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KOPIROX is a functional cosmetic active for anti-dandruff and scalp care, INCI name Piroctone Olamine, offered by Kumar Organic Products Limited. The product is chemically composed of a 1:1 salt of piroctone with monoethanolamine and is identified by CAS No 68890-66-4.
KOPIROX is used in shampoos, conditioners, hair tonics, hair care lotions, hair oils and hair styling products to help control microorganisms associated with dandruff formation. Kumar Organic Products Limited positions the product as anti-dandruff active and states that it can be used in both transparent and opaque shampoo systems.
One of the main advantages of KOPIROX is its use of Piroctone Olamine chemistry, which has shown efficacy against Malassezia strains associated with dandruff in scalp care. Current clinical and microbiome studies show that shampoos containing Piroctone Olamine can create measurable changes in the scalp microbiota with reduced dandruff symptoms. KOPIROX is safe to use on colored hair and does not fade or peel. KOPIROX not only controls the growth of Malassezia but also inhibits the growth of other fungi that can lead to scalp problems. KOPIROX has been shown to last longer than some other dandruff-fighting ingredients, meaning you can last longer between washes.
KOPIROX should not be considered as a simple preservative with only antimicrobial activity. Its main commercial role in cosmetic applications is anti-dandruff and anti-seborrheic active; however, Piroctone Olamine is also included in the list of preservatives permitted by certain conditions of use in the cosmetic legislation of the European Union.
KOPIROX is a high-purity Piroctone Olamine raw material available in white or near-white powder form. During use, it is important to evaluate the solubility of the product against the formulation medium rather than simply adding it to water; Piroctone Olamine can be formulated more easily in hydroalcoholic systems and surfactant-containing environments.
KOPIROX is gentle on the scalp, making it suitable for sensitive skin. KOPIROX is known for its bacteriostatic and fungicidal properties; it is particularly effective against Pityrosporum ovale, which lives on the skin. KOPIROX is associated with dandruff and other manifestations of facial and scalp flaking.
KOPIROX is also known as Octopirox.
KOPIROX is a 1:1 salt formed by combining piroctone with monoethanolamine and is widely used in anti-dandruff cosmetic and dermatological formulations due to its good stability and compatibility with surfactants.
KOPIROX is the 1:1 salt form of piroctone combined with monoethanolamine and is commonly used in anti-dandruff cosmetic products.
The antifungal activity of KOPIROX is particularly effective against Malassezia species, helping to regulate the microbial balance in the scalp.
KOPIROX is widely preferred as an alternative to zinc pyrithione in shampoos, hair lotions, and medicated scalp treatments.
Its antifungal efficacy is particularly potent against Malassezia species, which are considered the primary microorganisms responsible for dandruff formation, and by inhibiting their growth, it restores and helps maintain the natural microbial balance in the scalp.
For this reason, it is often used as a more effective and safe alternative to KOPIROX in shampoos, hair tonics, leave-on scalp treatments, and other medicated personal care products designed for sensitive or irritated scalp diseases.
The recommended usage level for rinse-off products is given as 1.0% and 0.5% for other products in the manufacturer's leaflet of KOPIROX. These values are also in line with the current maximum concentrations in the European Union for the use of Piroctone Olamine with a preservative function.
KOPIROX is especially advantageous in transparent anti-dandruff shampoos. Unlike some classical actives such as Zinc Pyrithione, which are insoluble in water and used in dispersion, it can allow the preparation of a more homogeneous formulation within the appropriate surfactant or solvent system.
The performance of KOPIROX does not depend solely on the percentage of actives used. The shampoo's surfactant system, pH, solubilization method, contact time, persistence on the scalp, and combination with other actives can affect the actual anti-dandruff performance.
WHAT IS KOPRIX?
KOPIROX is Kumar Organic Products Limited's commercial anti-dandruff active ingredient based on Piroctone Olamine. KOPIROX is a compound that is sometimes used in the treatment of fungal infections.
KOPIROX is a popular ingredient in hair care products that treat dandruff and other scalp diseases. KOPIROX is effective in controlling the growth of yeast called Malassezia, which can contribute to dandruff and other scalp problems. The INCI name for KOPIROX is Piroctone Olamine.
Chemically, Piroctone Olamine is a 1:1 ratio salt of 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridine-2(1H)-one to 2-aminoethanol. The molecule shows an ionic structure consisting of two components: Piroctone and monoethanolamine. The Piroctone section contains lipophilic alkyl chain, hydroxypyridone ring, and carbonyl functions. The monoethanolamine section provides salt formation as a basic counterion. This salt structure can alter the processability and solubility of Piroctone in cosmetic formulations compared to its neutral form used alone.
It should be noted that shampoos containing KOPIRON, Piroctone Olamine should not be used more than twice a week; unlike other daily use shampoos that do not contain this ingredient.
One of the major side effects of KOPIROX is that it causes irritation and itching of the head.
KOPIROX is a 1:1 ratio salt composed of piroctone and monoethanolamine and is widely used in cosmetic and dermatological formulations due to its high antifungal efficacy, chemical stability, and good solubility in surfactant-based systems.
The primary mechanism of action of KOPIROXs involves the chelation of metal ions in fungal cells; this, in turn, disrupts mitochondrial energy metabolism and leads to inhibition of cell growth and proliferation, particularly in Malassezia species associated with dandruff.
By reducing the fungal load and associated inflammatory responses, KOPIROX helps reduce scalp flaking, itching, erythema, and discomfort; thereby improving overall scalp health and hair appearance.
The molecular formula of KOPIROX is C₁₆H₃₀N₂O₃, Molecular weight is about 298.42 g/mol, CAS No is 68890-66-4, EC/EINECS No is 272-574-2.
