PRODUCTS

ISOPROPYL MYRISTATE

ISOPROPYL MYRISTATE = IPM

CAS Number: 110-27-0
EC Number: 203-751-4
Molar Mass: 270.457 g-mol-1

Isopropyl myristate is among the commonly used fatty acid ester and is isopropyl ester of tetradecanoic acid.
Isopropyl myristate is categorized mainly employed as synthetic oil and is produced by reaction of isopropyl alcohol and myristic acid.

Isopropyl myristate is among the foremost available substitutes for natural oil in the cosmetics industry.
Isopropyl myristate is also used as solvent in several trans-dermal pharmaceutical products and pharmaceuticals creams.

Major end user industries for isopropyl myristate include personal care, pharmaceuticals, food and lubricants among several others.
Personal care is the largest application segment for isopropyl myristate and the trend is anticipated to continue for a foreseeable future.

Isopropyl myristate is also used as a pesticide free product for killing lice.
Isopropyl myristate helps in enhancing skin penetration properties of products owing to which, pharmaceutical is anticipated to be the fastest growing application segment for isopropyl myristate.
Other applications of isopropyl myristate include solvents, plasticizer and bio diesel among others.

Isopropyl myristate is an emollient, Isopropyl myristate helps to strengthen the skin barrier, ensuring that moisture stays locked in.
As an emollient, Isopropyl myristate also helps soften and smooth dry skin, which is why this is a great ingredient for those with dry or flaky skin.

This fabulous ingredient can also acts as a lubricant, thickening agent or a moisturiser in your cosmetic product.
Isopropyl myristate is used to give your product a slicker, smoother feel rather than an oily one.

Isopropyl myristate is an emollient.
Isopropyl myristate nourishes the skin while preserving Isopropyl myristate hydration.
Isopropyl myristates main advantage is that Isopropyl myristate does not leave a greasy finish on the skin.

Isopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption.
Isopropyl myristate has been largely studied and impulsed as a skin penetration enhancer.

At the moment the primary usage for which isopropyl myristate is formally indicated is as the active ingredient in a non-prescription pediculicide rinse.
Isopropyl Myristate is an ester of isopropyl alcohol and myristic acid (a fatty acid that naturally occurs in coconut and palm oils).
Isopropyl myristate is a very lightweight emollient and can be used like a carrier oil in many applications.

Isopropyl myristate finds many applications in food, cosmetic and pharmaceutical industries as an emollient, thickening agent, or lubricant.
Isopropyl Myristate (IPM) is an emollient ester of low viscosity; light weight oil.
IPM is ester of isopropyl alcohol and myristic acid (vegetable-derived).

Isopropyl myristate is mainly used as a solubilizer, emulsifier and emollient in cosmetic and topical medicines.
Isopropyl myristate is also used as a flavoring agent in the food industry.

Isopropyl Myristate is a synthetic oil used as an emollient, thickening agent or lubricant in beauty products.
Isopropyl Myristate is a popular cosmetic and pharmaceutical ingredient.
Isopropyl Myristate is most often used as an additive in aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.

Isopropyl myristate IPM is the ester of myristic acid and isopropyl alcohol.
Isopropyl myristate is manufactured from high quality palmkernel or coconut oil.

Isopropyl Myristate is a thin fluid with high stability.
Isopropyl myristate is easy to spread onto the skin, is easily absorbed and in addition smoothens the skin.
IPM also helps bind certain cosmetic preparations (fine grain and powdery).

IPM is a multifunctional (emollient, solvent, spreading agent, penetrant) synthetically produced ester of vegetal myristic acid and petrochemical isopropyl alcohol
IPM is commonly found in formulations to help reduce the greasiness of whipped butters and emulsions.
IPM is not soluble in water, but Isopropyl myristate is soluble in castor and several other oils.

Isopropyl myristate (IPM) is used as a substitute for natural oils in cosmetics and a co-solvent with skin penetration enhancement properties of active ingredients in many topical and transdermal preparations.
Isopropyl myristate is a novel pediculicide rinse (50%) and a safe and effective therapy for the treatment of head lice in children and adults.
Isopropyl Myristate is a fast spreading emollient suitable for all cosmetic applications.

Isopropyl myristate is the synthetic oil widely used in the cosmetics as a lubricant and emollient.
This emmolient is manufactured by condensing myristic acid with isopropyl alcohol.

