LIDOCAINE HYDROCHLORIDE

Lidocaine hydrochloride is commonly used in medical, dental, dermatological, and minor surgical applications.
Lidocaine hydrochloride's predictable performance and established pharmacological profile support reliable formulation development.
Lidocaine hydrochloride can be incorporated into creams, gels, sprays, solutions, and injectable products.

CAS Number: 73-78-9
EC Number: 200-803-8
Molecular Formula: C14H23ClN2O
Molecular Weight: 270.80 g/mol

Synonyms: Lidocaine hydrochloride, 73-78-9, LIDOCAINE HCL, Lidothesin, Lignocaine hydrochloride, Laryng-O-jet, Anestacon, Lidocaton, Glydo, Xylocaine Viscous, LIDOCAINE VISCOUS, LTA II KIT, PEDIATRIC LTA KIT, LARYNG-O-JET KIT, Lidocaine hydrochloride anhydrous, LIDOPEN, Zingo, EC2CNF7XFP, XYLOCAINE PRESERVATIVE FREE, LARYNGOTRACHEAL ANESTHESIA KIT, Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride, XYLOCAINE 4% PRESERVATIVE FREE, Akten, Lidocaine hydrochloride viscous, ALPHACAINE HYDROCHLORIDE, 2-Diethylamino-2',6'-acetoxylidide hydrochloride, XYLOCAINE 5% W/ GLUCOSE 7.5%, XYLOCAINE 1.5% W/ DEXTROSE 7.5%, NSC-757420, alpha-Diethylamino-2,6-acetoxylidine hydrochloride, Lidocaine hydrochloride preservative free, omega-Diethylamino-2,6-dimethylacetanilide hydrochloride, Lidocaine hydrochloride in plastic container, DTXSID4058782, Lidocaine hydrochloride 0.2% in dextrose 5%, Lidocaine hydrochloride 0.4% in dextrose 5%, Lidocaine hydrochloride 5% and dextrose 7.5%, ANHYDROUS Lidocaine hydrochloride, Lidocaine hydrochloride preservative free in plastic container, Lidocaine hydrochloride 0.1% and dextrose 5% in plastic container, Lidocaine hydrochloride 0.2% and dextrose 5% in plastic container, Lidocaine hydrochloride 0.2% in dextrose 5% in plastic container, Lidocaine hydrochloride 0.4% and dextrose 5% in plastic container, Lidocaine hydrochloride 0.4% in dextrose 5% in plastic container, Lidocaine hydrochloride 0.8% and dextrose 5% in plastic container, Lidocaine hydrochloride 0.8% in dextrose 5% in plastic container, Lidocaini hydrochloridum, CHEBI:50512, burnrelief, Comfortcaine, Cutiecaine, Dequaspray, Germoloids, Hemporrhoid, Laryngojet, Trilocaine, Accucaine, Anodesyn, Bismodyne, Curacaine, Hemocane, Lidocoll, Lidodose, Lidogel, Lidonex, Lidopin, Lidorex, Lidostat, Lidotran, Lidozall, Lignokent, Lignostab, Medijel, Neurozyl, Oragard, Popstar, Suntone, Trilogel, Calgel, Denela, Unburn, RelivBliss, BonaDur, Bradosol plus, Burn, BurnZone, Bruselix Cream, Launch Medical, Lidocream Plus, Lignostab n, Lignostab-a, MyDerm, Numbify Smooth, Rugby Lidocaine, Sunburn Relief, Aramark Burn, Bruselix Gel, Lidozall Plus, Regenecare Ha, Xylocaine Mpf, BurnX, MediFirst Burn, Burn Relief, Cooling Gel, Delay Spray, Derma Numb, Exsel Aloe, Hexa-Caine, Jelcaine Sterile, Kroger Analgesic, Leader Lidocaine, Lido hcl, Numb Master, Panama Jack, Relief Gel, Sore Relief, Lidocaine HCLt, Lignospan special, Medi-first Burn, QC Lidocaine, Burn Care, Burn Ease, Burn Mist, CVS Lidocaine, GNP Lidocaine, Lidocaine HCI, Uber Numb, Bactine Max Dry, Burn Gel, Burn Jel, Burn Relief Gel, Numbing Lubricant, Walgreens Cooling, Xpect Burn Care, Zionodil External, Burn With