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Oleyl alcohol
Former Name: HD-Eutanol V PH
CAS No:143-28-2
Catalogue Number: O235935
Molecular FormulaC18H36O
Average mass268.478 Da
Monoisotopic mass268.276611 Da
ChemSpider ID4447562
Double-bond stereo - Double-bond stereo
Kollicream OA is a clear, slightly yellowish, almost odorless weak polar oil.
Kollicream OA is suited for application in pharmaceutical skin care preparations, such as low-fatting emulsions and skin oils.
Oleyl alcohol is a natural product found in Ruvettus pretiosus and Bombus hortorum with data available.
Kollicream OA is a long chain fatty alcohol that is octadecanol containing a double bond located at position 9 (the Z-geoisomer).
Kollicream OA has a role as a nonionic surfactant and a metabolite. It is a long-chain primary fatty alcohol and a fatty alcohol 18:1.
Kollicream OA, is an unsaturated fatty alcohol with the molecular formula C18H36O or the condensed structural formula CH3(CH2)7−CH=CH−(CH2)8OH.
Kollicream OA is a colorless oil, mainly used in cosmetics.
Kollicream OA can be produced by the hydrogenation of oleic acid esters by Bouveault–Blanc reduction, which avoids reduction of the C=C group (as would occur with usual catalytic hydrogenation).
The required oleate esters are obtained from beef fat, fish oil, and, in particular, olive oil (from which it gains its name).
The original procedure was reported by Louis Bouveault in 1904[3] and subsequently refined.
Oleyl alcohol has uses as a nonionic surfactant, emulsifier, emollient and thickener in skin creams, lotions and many other cosmetic products including shampoos and hair conditioners.
It has also been investigated as a carrier for delivering medications through the skin or mucus membranes; particularly the lungs.
Benefits of Kollicream OA
Medium spreadability
Solvent for lipophilic drugs
Enhances skin penetration
A medium spreading emollient with penetration enhancement properties, and a potential solvent for lipophilic solvents.
Kollicream OA is a clear, almost odorless polar oil produced by the hydrogenation of fatty acids and oils from palm and palm kernel oil.
Primarily, it can be used as an emollient oil, able to penetrate the skin and disorder stratum coreum lipid organizations; thereby enhancing dermal drug delivery.
Kollicream OA can also be used as a drug solubilizer and penetration enhancer in topical products (emulsions & creams, ointments, gels and foams) and transdermal patches.
Kollicream types can be used as emollient in creams and lotions.
This high performance emollient offers incredible flexibility and efficiency for topical drug delivery systems, allowing you to adapt variables such as spreading value, molecular weight, or water permeability in line with your needs.
With their moisture retention effect, fattening and re-fattening power, these topical excipients are able to care and protect the skin.
Within the formulation they also have an impact on the consistency and appearance of the cream or lotion.
Why use Kollicream OA?
Medium spreading emollient with penetration enhancement properties
Can act as a solvent for lipophilic APIs
Ideal for topical semi-solids and transdermal patches
Kollicream OA is a clear, almost odorless polar oil produced by the hydrogenation of fatty acids and oils from palm and palm kernel oil.
Primarily, it can be used as an emollient oil, able to penetrate the skin and disorder stratum coreum lipid organizations; thereby enhancing dermal drug delivery.
Kollicream OA can also be used as a drug solubilizer and penetration enhancer in topical products (emulsions & creams, ointments, gels and foams) and transdermal patches.
Kollicream OA's Description
Kollicream emollients and penetration enhancers deliver exceptional performance for a wide variety of applications.
Primarily known for their skin softening and smoothing properties, these emollients can also be used to greatly improve the penetration of APIs into the skin and adjust the consistency and appearance of creams and lotions.
The Kollicream portfolio includes excipients that feel like cosmetics on the skin, are mild resulting in formulations with minimal irritation, and can help achieve easy-to-apply products for large application areas.
Kollicream OA (oleyl alcohol) is an emollient with medium spreadability for use in all topical dosage forms.
Supplied as a weak polar liquid, this emollient can also act as a solvent for lipophilic drugs and improve skin penetration.
