JAPANESE KNOTWEED EXTRACT

Japanese Knotweed Extract also contains important minerals including zinc, potassium, phosphorus, and manganese.
Japanese Knotweed Extract is an herbaceous perennial plant native to Japan and China that grows persistently across the world. 

EC Number: Not specifically assigned
CAS Number: Varies depending on extract composition (e.g., Resveratrol from Japanese Knotweed has CAS# 501-36-0)
INCI Name: Polygonum Cuspidatum Root Extract
Latin Name: Fallopia japonica, Polygonum cuspidatum

SYNONYMS:
Fleeceflower, Huzhang, Japanese bamboo, Japanese knotweed, Mexican bamboo, Iitadori-kon or just itadori (Japanese), Bān gēn (Chinese), Tiger Cane, Fleeceflower, Himalayan fleece vine, Billyweed, Monkeyweed, Monkey fungus, Elephant ears, Pea shooters, Donkey rhubarb, American bamboo, Mexican bamboo, Japanese Knotweed Extract, Polygonum cuspidatum extract, Hu Zhang, Kojo-Kon, Itadori, Fleeceflower extract, Fo-ti extract, Resveratrol extract

Japanese Knotweed root, a member of the Buckwheat family, has many benefits, some of which are due to its high level of resveratrol which offers cardio-vascular support, including protection of the blood vessels. 
Japanese knotweed root may also support brain and immune function, protect the body from endotoxins and address the inflammatory process. 

Honeybees and other pollinators love to visit the late-blooming flowers of this tall, bamboo-like plant in the early fall.
Japanese Knotweed Extract (Polygonum cuspidatum) contains resveratrol which shows anti-oxidant and anti-inflammatory effects by inducing a significant reduction of the generation of reactive oxygen species and inflammation-inducing cytokines. 

An extract of Japanese Knotweed Extract also exhibited a strong anti-microbial effect against common food-borne bacteria such as B. cereus and S. aureus.
Japanese Knotweed Extract is packed with valuable nutrients such as vitamin A, vitamin C and an important antioxidant and cardio-protective flavonoid called rutin. 

Japanese Knotweed Extract also contains important minerals including zinc, potassium, phosphorus, and manganese. 
This nutritive quality of Japanese Knotweed Extract makes it particularly nourishing as a food and an excellent tonic for blood health
Polygonum cuspidatum (also known as Reynoutria japonica or Japanese knotweed) root has been used as an oriental medicine for more than 2000 years. 

From the perspective of traditional Chinese medicine theory, this plant was used to remove jaundice and clear heat-toxin, thereby promoting blood circulation, dispelling stasis, expelling wind and dampness, dissipating phlegm, and suppressing cough.
This plant has recently become popular with researchers and practitioners alike in the West due to its polyphenol content, especially resveratrol. 

Rich in Resveratrol, Japanese Knotweed Extract leaves remarkable antioxidant, anti-inflammatory, and antimicrobial effects on the skin.
Recent scientific research showed that Japanese Knotweed Extract speeds up wound healing, protecting skin fibroblasts, lessening inflammation, and stimulating collagen organization. 

In addition, Japanese Knotweed Extract suppresses tyrosinase activity and decreases melanin production exhibiting skin whitening effects.
Japanese Knotweed Extract is an ideal natural anti-aging ingredient for skincare formulas that fights toward hyperpigmentation and dark spots, enhances skin elasticity, and protects against oxidative stress and premature aging.

Japanese Knotweed Extract is an herbaceous perennial plant native to Japan and China that grows persistently across the world. 
Japanese Knotweed Extract is a potent source of resveratrol and other phytochemicals that offer powerful medicinal benefits.
Japanese Knotweed Extract acts as an anti-oxidant, anti-inflammatory, anti-bacterial and wound healing agent. 

It is an extract of the roots of the Japanese knotweed, polygonum cuspidatum. 
Japanese Knotweed Extract contains polygonin, emodin and stilbenes as active compounds. Japanese Knotweed Extract finds application in formulating cosmetic products.

