel among others.

Low production cost as compared to other available substitute is among the foremost driver for demand of isopropyl myristate.
Moreover the apparatus employed in the production of isopropyl myristate can be used for production of several other products.
Therefore low capital investment is among the major growth drivers for isopropyl myristate market. Isopropyl myristate is employed in several pharmaceutical products primarily creams.
Therefore, high growth in pharmaceutical industry across the globe is a major factor fuelling demand for isopropyl myristate.
Increasing disposable income leading to surge in demand for personal care products including oil and other skin products is anticipated to drive isopropyl myristate market growth during the forecast period.

Isopropyl myristate is used in combination with several other products including petroleum products.
Isopropyl myristate is easily penetrated into the skin whereas the petrochemicals get clogged in pores leading to a decline in supply of oxygen to the skin resulting in several skin related issues. Isopropyl myristate when in contact with diethanolamine leads to production of carcinogenic compounds.
Therefore intensive care has to be taken while using isopropyl myristate based products which has been a major restraint for isopropyl myristate market growth.
Increasing research and development for increasing the application scope of isopropyl myristate is expected to offer huge growth opportunity in the market.

Specs of IPM for Guidance ONLY:

Acid Value, mgKOH/g: 1.0 max   ASTM D 1980-87
Saponification Value, mgKOH/g: 202 – 212   ASTM D 5558-95
Iodine Value, g/100g: 1.0 max   ASTM D 5554-95
Color APHA (Hazen): 30 max   ASTM D 1209-84
Dyn. Viscosity @ 20°C, mPas: 5 – 6   ASTM D 445-88
Moisture (m/m), %   : 0.1 max   ASTM D 1744-92
Specific Gravity @ 25°C: 0.846 – 0.854   ASTM D 1298-85
Residue on Ignition (m/m), %:    0.1 max
Refractive Index @ 25°C: 1.432 – 1.436   ASTM D 1747-99
Residual Solvents: Passes Test   In-USP/NF Method
C14 Ester (m/m), %: 98.0 min

Isopropyl Myristate is a highly refined and distilled ester obtained by the esterification of isopropyl alcohol with myristic acid. It is a waterclear, low viscous oily liquid with a very good spreading capacity on the skin. Isopropyl Myristate is mainly used in cosmetics as an oil
component for emulsions, bath oils and as a solvent for active substances.

Low production cost as compared to other available substitute is among the foremost driver for demand of isopropyl myristate. Moreover the apparatus employed in the production of isopropyl myristate can be used for production of several other products. Therefore low capital investment is among the major growth drivers for isopropyl myristate market. Isopropyl myristate is employed in several pharmaceutical products primarily creams. Therefore, high growth in pharmaceutical industry across the globe is a major factor fuelling demand for isopropyl myristate. Increasing disposable income leading to surge in demand for personal care products including oil and other skin products is anticipated to drive isopropyl myristate market growth during the forecast period.

Isopropyl myristate is used in combination with several other products including petroleum products. Isopropyl myristate is easily penetrated into the skin whereas the petrochemicals get clogged in pores leading to a decline in supply of oxygen to the skin resulting in several skin related issues. Isopropyl myristate when in contact with diethanolamine leads to production of carcinogenic compounds. Therefore intensive care has to be taken while using isopropyl myristate based products which has been a major restraint for isopropyl myristate market growth. Increasing research and development for increasing the application scope of isopropyl myristate is expected to offer huge growth opportunity in the market.

Isopropyl Myristate (IPM) is a synthetic oil used as an emollient, thickening agent, or lubricant in beauty products such as aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.

A unique characteristic of Isopropyl Myristate is its ability to reduce the greasy feel caused by the high oil content of other ingredients in a product. This synthetic oil is often added to beauty products to give them a slicker, sheer feel rather than an oily one.

Isopropyl Myristate is easily absorbed by the skin, ensuring quick penetration of a formula's ingredients. We use 2% in all of our lotions and creams which leaves us with a less greasy product but still slick enough to feel like a lotion.

