IVY LEAF EXTRACT

Ivy Leaf Extract (Hedera helix) is an evergreen, climbing vine native to Europe and Asia. 
Ivy leaf, also called English ivy leaf, comes from the Hedera helix L plant. 

CAS Number: 84929-22-0
EC Number: 232-268-1
INCI Name: HEDERA HELIX LEAF EXTRACT
Botanical names: Hedera helix
Parts Used & Where Grown
INCI: Glycerin (or) (Aqua (Water), Ivy Extract (Hedera Helix (Ivy) Leaf Extract), (or) Propylene Glycol (or) Pentylene Glycol

SYNONYMS:
Hedera helix leaf extract, Common Ivy leaf extract, English Ivy leaf extract, Hedera helix extract, Ivy leaf dry extract, Hedera extract, Hederae Folium, Ivy leaf powder, Ivy leaf fluid extract, Extract of Ivy Leaf

Ivy Leaf Extract is the leaf of the common ivy plant, also known as English ivy or Hedera helix.
Ivy Leaf is a green climbing plant that is often used as a decoration on the sides of houses and fences. 
What you may not know is that ivy leaf can also thin, loosen and help expel mucous.

Ivy leaf, also called English ivy leaf, comes from the Hedera helix L plant. 
The plant can now be found across the United States, Canada and across the world and is native to Europe and Asia.
For decades, the leaves have been used to make extracts for use in herbal medicine as a remedy for combating respiratory infections.

Before the plant can be used as a medicinal ingredient, it must undergo an extraction process. 
Acquiring Ivy Leaf Extract involves the utilization of a solvent such as ethanol to dissolve the compounds present in the plant and create a liquid extract. 
The solvent is then partially or completely evaporated, resulting in the formation of a soft or dry extract.

Ivy Leaf Extract (Hedera helix) is an evergreen, climbing vine native to Europe and Asia. 
The leaves are sometimes used to make extracts for medicine.
People use Ivy Leaf Extract for bronchitis, burns, rheumatoid arthritis (RA), and many other purposes, but there is no good scientific evidence to support these uses.

Ivy Leaf Extract belongs to the class of herbal medications used to treat sore throat, cough, and phlegm in adults and children over two years. 
Coughing is the body's mechanism of removing irritants from the airways and protecting itself against illness. 
There are two sorts of coughs: dry cough and chesty cough. 

A tickly cough or dry cough produces no harsh or thick mucus, whereas a chesty cough (wet cough) produces mucous or sputum to help clear the airways.
Ivy Leaf Extract contains a herbal medication. 
Ivy Leaf Extract acts as a mucolytic agent that works by thinning and loosening phlegm or mucus in the lungs, windpipe and nasal passage, thereby helping to cough out easily.

Your doctor will decide the dose and duration of Ivy Leaf Extract based on your medical condition. 
In very rare cases, Ivy Leaf Extract may cause stomach upset, diarrhoea, nausea, and vomiting. 
Do not use Ivy Leaf Extract without a doctor's advice if you had a skin reaction or irritation to any medicine. 

Consult your doctor before using Ivy Leaf Extract if you are pregnant or breastfeeding. 
Before taking Ivy Leaf Extract, inform your doctor about your medical history and other medications you are currently taking in order to rule out any possible negative effects.

It is unknown whether it is safe to consume alcohol with Ivy Leaf Extract. 
However, Ivy Leaf Extract is advisable not to take or limit alcohol as a safety measure. 
Ivy Leaf Extract should be used with caution in children below two years.

Ivy is an evergreen climber native to the damp woods of western, central, and southern Europe. 
Ivy Leaf Extract, Hedera Helix, also known as English Ivy, is an evergreen plant which is used for its medicinal properties. 
The leaves of the plant are used in medicinal preparations and can assist in respiratory conditions such as bronchial swelling, cough and congestion.

Ivy Leaf Extract commonly known as Ivy, is an evergreen climbing plant in the Araliaceae family, native to Central Europe, North and Central Asia. 
Ivy Leaf Extract is also cultivated in different regions of Iran. 
The most important characteristic of Ivy Leaf Extract is its dark evergreen leaves and the development of juvenile and adult foliage. 

