PRODUCTS

KOLLIPHOR PS 80

CAS NUMBER: 9005-65-6

EC NUMBER: E433

MOLECULAR FORMULA: C32H60O10

MOLECULAR WEIGHT: C32H60O10

IUPAC NAME: 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl (E)-octadec-9-enoate

Kolliphor PS 80 is an amber liquid with a faint characteristic odor.
Kolliphor PS 80 is used as a non-ionic surfactant and oil-in-water emulsifier, as plasticizer in a range of solid dispersions and oral dosage forms.
Kolliphor PS 80 is a non-ionic, hydrophilic emulsifier with broad pH range applicability and good skin tolerance in topical formulations.

Benefits:
-Suitable for oral, semi solid and liquid dosage forms as well as softgels
-Plasticizer in a range of solid dispersions and oral dosage forms
-Broad pH range applicability and good skin tolerance in topical formulations
-Solubilizing agent in a variety of pharmaceutical formulations

In addition to these robust functionalities, Kolliphor PS 80 is also a non-ionic surfactant and oil-inwater emulsifier that offers broad pH range applicability and good skin tolerance.
Kolliphor PS 80 is applicable for the development of oral and topical formulations.

Kolliphor PS 80 is an amber liquid with a faint characteristic odor.
Kolliphor PS 80 is used as a non-ionic, hydrophilic emulsifier for pharmaceutical creams and ointments.

*Suitable for use as solubilizer, emulsifier, suspension stabilizer or skin penetration enhancer
*Broad pH range
*Good skin tolerance
*Suitable for oral solid, semi solid and liquid dosage forms as well as softgels

Kolliphor PS 80 is a non-ionic, hydrophilic emulsifier, co-emulsifier and solubilizer for pharmaceutical preparations like emulsions and creams, gels and foams as well as softgels.
Kolliphor PS 80 is non-ionic surfactants and emulsifiers derived from polyethoxylated sorbitan and stearic or oleic acid.

Kolliphor PS 80 is mainly used as a solubilizer, emulsifier or suspension stabilizer for pharmaceutical application. Depending on the HLB value of the product they can either act as solubilzer or emulsifier.
Kolliphor PS 80 is its high HLB value more suitable as a solubilizer of poorly water soluble drug substances in either liquid or solid dosage forms.
Kolliphor PS 80 is suitable for usage in physical mixing, melt granulation, spray drying and hot melt extrusion processes.

Applications:
-Semi-Solids and Liquid Dosage
-Creams & Emulsions
-Gels
-Foams
-Solid Dosage
-Tablets
-Capsules
-Solutions

Kolliphor PS 80 is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics.
This synthetic compound is a viscous, water-soluble yellow liquid.

Kolliphor PS 80's Chemistry:
Kolliphor PS 80 is derived from polyethoxylated sorbitan and oleic acid.
The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide.

In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case, the oleic acid (see polysorbate for more detail).
The full chemical names for polysorbate 80 are:
*Polyoxyethylene (20) sorbitan monooleate
*(x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl)

The critical micelle concentration of Kolliphor PS 80 in pure water is reported as 0.012 mM

Other names:
E number: E433

Brand names:
Kolliphor PS 80 - Kolliphor is a registered trademark of BASF
Alkest TW 80
Scattics
Canarcel
Poegasorb 80
Montanox 80 – Montanox is a registered trademark of Seppic
Tween 80 – Tween is a registered trademark of Croda Americas
Kotilen-80 - Kotilen is a registered trademark of Kolb AG

USES:
Food:
Kolliphor PS 80 is used as an emulsifier in foods.
For example, in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting.
Adding this substance prevents milk proteins from completely coating the fat droplets.
This allows them to join in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.

Health and beauty:
Kolliphor PS 80 is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer, such as in a mouthwash.
The cosmetic grade of polysorbate 80 may have more impurities than the food grade.

Medical:
Kolliphor PS 80 is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products.
Kolliphor PS 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone.
Kolliphor PS 80 is also used as an excipient in some European and Canadian influenza vaccines.
Influenza vaccines contain 2.5 μg of polysorbate 80 per dose.
Kolliphor PS 80 is found in many vaccines used in the United States, including the Janssen COVID-19 vaccine.
Kolliphor PS 80 is used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth.
Kolliphor PS 80 is also used as an emulsifier in the estrogen-regulating drug Estrasorb.
Kolliphor PS 80 is also used in granulation for stabilization of drugs and excipients when IPA binding.

