PRODUCTS

L-ARGININE MONOCHLORIDE

L-Arginine Monochloride plays a role in the immune system and in the detoxification of nitrogenous wastes.
L-Arginine Monochloride is commonly used in cell culture media and drug development.
L-Arginine Monochloride is one of the major non-essential amino acids.

CAS Number: 1119‑34‑2
EC Number: 214‑275‑1
Molecular Formula: C6H14N4O2.ClH / C6H15ClN4O2
Molecular Weight: ~210.66 g/mol

SYNONYMS:
L‑Arginine HCl, L‑Arginine monohydrochloride, Arginine hydrochloride, Arg HCl, L‑α‑Amino‑δ‑guanidinovaleric acid hydrochloride, Levargin, Argivene, 1119-34-2, Arginine Hydrochloride, L-ARGININE HCL, R-Gene, R-gene 10, L-Arginine, monohydrochloride, F7LTH1E20Y, NSC-7914, NSC-203450, Hydrochloride, arginine, NSC203450, NSC7914, 214-275-1, L-Arginine hydrochloride, L-Arginine monohydrochloride, Arginine HCl, H-Arg-OH.HCl, 15595-35-4, MFCD00064550, Arginine monohydrochloride, Argamine, Argivene, Detoxargin, L-(+)-Arginine monohydrochloride, Levargin, Minophagen A, (S)-2-Amino-5-guanidinopentanoic acid hydrochloride, L-Arginine (hydrochloride), C6H15ClN4O2, L-(+)-Arginine Hydrochloride, L(+)-Arginine hydrochloride, Arginine monochloride, L-Arginine, hydrochloride (1:1), (2S)-2-amino-5-carbamimidamidopentanoic acid hydrochloride, L-arginine, hydrochloride, Tivortin, (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;hydrochloride, MFCD00166393, (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, R-gene (TN), Arginine, hydrochloride, L-, (+)-L-Arginine hydrochloride, L-Arginine hydrochloride (VAN), Arginine Hydrochloride [USAN:JAN], NSC 7914, EINECS 214-275-1, UNII-F7LTH1E20Y, NSC 203450, AI3-18300, (S)-(+)-Arginine hydrochloride, 2-Amino-5-guanidinopentanoic acid hydrochloride, L-Argininexhydrochloride, nBu-PArg(20)*HCl, nBu-PArg(50)*HCl, l-arginine monochlorhydrate, nBu-PArg(100)*HCl, Argininine monohydrochloride, EC 214-275-1, SCHEMBL44977, Arginine hydrochloride (USP), HY-N0455AR, orb1310400, CHEMBL1200381, SCHEMBL29361849, SCHEMBL30435515, CHEBI:31235, HY-N0455A, DTXSID20883650, L-Arginine hydrochloride (JP17), ARGININE HYDROCHLORIDE [MI], L-Arginine, monohydrochloride, L-, ARGININE, L-, HYDROCHLORIDE, ARGININE HYDROCHLORIDE [USAN], CCG-43265, s3174, ARGININE HYDROCHLORIDE [VANDF], AKOS015906195, AKOS015924214, ARGININE HYDROCHLORIDE [MART.], L-ARGININE HYDROCHLORIDE [JAN], ARGININE HYDROCHLORIDE [USP-RS], ARGININE HYDROCHLORIDE [WHO-DD], CS-2046, DS-2054, FA15785, L-Arginine (hydrochloride) (Standard), AC-23975, L-ARGININE MONOHYDROCHLORIDE [FCC], ARGININE HYDROCHLORIDE [ORANGE BOOK], DB-029943, A0528, ARGININE HYDROCHLORIDE [EP MONOGRAPH], CS-0368604, NS00085581, ARGININE HYDROCHLORIDE [USP MONOGRAPH], D01126, D70773, EN300-249105, Arginine Hydrochloride (L-Arginine Hydrochloride), L-Arginine monohydrochloride, Vetec(TM), 98.5%, SR-01000075479-3, (2S)-2-amino-5-guanidino-pentanoic acid;hydrochloride, Q27277776, L-Arginine hydrochloride, SAJ special grade, >=99.0%, L-Arginine monohydrochloride, BioUltra, >=99.5% (AT), L-Arginine monohydrochloride, Vetec(TM) reagent grade, >=98%, L-Arginine monohydrochloride, reagent grade, >=98% (HPLC), powder, Arginine hydrochloride, British Pharmacopoeia (BP) Reference Standard, Arginine hydrochloride, European Pharmacopoeia (EP) Reference Standard, L-Arginine monohydrochloride, certified reference material, TraceCERT(R), Arginine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material, L-Arginine monohydrochloride, not synthetic, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%, (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride, (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride, Arginine; Arg; 2-amino-5-guanidinovaleric acid; (S)-2-amino-5-[(aminoiminomethyl)-amino]pentanoic acid

L-Arginine Monochloride is a precursor of nitric oxide synthesis that induces vasodilation, thereby relaxing blood vessels.
L-Arginine Monochloride is an important intermediate in the urea cycle and involved in the detoxification of nitrogenous wastes.
L-Arginine Monochloride is the left-handed enantiomer of the amino acid arginine, an essential amino acid in juvenile humans.