Japanese Knotweed Extract including 50% resveratrol. 
Resveratrol is a natural compound found in certain plants, including grapes, and is often associated with health benefits. 
It is thought to have positive effects on aging, heart health, and reducing inflammation.

Extraction Ratio: 1:3, Alcohol Volume: 25%
Produced to GMP standards . 
Japanese Knotweed Extract is suitable for vegetarians and vegans 

Japanese Knotweed Extract is a nutritional supplement made from the Japanese knotweed plant, a perennial species native to East Asia. 
This plant, which is also referred to as Polygonum cuspidatum, Reynoutria japonica, and Fallopia japonica, has spread over the world and is now considered an invasive species in North America, Europe, and Canada. 

Japanese Knotweed Extract is gluten free 
It is distinguished by its bamboo-like stems and quick growth, which can reach heights of up to 15 feet. 
The plant is known to be a difficult invasive species because to its aggressive behaviour and large root system.

Japanese Knotweed Extract (INCI: Polygonum Cuspidatum Root Extract) is a natural botanical extract from the root of the Japanese knotweed tree. 
Japanese Knotweed Extract is known to be an excellent source of potent antioxidant resveratrol and may help inhibit the formation of collagen-degrading substances in skin. 

In higher amounts, Japanese Knotweed Extract aims to visibly improve hyperpigmentation. 
In addition, Japanese Knotweed Extract is known to be capable of reducing signs of irritation. 
Japanese Knotweed Extract is sustainably sourced and supplied in water without additional solvents and is suitable for all water-containing home and personal care formulations.

Japanese Knotweed Extract provides ease of use in formulating and manufacturing. 
Japanese Knotweed Extract is gentle and non-irritating in use and is therefore suitable for hypoallergenic products and products for use on sensitive skin. 
Japanese Knotweed Extract imparts enhanced mildness in cleansing applications and has broad compatibility with many personal care ingredients. 

Japanese Knotweed Extract has exceptional formulating latitude. 
Japanese Knotweed Extract should be added when the formulation is below 50°C.
Ingredients: Dried Japanese Knotweed roots, certified organic non-GMO cane alcohol and pure Adirondack water.

Japanese Knotweed Extract (Reynoutria japonica) is a fascinating plant in many ways. 
In Japan, where Japanese Knotweed Extract is native, the young stalks are used as a delicacy in the spring and known by many different names. 
In recent years Japanese Knotweed Extract has been discovered to one of the best natural sources of the potent antioxidant resveratrol (found in grape skins, and the primary reason red wine is considered healthy in moderation). 

But not only does it contain the coveted resveratrol molecule in higher concentration than in any other plant, Japanese Knotweed Extract has the trans isomer of this molecule, which is more biologically available and active. (Many plants only contain cis-resveratrol, which is less bioactive)
Trans-resveratrol's primary physiological action was originally thought to be as a straight-forward antioxidant, but recent studies have shown that it's powerful benefits may be due to a more direct action on the Nrf2 pathway. 

This gets pretty esoteric pretty quickly, but, in a nutshell, triggering the activation of this pathway in our bodies causes a cascade of beneficial effects on a genetic and cellular level. 
In effect, we may see results in a wide range of physiological and metabolic processes including mediating diabetes (anti-diabetic), heart disease (cardio-protective), liver disease (hepatoprotective), as well as anti-inflammatory, and anti-carcinogenic benefits. 

All of these actions are supported by recent science, and by traditional medicine. 
The ecology and ethnobotany of Japanese Knotweed are a little complicated too. 
Although it is well-loved as a seasonal delicacy in East Asia, it has been loathed and feared in many other parts of the world for its invasive nature. 

It can quickly spread after introduction to a new habitat, and can form thick mats of roots that outcompete native flora. 
It's often listed as one of the world's most invasive plants. 

Yet, if we look at this plant through the lens of the philosophy that the global ecosystem as a whole (Gaia) is attempting to alert and awaken her most problematic children (humans) to the myriad wonders and healing powers of the natural world, then we can see the intense invasiveness of this plant as a light meant to guide us back to the right path. 

