KOPYRROL

Kopyrrol is used in hair cosmetics to combat hair loss due to premature exhaustion of hair roots.
Kopyrrol is very effective in beard growth formulations.
Kopyrrol is used in hair-care products (such as shampoos, hair tonics, serums, scalp treatments) to help prevent hair loss and to stimulate hair growth.

CAS Number: 55921‑65‑8
EC / EINECS Number: Not listed in ECHA or public EC databases
INCI Name: Pyrrolidinyl Diaminopyrimidine Oxide
Molecular Formula: C₈H₁₃N₅O 
Molecular Weight: ~195.22 g/mol

SYNONYMS:
PYRROLIDINYL DIAMINOPYRIMIDINE OXIDE, 2,4-Diamino-6-pyrrolidinopyrimidine 3-oxide, 6-(1-Pyrrolidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(pyrrolidin-1-yl)pyrimidine-2,4-diamine 3-oxide, 2,4-PyriMidinediaMine,6-(1-pyrrolidinyl)-, 3-oxide, 2,6-diamino-4-(pyrrolidin-1-yl)pyrimidine 1-oxide, 3-oxy-6-pyrrolidin-1-yl-pyrimidine-2,4-diamine, PYRROLIDINYL DIAMINOPYRIMIDINE OXIDE ISO 9001：2015 REACH, 2,4-Diamino-6-pyrrolidinopyrimidine 3-oxide, 6-(1-Pyrrolidinyl)-2,4-pyrimidinediamine 3-oxide, Kopyrrol, Pyrrolidinyl Diaminopyrimidine Oxide, 6‑Pyrrolidino‑2,4‑diaminopyrimidine 3‑oxide, 2,6‑Diamino‑4‑(pyrrolidin‑1‑yl)pyrimidine 1‑oxide

Kopyrrol (Pyrrolidinyl Diaminopyrimidine Oxide) recovers weak follicle cells by supplying the nutrition that hair needs for growth and increases the volume of hair in growth stage.
Kopyrrol works at the level of hair root, which is responsible for a healthy scalp and hair.

Kopyrrol is very effective in beard growth formulations.
Kopyrrol is a white crystalline powder with a slight characteristic odor.
Kopyrrol is the trade name for Pyrrolidinyl Diaminopyrimidine Oxide, a molecule used primarily as a hair‑growth active ingredient in cosmetic and dermocosmetic formulations.

Kopyrrol's INCI name is Pyrrolidinyl Diaminopyrimidine Oxide.
Kopyrrol is often described as an analogue of minoxidil, but works via different (or additional) mechanisms in hair follicle biology.

Kopyrrol shows the same activity as the well known drug Minoxidil to stimulate follicular epithelial cells and to open the potassium channels of fibroblasts (in vitro data).
Kopyrrol can reverse the hair loss process and help hair regrowth.

The limitation of "Kopyrrol" is that it is practically insoluble in water which limits its use in the formulations having relatively low proportion of water and containing high concentrations of alcohol or poly alcohol are in general not well tolerated.
Alcohol present in topical preparations may dry the scalp, resulting in dandruff.

Combinations of hair growth stimulants Kopyrrol and a multifunctional compound which cannot only prevent hair loss but can stimulate new hair growth also.
Kopyrrol, also known as Pyrrolidinyl Diaminopyrimidine Oxide, is a synthetic small molecule widely used as an active ingredient in hair-care and dermocosmetic formulations.

Its chemical structure is a pyrimidine derivative with an N-oxide functional group, which gives Kopyrrol unique biological activity related to hair follicle support.
Kopyrrol is chemically related to compounds like Aminexil but differs in its pyrrolidinyl substitution, which may influence its solubility and interaction with scalp tissues.

Kopyrrol is similar to minoxidil in molecular structure, and has the effects of preventing hair loss, restoring hair follicle vitality, promoting hair growth, strengthening and fixing hair.
Physically, Kopyrrol is a pale white to off-white crystalline powder.

Kopyrrol has a molecular formula of C₈H₁₃N₅O and a molecular weight of approximately 195.22 g/mol.
The CAS number is 55921‑65‑8, although Kopyrrol may be listed under alternative trade or tautomeric names.
Kopyrrol is slightly soluble in water but more soluble in alcohols and glycols, making it suitable for incorporation into serums, lotions, tonics, and shampoo formulations.

Its decomposition temperature is reported around 278 °C, and Kopyrrol should be stored in a cool, dry, and light-protected environment to maintain stability.
Kopyrrol is a cosmetic-grade hair care ingredient approved by the US FDA.