Aloe, Aramark Burn Gel, Burn Relief Aloe, Green Guard Burn, Pain Itch Relief, Alocane Botanicals, DCH Burn Relief, DCH Pain Relief, Pain Relief CVS, Serum X, SunBurnt PLUS, WAXUP Numbing, Westlake Lidocaine, ZeroPain 5, Amour CBD, Co-phenylcaine fte, Dologesic Roll-On, Germoloids complete, Lidocaine 2%, Lidocaine 4%, Lidocaine 5%, Redicare Burn Gel, Comfortox Lidocaine, Dermacinrx Lidotral, equate Burn Relief, Lidenzal 1%, Lidenzal 2%, XeroBurn Burn Gel, Xylotox e80, Zionodil 50, DermaNumb Analgesic, Ear Pain MD, Electrum Numb Foam, Keeps Climax Delay, Lido-Sorb External, Lidotral 5% Gel, NumbR-X, Pain Relief Equate, Publix Burn Relief, Sunburn Relief Gel, RECOVERY Numbing, Sunburn Pain relief, Bactine Max Bandage, Dragon Pain Numbing, Dressing Change Kit, lidocaine cream 4%, Lignostab a 100, Numb Gel Anesthetic, The Davinci Company, Topical Pain Relief, 4% Lidocaine HCl, ENT Kit, Lidocaine HCl 4%, Zionodil 100, Bio-scriptives Lidum, Lidocaine 4 Percent, Lidocaine HCI 4%, Dressing Change Tray, Ebsl-5, Ebss-5, JJ Care BURN, LIDOCORE, Lidoplus Pain Relief, Lidotral Two Percent, PETCO, Zone 1, First Aid Only Burn, Walgreens Burn relief, Extra Strength Pretat, Inspec Solutions LLC, Lidocaine Pain Relief, lidocream hydrochloride, Lidotral Five Percent, Numbify Tropical Gold, OBGYN Procedure Kit, Precision Pain Relief, QC Burn Relief Aloe, Sunburn Pain Reliever, Burn Ease 3.5G, FOOT HANGOVER, Pain Relief Rite Aid, Rite Aid Burn Relief, WALGREENS BURN, Will Relieve Roll-On, 1168 Burn Spray, BLACK LABEL, Burn Ease, 3.5g, FIRST SHIELD, IKONIK TONIK, STING MASTER, Alocane Emergency Burn, Dr Saymans Wonder Rub, RR Roll-On for Pain, TopCare Pain Relieving, Totally Fun After Sun, XYLOCAINE DENTAL, Extra Strength Aftertat, Fsk-5, Iwk-5, Lidocaine Numbing Cream, Numb520, Painless Tattoo Numbing, RefChem:5947, SYREN Intimate Relief, Walgreen Pain Relieving, Aloe Gel Pain Reliever, Derma Numb Pain Relief, Ear Pain MD for Kids, LIDO-K, myDerm Numbing Roll-On, Now Numb Numbing Cream, Lidocaine HCl 0.5%, Duane Reade Burn Relief, Kroger Burn Relief Aloe, Lidocaine HCI 2.0%, Tattoo Numbing Cream Co, Topical Anesthetic Cream, Ear Pain MD Unit Dose, Lydexa 4.12%, Dg Health Pain Relieving, Equate Pain Relief Cream, Extra Strength First Aid, Lidocaine HCl 4 Percent, Select Brand Burn Relief, Sunset Novelties Herquake, Warrior Burn Relief Aloe, Xesso Rear Comfort Glide, Burn relief aloe Daylogic, UniShield First Aid Burn, 1% LIDOCAINE HCI, 2% LIDOCAINE HCI, American Safety First Aid, DCH Pain Relief Roll-On, Eclipse Topical Anesthetic, Extra Strength Wound Care, Kroger Analgesic Analgesic, Lidocaine HCI 3.88%, Lidocaine Monohydrochloride, Meijer Analgesic Lidocaine, Mentholatum Lidocaine Heat, Restoriden Lidocaine Cream, BLACK LABEL B NUMB, BurnX Pain Relieving Burn, GoodSense Burn Relief Gel, Extra Strength Numbing Gel, Extra Strength Skin Repair, Odorless Analgesic Roll-on, Pain Relief with Lidocaine, Sunburn Pain Reliever CVS, Icy Hot Lidocaine No-Mess, Lidocaine HCl 4.12 %, Lidocaine hydrochloride 2%, NeuroMed Topical Anesthetic, SunBurnt PLUS Pain Relief, THE SOLUTION 2.0, THE SOLUTION NUMBING, CVS Health Lidocaine Cream, Lidotral 3.88% Roll