Usage rates: 2-5% in lotions and creams
30-40% in bath oils

INCI: Isopropyl myristateIsopropyl Myristate (IPM) is a synthetic oil used as an emollient, thickening agent, or lubricant in beauty products such as aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.

Isopropyl Myristate is easily absorbed by the skin, ensuring quick penetration of a formula's ingredients.
Some of our customers prefer to us 2% in all of their lotion and cream formulations which leaves us with a less greasy product but still slick enough to feel like a lotion.

Usage rates:
2-5% in lotions and creams
30-40% in bath oils

INCI: Isopropyl myristate

1. Isopropyl Tetradecanoate
2. 110-27-0
3. Tetradecanoic Acid, 1-methylethyl Ester
4. Estergel
5. Promyr
6. Bisomel
7. Isomyst
8. Kesscomir
9. Tegester
10. Deltyl Extra
11. Sinnoester Mip
12. Crodamol Ipm
13. Plymoutm Ipm
14. Starfol Ipm
15. Unimate Ipm
16. Kessco Ipm
17. Emcol-im
18. Wickenol 101
19. Myristic Acid Isopropyl Ester
20. Stepan D-50
21. Emerest 2314
22. Deltylextra
23. Ja-fa Ipm
24. Kessco Isopropyl Myristate
25. Tetradecanoic Acid, Isopropyl
26. Crodamol I.p.m.
27. Myristic Acid, Isopropyl Ester
28. Caswell No. 511e
29. Tetradecanoic Acid, Isopropyl Ester
30. Unii-0re8k4lnjs
31. Propan-2-yl Tetradecanoate
32. 1-methylethyl Tetradecanoate
33. 1-tridecanecarboxylic Acid, Isopropyl Ester
34. Fema No. 3556
35. Hsdb 626
36. Einecs 203-751-4
37. Epa Pesticide Chemical Code 000207
38. Nsc 406280
39. Brn 1781127
40. Ncgc00164071-01
41. Dsstox_cid_6838
42. Isopropyl Tetradecanoic Acid
43. Dsstox_rid_78224
44. Dsstox_gsid_26838
45. Isopropylmyristate
46. Cas-110-27-0
47. Crodamol I.p.m
48. Estergel (tn)
49. Pubchem19813
50. Ipm-ex
51. Acmc-1bvuk
52. Ipm-r
53. E(r)eaeaoi+/-uo Yen
54. Isopropyl Myristate (nf)
55. 0re8k4lnjs
56. Agn-pc-0jk8cm
57. Ac1l1q4r
58. Isopropyl Myristate [usan]
59. Component Of Sardo Bath Oil
60. Ksc174s6r
61. M0757_sigma
62. W355690_aldrich
63. 172472_aldrich
64. Chembl207602
65. M0757_sial
66. Isopropyl Myristate [usan:nf]
67. Jsp000796
68. Wln: 13voy1&1
69. Ctk0h4968
70. Ipm 100
71. Molport-003-927-101
72. E(r)eai(1/4)eaoi+/-uo Yen
73. Tox21_112080
74. Tox21_202065
75. Tox21_303171
76. Anw-16142
77. Lmfa07010677
78. Nsc406280
79. Akos015902296
80. Myristic Acid, Isopropyl Ester (8ci)
81. Tox21_112080_1
82. Ag-c-86237
83. Ag-d-27612
84. Ls-2869
85. Nsc-406280
86. Rl00430
87. Rtr-002139
88. Ncgc00164071-02
89. Ncgc00164071-03
90. Ncgc00256937-01
91. Ncgc00259614-01
92. Kb-77952
93. R524
94. We(2:0(1me)/14:0)
95. Db-040910
96. Tr-002139
97. Ft-0629053
98. M0481
99. D02296
100. I14-13725
101. 3b3-027120
102. Tetradecanoic Acid,isopropyl Ester (myristate,isopropyl Ester)
103. 1405-98-7
104. 852553-53-8

Isopropyl myristate is a flexible ingredient that can be used in creams, lip balms, perfumes