PRODUCTS

LACTITOL

CAS NO:585-86-4
EC NO:209-566-5

Lactitol is a sugar alcohol used as a replacement bulk sweetener for low calorie foods with 30–40% of the sweetness of sucrose.
Lactitol is also used medically as a laxative.

Chemical and physical data:
Formula:   C12H24O11
Molar mass:   344.313 g·mol−1
Melting point:   146 °C (295 °F)

Lactitol is used in a variety of low food energy or low fat foods. High stability makes it popular for baking.
Lactitol is used in sugar-free candies, cookies (biscuits), chocolate, and ice cream, with a sweetness of 30–40% that of sucrose.
Lactitol also promotes colon health as a prebiotic. Because of poor absorption, lactitol only has 2–2.5 kilocalories (8.4–10.5 kilojoules) per gram, compared to 4 kilocalories (17 kJ) per gram for typical saccharides. Hence, lactitol is about 60% as caloric as typical saccharides.

Medical
Lactitol is listed as an excipient in some prescription drugs.

Lactitol is a laxative and is used to prevent or treat constipation, e.g., under the trade name Importal.

In February 2020, Lactitol was approved for use in the United States as an osmotic laxative for the treatment of chronic idiopathic constipation (CIC) in adults.

Lactitol in combination with Ispaghula husk is an approved combination for idiopathic constipation as a laxative and is used to prevent or treat constipation.

Lactitol is a glycosyl alditol consisting of beta-D-galactopyranose and D-glucitol joined by a 1->4 glycosidic bond.
Lactitol is used as a laxative, as an excipient, and as replacement bulk sweetener in some low-calorie foods.
Lactitol has a role as a laxative, an excipient and a cathartic.

Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from [lactose].
Lactitol is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. [sucrose]). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides such as [lactulose], in the treatment of hepatic encephalopathy in patients with cirrhosis. Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in chronic idiopathic constipation in February 2020.

Lactitol is used as a noncariogenic replacement for sucrose.
Lactitol is also used as a diluent in solid dosage forms. A direct-compression form is available, as is a direct-compression blend of lactose and lactitol.

Lactitol is used to treat chronic idiopathic (unknown cause) constipation (CIC). Lactitol works by increasing peristalsis (contractions) in the colon, leading to an increase in the number of bowel movements.
Lactitol is an orally administered osmotic laxative used to treat chronic idiopathic constipation.
Lactitol is an odorless, colorless, sweet, nonhygroscopic, and stable sugar alcohol.

Lactitol is used in constipation.
Lactitol, a sugar alcohol derived from lactose (milk sugar), is a versatile, reduced calorie sweetener.

Lactitol is used to treat constipation.
Lactitol is also used to prevent the loss of brain function due to liver damage by removing certain toxic chemicals from the blood.

Lactitol is a member of the family of bulk sweeteners known as polyols ( sugar alcohols ).

Lactitol was first discovered in 1920, but it wasn’t until the 1980’s when it was first used in foods as a reduced-calorie sweetener.

Despite only being 40% as sweet as sucrose, the sugar alcohol is very similar in taste.

Due to its stability, solubility, low calorie value and similar taste to sucrose, lactitol can be used in a range of low-calorie, low-fat and/or sugar-free foods such as:

Chocolate
Ice cream
Baked goods
Hard and soft candies
Chewing gums and
Sugar substitutes

Lactitols mild sweetness also makes it suitable for blending with other low-calorie sweeteners that are several hundred times sweeter than sucrose, but do not provide the necessary volume.

Lactitol is produced by reducing the glucose part of the disaccharide lactose.
Lactitol is not hydrolysed or absorbed in the small intestine.

Benefits of Lactitol
The benefits of lactitol include:

Mild sweet flavour with no aftertaste
Lactitol has a clean sweet, sugar-like taste, which allows it to be mixed with other low-calorie sweeteners.

The relative sweetness of lactitol rises as its concentration in a food is increased and it leaves no aftertaste.

Low in calories
Lactitol is metabolised in the large intestine and yields roughly 2 calories per gram compared to a typical carbohydrate (or sugar) which contributes the usual 4 kcal/g.

In Europen, the EU Nutrition Labelling Directive states that all sugar alcohols, including lactitol, have a caloric value of 2.4 kcal/g.

Lactitol, a polyol (sugar alcohol), is currently used as a bulk sweetener in calorie-controlled foods. Discovered in 1920, it was first used in foods in the 1980’s.
Lactitol has a clean sweet taste that closely resembles the taste profile of sucrose.
Lactitol has only 40 percent of sucrose’s sweetening power.

Sweet and clean taste:
Lactitol has a clean sweet, sugar-like taste with no aftertaste. The relative sweetness of lactitol rises as its concentration in a food is increased.
Lactitols mild sweet taste allows other flavors to be clearly perceived.
Lactitol is a white crystalline powder.