Because Kopyrrol's molecular structure is very similar to Minoxidil, experiments have confirmed that Kopyrrol has similar effects.
In the United States, Kopyrrol can be used without a doctor's prescription; unlike Minoxidil, which is an indicated medication and requires a doctor's prescription to purchase from a pharmacy.

Propylene glycol ensures even dispersion of Kopyrrol; a 2-5% 
Kopyrrol is a structural analogue of minoxidil, which is considered to be one of the most effective means for hair growth today.
But Kopyrrol, unlike minoxidil, is not addictive and does not provoke withdrawal syndrome.

USES and APPLICATIONS of KOPYRROL:
Applications of Kopyrrol: Hair care products, personal care products.
Kopyrrol is an active substance with good anti-hair loss and hair growth effects.
Kopyrrol has high water solubility, is alcohol-free, and has a mild formula.

Kopyrrol is widely used in hair care products such as hair oil, hair cream, hair gel, scalp lotion, hair conditioner, hair growth agent, shampoo, seasonal hair loss treatment and other products.
Kopyrrol (Pyrrolidinyl Diaminopyrimidine Oxide) recovers weak follicle cells by supplying the nutrition that hair needs for growth and increases the volume of hair in growth stage.

Kopyrrol works at the level of hair root, which is responsible for a healthy scalp and hair.
Kopyrrol is used in hair cosmetics to combat hair loss due to premature exhaustion of hair roots.
Kopyrrol is very effective in beard growth formulations.

Kopyrrol is used in hair-care products (such as shampoos, hair tonics, serums, scalp treatments) to help prevent hair loss and to stimulate hair growth.
Kopyrrol is used in hair cosmetics to combat hair loss due to premature exhaustion of hair roots.

Kopyrrol as the effect of promoting the proliferation of dermal papillae cells.
Kopyrrol act as potassium channel opener.
Kopyrrol is an active ingredient, and thus inhibits general male-pattern or female pattern hair loss and promotes hair growth.

Suggested dosage level of Kopyrrol is 0.2 to 1.5%.
Kopyrrol can be used in the following formulations: Hair Conditioners, Hair Serum, Hair Shampoo, Hair Lotion, Hair Cream, Hair Spray, Eye Liner and Mascara.

Kopyrrol (pyrrolidino diamino pyrimidine oxide) is an active ingredient that promotes hair growth and protects against hair loss by rejuvenating hair follicles and providing necessary nutrients.
Up to 85% of men and 15% of women experience hair loss, which impacts self-esteem and confidence, making effective treatments essential.

Kopyrrol works at the hair root level, facilitating the transition between hair growth phases and is incorporated into various hair care products.
Kopyrrol (Pyrrolidinyl Diaminopyrimidine Oxide) recovers weak follicle cells by supplying the nutrients that hair needs for growth and increases the volume of hair in the growth stage.

Kopyrrol works at the level of the hair root, which is responsible for a healthy scalp and hair.
Kopyrrol is used in hair cosmetics to combat hair loss due to premature exhaustion of hair roots.
Kopyrrol is very effective in beard growth formulations.

Pyrrolidyl diaminopyrimidine oxide, also known as the Kopyrrol, is a new type of anti-hair deactivation substance.
The action mechanism of Kopyrrol is to repair the weakened hair follicle cells on the scalp, prolong the hair growth cycle, act on the deep structure of hair roots, stimulate hair regeneration, open the potassium channel, promote the proliferation of hair papilla cells, and achieve the purpose of strengthening hair and accelerating the growth of new hair.

Kopyrrol is currently the highest effective index component in the global anti-hair loss raw material library, and the data index is higher than minoxidil.
As a new anti stripping raw material, Kopyrrol has high water solubility, no alcohol and mild formula, and is often used in hair lotion, hair cream, hair conditioner, scalp lotion, hair spray and other anti stripping products.

Kopyrrol’s primary application is in hair-loss prevention and hair growth stimulation.
Kopyrrol's proposed mechanism involves supporting hair follicle cells and enhancing microcirculation around the hair root, which may promote the anagen (growth) phase of hair and reduce follicle miniaturization.

Kopyrrol may also influence collagen remodeling in the scalp, softening perifollicular tissue and improving hair anchoring.
Cosmetic formulations typically use Kopyrrol at concentrations ranging from 0.5% to 2%, depending on product type and desired effect.
Kopyrrol propylene glycol solution can be evenly distributed on the application site, is easily absorbed by the skin, and has been widely used to promote hair growth.

With daily use of Kopyrrol, results can be seen after several months, and the effect is only present during the period of use; there is no need to worry about subsequent problems after discontinuation.
5% Kopyrrol is recommended for men only; female users may experience excessive hair growth if using higher concentrations of Kopyrrol.

