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Lanette 22 shortens the duration of symptoms of cold sores and fever blisters but does not provide symptomatic relief.
Lanette 22 is a behenyl alcohol that is used for viscosity regulation in cosmetic and pharmaceutical oil-in-water emulsions, on account of its consistency giving characteristics.
Lanette 22 is a white to light yellowish hydrophilic wax that is supplied in pellets.
CAS Number: 661-19-8
Molecular Formula: C22H46O
Molecular Weight: 326.6
EINECS Number: 211-546-6
Synonyms: 1-DOCOSANOL, Docosanol, docosan-1-ol, Behenyl alcohol, 661-19-8, Behenic alcohol, Abreva, n-Docosanol, Docosyl alcohol, Lidavol, Tadenan, Stenol 1822, Lidakol, Lanette 22, Stenol 1822A, Docosanol [USAN], Nacol 22-97, IK 2, 30303-65-2, NAA 422, IK.2, NSC 8407, HSDB 5739, NSC-8407, EINECS 211-546-6, UNII-9G1OE216XY, Docosanol (Abreva), Docosanol (USAN), BRN 1770470, 9G1OE216XY, CCRIS 8943, DTXSID4027286, CHEBI:31000, AI3-36489, MFCD00002939, DTXCID907286, NSC8407, EC 211-546-6, 4-01-00-01906 (Beilstein Handbook Reference), NCGC00159370-02, DOCOSANOL (II), DOCOSANOL [II], DOCOSANOL (MART.), DOCOSANOL [MART.], Docosanol (VAN), C22H46O, Erazaban, Herepair, Healip, Cachalot BE-22, Abreva (TN), Loxiol VPG 1451, n-Docosan-1-ol, Docosanol-(1), 1-Docosanol, 98%, Cold Sore Fever Blister, DOCOSANOL [HSDB], DOCOSANOL [VANDF], N-DOCOSANOL [MI], DOCOSANOL [WHO-DD], SCHEMBL51925, DOCOSANOL [ORANGE BOOK], CHEMBL1200453, Cold Sore Fever Blister Treatment, HMS2093P22, Pharmakon1600-01505729, HY-B0222, Tox21_111611, LMFA05000008, NSC759235, s1637, AKOS015902887, CCG-213539, DB00632, NSC-759235, Behenyl alcohol, AI3-36489, Behenic alcohol, 1-Docosanol, Docosyl alcohol, IK-2, Tadenan, NCGC00159370-03, NCGC00159370-04, NCGC00159370-05, 1-Docosanol, purum, >=97.0% (GC), AC-19852, CAS-661-19-8, DA-69546, SBI-0206938.P001, D0964, NS00009524, D03884, D70615, AB01563123_01, AB01563123_02, EN300-6495479, SR-05000001915, Q3033497, SR-05000001915-1, BRD-K50050533-001-02-1, BRD-K50050533-001-03-9, BRD-K50050533-001-04-7, A3D72D45-625E-49B5-B0FC-394010B3485D, InChI=1/C22H46O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23/h23H,2-22H2,1H, ALCOHOL C22,BEHENYLIC ALCOHOL,Behenic alcohol,behenicalcohol,Cachalot BE-22,Dehydag wax 22 (lanette),Docosan-1-ol,Docosanol-(1)
Lanette 22, also known as Behenyl Alcohol or Docosanol, is a fatty alcohol derived from natural sources, such as vegetable oils.
Its primary structure is docosan-1-ol, with a long carbon chain (C22H46O) that gives it a waxy, solid form at room temperature.
Lanette 22 cream is approved for the over-the-counter treatment of herpes labialis.
Lanette 22 has a peroxide value of max. 8.0, a hydrocarbon content of max. 1.0%, and a hydroxy value of 170-180.
Lanette 22 is a fatty alcohol used for viscosity regulation in O/ W emulsions
Lanette 22 is a consistency giving agent.
Lanette 22 is a white to light yellowish hydrophilic wax.
Lanette 22 is used in cosmetic O/W emulsions for viscosity regulation.
Lanette 22 finds application in antiperspirants & deodorants, sun-care (after-sun, sun-protection, self-tanning), color-, body & face care and face cleansing formulations.
Also used in baby care & cleansing and conditioning formulations.
On account of its consistency giving characteristics, Lanette 22 is mainly used for viscosity regulation in cosmetic and pharmaceutical O/W emulsions.
