PRODUCTS

ISOPROPYL MYRISTATE

CAS NO:110-27-0
EC NO:203-751-4

SYNONYMS:
ISOPROPYL MYRISTATE; 110-27-0; Isopropyl tetradecanoate; Tetradecanoic acid, 1-methylethyl ester; Bisomel; Estergel; Isomyst; Promyr; Deltyl Extra; Kesscomir; Tegester; Wickenol 101; Sinnoester MIP; Crodamol IPM; Plymoutm IPM; Starfol IPM; Unimate IPM; Kessco IPM; Emcol-IM; Stepan D-50; Emerest 2314; 1-Methylethyl tetradecanoate; Myristic acid isopropyl ester; JA-FA IPM; Kessco isopropyl myristate; Crodamol I.P.M.; Tetradecanoic acid, isopropyl; Myristic acid, isopropyl ester; Tetradecanoic acid, isopropyl ester; UNII-0RE8K4LNJS; 1-Tridecanecarboxylic acid, isopropyl ester; MFCD00008982; Estergel (TN); NSC 406280; methylethyl tetradecanoate; 0RE8K4LNJS; iso-Propyl N-tetradecanoate; Isopropyl tetradecanoic acid; CHEBI:90027; tetradecanoic acid isopropyl ester; Tetradecanoic acid methyethyl ester; NCGC00164071-01; Deltylextra; WE(2:0(1Me)/14:0); DSSTox_CID_6838; Isopropyl myristate, 96%; Isopropyl myristate, 98%; DSSTox_RID_78224; DSSTox_GSID_26838; propan-2-yl tetradecanoate; Caswell No. 511E; Isopropyl myristate [USAN]; CAS-110-27-0; FEMA No. 3556; HSDB 626; IPM-EX; IPM-R; EINECS 203-751-4; EPA Pesticide Chemical Code 000207; BRN 1781127; Tegosoft M; Isopropyl myristate [USAN:NF]; Liponate IPM; Crodamol 1PM; IPM 100; Lexol IPM; myristic acid isopropyl; PubChem19813; ACMC-1BVUK; Radia 7190; Isopropyl myristate (NF); EC 203-751-4

Isopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption. Isopropyl myristate has been largely studied and impulsed as a skin penetration enhancer. At the moment the primary usage for which isopropyl myristate is formally indicated is as the active ingredient in a non-prescription pediculicide rinse.Soluble in castor oil, cottonseed oil, acetone, chloroform, ethyl acetate, ethanol, toluene, and mineral oil; practically insoluble in glycerol, propylene glycol.Soluble in ether, very soluble in acetone, benzene; insoluble in water.Withstands oxidn & does not readily become rancid.When heated to decomposition it emits toxic smoke and fumes.Dissolves many waxes, cholesterol, lanolin; decomposes at 208 °C; boiling point: 192.6 °C at 20 mm Hg, 140.2 °C at 2 mm Hg; density: 0.7942 g/cu cm at 99 °C.The primary medical indication for which isopropyl myristate is formally used as an active ingredient in a patient care product is as a non-prescription pediculicide rinse.A pediculicide rinse, 50% isopropyl myristate (IPM), was assessed in two phase 2 trials conducted in North America. The first trial was a nonrandomized (proof of concept) trial without a comparator conducted in Winnipeg, Canada. The second trial, conducted in the United States, was an evaluator-blinded, randomized superiority trial comparing 50% IPM rinse with a positive control (RID; pyrethrin 0.33%, piperonyl butoxide 4%). The primary end points were to determine the safety and efficacy of 50% IPM as a pediculicide rinse. METHODS: Subjects meeting inclusion criteria were enrolled in the above-mentioned trials with efficacy end points 7 and 14 days post-treatment. Subjects were also evaluated on days 0, 7, 14, and 21 for the presence of erythema and edema using the Modified Draize Scale. Other comments associated with the safety evaluation (ie, pruritus) were collected. RESULTS: IPM was found to be effective in the proof of concept study and comparator trial using a positive control. IPM was also well tolerated, with minimal adverse events. All adverse events were mild, resolving by completion of the study. CONCLUSION: Data suggest that IPM is a safe and effective therapy for the treatment of head lice in children and adults. IPM's mechanical mechanism of action makes development of lice resistance unlikely.Due to their distinct advantages such as enhanced drug solubility, thermodynamic stability, facile preparation, and low cost, uses and applications of microemulsions have been numerous. Recently, there is a surge in the exploration of microemulsion for transdermal drug delivery for their ability to incorporate both hydrophilic (5-fluorouracil, apomorphine hydrochloride, diphenhydramine hydrochloride, tetracaine hydrochloride, and methotrexate) and lipophilic drugs (estradiol, finasteride, ketoprofen, meloxicam, felodipine, and triptolide) and enhance their permeation.... Besides surfactants, oils can also act as penetration enhancers (oleic acid, linoleic acid, isopropyl myristate, isopropyl palmitate, etc.).Alpha-tocopherol (AT) is the vitamin E homologue with the highest in vivo biological activity. AT protects against the carcinogenic and mutagenic activity of ionizing radiation and chemical agents, and possibly against UV-induced cutaneous damage. For stability consideration, alpha-tocopherol is usually used as its prodrug ester, alpha-tocopherol acetate (ATA), which once absorbed into the skin is hydrolyzed to alpha-tocopherol, the active form. ... Permeation studies were conducted using modified Franz diffusion cells and human cadaver skin as the membrane. Specifically, 5% (w/w) alpha-tocopherol acetate was formulated in the following vehicles: ethanol, isopropyl myristate, light mineral oil, 1% Klucel gel in ethanol, and 3% Klucel gel in ethanol (w/w). ... The permeabilities of ATA through human cadaver skin were 1.0x10-4, 1.1x10-2, 1.4x10-4, 2.1x10-4, and 4.7x10-4 cm/hr for the ethanol solution, isopropyl myristate solution, light mineral oil solution, 1% Klucel gel, and 3% Klucel gel, respectively. The results show that the formulation had relatively minor effects on the permeability coefficients of ATA through cadaver skin in all cases except for the isopropyl myristate solution.The purpose of this research was to prepare a pseudolatex transdermal delivery system for terbutaline sulfate and to evaluate the effect of pH and organic ester penetration enhancers on permeation kinetics of terbutaline sulfate through mice abdominal skin and human cadaver skin. ... The permeation profile and related kinetic parameters of terbutaline sulfate was determined in presence of 3 ester-type permeation enhancers incorporated in the films, viz methyl laureate, isopropyl lanolate, and isopropyl myristate. Among the 3, the more pronounced enhancing effect was obtained with isopropyl myristate, regarding the permeation flux, permeability coefficient, and diffusion coefficient. This was attributed to solubility parameter of isopropyl myristate being closer to the solubility parameter of human skin, and such a pronounced enhancing effect was probably caused by its passage across the skin barrier through the lipid pathway.A transdermal dosage form of trazodone hydrochloride (TZN) may be useful in the treatment of moderate to severe depression in schizophrenic patients by providing prolonged duration of action. ... The aim of /this/ investigation was to evaluate its flux and the effects of various penetration enhancers, viz., isopropyl myristate (IPM), isopropyl palmitate (IPP), butanol and octanol on transdermal permeation from matrix-based formulations through the skin. The enhancing effect on the permeation of TZN was determined using the mouse and human cadaver epidermis. ... The highest enhancing effect was obtained with IPM followed by butanol, octanol and IPP. In general, higher fluxes were observed through mouse epidermis as compared with the human cadaver epidermis...The purpose of this study was to mechanistically investigate effects of isopropanol (IPA)-isopropyl myristate (IPM) binary enhancers on transport of a model drug, estradiol (E2) in human epidermis (stratum corneum + viable epidermis) in vitro. The study was focused on use of the same IPA-IPM compositions on both sides of the skin ("symmetric" configuration) with saturated E2 (maximum thermodynamic activity). For E2 transport in all IPA-IPM compositions tested, stratum corneum still was the rate-limiting layer of human epidermis. The relative contributions to E2 flux enhancement were separated into the changes in solubility and diffusivity of E2 in stratum corneum. As a major factor, E2 solubility in stratum corneum was enhanced by 35 times with increasing IPA from neat IPM to neat IPA. E2 diffusivity in stratum corneum also played a significant role, which increased by 8 times from neat IPM to 50% IPA. Stratum corneum swelled more in IPM-rich region, decreased with increasing IPA, and even deswelled in neat IPA. IPA uptake correlated well to E2 solubility in stratum corneum; both linearly increased with increasing IPA. IPM uptake appeared to correlate to E2 diffusivity in stratum corneum; both maximized around 50% IPA.One must, however, look carefully for an intensification of possible risks related to the method of application, the condition of the skin, the site of application, supporting therapeutic measures or changes in the composition of the vehicle. Lanolin, cetyl alcohol and myristyl alcohol, sorbitol, isopropyl-myristate as well as polyethylene glycols (PEG) penetrate the skin like active substances.Many enhancers are concentration-dependent; therefore, optimal concentration for effective promotion should be determined. The delivery rate is dependent on the type of the drug, the structure and ingredients of the carrier, and on the character of the membrane in use. Each formulation should be examined very carefully, because every membrane alters the mechanism of penetration and can turn an enhancer to a retarder.Cosmetics continue to be used by acne-prone individuals. ... The data presented were gleaned from the rabbit ear assay, which is not an ideal animal model but is the best we have. If an ingredient is negative in the rabbit ear assay, we feel it is safe on the acne-prone skin. A strong, positive ingredient or cosmetic should be avoided. Ingredient offenders include isopropyl myristate and its analogs, such as isopropyl palmitate, isopropyl isostearate, butyl stearate, isostearyl neopentanoate, myristyl myristate, decyl oleate, octyl stearate, octyl palmitate or isocetyl stearate, and new introductions by the cosmetic industry, such as propylene glycol-2 (PPG-2) myristyl propionate.How the alternative use of three lipophilic excipients ... , differing in their polarity indexes (medium chain triglycerides (MG), decyl oleate (DO), and isopropyl myristate (IPM), respectively), affects the colloidal structure of the alkylpolyglucoside-based vehicles and in vitro permeation profiles of two model drugs: diclofenac sodium (DC) and caffeine (CF), both sparingly soluble in water /were investigated/ . ... Varying of lipophilic excipient influenced noteworthy variations in the colloidal structure demonstrated as different rheological profiles accompanied to the certain degree by different water distribution modes, but notably provoked by drug nature (an amphiphilic electrolyte drug vs. nonelectrolyte). In vitro permeation data obtained using ASC membranes in an infinite dose-type of experiment stressed the importance of the vehicle/solute interactions in case of small variation in formulation composition, asserting the drug properties in the first hours of permeation and rheological profile of the vehicles in the later phase of experiment as decisive factors.Isopropyl myristate is an emollient vehicle that is effective at enhancing the penetration of other medical agents that may be incorporated into the vehicle as active agents [L1963]. In one study, a 50:50 isopropanol-isopropyl myristate binary enhancer synergistically increased the transport of estradiol across a two-layer human epidermis in vitro.Any isopropyl myristate that is absorbed is likely to be hydrolyzed to its component compounds of isopropylalcohol and myristic acid.The myristates can be expected to undergo chemical or enzymatic hydrolysis to myristic acid and the corresponding alcohol.Like other high molecular weight aliphatic esters, the myristates are readily hydrolyzed to the corresponding alcohols and acids which are then further metabolized.As a pediculicide, isopropyl myristate is capable of physically coating the exoskeleton bodies of lice [L1964, L1966, A32333, A32335]. This physical coating subsequently immobilizes the lice and works to dissolve the wax covering on the insect exoskeleton and blocks the insects' airways, leading to death by dehydration [L1964, L1966, A32333, A32335]. Although this physical action of isopropyl myristate results in little lice resistance (given the lack of immunologic or chemical activity in this mechanism of action), the substance is also not ovicidal, which means any eggs that may have been laid by lice would not be affected [L1964, L1966, A32333, A32335]. Moreover, isopropyl myristate is capable of eliciting its pediculicide action in a contact time of only 10 minutes per each necessary administration [L1964, L1966, A32333, A32335].Isopropyl myristate is an effective agent for solubilizing lanolin; mixtures of up to about 50% lanolin in isopropyl myristate remain stable, free-flowing liquid at room temperature. Therefore, isopropyl myristate is used as a solubilizing, spreading, and penetrating agent in anhydrous skin lubricating lotions with high lanolin content. Isopropyl myristate leaves the skin soft and smooth without an oily surface film. It is used in bath oils, perfumes, creams lotions, lipsticks, hair preparations, shaving lotions, aerosol toiletries, and pharmaceutical ointments.In cosmetic and topical medicinal preparations.EMOLLIENT & EMULSIFIER IN COSMETIC OILS, CREAMS & LOTIONS, MAKEUP, LIPSTICK, SKIN LUBRICANTS, DEODORANTS, SUN SCREENS, HAIR PREPARATIONS, NAIL LACQUER REMOVER; PARENTERAL SOLVENT IN MEDICINE; REAGENT IN MEDICAL TEST FOR STERILITY.Isopropyl myristate is commercially produced by distillation, which is preceded by the esterification of myristic acid and isopropanol, alkali refined to neutralize the catalyst, and the product is then distilled to obtain isopropyl myristate.By reacting myristoyl chloride with 2-propanol with the aid of a suitable dehydrochlorinating agent.Esterification of isopropyl alcohol with myristic acid.The commercial product may contain small amounts of esters of palmitic and other saturated fatty acids.Myristic acid and other free fatty acids are present at a maximum concentration of 1.0%, and unsponifiable material is present at a maximum concentration of 0.2%. There are no known dilutents, solvents, or adhesives present.Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention.Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation.Isopropyl myristate's production and use in cosmetics and topical medicinal preparations may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 9.35X10-5 mm Hg at 25 °C indicates isopropyl myristate will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase isopropyl myristate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 20 hours. Particulate-phase isopropyl myristate will be removed from the atmosphere by wet or dry deposition. Isopropyl myristate does not contain chromophores that absorb at wavelengths >290 nm, and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, isopropyl myristate is expected to be immobile based upon an estimated Koc of 1.2X10+4. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 2.34X10-2 atm-cu m/mole. However, adsorption to soil is expected to attenuate volatilization. If released into water, isopropyl myristate is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Isopropyl myristate, present at 100 mg/L, reached 94% of its chemical oxygen demand in 28 days using a municipal waste water inoculum in the closed bottle test, suggesting that biodegradation may be an important environmental fate process. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 4.9 hours and 6.5 days, respectively. However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. An estimated BCF of 2800 suggests the potential for bioconcentration in aquatic organisms is very high, provided the compound is not metabolized by the organism. An estimated base-catalyzed second-order hydrolysis rate constant of 2.14X10-2 L/mole-sec corresponds to half-lives of 10 years and 1 year at pH values of 7 and 8, respectively. Occupational exposure to isopropyl myristate may occur through dermal contact with this compound at workplaces where isopropyl myristate is produced or used. Use data indicate that the general population may be exposed to isopropyl myristate via dermal contact due to its use in cosmetics and topical medicinal preparations.The Henry's Law constant for isopropyl myristate is estimated as 2.34X10-2 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that isopropyl myristate is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 4.9 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 6.5 days(SRC). Isopropyl myristate's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The volatilization half-life from a model pond is about 99 days when adsorption is considered(3). Isopropyl myristate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 9.35X10-5 mm Hg(4).Isopropyl alcohol is well-suited for rinsing contaminated acetone as well as removing particles from surfaces. Therefore, this solvent is often used in the second substrate cleaning step after acetone. Additionally, isopropyl alcohol is used as additive for anisotropic Si-etching.Isopropyl myristate (IPM) is the ester of isopropyl alcohol and myristic acid.Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. Isopropyl myristate is being studied as a skin enhancer. It is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.It is used in the same way in flea and tick killing products for pets.It is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product "Dentyl pH".Isopropyl myristate is also used as a solvent in perfume materials, and in the removal process of prosthetic make-up.Hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol. The acid could be responsible for decreasing of the pH value of formulations.Isopropyl myristate is an ingredient that you may have unknowingly used many times before. Isopropyl myristate is a synthetic oil made from two components. The first component is isopropyl alcohol, the antimicrobial agent used in some hand sanitizers, baby wipes, and antiseptic formulations. The second component is myristic acid, which is a naturally occurring fatty acid often found in coconut oil, nutmeg, and animal fats such as butter—the two elements when they are combined form an exceptional emollient.Emollients are thick, slightly waxy ingredients that help to maintain the skin’s natural barrier and provide the skin with that desired hydrated look. The skin’s natural barrier is the first few layers of skin and the protective oils that are produced, sebum. Disruption of the skin’s natural barrier has been linked to skin conditions such as eczema, so skin barrier health is vital to clear healthy-looking skin.Isopropyl myristate has the added benefit of also enhancing the penetration of ingredients into the skin. This means that key ingredients in your skincare can penetrate deeply into the skin, working to improve the appearance of the skin.Myristic Acid is a fatty acid that occurs naturally in some foods. Purified Myristic Acid occurs as a hard, white or faintly yellow, glossy crystalline solid, or as a white or yellow-white powder. Salts of Myristic Acid (Aluminum Dimyristate, Aluminum Isostearates/Myristate, Aluminum Myristate, Aluminum Myristates/Palmitates, Calcium Myristate, Magnesium Myristate, Potassium Myristate, Sodium Myristate, Zinc Myristate) and esters of Myristic Acid (Butyl Myristate, Cetyl Myristate, Decyl Myristate, Ethylhexyl Myristate, Ethyl Myristate, Glyceryl Dimyristate, Glyceryl Isostearate/Myristate, Glyceryl Myristate, Isobutyl Myristate, Isocetyl Myristate, Isodecyl Myristate, Isopropyl Myristate, Isostearyl Myristate, Isotridecyl Myristate, Lauryl Myristate, Methyl Myristate, Myristyl Myristate, Octyldodecyl Myristate, Oleyl Myristate, Propylene Glycol Myristate, Tetradecyloctadecyl Myristate, Tridecyl Myristate) may also be used in cosmetics and personal care products. Myristic Acid and its salts and esters may be used in eye makeup, soaps and detergents, hair care products, nail care products, shaving products and other skin care products.