USES and APPLICATIONS of JAPANESE KNOTWEED EXTRACT:
Japanese Knotweed Extract is used internal abscesses, Cough with yellow phlegm.
Japanese Knotweed Extract has also traditionally been applied topically alone and with other herbs to treat burns, abscesses, skin infections and snake bites. 

Japanese Knotweed Extract is widely used as a food in Asia. 
When foraging for Japanese Knotweed Extract in non-native countries, one must consider the risk of contamination with chemicals such as herbicides. 
As it is considered a highly invasive species, Japanese Knotweed Extract is often subject to treatment with highly toxic pesticides. 

It is sometimes used for viral respiratory tract infections as Japanese Knotweed Extract clears phlegm and relieves coughs. 
As a tincture Japanese Knotweed Extract may be taken to help bolster the defences and reduce stagnation and congestion associated with the common cold and other respiratory infections.

Japanese Knotweed Extract is recorded for use as medicine as far back as the late Han Dynasty around 2000 years ago. 
Japanese Knotweed Extract is used widely in herbal medicine today. 
In traditional Chinese medicine, Japanese Knotweed Extract is used to invigorate the blood, reduce heat and to resolve toxicity.

Japanese Knotweed Extract has been used in traditional Chinese medicine as well as in Japan and Korea for many years. 
Although used for various applications, few clinical studies validate claims and guidance regarding dosing or safety is limited.

Recommended Dosage of Japanese Knotweed Extract: 30-60 drops OR 1/4-1/2 tsp, 3-6 times per day in juice or water. 
End uses of Japanese Knotweed Extract include facial skin care, hair care and styling, facial cleansers, hand and body care, moisturizers, toners and serums, personal cleansers, pet care, sun care, foundations and liquid make-up, and laundry detergents.

-Traditional uses of Japanese Knotweed Extract:
Japanese Knotweed Extract has a long history of human use in China and Japan and is to this day used as a food source; the shoots being most commonly consumed. 

In traditional Eastern medicine Japanese Knotweed Extract has been a herbal ally since at least 500CE where it was first recorded in the Ming Yi Za Zhu (Miscellaneous Records of Famous Physicians). 

In this written text Japanese Knotweed Extract is included in more than 77 classic formulas and used frequently by physicians of the time. 
Japanese Knotweed Extract’s blood-activating and heat-, phlegm- and damp-clearing properties have traditionally been applied to alleviate the conditions of:

Menstrual pain, pain from traumatic injury and bi zheng (painful obstruction syndrome in particular, caused by the pathogenic factors wind and damp and primarily characterised by pain and limited movement in the joints, muscles or tendons)
Jaundice, gallstones and abnormal vaginal discharge

WHAT IS JAPANESE KNOTWEED EXTRACT USED FOR?
In addition to the popular antioxidant Resveratrol, Japanese Knotweed Extract also contains a chemical known as emodin. Emodin has the ability to regulate bowel motility among other things. 
The Japanese used an alcohol extract of this plant as a natural laxative. 

Modern preparations from Japanese Knotweed Extract are concentrated to maximize the Resveratrol and contain very little emodin. 
The phytochemical Japanese Knotweed Extract has garnered considerable scientific attention for its potential to support healthy blood vessel function and promote heart health. 
A recent search for studies on Japanese Knotweed Extract through the national library of medicines database; PubMed, yielded over two thousand results.

WHAT ARE THE BENEFITS OF JAPANESE KNOTWEED EXTRACT?
Scientific research has looked at the many health benefits that Japanese knotweed extract, which is made from a resveratrol-rich plant, is said to provide. Here are a few of these benefits:

*Rich in Antioxidants: 
The main ingredient in Japanese knotweed extract, resveratrol, is well known for having potent antioxidant qualities. 
Free radicals are very reactive chemicals that can harm cells and cause a variety of health disorders. 
Japanese Knotweed Extract is known to counteract oxidative stress by neutralising these molecules. 