KOPIROX, also known as Octopirox, is an antifungal and antibacterial agent commonly used in cosmetics and personal care products such as shampoos, conditioners, and lotions.
KOPIROX works by inhibiting the growth of various microorganisms, including yeasts and fungi, disrupting their cell membranes and interfering with their metabolism.
Specifically, piroctone olamine targets the enzymes responsible for synthesizing the cell membrane of microorganisms; these enzymes inhibit their growth and cause its eventual death.
Piroctone Olamine is used in the cosmetics industry, especially as one of the anti-dandruff hair care actives.
There is not only one cause of dandruff formation. Oil production on the scalp, the rate of epidermal regeneration, the barrier status and the relative amount of Malassezia species can all play a role.
At the heart of Piroctone Olamine's commercial importance is the control it exerts over Malassezia and other dandruff-related microorganisms. In its current introduction, Kumar Organic Products Limited describes KOPIROX as an anti-dandruff active with bacteriostatic and fungistatic properties.
In particular, the manufacturer cites the control of scalp exfoliation associated with Malassezia and Pityrosporum ovale as its area of use.
The name Pityrosporum ovale is one of the older terminologies associated with Malassezia in the current mycological literature. It is more appropriate to use the current Malassezia terminology in technical and scientific texts.
The use of KOPIROX in shampoo ensures its active distribution throughout the scalp.
Since the contact time is short in rinsed systems, it is important that the active dissolves in the surfactant system and reaches the scalp.
Active in leave-on hair tonics or scalp lotion products can come into contact with the scalp for a longer period of time.
However, the maximum concentration that can be used in leave-on products is lower than rinse-off systems in some regulations.
COMMON PRODUCT AND CHEMICAL NAMES
KOPIROX
Kopirox
Piroctone Olamine
Piroctone Olamine
Octopirox
Piroctone Ethanolamine
Piroctone Monoethanolamine Salt
CAS 68890-66-4
EC 272-574-2
CAS NO, EC / EINECS NO AND CHEMICAL IDENTIFICATION
Product Name: KOPIROX
Manufacturer: Kumar Organic Products Limited
INCI name: Piroctone Olamine
Generic name: Piroctone Olamine
English name: Piroctone Olamine
Chemical name: 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
CAS No: 68890-66-4
EC/EINECS No: 272-574-2
PubChem CID: 50258
Molecular formula: C₁₆H₃₀N₂O₃
Molecular weight: Approximately 298.42 g/mol
Chemical class: Hydroxypyridone derivative/ethanolamine salt
Molar ratio: Piroctone : Monoethanolamine = 1:1
Physical form: White or near-white powder
Basic cosmetic function: Anti-seborrheic
Additional cosmetic function: Preservative
Major application: Anti-dandruff hair and scalp products
Manufacturer recommended dosage: 1.0% in rinse-off products
Manufacturer recommended dosage: 0.5% for other products
CHEMICAL STRUCTURE AND MOLECULAR PROPERTIES OF KOPIROX
The active ingredient in KOPIROX, Piroctone Olamine, is a hydroxypyridone derivative.
A six-membered heterocyclic pyridone ring is present in the piroctone portion of the molecule.
Hydroxyl and carbonyl functions are present on this ring.
The molecule also contains branched hydrophobic alkyl chain.
This structure gives the molecule both polar and lipophilic properties.
The formation of salts with monoethanolamine changes the ionic character of the molecule and its behavior within the formulation.
The oxygen-containing functions in the heterocyclic ring of Piroctone Olamine have the potential to coordinate with metal ions.
This property is one of the mechanisms that may play a role in the hydroxypyridone class affecting microbial metabolism.
Reducing the accessibility of metal ions necessary for the growth of microorganisms like Malassezia can contribute to the suppression of microbial proliferation.
However, the cosmetic performance of KOPIROX should not be reduced to a single molecular mechanism.
The antifungal effect of Piroctone Olamine can be evaluated through multiple interactions on cellular metabolism and membrane functions.
The branched lipophilic region of the molecule can promote its interaction with the lipid environment in the scalp.
This feature is important for scalp substantivity.
If the active shampoo is completely removed from the environment after rinsing, the contact time may be limited.
Therefore, if the formulation supports an adequate amount of the active on the scalp, it may affect the actual performance.
In a clinical study published in 2011, it was reported that a shampoo containing 0.5% Piroctone Olamine and 0.45% Climbazole showed higher permanence on the scalp than the Zinc Pyrithione system, which was compared in terms of antimycotic substantivity.
The pH-dependent ionization behavior of Piroctone Olamine can also impact solubility and formulation stability.
Monoethanolamine salt provides more favorable processability in cosmetic systems than free piroctone.
The main properties of KOPIROX at the molecular level are:
Hydroxypyridone ring structure carry
Creating a 1:1 salt with monoethanolamine
Including polar and lipophilic regions together
Interacting with the scalp surface
Contributing to Malassezia control
Showing bacteriostatic properties
Showing fungistatic/antifungal properties
Demonstrate potential for interaction with metal ions
To be able to be formulated in surfactant systems
Supporting dandruff control on the scalp
PHYSICAL AND CHEMICAL PROPERTIES OF KOPIROX
KOPIROX is a solid cosmetic active based on Piroctone Olamine.
