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L-LEUCINE

CAS NUMBER: 61-90-5

EC NUMBER: 200-522-0

MOLECULAR FORMULA: C₆H₁₃NO₂ 

MOLECULAR WEIGHT: 131.17 g/mol

 


L-Leucine is one of the amino acids encoded by DNA. 
L-Leucine is a type of essential amino acid. 

The body cannot synthesize L-Leucine, L-Leucine must be taken from the outside with food. 
While L-Leucine is required for growth and development in children, L-Leucine is necessary for nitrogen balance in adults. 

L-Leucine participates in protein synthesis as in other types of amino acids. 
L-Leucine is one of the 3 essential amino acids that make up BCAA. 

L-Leucine is effective in the formation of many metabolic reactions in the body, such as balancing the feeling of hunger and satiety, regulating energy, insulin sensitivity and controlling the inflammation process. 
L-Leucine acts directly on muscle cells. 

L-Leucine is effective in reducing adiposity. 
L-Leucine functions in glucose homeostasis and creates resistance against obesity. 

L-Leucine is found in plant and animal protein sources. 
Especially soybeans, lentils, cow's milk, lamb, cow meat, chicken meat, fish, eggs, tofu and feta cheese are foods rich in leucine.

L-Leucine is one of the essential amino acids. 
L-Leucine cannot be synthesized in the body and must be taken from the outside. 

L-Leucine has two isomers. 
L-Leucines molecular mass is 131.18 g·mol−1. 

L-Leucine has low water solubility. 
L-Leucines melting point is between 293°C and 295°C. 

L-Leucine is one of the 3 amino acids that make up BCAA. 
L-Leucine is effective in the formation of many basic metabolic reactions in the body. 

L-Leucine ensures optimal growth and development for babies and children. 
L-Leucine takes part in maintaining the nitrogen balance in adults. Leucine acts directly on muscle and bone cells. 

L-Leucine plays a role in the protein breakdown and synthesis process that occurs in the muscles.
L-Leucine is an essential amino acid that is used in the biosynthesis of proteins. 

L-Leucine is an α-amino acid, meaning it contains an α-amino group, an α-carboxylic acid group, and a side chain isobutyl group, making it a non-polar aliphatic amino acid. 
L-Leucine is essential in humans, meaning the body cannot synthesize it.

L-Leucine must be obtained from the diet. 
L-Leucine is encoded by the codons UUA, UUG, CUU, CUC, CUA, and CUG.

Like valine and isoleucine, L-Leucine is a branched-chain amino acid. 
The primary metabolic end products of leucine metabolism are acetyl-CoA and acetoacetate; consequently, L-Leucine is one of the two exclusively ketogenic amino acids, with lysine being the other.

L-Leucine is the most important ketogenic amino acid in humans.
As a food additive, L-leucine has E number E641 and is classified as a flavor enhancer.

L-Leucine is a dietary amino acid with the capacity to directly stimulate myofibrillar muscle protein synthesis.
This effect of L-Leucine arises results from its role as an activator of the mechanistic target of rapamycin, a serine-threonine protein kinase that regulates protein biosynthesis and cell growth. 

The activation of mTOR by L-Leucine is mediated through Rag GTPases, leucine binding to leucyl-tRNA synthetase, leucine binding to sestrin 2, and possibly other mechanisms.
L-Leucine is a branched-chain amino acid (BCAA) since it possesses an aliphatic side-chain that is not linear.

L-Leucine had been subjected to circularly polarized synchrotron radiation to better understand the origin of biomolecular asymmetry. 
L-Leucine is one of nine essential amino acids in humans.

L-Leucine is important for protein synthesis and many metabolic functions. 
L-Leucine contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. 

L-Leucine also prevents breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. 
L-Leucine is available in many foods and deficiency is rare.

L-Leucine is the L-enantiomer of leucine. 
L-Leucine has a role as a plant metabolite, an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite, a human metabolite, an algal metabolite and a mouse metabolite. 

L-Leucine is a pyruvate family amino acid, a proteinogenic amino acid, a leucine and a L-alpha-amino acid. 
L-Leucine is a conjugate base of a L-leucinium. 

L-Leucine is a conjugate acid of a L-leucinate. 
L-Leucine is an enantiomer of a D-leucine. 

L-Leucine is a tautomer of a L-leucine zwitterion.
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.

L-Leucineis one of the essential amino acids since the body is not capable of producing it and it has to be obtained through food and supplementation.
L-Leucine is a precursor of amino acids such as alanine and glutamine and it favors the uptake of nutrients in the muscle cell and stimulates protein synthesis, thus acting on muscle growth processes and blood glucose control.

L-Leucine is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. 
L-Leucine contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. 

L-Leucine is widely used as an ingredient in infusion and infant formula.
L-Leucine is a branched-chain aliphatic essential amino acid in humans that is important for protein synthesis and many metabolic functions.

L-Leucine is an essential amino acid that has an important role in the growth and repair of muscle and bone tissue.
L-Leucine functions to preserve muscle glycogen and helps to prevent the breakdown of muscle proteins after trauma or severe stress.

L-Leucine is also involved in hemoglobin formation and metabolic functions. 
L-Leucine cannot be synthesized to meet the body's needs from simpler molecules, and therefore must be provided in the diet.

L-Leucine stimulates protein synthesis by the initiation of mRNA translation.
L-Leucine is an essential amino acid, specifically classified as a "branched-chain amino acid" (BCAA). 

L-Leucine makes them especially important for body builders and other athletes in sports that demand explosive strength.
L-Leucine is an essential amino acid is used in metabolism studies.