on, PO First Aid Series BURN, Rite Aid Lidocaine Roll on, Alocane Emergency Burn Pads, Exchange Select Burn Relief, IceQuake Lidocaine Analgesic, Rite Aid Pain Relief Cream, BLT 2, LIDOSOLVE PAIN RELIEF, Dragon Pain Numbing Roll-On, Extra Strength Pruritis Care, extra strength sunburn relief, Good Sense Burn Relief Aloe, Maximum Stremgth Pain Relief, Medicated Dna Collection Kit, Mirakel Pain Relief Roll-On, Panama Jack Burn Relief Gel, Uber Numb Topical Anesthetic, Warrior Pain Relief Roll-On, 0.5% LIDOCAINE HCl, Burn ReliefPreferred Plus Ph, General Surgery Procedure Kit, Painless Tattoo Numbing Cream, Publix Burn Relief Aloe Vera, Superior pain and itch relief, CVS Burn Relief w/Lido 8oz, QC Lidocaine Maximum Strength, TheraCare 4% Lidocaine Cream, CBD Clinic-Mild Pain Therapy, Extra Strength AfterTAT Slime, Extra Strength Pruritis Relief, Extra Strength Scar Prevention, Lidocaine hydrochloride 0.5%, Lidocaine Pain Relief Roll-On, Lidocaine Pain Relieving Creme, NeuroMed Topical Anesthetic 7, Pain Relief Roll-on Rite Aid, Pain Relief Well At Walgreens, Signature Care Lidocaine Cream, Topical Lidocaine (4% w/w), Topical Lidocaine (5% w/w), Walgreens Pain Relieving Cream, ALOE ICE SUNBURN RELIEF, CVS Lidocaine Maximum Strength, ELECTRUM NUMB ANESTHETIC, GNP Lidocaine Maximum Strength, HealthWise 4% Lidocaine Cream, INTIMALE LIDOCAINE DELAY, MEDI-FIRST Topical Analgesic, WALG AFTRSN BURN RELIEF, Maximum Stremgth Pain Relieving, POWERECT Lidocaine Male Delay, JUST CBD RELIEF SOOTHING, Lidocaine HCl Jelly USP, 2%, Lidocaine hydrochloride 4.00%, Neuromed 7 Topical Pain Relief, XYLOCAIN (LIDOCAINE HCl), DTXCID0047458, Extra Strength Numbify Anorectal, Extra Strength Postpartum Relief, Lidocaine hydrochloride, glycerin, Pain Relief Roll On Evora Labs, Pain Relief Roll-on Good Sense, POWERECT Max Power Male Delay, Walgreens Aloe Vera Burn Relief, Walgreens Cool n Heat Lidocaine, Lidotral 5 Percent Roll On Gel, Lightning Products BURN RELIEF, Sea and Ski Coolest Burn Relief, Solarcaine Burn Pain Relief 4oz, TopCare Pain Relieving Analgesic, XYLOCAINE (LIDOCAINE HCl), CBD Clinic Pain Relief-Level 1, Good Neighbor Pharmacy Aloe Vera, INTIMALE Maximum Strength Delay, POMODA DRAGON PAIN NUMBING, SYREN INTIMATE PAIN RELIEF, CVS Health Lidocaine Pain Relief, Extra Strength Liquid Numbing Gel, KARMA RUB Elemental Pain Relief, Odorless Analgesic Roll-on Meijer, CVS Health Sunburn Relief Cooling, GREEN GUARD Topical Pain Relief, PS-3866 Burn Ease, 0.9g, PS-3885 Burn Ease, 3.5g, ADVANCED NUMB Topical Anesthetic, TopCare Everyday After Sun Cooling, Arte Maximum strength Numbing Cream, extra strength foot care liquid gel, Lidocaine hydrochloride and Dextrose, Lidocaine Pain Relief with Lavender, PharmapureRx Lidocaine HCl 4.12%, Restore Lidocaine Pain Relief Cream, CBD Medic-Odor-Free Serious Relief, Naturally HL Extra Strength Numbing, RadiaGuard Advanced Radiation Relief, Sx1 Medicated Post-Operative System, Target Up and Up After Sun Cooling, Yowch for Minor Burns By Pain Balm, Aspercreme Lidocaine Foot (Diabetic), extra strength naturally hl hand care, Extra Strength Postherpetic Neuralgia, SCLERA CARE Topical Anesthetic