General technical specifications:
Physical appearance: White or near-white powder
INCI: Piroctone Olamine
CAS No: 68890-66-4
EC/EINECS No: 272-574-2
Molecular formula: C₁₆H₃₀N₂O₃
Molecular weight: Approximately 298.42 g/mol
Chemical form: 1:1 salt of monoethanolamine with piroctone
PubChem CID: 50258
Melting/decomposition behavior: Melting can be reported with degradation around 135 °C
Physical form: Powder
Color: White
Water solubility: Limited / depending on formulation conditions
Behavior in hydroalcoholic media: Can provide proper solubility
Behavior in surfactant systems: Can be incorporated into formulation
Main Usage: Anti-dandruff active
Cosmetic function: Anti-seborrheic
Cosmetic Function: Preservative
Producer use level: 1.0% for rinse-off products
Producer use level: 0.5% for other products
The solubility of Piroctone Olamine is the important parameter in the formulation.
Adding the powder only to pure water at room temperature may not provide rapid and complete dissolution in all cases.
Therefore, the surfactant phase, appropriate solvent, controlled temperature, or pre-dissolution approach can be used.
In the production of transparent shampoo, it is important that the active is completely dissolved in terms of product clarity.
Undissolved particles can form sedimentation, crystallization, or turbidity.
Although the melting and degradation temperature of Piroctone Olamine is high, it is not recommended to keep it at an unnecessarily high temperature for extended periods during production.
The application process should be determined based on the supplier's current technical document and actual formulation stability.
KOPIROX's exact purity, moisture, ash, color, and other acceptance criteria must be verified from the commercial batch COA document.
HOW DOES KOPIROX WORK AT THE MOLECULAR LEVEL?
The anti-dandruff effect of KOPIROX is based on Piroctone Olamine's control of the growth of dandruff-related microorganisms in the scalp microbiota.
Malassezia species can also be found on healthy human scalp.
Therefore, the goal is not to eliminate all microorganisms, but to help control the microbial balance associated with dandruff.
Current microbiome studies show that the relative amount of some groups of microorganisms, such as Malassezia restricta, may be different from healthy scalps on scalps with dandruff.
A decrease in the amount of Malassezia and a change towards a healthier scalp microbiome have been reported after using shampoo containing Piroctone Olamine.
This approach indicates that KOPIROX should not be considered solely as a broad-spectrum germicide.
Piroctone Olamine can exert fungistatic and antifungal action, limiting fungal growth on the scalp.
The manufacturer also states bacteriostatic properties.
The hydroxypyridone structure in the molecule can form a complex with metal ions.
Reducing the accessibility of metal ions necessary for the growth and metabolism of microorganisms can limit cellular functions.
The lipophilic alkyl chain, on the other hand, can support the interaction of the active with the lipid-rich scalp environment.
When the shampoo is applied, it is transported to the entire scalp within the KOPIROX surfactant system.
During the massage, it reaches the surface of the active scalp.
It acts on the microorganism population during contact.
Most of it is removed during rinsing, but depending on the formulation, some may remain on the active surface.
Therefore, substantivity is important for anti-dandruff performance.
The main functions of KOPIROX at the molecular and scalp level are:
Helping to control Malassezia growth
Helping to reduce the fungal load associated with dandruff
Supporting scalp microbial balance
Showing bacteriostatic behavior
Showing fungistatic behavior
Contributing to the reduction of dandruff flake formation
Helping to reduce the itching sensation associated with dandruff
Supporting seborrheic scalp care
Improving scalp hygiene
To be able to provide cosmetic protective function
IN WHICH SECTORS IS KOPIROX USED?
KOPIROX is actively used for scalp and anti-dandruff products, especially in the personal care and cosmetics industry.
Main areas of use:
Anti-dandruff shampoos
Transparent anti-dandruff shampoos
Opaque anti-dandruff shampoos
Daily scalp shampoos
Shampoos for oily scalp
Hair care creams
Anti-dandruff conditioners
Hair tonics
Scalp tonic products
Scalp lotions
Leave-on scalp serums
Hair styling gel products
Hair styling creams
Hair oils
Hair masks
Scalp mask products
Anti-dandruff hair care systems
Anti-seborrheic cosmetic products
Scalp hygiene products
Some deodorant systems
Cosmetic formulations permitted as preservatives
In its current product communication, Kumar Organic Products Limited actively mentions KOPIROX as suitable for shampoo, conditioner, hair tonic, gel, oil and scalp care products.
It can be used in transparent and opaque shampoo systems, increasing the formulation flexibility of the product.
In transparent shampoos, it is especially important that the active is completely dissolved and does not crystallize over the long term.
KOPIROX'S SHAMPOO, SCALP CARE AND ANTI-DANDRUFF APPLICATIONS
Anti-dandruff shampoos are the most important application area of KOPIROX.
The possible functions of KOPIROX in shampoo and scalp care are:
Helping to control dandruff formation
Helping to reduce visible flaking on the scalp
Supporting Malassezia control
Supporting scalp hygiene
Contributing to reducing the itching sensation associated with dandruff
Supporting oily dandruff scalp care
Develop transparent anti-dandruff shampoo
Develop opaque anti-dandruff shampoo
Activating scalp tonic products
Providing antifungal support in scalp lotions
Creating a scalp care function in conditioners
Adding anti-dandruff properties to hair styling gel products
Supporting scalp care in hair oil and scalp oil products
Piroctone Olamine can be used alone or in combination with other actives in anti-dandruff shampoos.
When used in conjunction with Salicylic Acid, antifungal control and keratolytic scaling control can be combined in the same formulation.
In a double-blind study published in 2000, it was shown that a shampoo containing 0.75% Piroctone Olamine and 2% Salicylic Acid reduced the severity of dandruff.
In another clinical study, a system containing 0.5% Piroctone Olamine and 0.45% Climbazole was compared with a shampoo containing 1% Zinc Pyrithione.
Both systems have been reported to be effective in reducing the amount of dandruff, and the Piroctone Olamine/Climbazole system has shown strong scalp persistence.