Kopyrrol can be incorporated into hair loss treatments in skincare products, providing comprehensive care for healthy hair in daily life.
In medical products, Kopyrrol is usually used in a dosage of 2% and 5%.
Kopyrrol helps restore weak hair follicle cells, adding nutrients necessary for growth and increasing hair volume.

Kopyrrol acts at the level of the hair roots, which is an important part of maintaining a healthy scalp.
Kopyrrol restores weak follicle cells, providing nutrients necessary for hair growth, enhances their growth and increases volume at the growth stage, affecting the deep structure of the roots.

Through the bloodstream, Kopyrrol acts at the level of the hair root, which is responsible for a healthy scalp and beautiful hair.
Kopyrrol is used in hair cosmetics to combat hair loss due to premature root depletion.
Also suitable for beard, mustache and eyebrow growth products.

Products with Kopyrrol can be left on, so it is suitable for making active serums and lotions.
Kopyrrol can be effectively added to shampoo (at a dosage of 5%), but this product already requires rinsing.

-Formulation Application of Kopyrrol: 
Recommended dosage: 2-5%, add to the aqueous phase below 45℃, soluble in propylene glycol, and has a solubility of 2% in 70% alcohol solution.
Kopyrrol can be used in shampoos, lotions, serums, and gels.
Kopyrrol helps restore weak hair follicle cells by adding nutrients needed for growth and increase the volume of the hair.

Kopyrrol acts at the hair root level which is an important part of keeping the scalp healthy and shiny hair.
Kopyrrol is suitable for preventing and reducing hair loss due to weak hair roots that cause premature hair loss.
and also effective in increasing germination in mustache growth products.

*Restore and nourish hair roots.
*Increase hair growth.
*Prevent hair loss.
*Helps to make hair strong from root to tip.
*Helps make hair thicker.

FUNCTIONS of KOPYRROL:
Kopyrrol promotes vasodilation around hair follicles, increases blood flow, improves scalp blood circulation and nutrient supply, and activates hair growth function.
Clinically proven, Kopyrrol can promote hair follicle growth, promote hair regrowth, prevent hair thinning, and prevent hair loss.
Preventing Hair Loss: 

Kopyrrol can improve existing hair loss problems, especially premature hair loss, which is common in young people.
Promoting Hair Growth: 
Kopyrrol can rebuild hair; where hair follicles are not necrotic, it can activate areas where hair growth has stopped or slowed, causing hair regrowth and preventing thinning.

CHARACTERISTIC of KOPYRROL:
Kopyrrol normalizes the condition of hair follicles;
Kopyrrol enhances hair growth;
Kopyrrol protects against hair loss;
Kopyrrol strengthens hair.

FUNCTIONS of KOPYRROL:
Anti-dandruff, anti-hair loss, hair growth agent, hair growth.
Kopyrrol improves blood circulation on the surface of the skin and provides the necessary nutrients and oxygen to the hair roots, thereby inhibiting hair loss, strengthening hair roots, and promoting hair growth.

The mechanism of action of Kopyrrol includes: repairing the weakened hair follicle cells of the scalp and prolonging the hair growth cycle; acting on the deep structure of the hair root to stimulate the regeneration of hair follicles; opening potassium ion channels and promoting the proliferation of hair papilla cells.

Kopyrrol has a similar molecular structure to Minoxidil and has the effects of preventing hair loss, restoring hair follicle vitality, promoting hair growth, and strengthening and fixing hair.

Kopyrrol is safer than minoxidil and has no side effects.
Kopyrrol has been approved for use in personal care products in Europe, the United States, and Japan, and can be used as a cosmetic raw material.

PROPERTIES of KOPYRROL:
Kopyrrol exhibits the same activity as the well-known Minoxidil in stimulating follicular epithelial cells and opening fibroblast potassium channels (in vitro data).
Kopyrrol can stop hair loss and promote hair regrowth.

Solubility: 
in water (proportions 7g water and 3g Kopyrrol), also soluble in ethanol (2% Kopyrrol and 98% ethanol).
Transparency of aqueous or ethanol solution: completely transparent.

BENEFITS of KOPYRROL:
The benefits of Kopyrrol include reducing hair shedding, increasing hair density, strengthening hair, and improving overall scalp and hair appearance.
Kopyrrol is compatible with a variety of cosmetic vehicles, although due to limited water solubility, careful formulation is required for stable aqueous solutions.
Some manufacturers offer water-soluble salts or microemulsion forms to improve dispersion in shampoos and tonics.
From a safety standpoint, Kopyrrol is intended for topical cosmetic use.

HANDLING of KOPYRROL:
Kopyrrol requires standard protective measures, including gloves, masks, and eye protection, as dust may cause irritation.
While Kopyrrol is generally considered safe in cosmetic concentrations, there is limited data on systemic effects, and long-term pharmacological safety outside topical application has not been fully established.

PROPER STORAGE AND FORMULATION of KOPYRROL:
Proper storage and formulation of Kopyrrol are important to maintain efficacy and reduce potential degradation.
Kopyrrol (Pyrrolidinyl Diaminopyrimidine Oxide) helps revitalize weakened hair follicles by providing the nutrients the hair needs for growth and increasing the volume of hair during the growth phase.

Kopyrrol works at the root level, which is responsible for strengthening the scalp and hair.
Kopyrrol is used in hair products to reduce hair loss due to weakened hair follicles leading to premature hair loss and is also very effective in beard growth products.

Kopyrrol's limitation is that it is almost insoluble in water, or only very sparingly, which limits its use in formulations with relatively low water content and high concentrations of alcohols or polyalcohols.
The alcohols present in Kopyrrol can dry out the scalp, leading to dandruff.

MECHANISM of KOPYRROL:
Kopyrrol is believed to support weak follicle cells, supplying “nutrition” at a cellular level to the hair root.
Kopyrrol may also improve microcirculation around the hair follicle, enabling better nutrient delivery.
Some reports suggest Kopyrrol prolongs the hair growth (anagen) phase, thereby increasing hair volume.

BENEFITS of KOPYRROL:
Kopyrrol helps reduce hair loss due to weak follicle root cells.
Increases hair “volume” by acting on the growth phase.
Kopyrrol can be formulated into various cosmetic products: tonics, serums, shampoos, sprays.

CHARACTERISTICS of KOPYRROL:
Not strongly water soluble; Kopyrrol requires specific formulation strategies.
Low to moderate molecular weight active, making Kopyrrol more bioavailable in topical formulations.
Kopyrrol is stable in typical cosmetic pH ranges and in solid form (when stored correctly).

ADDITIONAL NOTES of KOPYRROL:
There is also a Kopyrrol Aqua variant (a water‑soluble salt), used in formulations where water content is very high (up to ~95 %) for tonics, shampoos, etc.
There is research / formulation work to improve Kopyrrol's solubility: for example, a microemulsion system was developed in a study to enhance its solubility and make a stable topical formulation.
Because Kopyrrol is active in hair follicle biology, its efficacy and safety depend strongly on formulation: skin penetration, pH, vehicle, and co‑actives matter.

 
PHYSICAL and CHEMICAL PROPERTIES of KOPYRROL:
CAS Number: 55921‑65‑8 
Molecular Formula: C₈H₁₃N₅O 
Molecular Weight: ~195.22 g/mol (per ChemicalBook) 
Appearance: Pale white / off-white crystalline powder. 
Solubility: According to its supplier, it dissolves in a mixture: for example, ~2% solution in ethanol / water (70:30) is clear. 
Melting / Decomposition: Per ChemicalBook, decomposition at ~278 °C (melting point not clearly separately listed). 
Density: According to ChemicalBook, ~1.60 g/cm³. 

Storage: Should be stored protected from light, in a cool and dry place. Some suppliers recommend 2‑8 °C.
CAS Number: 55921‑65‑8 
Molecular Formula: C₈H₁₃N₅O 
Molecular Weight: ~195.22 g/mol (per ChemicalBook) 
INCI Name: Pyrrolidinyl Diaminopyrimidine Oxide
CAS No.: 55921-65-8
INCI Name: Kopyrrol, Pyrrolidinyl Diaminopyrimidine Oxide
Application: Hair conditioner, hair essence, shampoo, hair care cream, hair cream, hair gel, eyeliner pencil, eye black, etc

Appearance: White powder
Assay: 99.0%
Solubility: Water soluble
Function: Hair care
Shelf life: 2 years
Storage: Keep container tightly closed and in a cool place. Keep away from heat.
Dosage: 5.0%
Chemical Name / INCI: Pyrrolidinyl Diaminopyrimidine Oxide
CAS Number: 55921‑65‑8

Molecular Formula: C8H13N5O
Molecular Weight: ~195.22 g/mol
EC / EINECS Number: Not listed
Appearance: Pale white to off-white crystalline powder
Melting / Decomposition Point: ~278 °C (decomposition)
Density: ~1.60 g/cm³
Solubility: Slightly soluble in water; more soluble in alcohols and glycols
Chemical Type: Pyrimidine derivative with N‑oxide and pyrrolidinyl functional groups
Stability / Storage: Store in a cool, dry, light-protected environment; stable under normal conditions

FIRST AID MEASURES of KOPYRROL:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of KOPYRROL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of KOPYRROL:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of KOPYRROL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of KOPYRROL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of KOPYRROL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available