Lanette 22 is a consistency giving agent.
Lanette 22 is used in cosmetic O/W emulsions for viscosity regulation.
Lanette 22, solid particles, fat-enriched agent in skin care products, moisturizing agent, emulsifier for pigments, wetting agent, co-solvent, viscosity regulator, lubricant, plasticizer in hair products, dispersing agent of pigments in hair dyeing, fragrance fixing agent.
Lanette 22 is chemically stable, which makes it resilient in formulations with various pH levels.
Lanette 22 is non-reactive with other common cosmetic ingredients, allowing it to be included in a wide range of products without concern for degradation.
Its long carbon chain structure gives Lanette 22 a smooth, silky feel that is non-greasy, making it ideal for products that require easy spreadability and a pleasant after-feel.
Lanette 22 is often used in formulations that require solidification at room temperature, helping creams and lotions maintain a stable, solid form until applied.
Lanette 22 acts as an occlusive agent, creating a protective barrier on the skin’s surface that helps lock in moisture and prevent water loss.
This makes it valuable in products designed for dry or sensitive skin.
Lanette 22 contributes to the smooth, rich texture in creams and lotions, enhancing the overall sensory experience of skincare products.
Consumers often appreciate the non-greasy, soft feel it imparts on the skin.
As a fatty alcohol, Lanette 22 is mild and typically does not cause irritation, even on sensitive or reactive skin types.
This is unlike traditional alcohols, which can be drying or sensitizing.
In conditioners and hair masks, Lanette 22 acts as an emollient that helps to smooth the hair cuticle, improving shine and softness.
Lanette 22 is often paired with other conditioning agents to enhance detangling and manageability.
Lanette 22, the active form of Behenyl Alcohol, is an FDA-approved ingredient for topical cold sore treatments.
Lanette 22 can help inhibit viral entry into cells, making it effective in reducing the duration and severity of cold sores.
Lanette 22 is sometimes included in sunscreen formulations to improve water resistance and provide a thicker, stable consistency that helps the sunscreen adhere better to the skin.
Lanette 22 is beneficial in formulations with oil and water phases.
It helps to thicken the product and stabilize emulsions, preventing separation of ingredients and extending shelf life.
Due to its stability, Lanette 22 can be safely used with a variety of active ingredients, including retinoids, alpha hydroxy acids (AHAs), and antioxidants, without risk of destabilizing or degrading the formula.
Lanette 22 is particularly useful in “rich” or “buttery” cream formulations, providing structure and consistency to products that consumers often associate with luxury skincare.
Lanette 22 is biodegradable and generally considered environmentally safe when used in personal care products, as it breaks down relatively easily and is derived from natural sources like vegetable oils.
Lanette 22 is typically non-sensitizing and is unlikely to cause allergic reactions, making it suitable for hypoallergenic and dermatologist-tested products.
Since it can be derived from plant sources (such as palm or rapeseed oil), Lanette 22 is compatible with vegan formulations, aligning with the trend for plant-based, cruelty-free cosmetics.
Often used in face and body moisturizers at concentrations around 1-5%.
Lanette 22 included at 2-10% for texture enhancement and stability.
Typically used at 0.5-5% in hair care products to improve smoothness and hydration.
As docosanol (10% concentration in products like Abreva), Lanette 22 has a specific medicinal role in antiviral creams for treating cold sores.
Lanette 22 is a long-chain fatty alcohol with the chemical formula C22H46O.
Its structure consists of a long hydrocarbon tail with a hydroxyl (–OH) functional group at one end.
This structure contributes to its emulsifying and moisturizing properties.
Lanette 22 has a relatively low HLB value, making it more lipophilic.
This characteristic is beneficial for creating oil-in-water emulsions, where it helps stabilize oil droplets in a water phase.
The viscosity of formulations containing Lanette 22 can be manipulated by adjusting the concentration used, allowing formulators to achieve the desired texture and feel in creams and lotions.
Lanette 22 is generally recognized as safe (GRAS) when used in food and personal care applications, and it is approved for use in cosmetics and personal care products by the U.S. Food and Drug Administration (FDA).
Lanette 22 has been evaluated by the CIR Expert Panel and found to be safe for use in cosmetics at concentrations typically used in formulations.
It complies with regulations in various regions, including the European Union, where it is listed in the Cosmetic Ingredient Inventory and can be used without restrictions.