The possibility for resveratrol to lessen oxidative damage has been investigated in numerous studies. 
In fact, a 2019 review in the journal “Molecules” emphasised resveratrol’s antioxidant capability and its possible significance in reducing disorders associated with oxidative stress.

*Cardiovascular Support: 
According to research, Japanese knotweed extract may have major cardiovascular advantages because of its high resveratrol concentration. 
It is thought that Japanese Knotweed Extract contributes to blood vessel health maintenance, which enhances circulation. 

A 2011 study that appeared in the “American Journal of Clinical Nutrition” discovered that supplementing with Japanese Knotweed Extract enhanced flow-mediated dilation, a blood vessel function indicator, in men who were obese. 
Additionally, Japanese Knotweed Extract might aid in controlling cholesterol and blood pressure. 

Together, these cardiovascular benefits can lower the chance of developing heart disease. 
Japanese Knotweed Extract’s effect on cardiovascular risk variables was examined in a meta-analysis that was published in “Nutrition, Metabolism & Cardiovascular Diseases” in 2020. 
The results indicated that Japanese Knotweed Extract had a favourable effect on lipid profiles and blood pressure.

*Anti Inflammatory: 
Chronic inflammation is linked to a wide range of health problems, from arthritis to neurological illnesses. 
Resveratrol and other bioactive components found in Japanese knotweed extract have shown promise as anti-inflammatory agents. 

In 2016, a study that was published in the “Journal of Medicinal Food” examined the anti-inflammatory properties of resveratrol and discovered that it inhibited the synthesis of chemicals that promote inflammation. 
This anti-inflammatory effect could be relevant to diseases in which inflammation is a major contributing factor.

Even though these studies suggest that resveratrol and Japanese Knotweed Extract may have health benefits, it’s important to remember that further study is required to validate and fully comprehend these effects in humans. 

Moreover, anyone thinking about adding Japanese knotweed extract to their regimen should consult a doctor, especially if they are also on other medications, to make sure the two are compatible and to figure out the right dosage for their individual circumstances.

WHAT CAN ı USE JAPANESE KNOTWEED EXTRACT FOR?
In traditional Chinese medicine (TCM), Japanese Knotweed Extract is used for clearing heat and toxicity in the body, improving blood quality and qi circulation. 

These combined actions mean that it deeply nourishes and supports systemic health. 
Japanese Knotweed Extract is believed to increase longevity and is taken as an anti-aging agent. 
This is unsurprising considering its broad range of health benefits, such as its cardiovascular tonic and antioxidant properties.

BENEFITS OF JAPANESE KNOTWEED EXTRACT:
How to Use the Knotweed Plant:
Japanese Knotweed Extract contains high amounts of resveratrol and anti-inflammatory nutrients, which people have used to treat mobility, immunity, and circulatory system issues. 

CLAIMS OF JAPANESE KNOTWEED EXTRACT:
*Antioxidants
*Healing Agents
*Antimicrobials
*Anti-inflammatories
*bio-based
*wound healing

JAPANESE KNOTWEED EXTRACT TREE:
Japanese knotweed extract has garnered attention due to its possible health advantages and is frequently used as a dietary supplement. 
Japanese Knotweed Extract may contain bioactive chemicals like resveratrol. 

Although studies on Japanese Knotweed Extract's effectiveness are still underway, some claim the extract may have anti-inflammatory and antioxidant qualities. 

People who are thinking about using Japanese Knotweed Extract in dietary supplements, however, should be cautious, get medical advice if necessary, and base their decision on scientific data when determining whether it is appropriate for a given health-related usage.

HOW DOES JAPANESE KNOTWEED EXTRACT WORK IN HUMAN BODY?
The bioactive chemicals in Japanese knotweed extract, particularly resveratrol, are what cause the plant’s benefits on humans when ingested. 
As a potent antioxidant, resveratrol is essential for lowering oxidative stress and free radical damage. 
The ageing and destruction of cells, as well as the emergence of numerous chronic illnesses, are linked to this oxidative stress. 