Gel, TopCare Pain Relief Maximum Strength, XYLOCAINE-MPF (LIDOCAINE HCl), Bactine Max Lidocaine Roll-on 2.5oz, Blue-Emu Lidocaine Pain Relief Cream, Dragon Pain Numbing Topical Analgesic, Equate Pain Relieving Cream Lidocaine, Western Family Aloe Vera Moisturizing, Yowch Extra Strength for Minor Burns, Bliss Republic Lidocaine Numbing Cream, Extra Strength Liquid Burn Relief Gel, Extra Strength Naturally HL Foot Care, Maximum Strength Burn Relief Aloe Gel, Naturally HL Extra Strength Hand Care, SKINS DELAY Climax Control Lidocaine, Walgreen Pain Relieving Fragrance Free, Walgreens Pain Relieving with Lavender, Walgreens Pain Relieving with Turmeric, extra strength naturally hl itch relief, INKED SCIENCE LIDOCAINE 4 Percent, Maximum Stremgth Pain Relief Good Sense, SKINS DELAY Maximum Strength Lidocaine, Theraworx Pain Relief Roll-On-Lidocaine, Extra Strength Liquid Bedsore Relief Gel, Extra Strength Naturally HL Warming Ice, Extra Strength Shingle Chickenpox Relief, TheraCare Pain Relieving Lidocaine Cream, Aloe Gel Pain Reliever Well At Walgreens, Aspercreme with Lidocaine Foot Pain Creme, DOCTORS TOUCH Erase The Pain Lidocaine, extra strength naturally hl sunburn relief, Extra Strength Shingles Chickenpox Relief, Gold Bond Medicated Pain and Itch Relief, Meijer Odor Free Analgesic Pain Relieving, Naturally HL Extra Strength Burn Numbing, POMG NIGHT TIME PAIN RELIEF ROLLER, Rite aid Pain Relief Cream Lidocaine 4%, Warrior Burn Relief Aloe Maximum Strength, Aspercreme Lidocaine No-Mess plus Lavender, Exchange Select Burn Relief Pain Relieving, Extra Strength Postherpetic Neuralgia Care, Family Wellness Pain Relief with Lidocaine, Maximum Stremgth Pain Relieving DG Health, PainPatrol CBD Pain Relief with Lidocaine, Rite Aid Pain Relief Cream with Lidocaine, WelAhead by Welmate Lidocaine 5% Roll-on, Aspercreme Lidocaine with Rosemary and Mint, Duane Reade Burn Relief Pain Relieving Gel, Extra Strength Liquid Hemorrhoid Relief Gel, HealthWise Pain Relief Cream with Lidocaine, Naturally HL Extra Strength Bedsore Numbing, Panama Jack Burn Relief Gel With Lidocaine, Aspercreme with Lidocaine No-Mess Applicator, Cannabicool Pain Relieving Lidocaine Roll-On, Extra Strength Postherpetic Neuralgia Relief, Meijer Analgesic Lidocaine Topical Analgesic, Precision Pain Relief Audacious Wreck Relief, Signature Care Aloe Vera Gel with Lidocaine, Extra Strength Liquid Insect Bite Relief Gel, Warrior Pain Relief Roll-On Maximum Strength, Aspercreme With Lidocaine Pain Relieving Creme, MAXOCAINE Lidocaine Hemp Oil Topical Analgesic, Naturally HL Extra Strength Hemorrhoid Numbing, Quality Choice Pain Relief 4% Lidocaine Cream, SUGAR BRANDS Rescue Pain Relief and Recovery, Walgreens Aloe Vera Burn Relief Pain Relieving, Meijer Burn Relief Aloe Vera Pain Relieving Gel, Naturally HL Extra Strength Insect Bite Numbing, SERA RELIEF ULTIMATE RAPID SOOTHING CREME, Suntone After Sun Burn Relief Gel with Lidocaine, Walgreens Pain Relieving with Lavender Analgesic, Walgreens Pain Relieving with Turmeric Analgesic, Yowch Extra Strength for Insect Bites and Stings, Yowch for Insect Bites and Stings By Pain Balm, Aspercreme Lidocaine with Eucalyptus