PRODUCTS

KOLLIDON VA 64 FINE (SPECIAL)

CAS NUMBER: 9003-39-08

EC NUMBER: 1312995-182-4

DESCRIPTION OF KOLLIDON VA 64 FINE (SPECIAL):

Kollidon VA 64 Fine (Special) is a white or slightly yellowish powder with a faint characteristic odor and practically no taste.
Kollidon VA 64 Fine (Special) readily dissolves in all hydrophilic solvents.
Kollidon VA 64 Fine (Special) is less soluble in ether, cyclic, aliphatic and alicyclic hydrocarbons.
Kollidon VA 64 Fine (Special) is vinylpyrrolidone-vinyl acetate copolymers.

Kollidon VA 64 Fine (Special) is used in the pharmaceutical industry as dry binder in tablets, as matrix formers for amorphous solid dispersions, as retarding and as film-forming agents.
Kollidon VA 64 Fine (Special) is vinylpyrrolidone-vinyl acetate copolymers which are soluble both in water and in alcohols.
Kollidon VA 64 Fine (Special) is well-known by their monographic name "Copovidone" or "Copolyvidone".
In the pharmaceutical industry they are widely used as dry and wet binder in tablets, as film forming agent or in retard formulations.
A major application of Kollidon VA 64 Fine (Special) is as matrix in amorphous solid dispersions.

Kollidon VA 64 Fine (Special) absorbs only about one third of the quantity of water absorbed by povidone.
Kollidon VA 64 Fine (Special) is excellent binders for tablets and granules.
Between 2% and 8%, as a proportion of the final weight of the preparation, is usually used.
An important property of Kollidon VA 64 Fine (Special) in this application is the plasticity, which distinguishes the products from povidone.
This property often gives granules and mixtures that are less susceptible to capping during tabletting, and tablets that are less brittle.

Kollidon VA 64 Fine (Special) has been found to be excellent dry binders for direct compression.
Especially Kollidon VA 64 Fine (Special) gives much better results than any of the Povidone grades or other dry-binders of the group of cellulose derivatives.
The hardness, friability, porosity and disintegration time of lactose and starch placebo tablets produced with Kollidon VA 64 Fine (Special) are directly related to the compression force used.
Kollidon VA 64 Fine (Special) can be added to materials such as sorbitol, mannitol, starch, or direct compression aids, e.g. micro crystalline cellulose, whose own binding strength is inadequate, to give tablets with very good properties.
Kollidon VA 64 Fine (Special) can also be used as a binder in wet granulation for the production of tablets and granules, since it is readily soluble in all the usual solvents.

Kollidon VA 64 Fine (Special) can then be added either as a solution during granulation, or dry to the other ingredients, in which case the solvent is added alone during granulation.
Trials so far conducted with both methods, using equal quantities of liquid, produced tablets of much the same hardness.
A combination of the two methods, i.e. mixing some of Kollidon VA 64 Fine (Special) with the active ingredient, and dissolving the rest in the solvent, sometimes gives the best results.
Kollidon VA 64 Fine (Special) was specifically suitable for the application in roller-compaction and is the material of choice in terms of particle size distribution and particle shape for this application.
Due to the particle size it is able to cover a bit surface area and to form numerous bridges in the tablet structure that lead to hard tablets with a reduced friability.

Kollidon VA 64 Fine (Special) forms films that are soluble at all pH values.
Kollidon VA 64 Fine (Special) is less hygroscopic and more elastic than those formed by povidone.
Kollidon VA 64 Fine (Special) usually still absorbs too much water, so that it can seldom be used as the sole film-forming agent in a formulation.
Kollidon VA 64 Fine (Special) is therefore recommended to combine it with less hygroscopic substances such as cellulose derivatives, shellac or poly- ethylene glycol.
Kollidon VA 64 Fine (Special) is used in sugar-coating to improve the adhesion of the coating to the surface of the tablet core and to increase the capacity of the coating solution for pigments and improve their dispersibility.

Kollidon VA 64 Fine (Special) helps not only in the application of sugar coatings but also in the automation of the sugar-coating process.
Because of its good film-forming properties, Kollidon VA 64 Fine (Special) can also be used in topical sprays.
The formulation in Table 6 provides a typical example of a spray bandage.
Kollidon VA 64 Fine (Special) exhibits these effects when utilized with poorly water-soluble compounds.
In this case, the oral dose primarily includes a hard or softgel capsule where Kollidon VA 64 Fine (Special) is dissolved in hydrophilic fill formulations
Kollidon VA 64 Fine (Special) is a white or slightly yellowish powder with a faint characteristic odour and practically no taste.