L-Arginine Monochloride residues are common active site components in enzymes.
L-Arginine Monochloride is involved in nitric acid production, and many biological processes depend on it.
L-Arginine Monochloride (L-Arginine hydrochloride or arginine HCl, CAS # 1119-34-2) is the salt of the essential amino acid arginine.

L-Arginine Monochloride is a clean, water‑soluble salt form of L‑arginine used extensively in biochemical research and as a dietary precursor to nitric oxide.
L-Arginine Monochloride features high solubility and stability, with minimal toxicity or environmental concern at typical use levels.

Proper handling and storage of L-Arginine Monochloride mitigate dust and moisture-related issues.
L-Arginine Monochloride is a L-alpha-amino acid.
L-Arginine Monochloride is the hydrochloride salt form of arginine, an essential amino acid in juvenile humans.

Arginine is a complex amino acid, often found at active sites in proteins and enzymes due to its amine-containing side chain.
Arginine may prevent or treat heart and circulatory diseases, combat fatigue, and stimulate the immune system.
L-Arginine Monochloride also boosts production of nitric oxide, relaxing blood vessels, and treating angina and other cardiovascular problems.

Arginine is also an important intermediate in the urea cycle and in detoxification of nitrogenous wastes. (NCI04).
L-Arginine Monochloride is a small molecule drug with a maximum clinical trial phase of IV (across all indications) and is indicated for pituitary dwarfism and has 4 investigational indications.

L-Arginine Monochloride is an essential amino acid that is physiologically active in the L-form.
In mammals, L-Arginine Monochloride is formally classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.

Infants are unable to effectively synthesize arginine, making L-Arginine Monochloride nutritionally essential for infants.
Adults, however, are able to synthesize L-Arginine Monochloride in the urea cycle.

L-Arginine Monochloride can be considered to be a basic amino acid as the part of the side chain nearest to the backbone is long, carbon-containing and hydrophobic, whereas the end of the side chain is a complex guanidinium group.
With a pKa of 12.48, the guanidinium group is positively charged in neutral, acidic and even most basic environments.

Because of the conjugation between the double bond and the nitrogen lone pairs, the positive charge is delocalized.
This group is able to form multiple H-bonds.
L-Arginine Monochloride is an amino acid that has numerous functions in the body.

L-Arginine Monochloride is found in plant and animal proteins, such as dairy products, meat, poultry, fish, and nuts.
The ratio of L-Arginine Monochloride to lysine is also important - soy and other plant proteins have more L-arginine than animal sources of protein.
L-Arginine Monochloride is an essential amino acid that is physiologically active in the L-form.

USES and APPLICATIONS of L-ARGININE MONOCHLORIDE:
L-Arginine Monochloride is suitable for biochemistry and in vitro research.
L-Arginine Monochloride contains an α-amino group, an α-carboxylic acid group, and a side chain consisting of a 3-carbon aliphatic straight chain ending in a guanidino group.

L-Arginine Monochloride is a compound that functions as a precursor in the biosynthesis of proteins.
L-Arginine Monochloride plays a role in the urea cycle, where it is converted into ornithine, leading to the production of urea.
L-Arginine Monochloride is involved in the synthesis of nitric oxide, which acts as a signaling molecule in various physiological processes.

L-Arginine Monochloride serves as a substrate for enzymes involved in the production of polyamines, which are for cell growth and proliferation.
At the molecular level, L-Arginine Monochloride interacts with various enzymes and receptors, influencing their activity and downstream signaling pathways.

L-Arginine Monochloride's mechanism of action involves modulating the activity of nitric oxide synthase and arginase enzymes, as well as serving as a substrate for protein synthesis and polyamine production.
L-Arginine Monochloride contains an α-amino group, an α-carboxylic acid group, and a side chain consisting of a 3-carbon aliphatic straight chain ending in a guanidino group.

L-Arginine Monochloride is a semi-essential amino acid.
This dibasic amino acid, L-Arginine Monochloride, acts as a precursor for creatinine and is a natural constituent of most of the dietary proteins.

L-Arginine Monochloride is commonly used in cell culture media and drug development.
L-Arginine Monochloride plays a role in the immune system and in the detoxification of nitrogenous wastes.
L-Arginine Monochloride is commonly used in cell culture media and drug development.