More information about Kollicream OA
Features of Kollicream OA
Emollient for the skin
Solvent for lipophilic drugs
Penetration enhancer
Applications of Kollicream OA
Liquid dosage
Topical & Dermal
Ointments
Creams & Emulsions
Gels
Foams
Kollicream OA
Manufacturer: BASF
Oleyl alcohol is mainly used in topical pharmaseutical formulations and has been used in transdermal delivery formulations.
Therapeutically, it has been suggested that oleyl alcohol exhibite antitumor properties via transmembrane permeation.
Product Description of Kollicream OA
Catalogue Number: O235935
Chemical Name: (9Z)-9-Octadecen-1-ol, 85%
CAS Number: 143-28-2
Molecular Formula : C18H36O
Appearance : Colourless Oil
Molecular Weight: 268.48
Storage: Refrigerator
SolubilityChloroform (Slightly), Methanol (Slightly)
CategoryStandards; Natural Products;
Applications(9Z)-9-Octadecen-1-ol, is an unsaturated fatty alcohol, that can be used a nonionic surfactant, emulsifier, emollient and thickener in skin creams, lotions and many other cosmetic products.
Product Information of Oleyl alcohol
Name:
Oleyl alcohol - 80%
143-28-2
Description:
Purity min. 80%
Chemical properties of Kollicream OA
Molecular weight:
268.48 g/mol
Formula:
C18H36O
Purity:
Min 80%
Oleyl alcohol /ˈoʊliˌɪl, ˈoʊliəl/,[1] or cis-9-octadecen-1-ol, is an unsaturated fatty alcohol with the molecular formula C18H36O or the condensed structural formula CH3(CH2)7−CH=CH−(CH2)8OH.
Kollicream OA is a colorless oil, mainly used in cosmetics.
Kollicream OA can be produced by the hydrogenation of oleic acid esters by Bouveault–Blanc reduction, which avoids reduction of the C=C group (as would occur with usual catalytic hydrogenation).
The required oleate esters are obtained from beef fat, fish oil, and, in particular, olive oil (from which it gains its name).
The original procedure was reported by Louis Bouveault in 1904[3] and subsequently refined.
Kollicream OA has uses as a nonionic surfactant, emulsifier, emollient and thickener in skin creams, lotions and many other cosmetic products including shampoos and hair conditioners.
Kollicream OA has also been investigated as a carrier for delivering medications through the skin or mucus membranes; particularly the lungs.
Properties of Kollicream OA
Chemical formula: C18H36O
Molar mass: 268.485 g·mol−1
Density 0.845-0.855 g/cm3
Melting point: 13 to 19 °C (55 to 66 °F; 286 to 292 K)
Boiling point: 330 to 360 °C (626 to 680 °F; 603 to 633 K)
Solubility in water: Insoluble
Product Description of Kollicream OA
Basic Info
Product Name: Oleyl alcohol
CAS No.: 143-28-2
InChIKeys: InChIKey=ALSTYHKOOCGGFT-KTKRTIGZSA-N
Molecular Weight: 268.48
Exact Mass: 268.48
BRN: 1723962
EC Number: 205-597-3
Categories: Hydrazine or Hydroxylamine Derivatives
Characteristics
PSA: 20.2
XLogP3: 7.50 (est)
Appearance: Clear almost colorless to yellow Viscous Liquid
Density: 0.8489 g/cm3 @ Temp: 20 °C
Melting Point: 13-19 °C
Boiling Point: 333 °C
Flash Point: >230 °F
Refractive Index: 1.462
Water Solubility: Miscible with alcohol and ether. Slightly miscible with carbon tetrachloride. Immiscible with water.
Storage Conditions: −20°C
Vapor Pressure: 9.3X10-5 mm Hg at 25 deg C (est)
Description
Supply Ability ：500 MT/Month
Storage ：store in cool, dry
Hazard Identification of Kollicream OA
Classification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s): No symbol.
Signal word
No signal word
Hazard statement(s)
none
Precautionary statement(s)
Prevention
none
Response
none
Storage
none
Disposal
none
Other hazards which do not result in classification
no data available
Handling and Storage of Kollicream OA
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing.
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Use non-sparking tools.
Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place.
Store apart from foodstuff containers or incompatible materials.