Kollidon VA 64 Fine (Special) readily dissolves in all hydrophilic solvents.
Solutions of more than 10 % concentration can be prepared in water, ethanol, isopropanol, methylene chloride, glycerol and propylene glycol.
Kollidon VA 64 Fine (Special) is less soluble in ether, cyclic, aliphatic and alicyclic hydrocarbons.
Due to its exceptionally high binding capacity, Kollidon VA 64 Fine (Special) can be used as a dry binder for direct compression tableting and as a soluble binder for granulation; these properties make it an attractive and cost-effective alternative to natural binders.
In addition, Kollidon VA 64 Fine (Special) is ideal as a solubilizer in hot-melt extrusion processes.
Kollidon VA 64 Fine (Special) is specifically designed for roller compaction and binding in DC formulations.

Kollidon VA 64 Fine (Special) is a vinylpyrrolidone-vinyl acetate copolymer that is soluble both in water and in alcohol.
Kollidon VA 64 Fine (Special) is used as a dry binder in tabletting, as a granulating auxiliary and as a film-forming agent in the pharmaceutical industry.
Kollidon VA 64 Fine (Special) is vinylpyrrolidone-vinyl acetate copolymers which are soluble both in water and in alcohols.
Kollidon VA 64 Fine (Special) is used in the pharmaceutical industry as binders in tablets and as granulating, retarding and fi lm-forming agents.
Kollidon VA 64 Fine (Special) is white or slightly yellowish, free-fl owing powders with a faint characteristic odor and practically no taste.

Kollidon VA 64 Fine (Special) has excellent extrudability due to its thermoplasticity and HPMC is known for its ability as a crystallinity inhibitor, as well as a controlled-release polymer.
Kollidon VA 64 Fine (Special) is white or slightly yellowish, free-flowing powder with a faint characteristic odour and practically no taste.
Kollidon VA 64 Fine (Special) is an excellent binder for tablets and granules.
Between 2% and 5%, as a proportion of the final weight of the preparation, is usually used.
An important property of Kollidon VA 64 Fine (Special) in this application is its plasticity, which distinguishes it from povidone.

This property often gives granules and mixtures that are less susceptible to capping during tabletting, and tablets that are less brittle.
Kollidon VA 64 Fine (Special) has been found to be the best dry binder for direct pression that gives much better results than any of the povidone grades.
Kollidon VA 64 Fine (Special) can be added to materials such as sorbitol, mannitol, starch, or direct compression aids, e.g. microcrystalline cellulose, whose own binding strength is inadequate, to give tablets with very good properties.
Kollidon VA 64 Fine (Special) can also be used as a binder in wet granulation for the production of tablets and granules, since it is readily soluble in all the usual solvents.
Kollidon VA 64 Fine (Special) can then be added either as a solution during granulation, or dry to the other ingredients, in which case the solvent is added alone during granulation.

Kollidon VA 64 Fine (Special) gives granules that have less tendency to stick to the punches of the tabletting machine, when operating under humid conditions.
Kollidon VA 64 Fine (Special) forms films that are soluble at all pH values.
Kollidon VA 64 Fine (Special) is less hygroscopic and more elastic than those formed by povidone.
Kollidon VA 64 Fine (Special) usually still absorbs too much water, so that it can seldom be used as the sole film-forming agent in a formulation.
Kollidon VA 64 Fine (Special) is therefore recommended to combine it with less hygroscopic substances such as cellulose derivatives, shellac or polyethylene glycol.

Kollidon VA 64 Fine (Special) significantly improves their brittleness and solubility when it is combined with cellulose derivatives.
When Kollidon VA 64 Fine (Special) is used in film coatings based on shellac, the properties of the film are more consistent.
Kollidon VA 64 Fine (Special) can also be used in topical sprays.
Kollidon VA 64 Fine (Special) is used in sugar-coating to improve the adhesion of the coating to the surface of the tablet core and to increase the capacity of the coating solution for pigments and improve their dispersibility.

