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L- Citrulline Base is also produced from arginine as a byproduct of the reaction catalyzed by NOS family.
L- Citrulline Base is also prevalent in trichohyalin at the inner root sheath and medulla of hair follicles, where it is synthesized from arginine.
L- Citrulline Base is first oxidized into N-hydroxyl-arginine, which is then further oxidized to citrulline concomitant with release of nitric oxide.
CAS Number: 1021439-17-7
Molecular Formula: C6H13N3O3
Molecular Weight: 175.19
Synonyms: L-Citrulline-[5,5-d2], 1021439-17-7, [5,5-2H2]-L-Citrulline;L-Citrulline D2
L- Citrulline Base is a naturally occurring amino acid that is commonly found in foods like watermelon and is also synthesized in the body.
L- Citrulline Base is a non-essential amino acid, meaning the body can produce it on its own, primarily in the kidneys, from another amino acid called L-arginine.
However, it plays an important role in several physiological processes, particularly in the production of nitric oxide.
Nitric oxide is a vasodilator, meaning it helps to relax and widen blood vessels, improving blood flow throughout the body.
L- Citrulline Base itself does not directly produce nitric oxide; instead, it acts as a precursor, being converted into L-arginine, which is then used to produce nitric oxide.
This process is particularly beneficial for cardiovascular health, as enhanced blood flow can lower blood pressure, improve oxygen and nutrient delivery to tissues, and support overall circulation.
L-Citrulline base is widely used as a dietary supplement, especially among athletes and bodybuilders, due to its ability to improve exercise performance.
One of the main benefits of supplementing with L-Citrulline is its potential to reduce fatigue and enhance endurance during high-intensity workouts. This is primarily because L-Citrulline helps to eliminate ammonia from the muscles, a byproduct of exercise that contributes to muscle fatigue.
By reducing the buildup of ammonia, L-Citrulline helps to delay the onset of fatigue, allowing individuals to exercise for longer periods at higher intensities.
Additionally, L-Citrulline has been studied for its potential to increase the production of growth hormone during physical activity.
Growth hormone plays a crucial role in muscle repair, growth, and recovery, making L-Citrulline a valuable supplement for those looking to improve muscle mass and recovery times.
Some studies have suggested that supplementing with L-Citrulline can enhance the release of growth hormone and support faster recovery after intense exercise, making it a favored addition to post-workout regimens.
Citrulline can be derived from: from arginine via nitric oxide synthase, as a byproduct of the production of nitric oxide for signaling purposes from ornithine through the breakdown of proline or glutamine/glutamate from asymmetric dimethylarginine via DDAH.
Citrulline is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle.
The organic compound citrulline is an α-amino acid.
Its name is derived from citrullus, the Latin word for watermelon.
Although named and described by gastroenterologists since the late 19th century, it was first isolated from watermelon in 1914 by Japanese researchers Yatarō Koga and Ryō Ōtake and further codified by Mitsunori Wada of Tokyo Imperial University in 1930.
L- Citrulline Base has the formula H2NC(O)NH(CH2)3CH(NH2)CO2H.
It is a key intermediate in the urea cycle, the pathway by which mammals excrete ammonia by converting it into urea.
L- Citrulline Base is also produced as a byproduct of the enzymatic production of nitric oxide from the amino acid arginine, catalyzed by nitric oxide synthase.
L-Citrulline base is a versatile supplement with applications in improving exercise performance, supporting cardiovascular health, enhancing sexual function, and potentially boosting the immune system.
Its primary benefit lies in its ability to enhance blood flow and circulation, making it a valuable addition to athletic and health-focused regimens.
L- Citrulline Base is a metabolic intermediate within the urea cycle, which is the pathway by which mammals excrete ammonia by converting it into urea.
L- Citrulline Base is also produced as a byproduct of the enzymatic production of nitric oxide from the amino acid arginine, catalyzed by nitric oxide synthase.
In the yeast species Saccharomyces cerevisiae, citrulline is a metabolic intermediate in the latter, cytosolic half of the arginine biosynthesis pathway.
Several proteins contain citrulline as a result of a post-translational modification.
These citrulline residues are generated by a family of enzymes called peptidylarginine deiminases (PADs), which convert arginine into citrulline in a process called citrullination or deimination with the help of calcium ions.
Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histone proteins, whereas other proteins, such as fibrin and vimentin are susceptible to citrullination during cell death and tissue inflammation.
Circulating citrulline concentration is a biomarker of intestinal functionality.
L- Citrulline Base is sold as a dietary supplement, usually in powder form.
Advocates suggest that since L- Citrulline Base boosts nitric oxide production, helping arterial function and thus blood flow throughout the body, this might be helpful in treating or preventing various ailments.
Lowering blood pressure in people with elevated blood pressure.
Easing symptoms of mild-to-moderate erectile dysfunction, with fewer risks than Viagra.
Ameliorating circulatory problems such as slow wound healing due to diabetes.
Raising muscle protein levels, preventing malnourishment in the elderly and possibly improving athletic performance.
Treating intestinal problems, including short bowel syndrome, celiac disease and radiation-caused small bowel damage.
Various genetic disorders and health conditions such as liver disease, Parkinson's disease and certain dementias.
These assertions are based on animal studies, and like most dietary supplement claims have not be endorsed by the Food and Drugs Administration.
L- Citrulline Base is added to certain energy drinks such as Reign and touted for its thermogenic effects.
L- Citrulline Base is a naturally occurring amino acid found in watermelon and the human body.
It helps to increase energy levels and eliminates ammonia from the body.
L- Citrulline Base is required for the synthesis of L-arginine.
Health benefits of L-citrulline include boosting the immune system as well as enhancing the blood flow in body.
L- Citrulline Base is an amino acid found in watermelon.
L- Citrulline Base is also made in the body.
The body changes L-citrulline into another amino acid called L- Citrulline Base.
The name citrulline comes from Citrullus vulgaris, the Latin term for watermelon.
Unlike some amino acids, L- Citrulline Base isn't used to make protein, but it might help increase other chemicals the body needs to make protein.
It might also help improve blood flow and reduce blood pressure.
L- Citrulline Base is also explored for its potential health benefits in various clinical settings.
L- Citrulline Base has shown promise in improving symptoms associated with erectile dysfunction (ED), particularly in cases where ED is related to poor blood flow.
Since L- Citrulline Basee helps to increase nitric oxide production and improve blood circulation, it can potentially enhance erectile function by promoting better blood flow to the penis.
Some studies suggest that L- Citrulline Base may be as effective, if not more effective, than L-arginine in improving erectile function, making it a more desirable option for individuals looking for a natural supplement to support sexual health.
L- Citrulline Base base may have applications in supporting overall cardiovascular health.
Due to its vasodilatory effects, L- Citrulline Base can help lower blood pressure by improving blood flow and reducing the strain on the heart.
Some research indicates that L- Citrulline Base supplementation may help individuals with high blood pressure or other cardiovascular conditions by improving vascular health and promoting better circulation.
L- Citrulline Base base has been explored for its potential role in enhancing the immune system.
Its ability to promote better circulation and nutrient delivery to tissues may help support immune function, particularly during times of stress or recovery from illness.
Additionally, the amino acid plays a role in the urea cycle, which is essential for detoxifying ammonia and other metabolic waste products, further supporting overall health and well-being.
Uses:
L- Citrulline Base is an isotopic labelled compound of L-Citrulline (C535700).
L- Citrulline Base is an amino acid first isolated from the juice of watermelon Citrullus vulgaris Schrad., Cucurbitaceae.
L- Citrulline Base is used in the treatment of asthenia.
L- Citrulline Base is gaining attention for its potential role in improving immune function.
The amino acid may support the immune system by promoting better circulation and ensuring that nutrients and oxygen are efficiently delivered to tissues, which can be particularly beneficial during times of physical stress or after illness.
By supporting the body's natural detoxification processes, L- Citrulline Base helps in eliminating waste products from the body, potentially enhancing overall health and well-being.
L- Citrulline Base has also been studied for its potential to enhance growth hormone release during physical activity.
Growth hormone plays a crucial role in muscle development, recovery, and repair.
Some research suggests that L- Citrulline Base supplementation can increase the release of growth hormone during exercise, contributing to muscle growth and faster recovery.
This makes L- Citrulline Base a useful supplement for those looking to maximize the benefits of their workouts, particularly when aiming for improved muscle mass and strength.