L-Leucine comes in the form of a white powder and is an essential amino acid found naturally in meat, dairy, eggs, soy and other foods. 
L-Leucine is used as a functional food additive and is thought to aid in weight loss and maintaining muscle mass.

L-Leucine is classified as an essential amino acid, meaning it must be obtained through dietary sources because the body can not make it. 
L-Leucine has been shown to inhibit protein breakdown and help maintain muscle mass.  

L-Leucine is the primary component of Branched Chain Amino Acids (BCAA’s), a popular supplement with bodybuilders to help build muscle mass.
L-Leucine plays an important role in boosting anabolic activity, which is the process of building muscle and tissues, and since the body cannot make it, it must be consumed through food or supplements. 

L-Leucine’s also important to your performance, helping to prevent muscle breakdown during exercise and promote repair and recovery after exercise.
L-Leucine is the most important of the 3 branched chained amino acids for initiating muscle protein synthesis which is necessary for muscle building and helps preserve muscle mass when you exercise or when your body becomes catabolic from dieting.

L-Leucine may help fight fatigue after training by reducing the amount of the amino acid tryptophan from getting into the brain, which can make you feel tired during and after training.
L-Leucine has been shown to preserve muscle mass under highly catabolic conditions where protein breakdown and muscle wasting could occur.

During exercise, breakdown of L-Leucine into energy is increased which helps reduce muscle breakdown. 
By providing supplemental L-Leucine, the body is less likely to consume its own amino acid (protein) stores.

L-Leucine is a type of amino acid that is derived from reactions taking place between pancreatic enzymes and protein.
L-Leucine also keeps lean muscle tissue intact during exercise and keeps levels of nitrogen in the body at a balanced level.

L-leucine is one of the eight essential amino acids, and belonging to the aliphatic amino acids within twenty kinds of proteins. 
L-leucine and L-isoleucine and L-valine are called three branched chain amino acids. 

L-leucineLeucine and D-leucine are enantiomers.
L-Leucine is a white shiny hexahedral crystal or white crystalline powder at room temperature , Odorless, slightly bitter.

In the presence of hydrocarbons, L-Leucine is stable in the aqueous mineral acid. 
L-Leucine can promote insulin secretion, can lower blood sugar; promote sleep, reduce sensitivity to pain, migraine headaches, anxiety and ease tension, reduce symptoms of chemical reactions disorder in the body caused by alcohol , and helps control alcoholism; it has a role in the treatment of dizziness , also can promote skin wound and bone healing, so doctors usually advise patients to take leucine supplements after surgery. 

L-Leucines are often formulated to be used in the treatment or health care.
L-Leucine can also be used as food, cosmetics and feed additives and plant growth promoter.

L-Leucine belongs to the essential amino acids,and adult men requirement is 2.2g/d. 
L-Leucine is necessary in normal growth for infants and maintaining normal nitrogen balance for adults.

L-Leucine is used as a nutritional supplement,an amino acid infusion preparation and a comprehensive amino acid preparation,a hypoglycemic agent, a plant growth promoter.
L-Leucine is sparingly soluble in alcohol, but is soluble in dilute hydrochloric acid and in solutions of alkali hydroxides and carbonates. 

L-Leucine may be synthesized by bromination, followed by amination of isocaproic acid.
L-Leucine plays a vital role in hemoglobin formation, protein synthesis and metabolic functions. 

L-Leucine assists the growth and repair of muscle and bone tissue. 
L-Leucine is used in the treatment.

L-Leucine prevents the breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. 
L-Leucine is also used as a food additive and flavor enhancer. 

L-Leucine is used to preserve muscle glycogen.
L-Leucine is used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

L-Leucine acts as a nutrient signal to stimulate protein synthesis. 
L-Leucine has also activates the mammalian target of rapamycin kinase that regulates cell growth.

 


APPLICATION:

-L-Leucine is used in the biosynthesis of proteins

-In vivo studies show that L-Leucine can be used when gene defects lead to an organism's inability to metabolize the amino acid phenylalanine

-L-Leucine also contributes to the regulation of blood-sugar levels, growth hormone production, and wound healing

-In research experiments this compound has been used as an activator of the mammalian target of rapamycin (mTOR)

 

PHYSICAL AND CHEMICAL PROPERTIES:

-Density: 1.17 g/cm3 (20 °C)

-Melting Point: 293 °C (decomposition)

-pH value: 5.5 - 6.5 (20 g/l, H₂O, 20 °C)

-Vapor pressure: <1 hPa (20 °C)

-Bulk density: 300 - 400 kg/m3

-Solubility: 18.9 g/l

 

SPECIFICATION:

-Formula Weight: 131.17

-Sublimation Point: 145.0 °C

-Specific Rota: +15.40 

-Melting Point: 286.0°C to 288.0°C

 


STORAGE:

Store at +5°C to +30°C.

 

SYNONYM:

61-90-5
(S)-2-Amino-4-methylpentanoic acid
(S)-Leucine
H-Leu-OH
(2S)-2-amino-4-methylpentanoic acid
(S)-(+)-Leucine
Leucin
L-Norvaline, 4-methyl-
(S)-2-Amino-4-methylvaleric acid
L-alpha-Aminoisocaproic acid
Leucin 
leu
Leucine 
LEUCINE, L-
Leucinum
(2S)-alpha-leucine
L-(+)-Leucine
L-(-)-2-Amino-4-methylpentanoic acid
L-leucin
Leucine 
Leucinum
Leucina 
FEMA No. 3297
Leucina 
alpha-Aminoisocaproic acid

 

 

 

 

 

 

 

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