Isopropyl myristate is readily absorbed by the skin and lessens the greasy nature of cosmetics while lending them a sheer, slick feel.
Generally Isopropyl myristate is considered to be safe.

Isopropyl myristate is non-occlusive, spreads well and provides an elegant, non-oily skin feel.
Isopropyl myristate may be used as a carrier for cosmetic and pharmaceutical additives, and is also an excellent solubilizer for lanolin.
Hence Isopropyl myristate finds broad application in topically applied cosmetic and pharmaceutical liquid, cream, lotion, powder and spray products.

Isopropyl Myristate is included in formulas to dramatically reduce the greasy/oily feel.
Isopropyl myristate’s brilliant in recipes with large amounts of butters that are famous for a heavier skin feel (like shea).

Isopropyl Myristate is also a great lightweight emollient.
You can include Isopropyl myristate in recipes as an alternative to a liquid carrier oil to make for a lighter, faster-absorbing product.

At higher concentrations IPM can also be used in products like makeup removers.

Isopropyl Myristate should be included in the oil phase of your products.
Isopropyl myristate can be hot or cold processed.
Isopropyl tetradecanoate is a fatty acid ester.

Isopropyl myristate is used as a thickening agent or as a moisturizer in common beauty products.
Isopropyl myristate is a synthetic oil that actually lessens the "greasy" or oily feeling found in some lotions and creams, while aiding in absorption.
While Isopropyl myristate is widely used in health items, isopropyl myristate is also used as a way to treat head lice and in a mouthwash that kills bacteria.

Isopropyl myristate is a synthetic oil widely used in the cosmetics and pharmaceutical industries as a lubricant, emollient, and as a non-toxic alternative for controlling head lice.
The oil is manufactured by condensing myristic acid with isopropyl alcohol and is colorless and mild in odor.

Isopropyl Myristate (IPM) in cosmetics has become universal.
Isopropyl myristates skin feel, its dry emollience, its skin penetration and clear miscibility with vegetable and mineral oils are just some of the sought after formulation properties.

Isopropyl Myristate is an ester of the fatty acid Myristic Acid.
Isopropyl Myristate has a silky feeling that makes skin (and hair) soft, smooth and supple.

Isopropyl myristate also reduces the greasy feel of other oils in the same product.
Rather than an oily mess, the cream is now sleek and light to the touch.

Isopropyl Myristate is a polar emoliant and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired.

Isopropyl Myristate is being studied as a skin enhancer.
Isopropyl myristate is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.

Isopropyl Myristate is used in the same way in flea and tick killing products for pets.
Isopropyl Myristate is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product "Dentyl pH".

Isopropyl Myristate is is also used as a solvent in perfume materials and in the removal process of prosthetic make-up.
Hydrolisis of the ester from Isopropyl Myristate is can liberate the acid and the alcohol.
The acid could be responsible for the decreasing of the pH value of formulations.

Isopropyl myristate is an ingredient that you may have unknowingly used many times before.
Isopropyl myristate is a synthetic oil made from two components.

The first component is isopropyl alcohol, the antimicrobial agent used in some hand sanitizers, baby wipes, and antiseptic formulations.
The second component is myristic acid, which is a naturally occurring fatty acid often found in coconut oil, nutmeg, and animal fats such as butter—the two elements when they are combined form an exceptional emollient.

Emollients are thick, slightly waxy ingredients that help to maintain the skin’s natural barrier and provide the skin with that desired hydrated look.
The skin’s natural barrier is the first few layers of skin and the protective oils that are produced, sebum.
Disruption of the skin’s natural barrier has been linked to skin conditions such as eczema, so skin barrier health is vital to clear healthy-looking skin.

Isopropyl myristate has the added benefit of also enhancing the penetration of ingredients into the skin.
This means that key ingredients in your skincare can penetrate deeply into the skin, working to improve the appearance of the skin.

Applications of Isopropyl myristate:
Isopropyl myristate is applied as a dispersant for lipstick, hair cream, lipstick, cleansing cream, fragrance powder and medical ointment and can be also used as perfume fixative.
Isopropyl myristate is applied as dispersant for cosmetics.

Carrier solvent.
Allowed food flavor additive according GB 2760-96.