More recent microbiome studies show that the use of shampoo containing 0.5% Piroctone Olamine lowers the relative amount of Malassezia species and is associated with an improvement in clinical dandruff scores.
These works belong to certain finished product formulations.
Therefore, it should not be assumed that all shampoos containing the same percentage of Piroctone Olamine will automatically perform the same.
The surfactant system and the capacity to activate it on the scalp are important.
KOPIROX may change shampoo viscosity.
Especially in classical systems such as SLES/CAPB, which are thickened with salt, the pure curve should be re-evaluated after adding the active.
If the active approaches the solubility limit with an excess of electrolytes or certain surfactant combinations, it may affect the clarity of the product.
Therefore, after production is completed, crystallization should be checked in room temperature, low temperature, and accelerated temperature stability tests.
USE OF KOPIROX IN CONDITIONER, TONIC, SERUM, GEL AND LEAVE-ON APPLICATIONS
KOPIROX is not only used in shampoo.
Kumar Organic Products Limited also mentions conditioner, hair tonic, styling gel, hair oil and scalp care products among its usage areas.
Leave-on scalp products may have a longer contact time than active shampoo.
However, the product concentration may have to be kept lower according to the legislation.
In the European Union, Piroctone Olamine can be used at a maximum of 1.0% in rinse-off products and at a maximum of 0.5% in other products with its protective function.
The recommended dosage of KOPIROX manufacturer is also rinse-off 1.0% and other products 0.5%.
Resolution is particularly important in scalp tonic systems.
Hydroalcoholic systems can provide an advantage in solubilizing Piroctone Olamine.
However, high alcohol can cause dryness or sensitivity on the scalp.
The alcohol level should be optimized not only for its active solubility, but also for the user experience.
In scalp serums, combination with humectant, niacinamide or different scalp care actives may be considered.
pH, solubility, and long-term stability should be rechecked with each combination.
Compatibility with cationic surfactants and fatty alcohols should be verified in conditioner systems.
The active should not be added directly to the molten oil phase of the conditioner; the phase and temperature suitable for the actual solubility of the product should be selected.
In hair styling gel systems, KOPIROX may indirectly affect the viscosity of carbomer, acrylates or other rheology modifiers.
Ionic environment change can change the gel structure of some polymeric thickeners.
Therefore, pH and viscosity should be readjusted after active addition in gel formulations.
Use in hair oil is more difficult because Piroctone Olamine may not show high solubility in the pure oil phase.
Although Kumar Organic Products Limited specifies the application of hair oil, the actual system may require appropriate solvent, carrier or dispersion technology.
IS KOPIROX USED IN FOOD, COSMETICS AND PHARMACEUTICAL APPLICATIONS?
KOPIROX is the active ingredient Piroctone Olamine, mainly intended for the cosmetics and personal care industry.
Cosmetic use is the main commercial application of the product.
The European CosIng registry states anti-seborrheic and protective functions for Piroctone Olamine.
Anti-dandruff shampoo, conditioner, tonic and scalp care products are the main areas of use.
KOPIROX is not a product that is directly positioned as a food additive or food ingredient.
It should not be assumed that it will be used in food formulations.
Piroctone Olamine may have a pharmaceutical reference standard or different medical application research.
However, KOPIROX does not automatically mean that the commercial cosmetic raw material is drug grade or pharmacopeia quality.
For pharmaceutical use, GMP, pharmacopoeia, active ingredient file, impurity profile and relevant legislation must be verified separately.
Marketing a cosmetic product for dandruff or seborrheic scalp as "cures" or "cures disease" may exclude the product from the scope of cosmetics in some countries.
Therefore, claim language should be evaluated according to the target market.
INDUSTRIAL APPLICATIONS OF KOPIROX
The industrial use of KOPIROX is mainly based on its inclusion in the formulation as an active ingredient in the production of cosmetics and personal care.
The following functions may stand out in industrial KOPIROX applications:
Anti-dandruff shampoo production
Production of transparent shampoo
Opaque shampoo production
Scalp tonic production
Scalp lotion production
Hair conditioner production
Hair styling gel production
Hair oil products development
Hair mask production
Anti-seborrheic cosmetic product development
Supporting Malassezia control
Supporting scalp microbial balance
Helping to reduce dandruff flakes
Providing cosmetic protective function
Supporting scalp care claims
When adding KOPIROX to the formulation, complete dissolution of the active is the main technical goal.
The solubility problem in transparent shampoo is easily noticed visually.
In opaque or pearlescent systems, the insoluble may not be visible to the active eye.
Therefore, not only appearance but also microscopic or filtration-based control may be required.
The concentration of surfactant can affect the solubility of the active.
Anionic, amphoteric and nonionic surfactant ratios should be evaluated separately.
The addition of KOPIROX may affect the pure curve behaviour of the shampoo.
The NaCl level should not be determined prior to its active addition.
The most appropriate process approach is to make the final viscosity adjustment after all the assets are added.
The perfume and solubilizer system can also affect the dissolution environment of KOPIROX.
The presence of high amounts of electrolytes in the formulation may alter the risk of crystallization.
This is why low-temperature tests are important.
The following issues should be evaluated in the use of KOPIROX in industrial systems:
Exact trade product ID
PEARL
CAS number
Purity
Outlook
Color
Melting/degradation behavior
Solubility
Usage rate
Rinse-off/leave-on separation
Formulation pH
Surfactant system
Anionic surfactant level
Amphoteric surfactant level
Nonionic surfactant level
Alcohol content
Solubilizer
Electrolyte level
NaCl amount
Viscosity
Clarity
Low temperature stability
High temperature stability
Crystallization
Microbiological protection
Scalp tolerance
TDS
SDS
COA
Regulatory documents
WHAT PROBLEMS CAN KOPIROX HELP SOLVE?