Computed Properties of Kollicream OA
Molecular Weight: 268.5
XLogP3: 7.4
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 15
Exact Mass: 268.276615768
Monoisotopic Mass: 268.276615768
Topological Polar Surface Area: 20.2 Ų
Heavy Atom Count: 19
Formal Charge: 0
Complexity: 175
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 1
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Mechanism of Action of Kollicream OA
Farnesol (FOH) inhibits the CDP-choline pathway for PtdCho (phosphatidylcholine) synthesis, an activity that is involved in subsequent induction of apoptosis /SRP: programmed cell death.
Interestingly, the rate-limiting enzyme in this pathway, CCTalpha (CTP:phosphocholine cytidylyltransferase alpha), is rapidly activated, cleaved by caspases and exported from the nucleus during FOH-induced apoptosis.
The purpose of the present study was to determine how CCTalpha activity and PtdCho synthesis contributed to induction of apoptosis by FOH and oleyl alcohol.
Contrary to previous reports, /the authors/ show that the initial effect of FOH and oleyl alcohol was a rapid (10-30 min) and transient activation of PtdCho synthesis.
During this period, the mass of DAG (diacylglycerol) decreased by 40%, indicating that subsequent CDP-choline accumulation and inhibition of PtdCho synthesis could be due to substrate depletion.
At later time points (>1 h), FOH and oleyl alcohol promoted caspase cleavage and nuclear export of CCTalpha, which was prevented by treatment with oleate or DiC8 (dioctanoylglycerol).
Protection from FOH-induced apoptosis required CCTalpha activity and PtdCho synthesis since (i) DiC8 and oleate restored PtdCho synthesis, but not endogenous DAG levels, and (ii) partial resistance was conferred by stable overexpression of CCTalpha and increased PtdCho synthesis in CCTalpha-deficient MT58 cells.
These results show that DAG depletion by FOH or oleyl alcohol could be involved in inhibition of PtdCho synthesis.
However, decreased DAG was not sufficient to induce apoptosis provided nuclear CCTalpha and PtdCho syntheses were sustained.
Synoyms of Kollicream OA
OLEYLALCOHOL
(Z)-ocadec-9-en-1-ol
143-28-
cis-9-Octadecen-1-ol
Ocenol
Dermaffine
Lancol
Novol
Oceol
Oleol
Satol
Oleic alcohol
Oleo alcohol
Crodacol-O
Conditioner 1
Loxanol M
Atalco O
Siponol OC
Sipol O
(Z)-9-Octadecen-1-ol
(Z)-Octadec-9-enol
Cachalot O-1
Cachalot O-3
Cachalot O-8
H.D. eutanol
HD-Ocenol K
Loxanol 95
Unjecol 50
Unjecol 70
Unjecol 90
Oleoyl alcohol
Olive alcohol
Cachalot O-15
Crodacol A.10
Unjecol 110
HD oleyl alcohol CG
cis-9-Octadecenyl alcohol
Adol 34
Adol 80
Adol 85
Adol 90
HD-Ocenol 90/95
HD oleyl alcohol 70/75
HD oleyl alcohol 80/85
HD oleyl alcohol 90/95
(9Z)-octadec-9-en-1-ol
Witcohol 85
Witcohol 90
9-Octadecen-1-ol, (Z)-
Adol 320
Adol 330
Adol 340
Z-9-Dodecen-1-ol
cis-octadecen-1-ol
9-Octadecen-1-ol
(Z)-9-octadecenol
Oleylalcohol
Polyoxyl 10 oleyl ether
HD-Eutanol
Octadec-9Z-enol
cis-9-octadecenol
UNII-172F2WN8DV
(9Z)-9-Octadecen-1-ol
9Z-Octadecen-1-ol
Oleyl alcohol (NF)
Oleyl alcohol [NF]
( Z)-9-octadecenol
Witcohol 85 (TN)
9-Octadecen-1-ol, (9Z)-
9-Octadecen-1-ol, cis-
172F2WN8DV
CHEBI:73504
MFCD00002993
NSC-10999
0leyl alcohol
9-Octadecenol
Poly(oxy-1,2-ethanediyl), alpha-((Z)-9-octadecenyl)-omega-hydroxy-
cis-Oleyl alcohol
HSDB 6484
EINECS 205-597-3
NSC 10999