L-Citrulline base is widely used for a variety of health and performance benefits, particularly due to its ability to enhance nitric oxide production, which improves blood circulation and cardiovascular function.
One of the most common uses of L- Citrulline Base is as a supplement to improve athletic performance. When taken before or during exercise, it helps increase blood flow to the muscles, delivering more oxygen and nutrients while flushing out metabolic waste products like lactic acid and ammonia.
This enhanced blood flow can reduce muscle fatigue, improve endurance, and support faster recovery, making L-Citrulline particularly popular among athletes, bodybuilders, and those involved in high-intensity training.
Studies have shown that supplementing with L- Citrulline Base can delay the onset of fatigue and extend the duration and intensity of physical activity by reducing the buildup of ammonia in the muscles, which is a byproduct of intense exercise.
L- Citrulline Base is also used to support cardiovascular health by improving circulation and lowering blood pressure.
As a precursor to L-arginine, which is then converted into nitric oxide, L- Citrulline Base plays a key role in vasodilation, the process that relaxes and widens blood vessels.
This can help reduce blood pressure in individuals with hypertension or those at risk for cardiovascular disease.
By promoting better blood flow, L- Citrulline Base supports healthy circulation, making it beneficial for individuals with poor blood circulation or those seeking to improve their overall vascular health.
In addition to its cardiovascular benefits, L- Citrulline Base is commonly used to improve erectile function. Since nitric oxide is essential for the relaxation of blood vessels in the penis, L-Citrulline has been studied for its ability to improve symptoms of erectile dysfunction (ED), especially in cases where ED is caused by poor blood flow.
Research has shown that L- Citrulline Base supplementation can increase nitric oxide production, improving blood circulation to the penis and thereby supporting better erectile function.
For some individuals, L- Citrulline Base may provide a more effective and natural alternative to other treatments for ED, such as prescription medications.
Another important use of L- Citrulline Base is in muscle recovery after intense physical activity.
After exercising, the body requires time to repair and rebuild muscle tissue.
L- Citrulline Base has been shown to enhance the recovery process by reducing muscle soreness and promoting the removal of metabolic waste products, such as lactic acid, which can contribute to post-workout muscle discomfort.
By accelerating the removal of these waste products and improving nutrient delivery to muscles, L- Citrulline Base helps to reduce delayed onset muscle soreness (DOMS) and can shorten recovery time between workouts, enabling athletes to train more frequently and intensely.
L- Citrulline Base may play a role in improving mental clarity and reducing fatigue.
By enhancing blood flow to the brain, L- Citrulline Base may support better oxygenation and nutrient delivery, which can improve cognitive performance, particularly in situations that require extended focus or mental exertion.
This makes L- Citrulline Base a potential supplement for individuals who need to maintain mental sharpness during periods of intense work or study.
Some preliminary research also suggests that L- Citrulline Base could help reduce symptoms of cognitive decline, such as in conditions like Alzheimer’s disease or age-related cognitive impairment, by improving blood circulation to the brain and supporting optimal brain function.
Another area where L- Citrulline Base is showing promise is in liver health.
L- Citrulline Base, through its conversion to arginine and subsequent nitric oxide production, may support liver function by improving blood circulation to the liver.
This can be especially important for individuals with liver conditions, such as fatty liver disease, where circulation may be impaired.
Enhanced blood flow ensures that the liver receives adequate nutrients and oxygen, helping it function more efficiently and repair any damage caused by the disease.
Additionally, L- Citrulline Base may have a detoxifying effect on the body by supporting the liver’s natural processes for breaking down and eliminating toxins.
For individuals who are undergoing intensive physical training or competing in endurance sports, L- Citrulline Base is often used as part of pre-workout supplementation routines.
L- Citrulline Base can help athletes push through intense physical exertion by increasing stamina and reducing the perception of fatigue during exercise.
This is particularly beneficial for long-distance runners, cyclists, and those participating in high-endurance activities, where the ability to maintain a consistent level of performance over time is critical.
L- Citrulline Base achieves this by promoting a more efficient use of energy, reducing the buildup of lactic acid and ammonia in muscles, and speeding up recovery after exercise.