APPLICATIONS OF KOLLIDON VA 64 FINE (SPECIAL):

-Solid Dosage
-Tablets
-Capsules
-Wet Granulation
-Solid Dispersions
-Hot Melt Extrusion
-Semi-solid Dosage
-Transdermal Films

BENEFITS OF KOLLIDON VA 64 FINE (SPECIAL):

-Suitable for increasing blend compressibility
-Highly effective binder even at low concentrations for medium and high dose formulations
-Very good plasticity combined with fine particle size distribution produce very hard tablets
-Amenable for processing and storage in all temperature zone markets

TECHNICAL PROPERTIES OF KOLLIDON VA 64 FINE (SPECIAL):

Kollidon VA 64 Fine (Special) is spray dried polymer powders of a copolymer derived from the monomers N-vinylpyrrolidone (NVP) and vinyl acetate (VAc) with a weight ratio of approx. 6:4.
The powders are white or slightly yellowish, have a faint characteristic odor and practically no taste.

SOLUBILITY OF KOLLIDON VA 64 FINE (SPECIAL):

Kollidon VA 64 Fine (Special) readily dissolves in all hydrophilic solvents.
Solutions of more than 10% concentration can be prepared in: water, ethanol, isopropanol, methylene chloride, glycerol and propylene glycol.
The bulk density of Kollidon VA 64 Fine (Special) usually lies in the range of 0.08 – 0.15 g/ml.
The bulk density of Kollidon VA 64 Fine (Special) is above that one of Kollidon VA 64 Fine (Special) and is in the range of about 0.2 – 0.4 g/ml.

FUNCTIONS OF KOLLIDON VA 64 FINE (SPECIAL):

-Binder
-coating
-Direct compression
-Hot-melt extrusion
-roller compaction

FEATURES OF KOLLIDON VA 64 FINE (SPECIAL):

-Excellent for high humidity exposure
-Excellent for peroxide sensitive actives

USAGE OF KOLLIDON VA 64 FINE (SPECIAL):

-Dry binder in tablets
-capsules and granules
-as a film-forming agent in tablet coatings and subcoatings
-as a film-forming agent in topical sprays
-Widely used in HME processes

SPECIFICATIONS OF KOLLIDON VA 64 FINE (SPECIAL):

-K-value (nominally 28): 25.2 – 30.8
-Relative viscosity (1% in water): 1.178 –1.255
-Nitrogen: 7.0 – 8.0 %
-Loss on drying: 5.0%
-Vinylpyrrolidone (by HPLC): 10 ppm
-Vinyl acetate (by HPLC): 10 ppm
-Monomers VP + VAc (by titration): 0.4%
-Saponification value: 230 – 270
-Sulfated ash:0.1%
-Heavy metals: 10 ppm
-pH value (10 % in water): 3 – 7
-Peroxides: 400 ppm
-Hydrazine: 1 ppm
-Vinyl acetate, polymerized: 35.3 – 41.4%
-Acetaldehyde (enzymatic determination): 500 ppm

SOLUBILITY OF KOLLIDON VA 64 FINE (SPECIAL):

Kollidon VA 64 Fine (Special) readily dissolves in all hydrophilic solvents.
Solutions of more than 10 % concentration can be prepared in:

-water
-ethanol
-isopropanol
-methylene chloride
-glycerol
-propylene glycol

STORAGE OF KOLLIDON VA 64 FINE (SPECIAL):

Kollidon VA 64 Fine (Special) can be stored at room temperature (max. 25 °C) in the unopened original containers for at least 3 years.

SYNONYM:

CHEBI:78916
beta-D-arabinosyl-(1->2)-alpha-D-arabinosyl-(1->3)-[beta-D-arabinosyl-(1->2)-alpha-D-arabinosyl-(1->5)]-alpha-Darabinosyl-(1->5)-alpha-D-arabinoside--copovidone glycoconjugate
beta-D-Araf-(1->2)-alpha-D-Araf-(1->3)-[beta-D-Araf-(1->2)-alpha-D-Araf-(1->5)]-alpha-D-Araf-(1->5)-alpha-D-Araf--copovidone
beta-D-Araf-(1->2)-alpha-D-Araf-(1->3)-[beta-D-Araf-(1->2)-alpha-D-Araf-(1->5)]-alpha-D-Araf-(1->5)-alpha-D-Araf--copovidone glycoconjugate
poly[N-(8-{[beta-D-arabinofuranosyl-(1->2)-alpha-D-arabinofuranosyl-(1->3)-[beta-D-arabinofuranosyl-(1->2)-alpha-D-arabinofuranosyl-(1->5)]-alpha-D-arabinofuranosyl-(1->5)-alpha-D-arabinofuranosyl]oxy}octyl)-N'-[(1-ethenyl-1H-1,2,3-triazol-4-yl)methyl]pentanediamide-co-ethenol-co-N-ethenylpyrrolidin-2-one]