Isopropyl myristate is one of the important ingredients of high-end cosmetics, has excellent penetration into the skin, moisture and softening effect and is used as emulsifier and wetting agent for cosmetics.
Isopropyl myristate is used for organic synthesis.

As solvent.
For the preparation of spices.

Oily raw materials of cosmetics, solvent for pesticide original drugs.
Isopropyl myristate is widely used as additives for high-end cosmetics, such as ointment, cream, and conditioner.

Most often used at between 1-10%.
This all-natural ester is used to empart a dry yet moisturising feel to skin creams.
In addition, Isopropyl Myristate is also used to help solubilise actives such as sunscreens, vitamins and perfumes into a base.

After Sun Antiperspirants & Deodorants
Baby Care and Cleansing
Body Care
Color Care
Conditioning Face Care
Face Cleansing
Personal Care Wipes
Self Tanning
Sun Protection

Benefits of Isopropyl myristate:
Emollient, thickening agent, lubricant or moisturiser in beauty products.
In cosmetic manufacturing this ingredient is used to give the finished product a slicker, smoother feel rather than an oily one.

Superior emollient for non-greasy bath, body and baby oils,
Lubricant and compression aid for pressed powders,
Light & non-tacky emollient for creams and lotions,
Readily adsorbed by the skin,
When used at high concentrations Isopropyl myristate gently lifts makeup and surface dirt,
Gives gloss and shine to hair,
Resistant to oxidation (does not become rancid),
Widely used as diluent for fragrance oils.

Recommendations of Isopropyl myristate:
Aftershaves, Shampoos, Bath oils, Creams and Lotions.

Dosage:
1-10%

Isopropyl myristate is classified as:
Binding
Emollient
Skin conditioning
Solvent
Perfuming

Absorption of Isopropyl myristate:
Isopropyl myristate improves the absorption of other products into the skin.
Isopropyl myristate is often used in medicated formulations so that the skin receives the medication effectively.

This is an excellent characteristic when Isopropyl myristate comes to getting the most out of your skincare ingredients.
However, Isopropyl myristate can be irritating to sensitive skin type or clogging to congested skin types.

Texture of Isopropyl myristate:
Isopropyl myristate can help to improve the texture of the products.
Isopropyl myristate helps to thicken the product, which enhances the feeling of the product on the skin as it is applied.
In formulation, Isopropyl myristate prevents oil-based ingredients from feeling too greasy or heavy but creating an even emulsion.

Chemical Properties of Isopropyl myristate:
Isopropyl myristate is a colorless and odorless liquid, and miscible with vegetable oil.
Isopropyl myristate is not easy to be either hydrolyzed or become rancid.
The refractive index nD20 is 1.435~1.438, and the relative density (20°C) is 0.85~0.86.

Content Analysis of Isopropyl myristate:
Weight 1.5 g sample.
Then Isopropyl myristate is determined by the method ester assay (OT-18).

The equivalent factor (e) in the calculation is 135.2.
Or Isopropyl myristate is determined by a non-polar column method of gas chromatography (GT-10-4).

Production Method of Isopropyl myristate:
Isopropyl myristate is a product of esterification of myristic acid derived from re-steamed coconut coil with isopropyl alcohol.
200 kg myristic acid and 450 kg isopropyl alcohol were added into the reaction vessel in turn.

After mixing, 360 kg sulfuric acid (98%) was added.
The reaction mixture was heated to reflux for 10 hours.

Isopropyl alcohol was then recovered, washed with ice water, and neutralized with Na2CO3 aqueous solution (10%).
Under normal pressure, isopropyl alcohol and water were distilled.

While under reduced pressure, isopropyl myristate was distilled (185°C/1.0kPa~195°C/2.7kPa).
90 kg isopropyl alcohol was added into the reaction vessel and then sulfuric acid as catalyst, with 5% of the total amount, was added.

During mixing, 228 kg myristic acid was added slowly.
The mixture was heated to reflux and water was continuously separated.

Until no water was separated, the reaction temperature was reduced and probe was obtained to measure the acid value.
When the acid value reached 1.5 mg KOH/g, the reaction was completed.

Alkali was then added for neutralization.
After the removal of water under reduced pressure, the pressure was further reduced for dealcoholization until the acid value was 0.05~1.0 mg KOH/g.
The final product is then isopropyl myristate.