L-Citrulline base is widely used for improving athletic performance, supporting cardiovascular health, enhancing erectile function, aiding muscle recovery, boosting immune function, and promoting the release of growth hormone.
Its ability to enhance nitric oxide production and improve blood flow is central to many of these benefits, making it a versatile supplement for individuals looking to improve overall health, fitness, and performance.
L- Citrulline Base is also being explored for its potential benefits in managing certain medical conditions, particularly those related to the circulatory system.
For individuals with chronic conditions like peripheral artery disease (PAD), L-Citrulline may offer therapeutic benefits by improving blood circulation and reducing symptoms like leg pain and fatigue.
Since the body’s ability to produce nitric oxide diminishes with age or due to certain health conditions, supplementing with L-Citrulline helps support vascular health and enhance circulation, potentially alleviating symptoms associated with poor peripheral blood flow.
L- Citrulline Base’s impact on nitric oxide production has led researchers to investigate its use in mitigating the symptoms of high blood pressure.
By promoting vasodilation (the relaxation and widening of blood vessels), L-Citrulline helps improve blood flow and lower blood pressure, which can be beneficial for individuals with hypertension or those at risk.
This makes it a valuable addition to the diet for individuals looking to manage blood pressure naturally, particularly in combination with other lifestyle changes such as increased physical activity and a balanced diet.
Additionally, some studies suggest that L- Citrulline Base supplementation may improve endothelial function, which is critical for maintaining healthy blood vessels and preventing atherosclerosis, a condition that can lead to heart disease.
L-Citrulline base has been incorporated into some skincare products for its potential to support skin health.
The improved blood circulation associated with L- Citrulline Base supplementation may contribute to healthier, more radiant skin by enhancing the delivery of oxygen and nutrients to skin cells.
Some studies also suggest that L- Citrulline Base may help reduce the appearance of wrinkles or skin aging by improving collagen production, which is vital for maintaining skin elasticity and strength.
While more research is needed in this area, the potential for L- Citrulline Base to contribute to skin rejuvenation through better circulation is an intriguing possibility.
L-Citrulline base extend beyond the realms of athletic performance and cardiovascular health.
Its ability to enhance nitric oxide production and improve blood flow has wide-ranging applications, from supporting cognitive function and liver health to offering potential benefits in the management of hypertension, peripheral artery disease, and even age-related conditions.
Whether used for its performance-enhancing properties, its support of cardiovascular function, or its potential therapeutic benefits in various health conditions, L-Citrulline base is a versatile compound with a growing number of uses in both health and wellness.
Safety Profile:
One of the most common side effects associated with L- Citrulline Base supplementation is gastrointestinal discomfort.
This can include symptoms such as bloating, diarrhea, nausea, or an upset stomach.
These side effects are typically mild and can be mitigated by reducing the dosage or taking the supplement with food.
However, in some cases, individuals may experience more severe digestive issues, which would require discontinuation of the supplement.
L- Citrulline Base works by increasing the production of nitric oxide, which helps dilate blood vessels and improve circulation.
While this can be beneficial for individuals with high blood pressure, it may not be suitable for those who already have low blood pressure.
Taking L- Citrulline Base in combination with blood pressure-lowering medications could potentially lead to dangerously low blood pressure levels (hypotension).
Individuals with hypotension or those on antihypertensive medications should consult their healthcare provider before using L-Citrulline to ensure it is safe.
L- Citrulline Base may interact with certain medications, particularly those used to treat cardiovascular conditions.
Since it promotes vasodilation (the widening of blood vessels), it could interact with medications like nitrates, PDE5 inhibitors (used for erectile dysfunction), and other vasodilators, potentially causing an excessive drop in blood pressure.
This interaction could lead to dizziness, fainting, or other serious complications.
L- Citrulline Base’s essential for individuals on these medications to consult their healthcare provider before using L-Citrulline.
There is some concern about the safety of L- Citrulline Base supplementation for individuals with kidney problems.
Since L- Citrulline Base is metabolized by the kidneys, individuals with pre-existing kidney conditions may be at risk of exacerbating their condition if they take high doses of the supplement.
L- Citrulline Base is crucial for individuals with kidney disease to seek medical advice before using L-Citrulline to ensure it does not negatively impact their health.