Triterpenoid saponins are mainly found in the leaves and fruits of Ivy Leaf Extract with its leaves containing 5-8 % of saponins. 
Hedera helix leaves contain α-hederin, β-hederin, hederasaponin B, and hederacoside C, which are known to be its main bioactive compounds. 

With its ability to strengthen the skin barrier and deeply moisturize the skin, Ivy Leaf Extract is a preferred choice for formulations aimed at restoring skin elasticity and protecting against environmental aggressors. 
Ivy Leaf Extract's anti-inflammatory properties also help to soothe irritated or sensitive skin.

Using Ivy Leaf Extract in your products not only supports skin health, but also helps to reduce the visible signs of ageing. 
Ideal for creams, lotions and serums, Ivy Leaf Extract offers a range of benefits that make it an essential ingredient in the development of skincare products.

USES and APPLICATIONS of IVY LEAF EXTRACT:
An expectorant is a type of cough medicine used to help clear mucus (phlegm) from your airways.
Several studies have shown that Ivy Leaf Extract has anti-inflammatory and expectorant properties. 
The anti-inflammatory and expectorant properties are from phenolic acids, flavonoids, and saponins that can reduce inflammation and swelling in the airways, loosen mucus and relieve chest congestion, thereby relieving cough symptoms

Ivy leaf extract is commonly used as an active ingredient in cough medicines such as cough syrups and has been proven to be both safe and effective in relieving cough symptoms.
Native to many parts of Europe, Ivy Leaf Extract has a long history of helping to clear mucus, and studies also suggest that it safely helps with cough associated with hoarseness, dry throat, and irritants.

Ivy Leaf Extract is used for Mucus and Cough.
Ivy Leaf Extract might help thin mucus in the airways. 
This might improve lung function in people with breathing difficulty. 

Ivy Leaf Extract might also have antioxidant effects.
Ivy Leaf Extract is used medicinally.
Ivy Leaf Extract should be carefully distinguished from poison ivy found in the Americas.

Ivy Leaf Extract is used active ingredient for the cosmetics and food industry
Due to its rich phytoconstituents, Ivy Leaf Extract is always been widely used in the pharmaceutical and food industries. 
Since the desired active ingredients of ivy are mainly found in its leaves, they are the plant part utilized by Zardband Pharmaceuticals in production of ivy dry extract. 

Ivy Leaf Extract has been approved for the treatment of respiratory tract diseases. 
Ivy Leaf Extract has also been known as an effective and safe treatment for cough and acute bronchitis.
Ivy Leaf Extract is an essential cosmetic raw material for skin care

Ivy Leaf Extract, derived from the plant, is a key ingredient in innovative and effective skincare products. 
Ivy Leaf Extract is particularly known for its intense moisturizing and antioxidant properties, making it ideal for anti-aging and reparative skincare lines.

Ivy Leaf Extract can be used in a variety of ways in skin care and hair cosmetics.
It is recommended to use Ivy Leaf Extract at a concentration of 2-5% within your formulations for optimal results. 
Combine Ivy Leaf Extract with other active ingredients such as vitamin C or hyaluronic acid for enhanced effects in moisturizing and anti-aging products.

-Treatment of Productive Cough uses of Ivy Leaf Extract:
*Medicinal Benefits:
Ivy Leaf Extract is an expectorant containing dry ivy leaf extract. 
Ivy Leaf Extract works by thinning and loosening phlegm or mucus in the lungs, windpipe and nasal passage, thereby helping to cough out easily. 

Ivy Leaf Extract soothes the airways as well. 
Ivy Leaf Extract is a sugar-free cough syrup suitable for people with diabetes.

ORIGIN OF IVY LEAF EXTRACT:
Europe and the rest of the world. 
Organic goods are preferred. 
Please note that this product contains biological ingredients whose biodegradability cannot be tested. 
Such ingredients were therefore not taken into account in the assessment.