Pharmacodynamics of Isopropyl myristate:
Isopropyl myristate is an emollient vehicle that is effective at enhancing the penetration of other medical agents that may be incorporated into the vehicle as active agents.
In one study, a 50:50 isopropanol-isopropyl myristate binary enhancer synergistically increased the transport of estradiol across a two-layer human epidermis in vitro.

Mechanism of action of Isopropyl myristate:
As a pediculicide, isopropyl myristate is capable of physically coating the exoskeleton bodies of lice.
This physical coating subsequently immobilizes the lice and works to dissolve the wax covering on the insect exoskeleton and blocks the insects' airways, leading to death by dehydration.

Although this physical action of isopropyl myristate results in little lice resistance (given the lack of immunologic or chemical activity in this mechanism of action), the substance is also not ovicidal, which means any eggs that may have been laid by lice would not be affected.
Moreover, isopropyl myristate is capable of eliciting Isopropyl myristate pediculicide action in a contact time of only 10 minutes per each necessary administration.

Identifiers of Isopropyl myristate:
Chemical Formula: C17H3402
Molar Mass: 270.457 g-mol-1
Density: 0.85 g/cm3
Boiling Point: 167'C (333'F)

CAS Number: 110-27-0
EINECS/ELINCS No: 203-751-4
INN Name: isopropyl myristate
Pharmaceutical European Name: isopropylis myristas
Chem/IUPAC Name: Tetradecanoic acid, isopropyl ester
INCI Name: Isopropyl Myristate

Names of Isopropyl myristate:

CAS names of Isopropyl myristate:
Tetradecanoic acid
1-methylethyl ester

IUPAC names of Isopropyl myristate:
IPM
ISOPROPYL MYRISTATE
Isopropyl Myristate
Isopropyl myristate
isopropyl myristate
Isopropyl myristate
isopropyl myristate
Isopropyl Myristate (Tetradecanoic acid, 1-methylethyl ester) CAS 110-27-0
Isopropylmyristate
propan-2-yl tetradecanoate
Tetradecanoic acid, 1-methylethyl ester

Trade names of Isopropyl myristate:
CHINT: FCE (i-Propyl)E C14
Crodamol IPM
DUB IPM
IPM-S
Isopropyl Palmitate
MMEster E1140
PALMESTER
Palmsurf IPM
Phase I REACH Kandidat
RADIA 7191
RADIA 7727
RADIA 7730
RADIA 7730K
RADIA 7730Q
WAGLINOL 6014
WAGLINOL 6014/95
WAGLINOL 6014/98
WAGLINOL 6014/N

Other names of Isopropyl myristate:
IPM
Isopropyl Tetradeconoate
Tetradecanoic acid 1- methylethyl ester
Isopropylis Myristas
Isopropyl Myristas
1-Methylethyl Tetradecanoate
Myristic acid Isopropyl ester
1-Methylethyl Ester Tetradecanoic acid
1-Methylethyl Tetradecanoate
Isopropyl Ester Myristic acid
Isopropyl Tetradecanoate
Tetradecanoic acid
1-Methylethyl Ester
Tetradecanoic acid
1Methylethyl Ester
1-Tridecanecarboxylic Acid
Isopropyl Ester
Bisomel
Crodacol IPM