L-Arginine Monochloride is one of the major non-essential amino acids.
L-Arginine Monochloride is commonly used for various bodily functions.
Basically, L-Arginine Monochloride is nothing but a synthetically created form of arginine, combining the amino acids along with the hydrogen chloride molecule.

Currently, L-Arginine Monochloride is available in capsule and powder form.
L-Arginine Monochloride is commonly used by athletes to increase the blood flow and oxygen delivery while exercising.
The hydrogen chloride is combined with the substance arginine to make the supplement palatable.

Plus, L-Arginine Monochloride is enhanced so that it can be absorbed by the digestive system.
Biochemistry / Cell Culture: L-Arginine Monochloride is widely used as a nitrogen donor, substrate in nitric oxide assays, or medium supplement in cell culture systems.

Clinical / Supplemental: L-Arginine Monochloride is employed to support cardiovascular health by promoting vasodilation, lowering blood pressure, improving symptoms of angina, peripheral arterial disease, and erectile dysfunction (though clinical use may require medical oversight).

Metabolic / Diagnostic: L-Arginine Monochloride is used in studies of urea cycle disorders, pituitary function, and ammonia detoxification.
L-Arginine Monochloride helps dispose of ammonia, is used to make compounds such as nitric oxide, creatine, L-glutamate, L-proline, and it can be converted to glucose and glycogen if needed.

In large doses, L-Arginine Monochloride also stimulates the release of hormones growth hormone and prolactin.
L-Arginine Monochloride is a known inducer of mTOR (mammalian target of rapamycin) and is responsible for inducing protein synthesis through the mTOR pathway.

mTOR inhibition by rapamycin partially reduces arginine-induced protein synthesis (A13142).
Catabolic disease states such as sepsis, injury, and cancer cause an increase in arginine utilization, which can exceed normal body production, leading to arginine depletion.

L-Arginine Monochloride also activates AMP kinase (AMPK) which then stimulates skeletal muscle fatty acid oxidation and muscle glucose uptake, thereby increasing insulin secretion by pancreatic beta-cells (A13143).

BENEFITS & KEY CHARACTERISTICS of of L-ARGININE MONOCHLORIDE:
*Highly water-soluble and stable salt form, ideal for biochemical preparations and oral formulations.
*Precursor for nitric oxide, essential in vascular physiology and blood flow regulation.
*L-Arginine Monochloride helps remove nitrogenous waste via urea cycle support.
*Pure enantiomeric form (L-arginine) ensures physiological compatibility.

KEY FUNCTIONS of of L-ARGININE MONOCHLORIDE:
L-Arginine Monochloride is the hydrochloride salt of L‑arginine, a semi‑essential amino acid.
The salt form of L-Arginine Monochloride enhances solubility and stability, making it widely used in biochemical applications.
L-Arginine Monochloride plays a central role in the urea cycle and nitric oxide (NO) synthesis—acting as a primary NO donor and vasodilator precursor.

WHY SHOULD YOU USE L-ARGININE MONOCHLORIDE?
There is a wide range of benefits in using the L-Arginine Monochloride.
Besides being one of the best performance enhancers for athletes, L-Arginine Monochloride has multiple usages.

As per various doctors, the benefit of L-Arginine Monochloride is treatment of congestive heart failure, reduction of bladder inflammation, lowering the chest pain especially for people suffering from coronary artery disease.

Also, L-Arginine Monochloride helps in the improving the functions of the kidney, treatment of erectile dysfunction, keeping a healthy body weight for individuals who are going through the muscle-wastage sickness like HIV.
Always make sure to consult your doctor before using L-Arginine Monochloride for the treatment of any of the above conditions.

WHO SHOULD USE L-ARGININE MONOCHLORIDE?
Many people commonly use the L-Arginine Monochloride for improving the functions of the kidney after the kidney transplant.
Also, people who want to avoid common cold, suffering from high blood pressure at the time of pregnancy (pre-eclampsia), improving the immune system of the body, etc use L-Arginine Monochloride.
Those athletics who aim at improving their performance and boosting their immune system can use L-Arginine Monochloride.
Some use the L-Arginine Monochloride for avoiding the inflammation of the digestive tracts among premature infants.