PROPERTIES AND MECHANISM OF ACTION OF IVY LEAF EXTRACT:
Ivy Leaf Extract contains saponins, flavonoids, and other phenolic compounds, and exhibits respiratory-supporting properties.
While Ivy Leaf Extract's mechanism of action is not known, the saponins in ivy leaf are believed to help clear mucus from the chest and to induce relaxation of the airway.
It has also been observed that Ivy Leaf Extract both widens the bronchi in the lungs and stimulates bronchial glands to secrete fluid.
 

SCIENTIFIC SUPPORT OF IVY LEAF EXTRACT:
The benefits of Ivy Leaf Extract in improving cough associated with hoarseness, dry throat, and irritants have been demonstrated in multiple clinical trials involving both adults and children.

INDICATIONS OF IVY LEAF EXTRACT:
Ivy Leaf Extract preparations can be used as an expectorant (a medicine that helps to bring up phlegm) for productive (chesty) coughs. 
Hederae helicis folium is used for the treatment of respiratory tract diseases with intense mucous formation, respiratory tract infections and in irritating cough which stems from common cold. 
Ivy Leaf Extract can be used in common cold associated with cough and for the symptomatic treatment of acute and chronic inflammatory bronchial disorders. 
Two galenical formulations of an Ivy Leaf Extract are cough syrup and cough drops.

IS IVY LEAF EXTRACT GOOD FOR CHRONIC BRONCHITIS?
Bronchitis occurs when the airways leading to your lungs become inflamed and filled with mucus. 
There are 2 main types of bronchitis, acute and chronic.

Acute bronchitis is a very common type of bronchitis and is often caused by cold or other respiratory infections. 
It typically goes away in 2 to 3 weeks. 
Chronic bronchitis, a more serious condition, is defined as inflammation of the airways. 

The condition is defined as a productive cough that can last at least three months.9
Studies have shown that Ivy Leaf Extract is effective and safe in the treatment of bronchitis, which is characterized by symptoms such as excessive mucus production and productive cough in adults.

HOW TO USE IVY LEAF EXTRACT?
Consuming raw or unprocessed Ivy Leaf Extract can be harmful and may cause adverse effects.
Ivy Leaf Extract is typically processed and used in the form of syrups or other formulations specifically designed for medicinal use. 
Cough products containing Ivy Leaf Extract is available in Canada in forms that include syrups and tablets.
It contains naturally derived Ivy Leaf Extract, which is used as an expectorant to support and improve the respiratory function of adults who have a cough and chronic bronchitis.  

HOW DOES IVY LEAF EXTRACT HELP?
Ivy Leaf Extract has been found to contain many compounds including saponins which, via the nervous system, activate cells in the lungs to remove excess mucous.
Ivy Leaf Extract has also been shown to liquefy thick, sticky mucous in the respiratory tract.

HOW TO USE IVY LEAF EXTRACT:
Ivy Leaf Extract can be found in cough medicines available in pharmacies and some supermarkets – ask your local pharmacist for more information.

CAN ı USE IVY LEAF EXTRACT FOR MY KIDS?
Bisolvon makes Ivy Leaf Extract products suitable for children. 
Bisolvon Cough Relief + Immune Support liquid and Bisolvon Cough Relief + Relax & Calm are both suitable for children from ages 2 and up and 5 and up respectively.

WHAT DO IVY LEAF EXTRACT TASTA LIKE?
Bisolvon Cough Relief + Immune Support has a delicious blackcurrant flavour, while Bisolvon Cough Relief + Relax & Calm has a Berry Flavour so even when your little one’s aren’t feeling their best, they can look forward to having their medicine.

HERB OF IVY LEAF EXTRACT:
Ivy Leaf is the common name for the leaves of the plant Hedera helix L., commonly known as ivy or 
English ivy, belongs to a family called Araliaceae. 

Hedera helix L. is an evergreen dioecious woody liana one of the 15 species of the genus Hedera, Araliaceae family. 
The whole leaves are coriaceous, 4-10 cm long and wide, cordate at the base. 
The lamina is palmately 3-5 lobed. 

The upper surface is dark green with a paler, radiate venation while the lower surface is more greyish green and the venation is distinctly raised. 
Ovate-rhomboic to lanceolate leaves 3 to 8 cm long form the flowering stems.

