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Kopirox is a compound that is known for its bacteriostatic and fungicidal properties specially working against Pityrosporum ovale that lives on the skin.
Kopirox is associated with dandruff and other manifestations of flaking of face and scalp.
Kopirox is also known as Octopirox.
CAS: 68890-66-4
MF: C16H30N2O3
MW: 298.43
EINECS: 272-574-2
Synonyms
2(1H)-Pyridinone,1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-,compd.with2-aminoethanol(1:1);4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon;octopiroxolamine;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1h)-pyridinoncompd.with2-aminoethanol(1:1);Hydroxyl pyrazole ketones;1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine;1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl);-one compound with 2-aminoethanol (1:1)
Kopirox is a compound sometimes used in the treatment of fungal infections.
Kopirox is the ethanolamine salt of the hydroxamic acid derivative piroctone.
Freely soluble in 10% ethanol in water; soluble in solution containing surfactants in water or in 1%-10% ethanol; slightly soluble in water and in oil.
The solubility in water varies by pH value, and is a litter larger in neutral or weak basic solution than in acid solution.
An organoammonium salt that is the ethanolamine salt of piroctone.
Kopirox Chemical Properties
Melting point: 134.0 to 138.0 °C
Boiling point: 135-235℃[at 101 325 Pa]
density: 1.1[at 20℃]
vapor pressure: 0-0Pa at 20-25℃
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly, Sonicated), Methanol (Slightly)
pka: 5.9-7.4[at 20 ℃]
form: Solid
color: White to Off-White
Water Solubility: 400-50000mg/L at 20-25℃
Merck: 14,7502
Major Application: agriculture
environmental
Cosmetics Ingredients Functions: PRESERVATIVE
ANTI-SEBORRHEIC
InChI: InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
InChIKey: BTSZTGGZJQFALU-UHFFFAOYSA-N
LogP: 1.05-3.86 at 20-25℃
CAS DataBase Reference: 68890-66-4(CAS DataBase Reference)
Uses
Kopirox is an anti-dandruff agent used in shampoo formulations.
Kopirox is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages.
Recently was shown, that Kopirox could induce apoptosis and possessed a significant in vivo effect against myeloma.
Benefits
Kopirox is a popular ingredient in hair care products that treat dandruff and other scalp conditions.
Controls dandruff: Kopirox is effective at controlling the growth of Malassezia, a yeast that can contribute to dandruff and other scalp issues.
By controlling the growth of this yeast, Piroctone Olamine can help to reduce or eliminate dandruff.
Soothes the scalp: Kopirox has moisturizing properties that can help to soothe and hydrate the scalp.
This can help prevent dryness, flakiness, and itching, common symptoms of dandruff and other scalp conditions.
Safe for coloured hair: Kopirox is safe for use on coloured hair and will not cause fading or strip colour.
Prevents fungal growth: Kopirox not only controls the growth of Malassezia, but it also prevents the growth of other fungi that can cause scalp problems.
Long-lasting effect: Kopirox has been shown to have a longer-lasting effect than some other dandruff-fighting ingredients, meaning you may be able to go longer between washes.
Gentle on the scalp: Kopirox is gentle on the scalp, making it suitable for sensitive skin.
Mechanism of action
Kopirox, also known as Octopirox, is an antifungal and antibacterial agent commonly used in cosmetic and personal care products, such as shampoos, conditioners, and lotions.
Kopirox works by inhibiting the growth of various microorganisms, including yeasts and fungi, by disrupting their cell membranes and interfering with their metabolism.
Specifically, Kopirox targets the enzymes responsible for synthesizing the cell membrane of microorganisms, inhibiting their growth and causing their eventual death.
Kopirox also has anti-inflammatory properties that help to reduce redness and itching on the scalp and skin.
Clinical Use
Kopirox has both antifungal and antioxidant properties.
Kopirox has been reported to be as effective as other antidandruff products at concentrations of 0.5–1% and is considered less toxic than zinc pyrithione when accidentally swallowed.
Kopirox products can be used by all patients and at any age.
Like zinc pyrithione, they should be used daily.
Because of their reduced toxicity, they may be preferred if used around small children.
Side effects
Kopirox should be kept in mind that shampoos with Kopirox should not be used more than twice a week, unlike other daily-use shampoos that don't have this ingredient.
One of the biggest side effects of Piroctone Olamine is that Kopirox can cause irritation and itchiness on the head.