Laboratory:
Some mycobacteria contain a type of lipase (enzyme that breaks up lipid molecules); when these species are added to a mixture of polysorbate 80 and phenol red, they cause the solution to change color, so this is used as a test to identify the phenotype of a strain or isolate.
On RODAC agar plates used in microbiological control, Kolliphor PS 80 counteracts disinfectants often found on sampled surfaces, thereby allowing the microbes found on these surfaces to grow

Kolliphor PS 80 is its high HLB value more suitable as a solubilizer of poorly water soluble drug substances in either liquid or solid dosage forms.
Kolliphor PS 80 is suitable for usage in physical mixing, melt granulation, spray drying and hot melt extrusion processes.
Kolliphor PS 80 can be used as an emulsifier in foods, medicines, cosmetics, textiles, agriculture, and occasionally in laboratory identification of bacteria.

Kolliphor PS 80 is a common fragrance and essential oil solublizer as well as an emulsifying agent.
Kolliphor PS 80 is soluble in water and alcohol and insoluble in oils.

Kolliphor PS 80 is typically a co-emulsifier that is used both as a viscosity modifier and a dispersing agent for fragrances and essential oils for room sprays and linen sprays.
When combined with liquid oils, Kolliphor PS 80 creates a blooming bath oil.
Kolliphor PS 80 can also be used in a self-emulsifying sugar or salt scrub.

Kolliphor PS 80 is a hydrophilic nonionic surfactant.
Kolliphor PS 80 is utilized as a surfactant in soaps and cosmetics and also as a lubricant in eye drops.

In food or pharmaceutical products, Kolliphor PS 80 can act as an emulsifier.
Kolliphor PS 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration or vaccinations.

A solubilizing agent acts as a surfactant and increases the solubility of one agent in another.
A substance that would not normally dissolve in a particular solution is able to dissolve with the use of a solubilizing agent.
Kolliphor PS 80 is also known as an emulsifier, which helps ingredients mix together and prevent separation, and water-containing small amounts of salts

What is Kolliphor PS 80?
This is a well known synthetic compound, also known as Tween 80.

Kolliphor PS 80 is an amber/golden-colored viscous liquid.
Kolliphor PS 80 is made from polyethoxylated sorbitan (chemical compounds derived from the dehydration of sugar alcohol) and oleic acid, a fatty acid found in animal and vegetable fats.

What does Kolliphor PS 80 do?
Kolliphor PS 80 is used as an emulsifier or defoamer in foods, vitamins, medicines, and vaccines.

Why is Kolliphor PS 80 used in food?
Kolliphor PS 80 is used as a defoamer for the fermenting process of some wines, and also to bind some ice-creams and other ‘puddings’, to keep their creamy texture without separating.
Kolliphor PS 80 is also used to bulk foods up and keep sauces smooth.

Why is Kolliphor PS 80 used in cosmetics?
Kolliphor PS 80 can also act as a surfactant in soaps and cosmetics, as well as a solubilizer – helping to dissolve ingredients so that they can more easily blend together.
Kolliphor PS 80 is used as a solubilizer.
Kolliphor PS 80 makes products look creamier and more attractive.

Why is Kolliphor PS 80 used in medicine?
It is used as an ingredient in some vaccines, as well as in some vitamins and supplements.
Kolliphor PS 80 is used to improve the consistency of gel capsules and to make pills disperse in the stomach.

What products is Kolliphor PS 80 used in?
Kolliphor PS 80 is a versatile and useful ingredient, so it is present in quite a few products.
Here is a short, generalized list of where Kolliphor PS 80 is most often found:

• Food shortening
• Chewing Gum
• Ice Cream
• Gelatin
• Vitamins
• Soap
• Shampoo
• Cosmetics
• Skin Creams
• Condiments
• Medicines
• Vaccines

PHYSICAL PROPERTIES:

-Molecular Weight: 604.8

-XLogP3-AA: 4.8

-Exact Mass: 604.41864811

-Monoisotopic Mass: 604.41864811

-Topological Polar Surface Area: 133 Å²

-Heavy Atom Count: 42

-Formal Charge: 0

-Complexity: 632

Kolliphor PS 80 is suitable for oral, semi solid and liquid dosage forms as well as softgels
Kolliphor PS 80 has broad pH range applicability and good skin tolerance in topical formulations

Kolliphor PS 80 is mainly used as solubilizers, emulsifiers, or suspension stabilizers for pharmaceutical applications.
Kolliphor PS 80 is a versatile, multifunctional excipient that acts as a solubilizing agent for a variety of pharmaceutical formulations and plasticizer for solid dispersions and oral dosage forms.
Kolliphor PS 80 is also a non-ionic surfactant and oil-inwater emulsifier that offers broad pH range applicability and good skin tolerance.