Essential Oil, Fruit Of The Earth Cool Blue Aloe Mist Continuous, Xesso Strawberry Rear Comfort Glide 4% Lidocaine, Burn Reliefpreferred Plus Ph Preferred Plus Pharmacy, Caring mill Lidocaine Aloe Gel Burn and Pain Relief, Maximum Strength Burn Relief Aloe Gel Scherer Labs, NATURES CRAFT LIDOCAINE Male Genital Desensitizer, Theraworx PM Nighttime Maximum Strength Pain Relief, Aspercreme with lidocaine No-Mess Applicator Two Pack, Thera Plus Max Strength Lidocaine Pain Relief Liquid, Lipo Flavonoid Ear Pain Relief Drops with 4% Lidocaine, Satohap Lidocaine hydrochloride 4 Percent Pain Relieving, Meijer Odor Free Analgesic Pain Relieving Topical Analgesic, Theraworx Pain Relief Roll-On with Lidocaine for Diabetics, CVS Health Sunburn Relief Cooling Lidocaine 0.5 Pain-Relieving, Meijer Pain Relieving Max Strength with Lavender Essential Oil, 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide Monohydrochloride, Wegmans Aloe After Sun Gel with Lidocaine HCl External Analgesic, Meijer Pain Relieving Max Strength with Lavender Essential Oil Analgesic, equate Maximum Strength Pain Relieving 4% Lidocaine with Lavender Essential Oil, 200-803-8, 612-079-4, equate Maximum Strength Pain Relieving 4% Lidocaine with Lavender Essential Oil Topical analgesic, Lidocaine hydrochloride usp, Lignocaine (as hydrochloride), V13007Z41A, Xylocaine hydrochloride, Xylocitin, Xylocard, Lidocaine (hydrochloride), 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride, MLS000069665, Xyloneural, SMR000058468, Xylocaine (TN), Xilina hydrochloride, Rucaina hydrochloride, Xycaine hydrochloride, Xylotox hydrochloride, Duncaine hydrochloride, Isicaine hydrochloride, Lidocain hydrochloride, Anestacon hydrochloride, Gravocain hydrochloride, Leostesin hydrochloride, Xylocitin hydrochloride, Lidothesin hydrochloride, Xylestesin hydrochloride, 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride, SR-01000000189, UNII-EC2CNF7XFP, EINECS 200-803-8, S 202, V 262, Dalcaine (TN), Prestwick_296, N-(Diethylaminoacetyl)-2,6-dimethylaniline hydrochloride, Lidoca ne hydrochloride, Opera_ID_351, SCHEMBL29130, SPECTRUM1500689, 73-78-9 (HCl); 6108-05-0 (monohydrate), CHEMBL541521, orb1224105, orb1309622, HY-B0185A, 2',6'-Acetoxylidide, 2-(diethylamino)-, monohydrochloride, GLXC-26369, HMS1568I21, HMS1921C22, HMS5083G12, Pharmakon1600-01500689, Lidocaine hydrochloride (JAN/USP), 2',6'-ACETOXYLIDIDE, 2-(DIETHYLAMINO)-, HYDROCHLORIDE, PXB95913, Tox21_500669, CCG-39281, Lidocaine hydrochloride [JAN], MFCD00034865, NSC757420, s4667, AKOS015889456, CS-3888, EBC-155044, LP00669, NSC 757420, SB19119, Lidocaine hydrochloride [WHO-DD], NCGC00094030-01, NCGC00094030-02, NCGC00094030-03, NCGC00094030-04, NCGC00094030-05, NCGC00261354-01, AC-11712, AS-35171, FL177823, EU-0100669, NS00093551, T1144, D02086, L 5647, EN300-7398170, Lidocaine hydrochloride ANHYDROUS [MART.], F468385, 2-Diethylamino-n-[2,6-dimethylphenyl]acetamide hcl, SR-01000000189-3, SR-01000000189-9, Q27122094, 2-(DIETHYLAMINO)-2',6'-ACETOXYLIDIDE MONOHYDROCHLORIDE, Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1), N-(2,6-Dimethylphenyl)-N~2~,N~2~-diethylglycinamide--hydrogen chloride (1/1)