CHEMISTRY OF IVY LEAF EXTRACT:
The major compounds responsible for the biological activity are triterpene saponins. 
For Ivy Leaf Extract's chemical constituents, triterpene saponins, flavonoids, polyacetylenes and some phenolic compounds have been isolated from Hedera helix. 

In particular, α-hederin, a triterpene saponin, has been revealed to be responsible for the therapeutic effect of Ivy Leaf Extract because of its β2-adrenergic effects, which leads to the spasmolytic, bronchodilatory, mucolytic and expectorant action. 
Another triterpene saponin, hederacoside C, is known to be metabolized into the active form and produces the effect of α-hederin in the organism.

DIRECTIONS FOR USE OF IVY LEAF EXTRACT:
Shake the bottle well before use. 
Check the label for directions and take Ivy Leaf Extract with or without food with a measuring cup in the dose and duration prescribed by the doctor.

STORAGE OF IVY LEAF EXTRACT:
Store Ivy Leaf Extract in a cool and dry place away from sunlight

IVY LEAF EXTRACT AND THYME DRY EXTRACT ARE INDICATED IN:
*Relieves Cough (chesty & mucosal)
*Liquefies Mucus
*Helps in Bronchitis (Catarrh or inflammation of the respiratory tract)
*Relieves shortness of breath

BENEFITS OF IVY LEAF EXTRACT:
*Reduce swelling
*Prevent intoxication
*Respiratory conditions such as bronchial swelling, cough and congestion
*Ivy Leaf Extract is used for arthritis and conditions associated with gout and rheumatism
*Ivy Leaf Extract is used for liver conditions
*Ivy Leaf Extract is used for gallbladder conditions
*Ivy Leaf Extract is used for spleen disorders
*Ivy Leaf Extract may be applied topically to treat skin infections, burn and calluses

RELIEVING COUGH WITH IVY LEAF EXTRACT:
When you catch a cold virus, Ivy Leaf Extract can cause inflammation in your mucous membranes and the rest of your airway, leading to an increase in mucus production.
Coughing is your body's natural response to help clear mucus from the airways in an effort to restore the body’s respiratory function back to normal.

PHYSICAL and CHEMICAL PROPERTIES of IVY LEAF EXTRACT:
Solubility: good in water
Liquid extract: grams (g) or milliliters (ml) are similar
Vegan
pH: 3.9-7.2
Density: 1.03-1.06
Refractometry: 1.28-1.43
Physical State: Solid (typically provided in powdered form)
Color: Light brown to brown powder
Odor: Characteristic, herbal
Solubility: Soluble in water
pH: 3.5 - 5.5 (in solution)
Safety Information:
Flammability: Not available

Vapor Pressure: Not available
Density: Not available
Viscosity: Not available
Explosive Properties: Not available
Oxidizing Properties: Not available
EC Number: 232-268-1
CAS Number: 84929-22-0
Physical State: Solid (typically provided in powdered form)
Color: Light brown to brown powder
Odor: Characteristic, herbal

Melting/Freezing Point: Not available
Boiling Point: Not available
Flash Point: Not available
Autoignition Temperature: Not available
pH: 3.5 - 5.5 (in solution)
Water Solubility: Soluble in water
Partition Coefficient: Not available
Vapor Pressure: Not available
Density: Not available
Viscosity: Not available

Explosive Properties: Not available
Oxidizing Properties: Not available
CAS Number: 84929-22-0
EC Number: 232-268-1
INCI Name: HEDERA HELIX LEAF EXTRACT
Botanical names: Hedera helix
Parts Used & Where Grown
INCI: Glycerin (or) (Aqua (Water), Ivy Extract (Hedera Helix (Ivy) Leaf Extract), 
(or) Propylene Glycol (or) Pentylene Glycol

FIRST AID MEASURES of IVY LEAF EXTRACT:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of IVY LEAF EXTRACT:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of IVY LEAF EXTRACT:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of IVY LEAF EXTRACT:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of IVY LEAF EXTRACT:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of IVY LEAF EXTRACT:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available