CHEMICAL PROPERTIES:

-Hydrogen Bond Donor Count: 3

-Hydrogen Bond Acceptor Count: 10

-Rotatable Bond Count: 31

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 0

-Undefined Atom Stereocenter Count: 4

-Defined Bond Stereocenter Count: 1

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 1

-Compound Is Canonicalized: Yes

Kolliphor PS 80 is applicable for the development of oral and topical formulations.
Kolliphor PS 80 is an amber liquid with a faint characteristic odor.
Kolliphor PS 80 is used as a non-ionic, hydrophilic emulsifier for pharmaceutical creams and ointments.

Kolliphor PS 80 is suitable for usage in physical mixing, melt granulation, spray drying and hot melt extrusion processes.
Kolliphor PS 80 is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics.
This synthetic compound is a viscous, water-soluble yellow liquid.

Kolliphor PS 80 is derived from polyethoxylated sorbitan and oleic acid.
Kolliphor PS 80 is used as an emulsifier in foods.

Kolliphor PS 80 is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer, such as in a mouthwash.
Kolliphor PS 80 is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products.

Kolliphor PS 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone.
Kolliphor PS 80 is also used as an excipient in some European and Canadian influenza vaccines.
Kolliphor PS 80 is found in many vaccines used in the United States, including the Janssen COVID-19 vaccine.

Kolliphor PS 80 is used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth.
Kolliphor PS 80 is also used as an emulsifier in the estrogen-regulating drug Estrasorb.

Kolliphor PS 80 is also used in granulation for stabilization of drugs and excipients when IPA binding.
Kolliphor PS 80 is suitable for usage in physical mixing, melt granulation, spray drying and hot melt extrusion processes.

Kolliphor PS 80 can be used as an emulsifier in foods, medicines, cosmetics, textiles, agriculture, and occasionally in laboratory identification of bacteria.
Kolliphor PS 80 is a common fragrance and essential oil solublizer as well as an emulsifying agent.
Kolliphor PS 80 is soluble in water and alcohol and insoluble in oils.

Kolliphor PS 80 is typically a co-emulsifier that is used both as a viscosity modifier and a dispersing agent for fragrances and essential oils for room sprays and linen sprays.
Kolliphor PS 80 can also be used in a self-emulsifying sugar or salt scrub.

Kolliphor PS 80 is a hydrophilic nonionic surfactant.
Kolliphor PS 80 is utilized as a surfactant in soaps and cosmetics and also as a lubricant in eye drops.

Kolliphor PS 80 can act as an emulsifier.
Kolliphor PS 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration or vaccinations.
Kolliphor PS 80 is also known as an emulsifier, which helps ingredients mix together and prevent separation, and water-containing small amounts of salts

Kolliphor PS 80 is used as an emulsifier or defoamer in foods, vitamins, medicines, and vaccines.
Kolliphor PS 80 is used as a defoamer for the fermenting process of some wines, and also to bind some ice-creams and other ‘puddings’, to keep their creamy texture without separating.

Kolliphor PS 80 is also used to bulk foods up and keep sauces smooth.
Kolliphor PS 80 can also act as a surfactant in soaps and cosmetics, as well as a solubilizer – helping to dissolve ingredients so that they can more easily blend together.

Kolliphor PS 80 is used as a solubilizer.
Kolliphor PS 80 makes products look creamier and more attractive.

Kolliphor PS 80 is used as an ingredient in some vaccines, as well as in some vitamins and supplements.
Kolliphor PS 80 is used to improve the consistency of gel capsules and to make pills disperse in the stomach.
Kolliphor PS 80 is a versatile and useful ingredient, so it is present in quite a few products.

SYNONYMS:

Alkest TW 80
Scattics
Canarcel
Poegasorb 80
Montanox 80
Tween 80
Kolliphor PS 80
2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl (E)-octadec-9-enoate
Polysorbate 80 (JP17/NF/INN)
2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl(e)-octadec-9-enoate
Polysorbate 80 (glycol)
sorbate80
Tween™ 80
Polyoxyethylene 20 sorbitan monooleate
Polyoxyethylene (20)
Inhibited ethylene glycol
NCGC00257261-01
2-hydroxyethyl 2-deoxy-3,5-bis-O-(2-hydroxyethyl)-6-O-{2-[(9E)-octadec-9-enoyloxy]ethyl}hexofuranoside
2-[2-[3,5-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl (E)-octadec-9-enoate
Sorbitan monooleate ethoxylated (CAS # 9005-65-6)
SORBITAN MONOOLEATE, ETHOXYLATED
Sorbitan monooleate, ethoxylated
Tween 80