Isopropyl Myristate
THE GOOD:Isopropyl myristate works as an emollient, helping to maintain the skin’s natural barrier and retain moisture. It also helps to increase the penetration of key ingredients in your product.

THE NOT SO GOOD:Isopropyl myristate can be too heavy for congestive skin types and can increase the penetration of ingredients, potentially increasing the likelihood of a product clogging the skin.

WHO IS IT FOR?Dry to normal skin types will benefit most from the moisture-locking abilities. Still, it is suitable for most skin types except those that have an identified allergy to it, or those that are actively trying to decongest their skin.

What Are The Benefits of Isopropyl Myristate?
Moisture retaining
Working as an emollient isopropyl myristate helps to maintain the integrity of the skin’s natural barrier. Products with isopropyl myristate help to create a protective coating on the surface of the skin. This helps to prevent moisture loss and limit the skin’s exposure to allergens and bacteria.

Absorption
Isopropyl myristate improves the absorption of other products into the skin. It is often used in medicated formulations so that the skin receives the medication effectively. This is an excellent characteristic when it comes to getting the most out of your skincare ingredients; however, it can be irritating to sensitive skin type or clogging to congested skin types.

Texture
Isopropyl myristate can help to improve the texture of the products. It helps to thicken the product, which enhances the feeling of the product on the skin as it is applied. In formulation, it prevents oil-based ingredients from feeling too greasy or heavy but creating an even emulsion.

Is Isopropyl Myristate Safe?
According to research conducted by the Cosmetic Ingredient Review Expert Panel, it is safe for its indicated use. However, isopropyl myristate can cause some sensitivity issues. In a case study published in the journal, Contact Dermatitis examined the potential for irritation to occur in sensitive skin types using isopropyl myristate products. They were able to identify that there is some sensitivity associated with the ingredient in some people, about 2%.

The other issue with isopropyl myristate is that it is considered to be comedogenic, meaning that it can create blockages of the pores. This can increase the visibility of pores and might contribute to the presence of blemishes. For this reason, it may be best to avoid products with high levels of isopropyl myristate if you have congested skin. There is a broad range of concentrations used in products with a range between 0.001-20%. Higher concentrations tend to be present in products such as foundations and heavy moisturizers; other products tend to utilize lower strength.

Other Uses:
Isopropyl myristate is sometimes used as an artificial flavor in food. It is also used in some head lice treatments as the waxy ingredient coats the lice and prevents them from sourcing water or food.