Synonyms of Isopropyl myristate:
Isopropyl Myristate, 96% 25GR
IPM 100
IPM-EX
IPM-R
Radia 7730 (IPM)
Isopropyl myristate Vetec(TM) reagent grade, 98%
MYRISTIC ACID ISOPROPYL ESTER MINIMU
ISO-PROPYL N-TETRADECANOATE
ISOPROPYL TETRADECANOATE
BISOMEL
ISOPROPYL MYRISTATE
ESTERGEL
FEMA 3556
MYRISTIC ACID ISOPROPYL ESTER
TETRADECANOIC ACID 1-METHYLETHYL ESTER
TETRADECANOIC ACID ISOPROPYL ESTER
kesscoipm
kesscoisopropylmyristate
Kesscomir
Lexol IPM-NF
Liponate IPM
Plymoutm IPM
plymoutmipm
Promyr
Propyl myristate
Radia 7190
Revenge
Sinnoester MIP
sinnoestermip
Starfol IPM
starfolipm
Stepan D-50
1-Methylethyl tetradecanoate
1-Methylethyltetradecanoate
1-Tridecanecarboxylic acid, isopropyl ester
ISOPROPYLMYRISTATE,NF
Isopropylmyristat
Myristic acid, isopropyl ester: (Tetradecanoic acid, isopropyl: Isopropyl myristate),
ISOPROPYL MYRISTATE pure
tetraclecyl isopropyl ester
Isoprooyl myristate
Isopropyl tetradecanoate, Myristic acid isopropyl ester
Propan-2-yl tetradecanoat
Isopropyl myristate,96%
Isopropyl Myristate (500 mg)
Isopropy1 myristate
Isopropyl Myristate 98% (IPM)
1-tridecanecarboxylicacid,isopropylester
component of Sardo Bath Oil
crodacolipm
Crodamol 1PM
Crodamol I.P.M.
Crodamol IPM
crodamolipm
D 50
Deltyl Extra
deltylextra
Emcol-IM
ISOPROPYL MYRISTATE
110-27-0
Isopropyl tetradecanoate
Tetradecanoic acid, 1-methylethyl ester
Bisomel
Estergel
Isomyst
Promyr
Deltyl Extra
Kesscomir
Tegester
Wickenol 101
Sinnoester MIP
Crodamol IPM
Plymoutm IPM
Starfol IPM
Unimate IPM
Kessco IPM
Emcol-IM
Stepan D-50
Emerest 2314
1-Methylethyl tetradecanoate
Myristic acid isopropyl ester
JA-FA IPM
Kessco isopropyl myristate
Crodamol I.P.M.
Tetradecanoic acid, isopropyl
Myristic acid, isopropyl ester
Tetradecanoic acid, isopropyl ester
UNII-0RE8K4LNJS
1-Tridecanecarboxylic acid, isopropyl ester
MFCD00008982
Estergel (TN)
NSC 406280
methylethyl tetradecanoate
0RE8K4LNJS
iso-Propyl N-tetradecanoate
Isopropyl tetradecanoic acid
CHEBI:90027
tetradecanoic acid isopropyl ester
Tetradecanoic acid methyethyl ester
NCGC00164071-01
Deltylextra
WE(2:0(1Me)/14:0)
DSSTox_CID_6838
Isopropyl myristate, 96%
Isopropyl myristate, 98%
DSSTox_RID_78224
DSSTox_GSID_26838
propan-2-yl tetradecanoate
Caswell No. 511E
Isopropyl myristate [USAN]
CAS-110-27-0
FEMA No. 3556
HSDB 626
IPM-EX
IPM-R
EINECS 203-751-4
EPA Pesticide Chemical Code 000207
BRN 1781127
Tegosoft M
Isopropyl myristate [USAN:NF]
Liponate IPM
Crodamol 1PM
IPM 100
Lexol IPM
myristic acid isopropyl
PubChem19813
ACMC-1BVUK
Radia 7190
Isopropyl myristate (NF)
EC 203-751-4
SCHEMBL2442
component of Sardo Bath Oil
Myristic acid-isopropyl ester
Isopropyl myristate, >=98%
CHEMBL207602
IPM 90
DTXSID0026838
WLN: 13VOY1&1
FEMA 3556
ZINC8214588
Isopropyl myristate, >=90% (GC)
Tox21_112080
Tox21_202065
Tox21_303171
ANW-16142
LMFA07010677
NSC406280
s2428
AKOS015902296
Myristic acid, isopropyl ester (8CI)
Tox21_112080_1
DB13966
NSC-406280
component of Sardo Bath Oil (Salt/Mix)
NCGC00164071-02
NCGC00164071-03
NCGC00256937-01
NCGC00259614-01
R524
SC-19093
DB-040910
FT-0629053
M0481
D02296
Q416222
SR-01000944751
Isopropyl myristate, Vetec(TM) reagent grade, 98%
Q-201418
SR-01000944751-1
TERT-BUTYL[(1R)-1-CYANO-2-PHENYLETHYL]CARBAMATE
UNII-137MVX8C09 component AXISYYRBXTVTFY-UHFFFAOYSA-N
Isopropyl myristate, United States Pharmacopeia (USP) Reference Standard
TETRADECANOIC ACID,ISOPROPYL ESTER (MYRISTATE,ISOPROPYL ESTER)
Isopropyl myristate, Pharmaceutical Secondary Standard; Certified Reference Material