KOPIROX can help meet various technical needs, especially regarding dandruff, scalp flaking, Malassezia control, and modern anti-dandruff shampoo formulations.
Visible dandruff on the scalp
Piroctone Olamine may help control the dandruff cycle associated with Malassezia.
Increased level of Malassezia
The antifungal and fungistatic properties of Piroctone Olamine may limit the growth of Malassezia species.
Disruption of scalp microbial balance
Current microbiome research shows that the dandruff scalp microbiota may change closer to the dandruff-free group after Piroctone Olamine shampoo.
Itching associated with dandruff
Reducing dandruff levels can also contribute to reducing the feeling of scalp itching.
In clinical trials, some formulations containing Piroctone Olamine showed improvement in pruritus scores.
Difficulty in developing transparent anti-dandruff shampoo
Some particulate or dispersed anti-dandruff actives make it difficult to create a transparent system.
Piroctone Olamine can be used in transparent shampoos with a suitable dissolving system.
The need for a Zinc Pyrithione alternative
Piroctone Olamine is one of the options that can be considered instead of ZPT due to its distinct antifungal active mechanism and solubility behavior.
However, it should not be substituted exactly at the same rate.
The need for combination with climbazole
The combination of Piroctone Olamine and Climbazole has been clinically studied.
Concomitant use may alter the total antifungal profile of the product.
Low scalp persistence in shampoo
Strong substantivity has been demonstrated in certain formulations containing Piroctone Olamine.
However, the persistence depends on the final formulation.
Crystallization in shampoo
In this case, increasing the asset ratio is not the right solution.
The solubilizer system, surfactant ratio, temperature, pH, and electrolyte charge should be re-evaluated.
Viscosity change in shampoo
KOPIROX can change the viscosity of salt-thickened systems by contributing to the ionic environment.
The amount of salt should be re-optimized after active addition.
Not every scalp or dandruff problem can be solved by the addition of KOPIROX alone.
The formulation, frequency of use, duration of contact and scalp factors of the user should be evaluated together.
THINGS TO CONSIDER WHEN USING COPIROX
Solubility, product type, usage concentration, pH and target country legislation are the basic technical criteria for the use of KOPIROX.
The following issues should be considered when using KOPIROX:
The Exact KOPIROX product must be verified.
INCI should be checked.
CAS No 68890-66-4 should be verified.
Purity must be checked.
Color and appearance should be examined.
Rinse-off or leave-on product type should be determined.
The legal maximum level of use should be checked.
The manufacturer's recommended dosage should be taken into account.
The active must be completely dissolved.
Crystallization should be checked for transparent products.
The formulation pH should be measured.
The surfactant system should be evaluated.
The electrolyte level should be checked.
NaCl addition should be optimized at the final stage.
Perfume and solubilizer compatibility should be tested.
Low temperature stability should be carried out.
High temperature stability should be carried out.
If a freeze-thaw test is required, it should be performed.
Scalp tolerance should be assessed.
Microbiological challenge testing should be done.
It should not be assumed that the preservative properties of Piroctone Olamine alone provide sufficient protection.
TDS should be examined.
SDS should be examined.
The COA should be checked.
Target market legislation should be verified.
The fact that KOPIROX is on the preservative list as Piroctone Olamine in the European Union does not mean that all cosmetic products do not need an additional preservative system.
The microorganism risk of the final formulation should be confirmed by challenge testing.
Due to the fact that Piroctone Olamine is a salt of monoethanolamine, the relevant restrictions on monoalkanolamines in Europe should also be considered in terms of formulation.
Issues such as use with nitrosating systems should be checked through the exact legislation text.
INITIAL FORMULATION APPROACHES FOR KOPIROX
The following examples are laboratory initial approaches designed to illustrate how KOPIROX can be evaluated in hair and scalp formulations. These are not validated commercial recipes or final formulas that can be transferred directly to mass production.
Kumar Organic Products Limited reports a recommended dosage of 1.0% for KOPIROX rinse-off products and 0.5% for other products.
The actual level of use should be determined according to target market legislation, product type, efficacy and tolerance data.
EXAMPLE 1: KOPIROX CLEAR ANTI-DANDRUFF SHAMPOO DOSAGE SCAN
Purpose: To compare the effect of KOPIROX level on clarity, viscosity, low-temperature stability, and scalp performance.
Starting components:
Deionized water: 61.5%
Anionic surfactant: 20.0%
Amphoteric surfactant: 10.0%
KOPIROX: 1.0%
Humectant: 3.0%
Solubilizer: 1.5%
Perfume: 0.3%
Protective system: 0.8%
NaCl: 1.5%
pH regulator: 0.4%
Total: 100%
Starting approach:
KOPIROX can be screened at several points, for example, down to low, medium and maximum suitable rinse-off level.
The regulatory limit should be checked for each product.
Application approach:
The water and surface active system are prepared.
KOPIROX is added to the system by the appropriate dissolution method.
Controlled stirring is applied until the active is completely dissolved.
Perfume and other auxiliary components are added.
pH is adjusted.
NaCl is added gradually at the last stage.
Viscosity is measured.
Clarity is evaluated.
5°C stability is applied.
Room temperature stability is monitored.
Accelerated stability of 40–45 °C is applied.
Crystallization is controlled.
Scalp efficacy test is planned for suitable samples.
EXAMPLE 2: KOPIROX + SALICYLIC ACID ANTI-DANDRUFF SHAMPOO SCREENING
Objective: To evaluate antifungal scalp control and keratolytic scaling control in the same system.