Other Names:
Isopropyl myristate can also be known as 1-methylethyl ester tetradecanoic acid, tetradecanoic acid, IPM, isopropyl ester myristic acid, isopropyl myristate, isopropyl tetradeconoate, myristic acid, isopropyl ester, 1-methylethyl tetradeconoate, 1-methylethyl ester, and tetradecanoic acid.

Why is it used in cosmetics and personal care products?
The following functions have been reported for Myristic Acid and its salts and esters.

Anticaking agent - Aluminum Dimyristate, Aluminum Isostearates/Myristates, Aluminum Myristate, Aluminum Myristates/Palmitates, Calcium Myristate, Magnesium Myristate, Zinc Myristate
Binder - Isopropyl Myristate, Isostearyl Myristate, Tetradecyloctyldecyl Myristate
Emulsion stabilizer - Aluminum Dimyristate, Aluminum Isostearates/Myristates, Aluminum Myristate, Aluminum Myristates/Palmitates, Calcium Myristate, Tetradecyloctyldecyl Myristate
Film former - Tetradecyloctyldecyl Myristate
Hair conditioning agent - Ethyl Myristate, Isotridecyl Myristate, Lauryl Myristate, Oleyl Myristate
Opacifying agent - Myristic Acid, Tetradecyloctyldecyl Myristate
Slip modifier - Magnesium Myristate, Zinc Myristate
Skin-Conditioning Agent - Emollient - Butyl Myristate, Ethylhexyl Myristate, Ethyl Myristate, Glyceryl Dimyristate, Glyceryl Isostearate/Myristate, Glyceryl Myristate, Isobutyl Myristate, Isodecyl Myristate, Isopropyl Myristate, Isostearyl Myristate, Methyl Myristate, Propylene Glycol Myristate
Skin-conditioning agent - occlusive - Cetyl Myristate, Decyl Myristate, Isocetyl Myristate, Isotridecyl Myristate, Lauryl Myristate, Myristyl Myristate, Octyldodecyl Myristate, Oleyl Myristate, Tetradecyloctyldecyl Myristate, Tridecyl Myristate
Surfactant - cleansing agent - Myristic Acid, Potassium Myristate, Sodium Myristate
Surfactant - emulsifying agent - Potassium Myristate, Sodium Myristate, Glyceryl Isostearate/Myristate, Glyceryl Myristate, Propylene Glycol Myristate
Viscosity increasing agent - nonaqueous - Aluminum Dimyristate, Aluminum Isostearates/Myristates, Aluminum Myristate, Aluminum Myristates/Palmitates, Calcium Myristate, Magnesium Myristate, Zinc Myristate

Isopropyl Myristate
Catalog NumberACM110270
Product NameIsopropyl Myristate
Structure
CAS110-27-0
SynonymsBISOMEL; Myristic acid isopropyl ester; ESTERGEL; Isopropyl Tetradecanoate; Isopropyl-myristate; 1-methylethyl ester of tetradecanoic acid; i-propyl myristate; ja-faipm; Emcol-IM; myristic acid isopropyl ester; IPM 100,IPM-EX,IPM-R; Isomyst; IPM; D 50; isopropyl myristinate; Promyr; Revenge; Tegester;
EC Number203-751-4
IUPAC Namepropan-2-yltetradecanoate
CategoryMain Products
Molecular FormulaC17H34O2
Molecular Weight270
Exact Mass270.25600
Boiling Point167ºC (9 mmHg)
Melting Point-5°C
Flash Point308°F
Density0.856 (25°C)
AppearanceColorless or slightly yellow oily liquid
SMILESCCCCCCCCCCCCCC(=O)OC(C)C
InChI KeyAXISYYRBXTVTFY-UHFFFAOYSA-N
Safty DescriptionS26-S36
Hazard StatementsXi:Irritant
WGK Germany-
StabilityStable. Combustible. Incompatible with strong oxidizing agents.
Packing GroupI; II; III
Viscosity4.8cp (25°C)
Alpha SortIsopropyl myristate

Molecular Weight 270.5 g/mol
XLogP3-AA 7.2
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 14
Exact Mass 270.25588 g/mol
Monoisotopic Mass 270.25588 g/mol
Topological Polar Surface Area   26.3 Å²
Heavy Atom Count 19
Formal Charge 0
Complexity 199
Isotope Atom Count 0
Defined Atom Stereocenter Count   0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count   0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes