PRODUCTS

KTB/PTB (POTASSIUM TERT-BUTOXIDE)

CAS NUMBER: 865-47-4

EC NUMBER: 212-740-3

MOLECULAR FORMULA: C4H9KO

MOLECULAR WEIGHT: 112.21

IUPAC NAME: potassium;2-methylpropan-2-olate

KTB/PTB (Potassium Tert-Butoxide) is the chemical compound with the formula K+(CH3)3CO−.
This colourless solid is a strong base (pKa of conjugate acid around 17), which is useful in organic synthesis.

KTB/PTB (Potassium Tert-Butoxide) exists as a tetrameric cubane-type cluster.
KTB/PTB (Potassium Tert-Butoxide) is often seen written in chemical literature as potassium t-butoxide.
The compound is often depicted as a salt, and it often behaves as such, but it is not ionized in solution.

KTB/PTB (Potassium Tert-Butoxide) is used in the following products:
-laboratory chemicals
-pH regulators
-water treatment products

KTB/PTB (Potassium Tert-Butoxide) is used in- scientific research and development and formulation of mixtures or re-packaging.
KTB/PTB (Potassium Tert-Butoxide) is used for the manufacture of chemicals, rubber products and plastic products.

Preparation of KTB/PTB (Potassium Tert-Butoxide):
KTB/PTB (Potassium Tert-Butoxide) is commercially available as a solution and as a solid, but it is often generated in situ for laboratory use because samples are so sensitive and older samples are often of poor quality.
KTB/PTB (Potassium Tert-Butoxide) is prepared by the reaction of dry tert-butyl alcohol with potassium metal.
KTB/PTB (Potassium Tert-Butoxide) is obtained by evaporating these solutions followed by heating the solid.
KTB/PTB (Potassium Tert-Butoxide) can be purified by sublimation at 220 °C and 1 mmHg.
Sublimation can also take place at 140 °C and 0.01 hPa.
KTB/PTB (Potassium Tert-Butoxide) is advisable to cover the raw material with glass wool, as potassium tert-butanolate tends to "bounce", so parts can be thrown up during the sublimation.
The anhydrous removal using an inert sublimation apparatus is particularly advantageous.

Structure of KTB/PTB (Potassium Tert-Butoxide):
KTB/PTB (Potassium Tert-Butoxide) crystallises from tetrahydrofuran/pentane at −20 °C as [tBuOK·tBuOH]∞, which consists of infinite one-dimensional chains linked by hydrogen bonding.
KTB/PTB (Potassium Tert-Butoxide) affords the tetramer [tBuOK]4, which adopts a cubane-like structure.
Mild Lewis basic solvents such as THF and diethyl ether do not break up the tetrameric structure, which persists in the solid, in solution and even in the gas phase

Applications:
KTB/PTB (Potassium Tert-Butoxide) species is itself useful as a strong, non-nucleophilic base in organic chemistry.

KTB/PTB (Potassium Tert-Butoxide) is not as strong as amide bases, e.g. lithium diisopropylamide, but stronger than potassium hydroxide.
KTB/PTB (Potassium Tert-Butoxide)'s steric bulk inhibits the group from participating in nucleophilic addition, such as in a Williamson ether synthesis or an SN2 reaction.

Substrates that are deprotonated by KTB/PTB (Potassium Tert-Butoxide) include terminal acetylenes and active methylene compounds.
KTB/PTB (Potassium Tert-Butoxide) is useful in dehydrohalogenation reactions.

KTB/PTB (Potassium Tert-Butoxide) catalyzes the reaction of hydrosilanes and heterocyclic compounds to give the silyl derivatives, with release of H2.
KTB/PTB (Potassium Tert-Butoxide) is used in laboratory chemicals.

KTB/PTB (Potassium Tert-Butoxide) is also used for paint or stain related products
KTB/PTB (Potassium Tert-Butoxide) is used in pharmaceutical and medicine manufacturing

KTB/PTB (Potassium Tert-Butoxide) is used as a strong non-nucleophilic base in organic chemistry.
KTB/PTB (Potassium Tert-Butoxide) plays an active role in dehydrohalogenation reactions.

KTB/PTB (Potassium Tert-Butoxide) is also useful for greener amidation of esters.
KTB/PTB (Potassium Tert-Butoxide) serves as an intermediate in Mizoroki-Heck-type reactions.

Furthermore, KTB/PTB (Potassium Tert-Butoxide) is used as an initiator in anionic polymerization of carbazolyl-substituted oxiranes.
KTB/PTB (Potassium Tert-Butoxide) catalyzes the reaction of hydrosilanes and heterocyclic compounds to give the silyl derivatives with evolution of hydrogen.

KTB/PTB (Potassium Tert-Butoxide) is soluble in hexane, toluene, diethyl ether and terahydrofuran.
KTB/PTB (Potassium Tert-Butoxide) is used as a strong non-nucleophilic base in organic chemistry.

KTB/PTB (Potassium Tert-Butoxide) plays an active role in dehydrohalogenation reactions.
KTB/PTB (Potassium Tert-Butoxide) is used to prepare 3-potassiooxamethylpyridine catalyst.

KTB/PTB (Potassium Tert-Butoxide) is also used as a strong alkoxide base reagent.
KTB/PTB (Potassium Tert-Butoxide) is a strong, bulky base in organic chemistry that tends to give non-Zaitsev products in elimination reactions

KTB/PTB (Potassium Tert-Butoxide) solution is a strong non nucleophilic base.
KTB/PTB (Potassium Tert-Butoxide) is capable of deprotonating carbon and other Bronsted acids.

Reagent solutions in KTB/PTB (Potassium Tert-Butoxide) may be prepared by reacting anhydrous alcohol with potassium in nitrogen atmosphere.
KTB/PTB (Potassium Tert-Butoxide) is the chemical compound with the formula K+(CH3)3CO−.

KTB/PTB (Potassium Tert-Butoxide) is a strong base(pKa of conjugate acid around 17), which is useful in organic synthesis.
KTB/PTB (Potassium Tert-Butoxide) exists as a tetrameric cubane-type cluster.
KTB/PTB (Potassium Tert-Butoxide) is often seen written in chemical literature as potassium t-butoxide.

KTB/PTB (Potassium Tert-Butoxide) is an important kind of organic base with its alkalinity being stronger than potassium hydroxide.
Because of the induction effect of three methyl groups in the (CH3) 3CO-, it has stronger alkalinity and activity than other potassium alkoxides, thus being a very excellent catalyst.
In addition, as a kind of strong alkaline, KTB/PTB (Potassium Tert-Butoxide) is widely used in the organic synthesis of chemical, pharmaceutical, and pesticide such as trans-esterification, condensation, rearrangement, polymerization, loop opening and the production of heavy metal orthoester.

KTB/PTB (Potassium Tert-Butoxide) can be used to catalyze the Michael addition reaction, Pinacol rearrangement reaction and Ramberg-Backlund rearrangement reaction.
KTB/PTB (Potassium Tert-Butoxide) is used as a condensing agent, which can be used to catalyze Darzens condensation reaction and Stobbe condensation reaction.
KTB/PTB (Potassium Tert-Butoxide) is also the most effective alkaline for traditional akloxide-haloform reaction generating dihalogenated carbene.

Therefore, KTB/PTB (Potassium Tert-Butoxide) has attracted more and more attention from chemical, pharmaceutical, pesticide and other industries.
As KTB/PTB (Potassium Tert-Butoxide) has such a wide application, the domestic and international demand for high purity potassium tert-butoxide is very large.
However, due to its production cost is higher than other alkali metal alkoxides, the production technology needs to be improved, so in-depth study of potassium tert-butoxide is particularly important.

KTB/PTB (Potassium Tert-Butoxide) is a strong alkaline condensing agent with its alkalinity is stronger than sodium methoxide and sodium ethoxide.
At room temperature, KTB/PTB (Potassium Tert-Butoxide) is white or white-like solid powder with its chemical formula being (CH3) 3C-O-K, molecular weight being 112.21, density being 0.929, the melting point of 256-258°C and the boiling point being 275°C.
KTB/PTB (Potassium Tert-Butoxide) is easy to absorb moisture.

KTB/PTB (Potassium Tert-Butoxide) is soluble in tert-butanol with the solution being relative stable, and commonly used in the dehydrohalogenation reaction of halogenated hydrocarbon.
Being exposure to air decomposition, KTB/PTB (Potassium Tert-Butoxide) can be decomposed into potassium oxide and tert-butyl alcohol when coming across water.

KTB/PTB (Potassium Tert-Butoxide) can be manufactured through the reaction between butanol and potassium, followed by the vacuum distillation of tert-butanol in the system.
KTB/PTB (Potassium Tert-Butoxide) is used as a strong non-nucleophilic base in organic chemistry.
KTB/PTB (Potassium Tert-Butoxide) is widely used the condensation reaction, rearrangement and ring-opening reaction in organic synthesis.

People generally apply tert-butanol solution.
KTB/PTB (Potassium Tert-Butoxide) is a kind of organic alkaline corrosion products with strong moisture absorption property and should be sealed for storage. We need to pay attention to prevention of fire and sunshine during the storage and transportation.
KTB/PTB (Potassium Tert-Butoxide) should be stored in a cool, ventilated and dry place.

KTB/PTB (Potassium Tert-Butoxide), as a strong alkaline, is widely used in the condensation, rearrangement and ring opening reaction in organic production in the fields of chemical, pharmaceutical and pesticide.
KTB/PTB (Potassium Tert-Butoxide) can also be used:
-To synthesize aliphatic and aromatic amides from corresponding esters and amines.
-As a base in the intramolecular cyclization of aryl ethers, amines, and amides.
-As a catalyst to prepare styrene derivatives from aryl halides and alkenes by Mizoroki-Heck reaction.

KTB/PTB (Potassium Tert-Butoxide) is usually used for greener amidation of esters.
KTB/PTB (Potassium Tert-Butoxide) is used in the synthesis of many organic compounds primarily as a strong base.
In particular, KTB/PTB (Potassium Tert-Butoxide) is used as a reagent in the base- catalyzed carbonylation of amines for the synthesis of N-Formamides.

PHYSICAL PROPERTIES:

-Molecular Weight: 112.21

-Exact Mass: 112.02904639

-Monoisotopic Mass: 112.02904639

-Topological Polar Surface Area: 23.1 Å²

-Physical Description: Light yellow solid

-Chemical Classes: Metals -> Metal Alkoxides

-Melting point: 256 °C (493 °F; 529 K)

-Solubility in water: Reacts with water

-Solubility in diethyl ether: 4.34 g/100 g

-Solubility in Hexane: 0.27 g/100 g

-Solubility in Toluene: 2.27 g/100 g

-Solubility in THF: 25.00 g/100 g

KTB/PTB (Potassium Tert-Butoxide) exists as a tetrameric cubane-type cluster.
KTB/PTB (Potassium Tert-Butoxide) is often seen written in chemical literature as potassium t-butoxide.
KTB/PTB (Potassium Tert-Butoxide) is often depicted as a salt, and it often behaves as such, but it is not ionized in solution.

KTB/PTB (Potassium Tert-Butoxide) is used in laboratory chemicals
KTB/PTB (Potassium Tert-Butoxide) is used in pH regulators

CHEMICAL PROPERTIES:

-Hydrogen Bond Donor Count: 0

-Hydrogen Bond Acceptor Count: 1

-Rotatable Bond Count: 0

-Heavy Atom Count: 6

-Formal Charge: 0

-Complexity: 29

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 0

-Undefined Atom Stereocenter Count: 0

-Defined Bond Stereocenter Count: 0

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 2

-Compound Is Canonicalized: Yes

KTB/PTB (Potassium Tert-Butoxide) is also used for paint or stain related products
KTB/PTB (Potassium Tert-Butoxide) is used in pharmaceutical and medicine manufacturing
KTB/PTB (Potassium Tert-Butoxide) is used as a strong non-nucleophilic base in organic chemistry.

KTB/PTB (Potassium Tert-Butoxide) is used as a strong non-nucleophilic base in organic chemistry.
KTB/PTB (Potassium Tert-Butoxide) is also used as a strong alkoxide base reagent.

KTB/PTB (Potassium Tert-Butoxide) is a strong, bulky base in organic chemistry that tends to give non-Zaitsev products in elimination reactions
KTB/PTB (Potassium Tert-Butoxide) can be used to catalyze the Michael addition reaction, Pinacol rearrangement reaction and Ramberg-Backlund rearrangement reaction.

KTB/PTB (Potassium Tert-Butoxide) is used as a condensing agent, which can be used to catalyze Darzens condensation reaction and Stobbe condensation reaction.
KTB/PTB (Potassium Tert-Butoxide) is also the most effective alkaline for traditional akloxide-haloform reaction generating dihalogenated carbene.

KTB/PTB (Potassium Tert-Butoxide) is a strong alkaline condensing agent with its alkalinity is stronger than sodium methoxide and sodium ethoxide.
KTB/PTB (Potassium Tert-Butoxide) is soluble in tert-butanol with the solution being relative stable, and commonly used in the dehydrohalogenation reaction of halogenated hydrocarbon.

KTB/PTB (Potassium Tert-Butoxide) is widely used the condensation reaction, rearrangement and ring-opening reaction in organic synthesis.
KTB/PTB (Potassium Tert-Butoxide) is a kind of organic alkaline corrosion products with strong moisture absorption property and should be sealed for storage. We need to pay attention to prevention of fire and sunshine during the storage and transportation.
KTB/PTB (Potassium Tert-Butoxide), as a strong alkaline, is widely used in the condensation, rearrangement and ring opening reaction in organic production in the fields of chemical, pharmaceutical and pesticide.

KTB/PTB (Potassium Tert-Butoxide) can also be used to synthesize aliphatic and aromatic amides from corresponding esters and amines.
KTB/PTB (Potassium Tert-Butoxide) is usually used for greener amidation of esters.
KTB/PTB (Potassium Tert-Butoxide) is used in the synthesis of many organic compounds primarily as a strong base.

SYNONYMS:

Potassium tert-butoxide
865-47-4
Potassium tert-butanolate
Potassium T-butoxide
Potassium tert-butylate
potassium 2-methylpropan-2-olate
2-Methyl-2-propanol, potassium salt
potassium tert butoxide
potassium-tert-butoxide
potassium;2-methylpropan-2-olate
potassium t-butanolate
potassium 2-methyl-2-propanolate
potassium tertbutoxide
potassium tert.butoxide
potassium tert.-butoxide
potassium tert.-butanolate
potassium tertiary-butoxide
Potassium tert-butanolate;Potassium 2-methylpropan-2-olate
KOtBu
tert-butoxypotassium
potassium-t-butoxide
t-BuOK
Potassiumtert-butoxide
tert-Butoxide, potassium
t-butoxypotassium
KOtert-Bu
tBuOK
tert-BuOK
t-butoxy potassium
tert-butoxy kalium
potassium tbutoxide
potassiumt-butoxide
potassium-t-butoxid
EINECS 212-740-3
potassium t butoxide
potassium-t-butylate
KO-tBu
KOt-Bu
Potassium terbutoxide
tert-butoxy potassium
tert-C4H9OK
potasium-tert-butoxide
potassium ter-butoxide
potassium ter-butylate
potassium-t- butoxide
potassium-tert-butoxid
Potasium tert-butoxide
Potassium tert-butoxid
KO-t-Bu
tBuO-K+
(tert-butoxy)potassium
potassium-tert butoxide
tert-butyloxy potassium
potas-sium tert-butoxide
potassium -tert-butoxide
potassium tert -butoxide
potassium tert- butoxide
potassium tert- butylate
potassium tert-but oxide
potassium tert-but-oxide
potassium tert.but-oxide
potassium-tert. butoxide
Potassium tert. butoxide
t-BuO-K+
tertiary butoxy potassium
tertiary-butoxy potassium
potassium tertiarybutoxide
Potassium-tert-butanolate
potassium tert. butanolate
t-C4H9OK
potassium tertiary butoxide
C4H9KO
EC 212-740-3
potassium tertiary butanolate
(CH3)3COK
kalium 1,1-dimethyl ethoxide
KOC(CH3)3
potassium 1,1-dimethylethoxide
Potassium tert-butoxide solution
N-Butyllthum-potassum t-butoxde1
potassium (1,1-dimethylethoxide)
Potassium tert-butoxide 1.0M in THF
1M POTASSIUM TERT-BUTOXIDE in THF
2-Propanol, 2-methyl-, potassium salt (1:1)