Resveratrol aids in tissue and cell protection by scavenging free radicals, which may lower the chance of diseases like cancer and heart disease. 
Its antioxidant qualities lessen the negative consequences of oxidative damage, promoting general health and wellbeing.
The effects of Japanese knotweed extract also reach the cardiovascular system. 

It is thought that resveratrol strengthens blood vessels, which enhances circulation and may reduce the incidence of heart-related problems. 
It might possibly have a part in controlling cholesterol and blood pressure. 
Resveratrol and the extract as a whole improve blood vessel function and lower inflammation, which benefits cardiovascular health. 

It’s crucial to remember that each person may react differently, and the precise mechanisms of action are still being studied. 
As a result, further research is necessary to completely comprehend the full range of impacts that the compound has on the human body.

HOW MUCH JAPANESE KNOTWEED EXTRACT CAN A PERSON TAKE?
The right amount of Japanese knotweed extract to take depends on a person’s unique circumstances and health goals. 
The best dosage is still being studied, so Japanese Knotweed Extract’s important to proceed with caution and seek medical advice if necessary. 
A major ingredient in Japanese knotweed extract, resveratrol, has been the subject of numerous research looking at possible health benefits at various dosages. 

Depending on the particular medical condition being studied, dosages ranging from 100 milligrams to 1,500 milligrams per day have been utilised in certain studies. 
For example, a 2017 randomised, double-blind study that was published in “Nutrients” examined the effects of 75 milligrams of resveratrol per day on cognitive function in older persons.

It’s crucial to emphasise that different people may respond differently to resveratrol or Japanese knotweed extract, and that individual differences may also exist in the best and safest dosage. 
In addition, the right dosage may vary depending on your age, general health, and any other medications you are taking. 

Therefore, before adding Japanese knotweed extract to your diet, it is strongly advised that you speak with a healthcare professional. 
This minimizes any possible hazards or interactions and guarantees that the supplement is used safely and efficiently.

WHAT ARE THE VARIATIONS OF JAPANESE KNOTWEED EXTRACT?
Japanese Knotweed Extract is also available as:

Trans Resveratrol 20% (Polygonum cuspidatum)
Trans Resveratrol 25% (Polygonum cuspidatum)
Trans Resveratrol 5% (Polygonum cuspidatum)

Trans Resveratrol 50% (Polygonum cuspidatum)
Trans Resveratrol 8% (Giant Knotweed) (Fallopia sachalinensis)
Trans Resveratrol 95% (Polygonum cuspidatum)

Trans Resveratrol 98% (Polygonum cuspidatum)
Japanese Knotweed Extract is commonly available in:

Japanese Knotweed Extract tablets
Japanese Knotweed Extract capsules
Japanese Knotweed liquid extract

PHYSICAL and CHEMICAL PROPERTIES of JAPANESE KNOTWEED EXTRACT:
EC Number: Not specifically assigned
CAS Number: Varies depending on extract composition 
(e.g., Resveratrol from Japanese Knotweed has CAS# 501-36-0)
Appearance: Brown to light brown powder (depending on concentration)
Solubility: Water-soluble
Molecular Weight: Varies depending on the specific compound extracted
Melting Point: Not applicable for extracts (depends on the isolated compound)
Boiling Point: Not applicable
Flash Point: Not applicable
pH: Neutral to slightly acidic when dissolved in water
Botanical name: Polygonum cuspidatum
Part used: Dried roots
Percentage of alcohol used: 45-50%
Ratio plant to menstruum: 1:5
Safety considerations: None noted
Origin: USA & China 

FIRST AID MEASURES of JAPANESE KNOTWEED EXTRACT:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of JAPANESE KNOTWEED EXTRACT:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of JAPANESE KNOTWEED EXTRACT:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of JAPANESE KNOTWEED EXTRACT:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of JAPANESE KNOTWEED EXTRACT:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of JAPANESE KNOTWEED EXTRACT:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available