High quality low-calorie foods:
Lactitol’s many attributes as a bulk sweetener with mild sweetness make it a versatile ingredient for high quality low-calorie, low-fat and sugar-free foods.
Lactitol is not hygroscopic, meaning it will not absorb moisture into products, will maintain crispness and extend the shelf life of cookies and chewing gum.
Lactitol also has similar solubility to glucose, is stable in acid and alkaline conditions and remains stable under the high temperatures of food processing. Due to lactitol’s mild sweetness profile, it can be paired with low-calorie sweeteners commonly used in today’s low-calorie, sugar-free foods (e.g. acesulfame K, aspartame, neotame, saccharin and sucralose).

Low in calories:
Lactitol is not metabolized like a typical carbohydrate (or like sugar) and therefore does not contribute the usual 4 calories per gram.
Lactitol is metabolized in the large intestine and yields, according to tests, only 2 calories per gram. This value has been accepted for labeling purposes in the U.S. by the FDA. The EU Nutrition Labeling Directive states that all sugar alcohols, including lactitol, have a caloric value of 2.4 calories per gram.

Improving gut health:
Lactitol is fermented in the colon and consequently has beneficial effects on the colonic microflora. A reduction in the pH of the colon, along with an increase in probiotic bacteria and a significant reduction in potential pathogens emphasizes the beneficial effects of lactitol. In essence, lactitol functions as a prebiotic.

Lactitol is a sugar alcohol or polyol obtained from the catalytic hydrogenation of lactose. Although lactitol is commonly used to deliver sweetness at low caloric value, lactitol is a multipurpose compound having various applications in the field of food, dairy, and pharmaceutical.

Lactitol is primarily used for the treatment of constipation and hepatic encephalopathy.
Lactitol is a synthetic disaccharide.

Lactitol is a disaccharide binding a beta-D-galactopyranose and D-glucitol to produce the sugar alcohol also known as Lactitol.
Lactitol’s derived from lactose, a product of disaccharide’s glucose being reduced.
Lactitol has been used as a laxative agent, excipient, and low-calorie artificial sweetener. Other characteristics of Lactitol display antibiotic and prebiotic activity.

Lactitol is an artificial sugar alcohol currently used as a bulk sweetener in calorie-controlled foods.

Lactitol is listed as an excipient in some prescription drugs, such as Adderall. Lactitol is a sugar alcohol used as a replacement bulk sweetener for low calorie foods.
Lactitol is also used medically as a laxative.

About Lactitol
Helpful information
Lactitol is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 to < 10 tonnes per annum.

Lactitol is used by consumers, by professional workers (widespread uses) and in formulation or re-packing.

Consumer Uses
Lactitol is used in the following products: cosmetics and personal care products.
Other release to the environment of Lactitol is likely to occur from: indoor use as processing aid.
Article service life
ECHA has no public registered data on the routes by which Lactitol is most likely to be released to the environment. ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

Widespread uses by professional workers
Lactitol is used in the following products: cosmetics and personal care products.
ECHA has no public registered data on the types of manufacture using Lactitol. Other release to the environment of Lactitol is likely to occur from: indoor use as processing aid.
Formulation or re-packing
Lactitol is used in the following products: cosmetics and personal care products. Release to the environment of Lactitol can occur from industrial use: formulation of mixtures.

Uses at industrial sites
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the types of manufacture using Lactitol. ECHA has no public registered data on the routes by which Lactitol is most likely to be released to the environment.

Manufacture
ECHA has no public registered data on the routes by which Lactitol is most likely to be released to the environment.

Lactitol is primarily used for the treatment of constipation and hepatic encephalopathy.
Lactitol is a synthetic disaccharide.
Lactitol is similar to a lactulose-like glucose molecule that contains galactose and sorbitol.

IUPAC names
(2S,3R,4R,5R)-4-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexane-1,2,3,5,6-pentol
4-O-beta-D-galactopyranosyl-D-glucitol
D-Glucitol, 4-O-b-D-galactopyranosyl-

SYNONYMS:
Lactositol
209-566-5 [EINECS]
4-O-b-D-galactopyranosyl-D-glucitol
4-O-β-D-Galactopyranosyl-D-glucitol [ACD/IUPAC Name]
4-O-β-D-Galactopyranosyl-D-glucitol [German] [ACD/IUPAC Name]
4-O-β-D-Galactopyranosyl-D-glucitol [French] [ACD/IUPAC Name]
585-86-4 [RN]
6414
D-glucitol, 4-O-b-D-galactopyranosyl-
D-Glucitol, 4-O-β-D-galactopyranosyl-
D-Glucitol, 4-O-β-D-galactopyranosyl- [ACD/Index Name]
D-lactitol
E 966
Finlac DC
L2B0WJF7ZY
Lactit
Lactit M
Lactite
lactitol [Portuguese]
Lactitol [Wiki]
LACTITOL ANHYDROUS
Lactobiosit
MFCD00079407
Miruhen
no translation
(2S,3R,4R,5R)-4-(((2S,3R,4S,5R,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,5,6-pentaol
(2S,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol
(2S,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxyhexane-1,2,3,5,6-pentol
(2S,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxyhexane-1,2,3,5,6-pentol
(2S,3R,4R,5R)-4-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]hexane-1,2,3,5,6-pentol
[585-86-4]