PHYSICAL and CHEMICAL PROPERTIES of L-ARGININE MONOCHLORIDE:
Appearance: White to almost white crystalline powder or crystals
Density: ~1.42 g/cm³ at 20 °C
Melting Point: >235 °C (decomposes)
Bulk Density: ~1250 kg/m³
Solubility: Highly soluble in water (~730 g/L at 20 °C),
slightly soluble in hot alcohol, insoluble in most organics
pH (1 M aqueous): ~5.5–7.0
Log Kow: Approximately between –8.5 and –3.24 (very hydrophilic)

Optical Rotation: [α]²⁰_D +22.0° ± 0.5° (c = 5% in 5 M HCl)
Stability: Stable under normal conditions; hygroscopic, incompatible with strong oxidizers;
will darken or decompose with moisture or heat
CAS Number: 1119‑34‑2
EC / EINECS Number: 214‑275‑1
PubChem CID: 517302 (Arginine HCl)
ChemSpider ID: Not specific, but related to arginine hydrochloride
Molecular Formula: C₆H₁₄N₄O₂·HCl

Molecular Weight: ~210.66 g/mol
Synonyms: L‑Arginine HCl, Arg HCl, Levargin, etc.
CAS / EC Number: 1119‑34‑2 / 214‑275‑1
Formula / Mw: C₆H₁₄N₄O₂·HCl; 210.66 g/mol
Appearance: White crystalline powder
Density: ~1.42 g/cm³ (20 °C)
Melting Point: >235 °C (decomp.)

Solubility: ~730 g/L in water (20 °C); hygroscopic
pH (1 M sol’n): 5.5–7.0
Log Kow: ~–8.5 to –3.24 (hydrophilic)
Primary Uses: Nitric oxide precursor; cell culture; supplements
Benefits: Water-soluble, stable, essential amino acid function
Handling & Storage: Keep dry, sealed; avoid dust; standard PPE
Classification: Not classified as hazardous under CLP
Molecular Weight: 210.66 g/mol

Hydrogen Bond Donor Count: 5
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 5
Exact Mass: 210.0883534 Da
Monoisotopic Mass: 210.0883534 Da
Topological Polar Surface Area: 128 Å²
Heavy Atom Count: 13
Formal Charge: 0
Complexity: 176

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 1
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes
CAS: 1119-34-2

IUPAC Name: hydrogen (2S)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid chloride
Molecular Formula: C6H15ClN4O2
InChI Key: KWTQSFXGGICVPE-WCCKRBBISA-N
SMILES: [H+].[Cl-].NC@@HC(O)=O
Molecular Weight (g/mol): 210.66
Synonym: arginine hcl
Appearance (Color): White
Identification (FTIR): Conforms

Optical Rotation: +22? ?1? (c = 5 in 5N HCl)
Assay (Titration ex Chloride): ≥98.0 to ≤102.0%
Water Content (Karl Fischer Titration): <1.0%
Form: Crystals or powder or crystalline powder
Empirical Formula (Hill Notation): C6H14N4O2 · HCl
CAS Number: 1119-34-2

Molecular Weight: 210.66
Beilstein: 3631658
EC Number: 214-275-1
MDL Number: MFCD00064550
UNSPSC Code: 12352209
PubChem Substance ID: 24890944
NACRES: NA.26
Physical state: powder
Color: white

Odor: odourless
Melting point/freezing point: Melting point: > 235 °C at ca.1.013 hPa - Decomposes before melting.
Initial boiling point and boiling range: ca.235 °C at ca.1.013 hPa - Decomposes on heating.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: Not applicable
Autoignition temperature: does not ignite
Decomposition temperature: No data available

pH: 5,5 - 7 at 211 g/l at 25 °C
Viscosity: Viscosity, kinematic: No data available, Viscosity, dynamic: No data available
Water solubility: ca.730 g/l at 20 °C - completely soluble
Partition coefficient: n-octanol/water: log Pow: -3,24 at 25 °C - (calculated) - Bioaccumulation is not expected.
Vapor pressure: < 0,0 hPa at 20 °C - OECD Test Guideline 104
Density: 1,42 g/cm3 at 20 °C
Relative density: No data available

Relative vapour density: No data available
Particle characteristics: No data available
Explosive properties: Not classified as explosive.
Oxidizing properties: none
Other safety information: No data available
Appearance: Crystalline powder
Physical State: Solid

Solubility: Soluble in water (211 mg/ml at 20° C), and hot alcohol (slightly).
Storage: Store at 4° C
Melting Point: 226-230° C
Boiling Point: 235° C (dec.) at 760 mmHg
Density: 1.42 g/cm3 at 20° C
Refractive Index: n20D ~1.60 (Predicted)
Optical Activity: α20D +22.0±0.5, c = 5 in 5 M HCl; α20D +22.5±0.5, c = 8 in HCl(1+1)

FIRST AID MEASURES of L-ARGININE MONOCHLORIDE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of L-ARGININE MONOCHLORIDE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of L-ARGININE MONOCHLORIDE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of L-ARGININE MONOCHLORIDE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of L-ARGININE MONOCHLORIDE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of L-ARGININE MONOCHLORIDE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available