Starting components:
Water: 60.0%
Shampoo surfactant system: 30.0%
KOPIROX: 1.0%
Salicylic Acid: 2.0%
Salicylic Acid solvent system: 3.0%
Humectant: 2.0%
Perfume: 0.3%
Preservative: 0.8%
pH regulator: 0.9%
Total: 100%
Application approach:
Separate solubility strategies are determined for KOPIROX and Salicylic Acid.
The pH region where the actives do not precipitate is determined.
It is added to the Surfactant system in a controlled manner.
The final pH is measured.
The viscosity is adjusted.
Sedimentation is followed in a clear or opaque system.
Low temperature crystallization test is applied.
Challenge test is done.
Scalp tolerance is evaluated.
Dandruff and flaking performance are compared in a controlled user test.
EXAMPLE 3: KOPIROX SCALP TONIC / LEAVE-ON SCAN
Purpose: To evaluate KOPIROX solubility, clarity, and user feel in a low-viscosity leave-on scalp product.
Starting components:
Deionized water: 74.2%
KOPIROX: 0.5%
Ethanol or suitable solvent: 20.0%
Humectant: 3.0%
Scalp care assets: 1.0%
Preservative: 0.8%
pH regulator: 0.5%
Total: 100%
Application approach:
COPIROX is dissolved in the appropriate hydroalcoholic or other carrier phase.
The solution is added to the water phase in a controlled manner.
Clarity is observed.
pH is adjusted.
It is kept at room temperature.
Crystallization is checked at 5 °C.
At 40 °C, color and stability are evaluated.
Dry feeling and stickiness on the scalp are tested.
Leave-on tolerance assessment is made.
The necessary activity test for the target claim is planned.
ALTERNATIVES AND COMPARISON OF KOPIROX
When determining the KOPIROX alternative, one should not look solely at antifungal activity. Regulatory status, solubility, product appearance, pH compliance, scalp persistence, and target market should be evaluated together.
KOPIROX AND ZINC PYRITHIONE
Zinc Pyrithione is one of the classic antifungal actives that has been used in anti-dandruff shampoos for many years.
Piroctone Olamine and Zinc Pyrithione have different chemical structures.
Zinc Pyrithione is mostly formulated as a fine particle dispersion due to its low water solubility.
KOPIROX can be used dissolved in suitable systems.
For this reason, KOPIROX can provide a technical advantage in the development of transparent anti-dandruff shampoo.
In clinical trials, some formulations containing Piroctone Olamine have been compared to Zinc Pyrithione systems and have shown similar strong results in dandruff reduction.
Since the regulatory situation varies significantly by market, the two assets should not be evaluated solely on performance.
KOPIROX AND CLIMBAZOLE
Climbazole is an azole-structured antifungal cosmetic active.
KOPIROX is a hydroxypyridone derivative.
Both products can be used in anti-dandruff systems for Malassezia control.
Piroctone Olamine and Climbazole can also be formulated together.
In the clinical trial, the combination of 0.5% Piroctone Olamine + 0.45% Climbazole demonstrated effective dandruff control.
However, the regulatory limits and permitted product categories for Climbazole should be considered separately.
Two products should not be considered alternatives with the same weight directly.
KOPIROX AND KETOCONAZOLE
Ketoconazole is an antifungal active ingredient in the azole class and is used in pharmaceutical or medical anti-dandruff products in many markets.
KOPIROX is more commonly used as a cosmetic anti-seborrheic active.
Both products can have antifungal effects, but their regulatory status is not the same.
It is possible that the product containing ketoconazole is classified as a drug in many countries.
KOPIROX cosmetics can provide more convenient commercial positioning for scalp care products.
It should not be considered as a direct product equivalent.
KOPIROX AND CICLOPIROX OLAMINE
Ciclopirox Olamine also has antifungal chemistry close to the hydroxypyridone family.
Kumar Organic Products Limited's portfolio does not include this active KOPIROX, but as a separate product in the Kopcyclamine/Kopcyclo family.
Ciclopirox Olamine is actively used as a pharmaceutical antifungal in many markets.
Piroctone Olamine, on the other hand, has a more common position in cosmetic scalp care.
Due to the similarity in name, these two products should not be confused at the time of purchase.
KOPIROX AND SALICYLIC ACID
Salicylic Acid helps to remove the scales accumulated on the surface, mainly by keratolytic action in anti-dandruff products.
KOPIROX, on the other hand, predominantly targets the microbial factors associated with dandruff.
Therefore, the two raw materials are not direct alternatives.
When used together, microbial control and flaking control can be combined in the same formulation.
This combination has also been studied clinically.
QUALITY CONTROL AND PURCHASING CRITERIA FOR KOPIROX
When purchasing KOPIROX, only the name of Piroctone Olamine or the price should not be considered. The exact manufacturer's product, purity and impurity profile are important for cosmetic quality and formulation performance.
Recommended information to review before purchasing:
Full commercial product name
Manufacturer
KOPIROX product ID
PEARL
CAS number
EC/EINECS number
Purity / assay
Physical appearance
Color
Melting/degradation behavior
Moisture content
Ash content
Residual Piroctone or related impurities
Monoethanolamine level
Heavy metal limits
Resolution information
pH or pH in solution information
Batch number
Production date
Shelf life
Storage conditions
Packaging Type
Net quantity
Information of origin
TDS
SDS
COA
INCI document
Regulatory statements
EU Cosmetics Regulation compliance information
Cosmetics documents specific to the target market
The COA should show the assay and other critical quality values of the actual production batch.
TDS, or Product Bulletin, defines the dosage, application, and formulation characteristics of the product.
SDS are the essential source for safe handling, storage and physical hazards.
When buying KOPIROX, it should not be assumed that it is exactly equivalent to the product from another manufacturer under the general name "Piroctone Olamine".
Differences in purity, particle structure, color, and solubility can influence formulation behavior.
When switching to a new supplier, the clarity, viscosity, crystallization and efficacy properties of the shampoo should be compared.
STORAGE AND HANDLING OF KOPIROX
Storage: KOPIROX should be stored in dry, clean and tightly closed packaging.
Moisture protection: The powder product should be protected from unnecessary moisture contact. Moisture can affect the flow and clumping behavior of the product.
Light: It is good storage practice to protect it from long-term direct sunlight.
Temperature: The product should be stored under the temperature conditions recommended in the manufacturer's current SDS and technical documentation.
Contamination: Cross-contamination from other actives, pigments, fragrances or process raw materials should be avoided.
Opening the packaging: The packaging should be tightly closed again after use.
Dust control: Unnecessary ventilation should be avoided during weighing and transfer.
Transportation: The dangerous goods and transportation classification must be verified from the exact current KOPIROX SDS document.
Commercial packaging size and shelf life must be confirmed with the supplier prior to ordering.
KOPIROX SAFETY INFORMATION
KOPIROX is an active raw material of Piroctone Olamine used in low concentrations in cosmetic formulations.
When working with the powder product, unnecessary spreading of the powder into the eyes or respiratory area should be avoided.
Appropriate gloves and eye protection should be used.
In the safe use evaluation of KOPIROX, not only the general chemical name of the raw material but also the exact product SDS document should be taken as basis.
In the European Union, the use of Piroctone Olamine as a preservative is restricted under Annex V/35 to a maximum of 1.0% in rinse-off products and a maximum of 0.5% in other products.
The relevant Annex III conditions should also be considered during formulation due to the fact that it contains monoalkanolamine salt.
For the cosmetic final product, safety assessment, challenge test and legislative control appropriate to the target market should also be carried out.
WHAT TO CONSIDER WHEN BUYING KOPIROX?
In the supply of KOPIROX, first of all, it should be determined in which cosmetic system the product will be used.
The process and solubility requirements for shampoo, conditioner, scalp tonic and styling gel may not be the same.
If exact KOPIROX commercial quality is requested at the time of ordering instead of only "Piroctone Olamine", this must be clearly stated.
The following information should be clarified before purchasing:
Use sector
Final product type
Rinse-off or leave-on product
Target KOPIROX level
Target pH
Transparent or opaque product
Surfactant system used
Resolution requirement
Purity requirement
Color requirement
Particle characteristics
Residual impurity limits
Target country legislation
Manufacturer requirement
Origin requirement
Packaging Need
Estimated order quantity
Shelf life
The need for TDS
The need for SDS
The need for COA
Cosmetic legislation documents
If the existing product is to be substituted, the existing TDS and COA
The price of KOPIROX should not be compared only with the cost per kilogram.
The high purity of the asset, its dissolution in a transparent system, its ability to be used in low dosages and regulatory documentation can affect the total cost and product development process.
When evaluating an alternative Piroctone Olamine supplier, it should be noted that the same CAS number does not guarantee the same application performance.
KOPIROX SUPPLY FROM ATAMAN KIMYA
KOPIROX; It is a Piroctone Olamine-based cosmetic active used in anti-dandruff shampoo, conditioner, scalp tonic, hair care lotion, styling gel and different scalp care products.
Companies that want to get information about KOPIROX supply from Ataman Kimya can request information about product suitability, current supply conditions, packaging options and price offer by sharing their usage areas and target technical specifications.
The current stock status, manufacturer, origin, purity, packaging and other technical specifications of the product should be confirmed from Ataman Kimya before ordering.
Sharing the following information in the request for quotation facilitates the evaluation of the right KOPIROX product:
Use sector and end application
Shampoo, conditioner, tonic or leave-on product type
Rinse-off/leave-on information
Target utilization rate
Formulation pH
Transparency requirement
Surfactant system
Resolution expectation
Minimum purity requirement
Estimated order quantity
Type of packaging requested
Requested technical documents
TDS or COA information of the current Piroctone Olamine product, if applicable
FREQUENTLY ASKED QUESTIONS ABOUT KOPIROX
What is KOPIROX?
KOPIROX is an active anti-dandruff cosmetic based on Piroctone Olamine offered by Kumar Organic Products Limited.
What is KOPIROX INCI name?
The INCI name is Piroctone Olamine.
Who is the manufacturer of KOPIROX?
KOPIROX is a product of Kumar Organic Products Limited.
What is the CAS number of KOPIROX?
The CAS No is 68890-66-4.
What is the EC number of KOPIROX?
EC / EINECS No is 272-574-2.
What is the molecular formula of KOPIROX?
C₁₆H₃₀N₂O₃.
What is the molecular weight of KOPIROX?
It is approximately 298.42 g/mol.
What chemical does KOPIROX contain?
Piroctone contains Olamine.
What is Piroctone Olamine?
It is a hydroxypyridone derivative salt formed by piroctone and monoethanolamine in a 1:1 ratio.
What does KOPIROX do?
It is actively used as an antifungal/anti-seborrheic, which mainly helps in dandruff control and scalp care.
Is KOPIROX effective against Malassezia?
The antifungal and fungistatic effects of Piroctone Olamine on Malassezia species are supported by scientific studies.
Is KOPIROX used in shampoo?
Anti-dandruff shampoo is the most important application of the product.
Can KOPIROX be used in clear shampoo?
Kumar Organic Products Limited states that it can be used in transparent and opaque shampoos.
Is KOPIROX used in conditioner?
The manufacturer also specifies the conditioner application.
Can KOPIROX be used in hair tonic?
Hair tonic products are among the applications recommended by the manufacturer.
Is KOPIROX used in hair styling gel?
Hair styling gel is one of the manufacturer's specified uses.
Can KOPIROX be used in hair oil?
Kumar Organic Products Limited specifies the application of hair oil, but the solubility system must be specially designed.
What is the recommended use rate of KOPIROX?
The manufacturer recommends 1.0% for rinse-off products and 0.5% for other products.
What is the maximum utilization rate of KOPIROX in Europe?
Piroctone Olamine is listed as a preservative in Annex V/35 of the EU Cosmetics Regulation at a maximum level of 1.0% in rinse-off products and a maximum of 0.5% in other products.
Is KOPIROX easily soluble in pure water?
Its solubility is limited and depends on the formulation medium. The surfactant or suitable hydroalcoholic carrier system may facilitate dissolution.
Does KOPIROX affect shampoo viscosity?
It can change viscosity behavior, especially in salt-thickened surfactant systems.
Is KOPIROX the same as Zinc Pyrithione?
Their chemical structure, solubility, and regulatory profile are different.
Can KOPIROX be a Zinc Pyrithione alternative?
It can be considered as a technical alternative in anti-dandruff cosmetic products, but it should not be substituted at the same rate.
Is KOPIROX the same as Climbazole?
Piroctone Olamine is hydroxypyridone and Climbazole is an azole class antifungal active.
Can KOPIROX be used with Climbazole?
The combination of Piroctone Olamine and Climbazole has been clinically studied.
Can KOPIROX be used with Salicylic Acid?
Anti-dandruff shampoo systems containing Piroctone Olamine and Salicylic Acid have been evaluated in clinical trials.
Are KOPIROX and Ketoconazole the same?
Ketoconazole is common in antifungal systems with drug status, while KOPIROX cosmetic Piroctone Olamine is active.
Is KOPIROX protective?
Piroctone Olamine also has a preservative function in European CosIng. However, the exact preservative system requirement of the final product must be determined by challenge test.
Does KOPIROX alone protect shampoo?
This should not be assumed. Proper preservative system and challenge testing are required for the final formulation.
Does KOPIROX cure dandruff completely?
For the cosmetic product, no medical treatment claims should be made in this way. KOPIROX is used to help control dandruff formation and reduce visible flaking.
Is KOPIROX used against hair loss?
Some studies have reported improvement in hair loss measurements with shampoos containing Piroctone Olamine, but KOPIROX should not be considered directly as a hair loss medication.
Does KOPIROX increase hair thickness?
In a particular clinical study, an increase in mean hair diameter was reported in the group using 1% Piroctone Olamine shampoo. This result should not be directly translated into a product claim for all KOPIROX formulations.
What is the physical form of KOPIROX?
It is a white or almost white powder.
What is the melting point of KOPIROX?
A melting value of approximately 135 °C is reported for Piroctone Olamine.
What parameters should be checked when buying KOPIROX?
INCI, CAS, assay, appearance, impurities, solubility, and technical documentation are the key parameters.
What documents should be required when purchasing KOPIROX?
TDS or Product Bulletin, SDS, COA and cosmetic legislation documents should be requested.
How should KOPIROX be stored?
It should be stored in dry, clean and closed packaging, protected from moisture, contamination and temperature conditions not recommended by the manufacturer.
KOPIROX – TECHNICAL SUMMARY
KOPIROX is an anti-dandruff and scalp care active based on Piroctone Olamine offered by Kumar Organic Products Limited. The INCI name of the product is Piroctone Olamine, CAS No 68890-66-4 and EC No 272-574-2.
Piroctone Olamine is chemically the salt of piroctone and monoethanolamine in a 1:1 ratio. Its molecular formula is C₁₆H₃₀N₂O₃ and its molecular weight is approximately 298.42 g/mol.
The primary cosmetic function of KOPIROX is to aid in dandruff control and support scalp microbial balance. It is registered in the European CosIng system with the functions of Piroctone Olamine, Anti-Seborrheic and Preservative.
Piroctone Olamine helps control fungal activity associated with Malassezia. Current clinical and microbiome studies show that shampoos containing Piroctone Olamine can reduce dandruff scores and change the scalp microbiota towards a healthier profile.
KOPIROX; It can be used in shampoo, conditioner, hair tonic, scalp lotion, hair styling gel and hair care systems. Kumar Organic Products Limited positions the product as suitable for both transparent and opaque shampoos.
The manufacturer recommends a use level of 1.0% for KOPIROX in rinse-off products and 0.5% in other products. In the European Union, the maximum levels of Piroctone Olamine for use with preservative function are 1.0% in rinse-off products and 0.5% in other products.
It is important that the active is completely solubilized in the formulation. Especially in transparent shampoos, crystallization, clarity and long-term stability should be checked at low temperatures.
The addition of KOPIROX may alter the ionic balance and viscosity of the surfactant system. In shampoos thickened with salt, the NaCl level should be optimized after active addition.
KOPIROX Zinc Pyrithione is not the same chemical as Climbazole, Ketoconazole or Salicylic Acid. Some of these products can be considered as an alternative and some as a complementary scalp care ingredient.
When purchasing KOPIROX, exact manufacturer's product, INCI, CAS number, assay, appearance, solubility and batch-based COA information should be checked.
Companies planning to supply KOPIROX from Ataman Kimya are recommended to confirm the current product and offer conditions by sharing the final product type, rinse-off or leave-on use, target active level, formulation pH, surfactant system, transparency requirement, quantity and technical document needs.