When formulating with Lanette 22, it is often melted (around 70-75°C) and then combined with other lipid phases before emulsification with water.
This helps ensure even distribution within the formulation.
Lanette 22 can also be used in cold processes by dispersing it in a compatible solvent or carrier oil to aid in its incorporation into emulsions.
Melting point: 65-72 °C(lit.)
Boiling point: 180 °C0.22 mm Hg(lit.)
Density: d75 0.8063 g/ml; d85 0.7986 g/ml; d95 0.7911 g/ml
vapor pressure: 0Pa at 25℃
refractive index: n75 1.4360
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
pka: 15.20±0.10(Predicted)
form: Pellets or Tablets
color: White
Viscosity: 9.7mm2/s
Water Solubility: Insoluble
Merck: 13,3433
BRN: 1770470
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
LogP: 8.3 at 20℃
Lanette 22 is a long-chain saturated alcohol that is clinically effective against HSV.
It has in vitro activity against many enveloped viruses, including CMV, influenzavirus, and respiratory syncytial virus.
Lanette 22 is not directly virucidal; instead, it blocks the entry of the virion into the host cell by inhibiting the fusion of the viral envelope with the host plasma membrane.
Because it does not affect viral replication or protein production, it may be less susceptible to the development of resistance than other antiviral drugs.
Lanette 22 is a 22-carbon straight chain alcohol licensed for over-thecounter sales for the topical treatment of herpes labialis.
It is thought to act by blocking viral fusion with the host cell, although definitive studies are lacking.
The clinical relevance of the antiviral activity has been debated and the place of this medication as a treatment of herpes labialis remains to be established.
Lanette 22 is frequently combined with emulsifiers, humectants, and occlusive agents to enhance overall product performance.
Such as Lanette 22 or cetearyl alcohol to boost emulsification and stabilization.
Like glycerin or hyaluronic acid for additional moisture retention.
Such as dimethicone or shea butter to create a more protective barrier on the skin.
Other long-chain fatty alcohols that serve similar functions include.
A mixture of cetyl and stearyl alcohols, commonly used for thickening and emulsification.
Stearyl Alcohol: Another fatty alcohol that provides similar emollient and thickening properties.
Derived from coconut oil, these provide moisturizing properties.
A liquid wax that mimics the skin's natural oils and can also act as an emollient and moisturizer.
Lanette 22 aligns with the growing trend for natural and clean beauty products.
Its plant-derived sources appeal to consumers looking for sustainable and environmentally friendly options.
As consumers become more ingredient-savvy, products containing Lanette 22 are often marketed with a focus on their safety, effectiveness, and natural origin.
With increasing consumer demand for anti-aging products, Lanette 22's role in moisture retention and skin barrier enhancement is particularly valued.
Lanette 22 is widely utilized in formulations from major cosmetic brands and indie companies alike, appearing in products such as moisturizers, sunscreens, and conditioners.
Its efficacy as a stabilizing and film-forming agent has led to its inclusion in various therapeutic formulations, particularly those targeting skin conditions like cold sores.
Researchers are continuously exploring the potential applications of Lanette 22 in newer formulations, including its effectiveness in delivering active ingredients more effectively through the skin.
There is growing interest in combining Lanette 22 with other innovative materials, such as nanotechnology for improved penetration of active ingredients.
According to safety data sheets (SDS), Lanette 22 is non-toxic when used as intended in cosmetic formulations.
However, proper handling procedures should be followed to avoid exposure to high temperatures during processing.
Although generally well-tolerated, formulators are encouraged to conduct patch testing for new products containing Lanette 22, especially when combined with other active ingredients.
Uses Of Lanette 22:
Lanette 22 works as a surfactant in cosmetics.
Lanette 22 cream has also been approved by the US Food and Drug Administration as a safe and effective topical treatment for herpes labialis.
Lanette 22 is a binder and an emulsion stabilizer.
It is also used to increase a formulation’s viscosity.
This is a mixture of fatty alcohols.
Lanette 22 may be used for any number of purposes in a cosmetic formulation, including as an emollient, a binder, an emulsion stabilizer, or to increase a product’s viscosity.
Lanette 22 may be derived either synthetically or from plants.
Lanette 22 is widely used in cosmetics and personal care products.
Lanette 22 helps soften and smooth the skin.
Commonly used in creams, lotions, and ointments to give a richer, more luxurious texture.
Helps stabilize emulsions by preventing ingredients from separating over time.
Provides a barrier on the skin to retain moisture.
Found in skincare products, such as moisturizers, body lotions, and anti-aging creams.
Lanette 22 is used in conditioners and treatments to improve hair texture and manageability.
Lanette 22 is used in some over-the-counter medications, such as antiviral creams for cold sores (e.g., docosanol-based creams).
Used in creams, lotions, and ointments to stabilize oil-in-water emulsions, helping to keep ingredients mixed and preventing separation.
Enhances the viscosity and texture of formulations, providing a rich, creamy feel in products like moisturizers and body butters.
Acts as a moisturizing agent that softens and smooths the skin, making it beneficial in formulations for dry skin.
Helps maintain the stability of cosmetic products over time, ensuring that they remain effective and visually appealing.
Commonly found in hair conditioners and masks, Lanette 22 improves the texture and manageability of hair by smoothing the cuticle.
Lanette 22 is used in cold sore creams and other topical ointments for its role as an active ingredient (as docosanol) that inhibits viral replication and promotes healing.
Included in formulations designed to treat skin conditions due to its emollient properties and ability to form a protective barrier on the skin.
Enhances the water resistance of sunscreens, helping them adhere to the skin and maintain effectiveness during swimming or sweating.
Lanette 22 slip and improves the feel of hair, making it easier to detangle while adding moisture and shine.
Lanette 22 is used in hair gels and pomades to provide hold while maintaining moisture.
Occasionally found in formulations of cleaning agents, where it serves as a surfactant and stabilizer.
Lanette 22 is used in various applications requiring thickening and emulsifying properties, such as lubricants and greases.
While not commonly used in food, certain fatty alcohols are utilized as food additives and emulsifiers in processed foods, subject to regulatory approval.
Due to its gentle nature, Lanette 22 is often used in hypoallergenic products and those designed for sensitive or reactive skin.
Common in products aimed at restoring the skin barrier, particularly beneficial for those with compromised skin conditions.
Acts as a primary emulsifier and thickening agent in creams and lotions, enhancing their texture and stability.
Helps create a smooth application and a luxurious feel on the skin.
Used in facial cleansers and body washes to provide a creamy texture and aid in emulsifying oils and dirt, allowing for easier rinsing.
Found in foundations and primers to enhance product spreadability and provide a hydrating effect.
Included for its soothing properties, helping to retain moisture around the delicate eye area.
Present in body butters and balms to provide emolliency and enhance skin softness.
The active ingredient in topical treatments for cold sores, it works by blocking the virus from entering cells and promoting healing.
Barrier Creams:
Lanette 22 is used in creams that protect the skin from irritants, often beneficial in occupational skin care where hands are exposed to harsh substances.
Acts as a conditioning agent, providing a smooth feel and improving manageability post-wash.
Helps to restore moisture and improve hair texture, often included in deep conditioning treatments.
Lanette 22 is used in mousses and sprays for added hold and shine without leaving hair feeling greasy.
Contributes to the formulation's ability to withstand water exposure, ensuring continued sun protection during swimming or sweating.
Helps in soothing and moisturizing the skin post-sun exposure, reducing dryness and irritation.
Incorporated into fabric softeners to enhance softness and reduce static cling in clothing.
Lanette 22 is used as a stabilizer in cleaning solutions to improve texture and effectiveness.
While Lanette 22 itself is not typically used in food, similar long-chain fatty alcohols are utilized in various food emulsification processes.
Some fatty alcohols derived from natural sources can act as emulsifiers in processed foods, ensuring consistent texture and stability.
Safety Profile Of Lanette 22:
In some individuals, especially those with sensitive skin, Lanette 22 can cause mild skin irritation or allergic reactions.
Symptoms may include redness, itching, or rash.
The likelihood of irritation can increase with higher concentrations or prolonged exposure.
Products designed for sensitive skin usually contain lower levels or are formulated to minimize irritation.
Although rare, some individuals may develop contact dermatitis from exposure to Lanette 22.
Patch testing is recommended for those with a history of allergies to cosmetic ingredients.
Allergic reactions can manifest as localized swelling, redness, or blistering upon contact with the skin.
Direct contact with the eyes may cause irritation, leading to redness or watering.
Formulations should be designed to minimize eye exposure.
Manufacturers often include warnings to avoid contact with the eyes, and formulations should be carefully tested for ocular safety.