Lidocaine hydrochloride is originally developed as a local anesthetic, also has properties as a class IB antiarrhythmic, a long-acting membrane stabilizing agent used against ventricular arrhythmia.
Lidocaine hydrochloride is the hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics.
Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+.

This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation.
Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects.
The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.

Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent.
Lidocaine hydrochloride's actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.

Lidocaine hydrochloride is the hydrochloride salt of lidocaine, a well-known amide-type local anesthetic compound.
Lidocaine hydrochloride is typically supplied as a white or almost white crystalline powder with good water solubility compared with the free-base form.

Lidocaine hydrochloride is widely used in pharmaceutical formulations intended to produce temporary local or regional loss of sensation by reducing nerve impulse transmission.
Lidocaine hydrochloride is commonly formulated in injectable solutions, topical preparations, gels, creams, sprays, and other dosage forms depending on regulatory approval and intended medical use.

Lidocaine hydrochloride is valued for its relatively rapid onset of action, established pharmaceutical use, and compatibility with numerous formulation systems.
Manufacturing, handling, and formulation should follow appropriate pharmaceutical quality standards and applicable regulatory requirements.

Lidocaine hydrochloride is an amide type local anaesthetic that belongs to the class of 1b antiarrhythmics.
Lidocaine hydrochloride is used for regional nerve blocks and infiltrative administration of anaesthesia.
Lidocaine hydrochloride prevents the entry of sodium ions into nerve endings, at the site of pain, and disrupts the electrical signal from reaching the brain.

Applications of Lidocaine Hydrochloride:
Lidocaine hydrochloride is characterized by strong penetration, strong dispersion, rapidly onset.
The anesthetic performance is twice that of procaine and the toxicity is 1.

There is an anesthetic effect after 5 minutes treatments, and anesthesia can last 1 to 1.5 hours, 50% longer than procaine.
The drug is effective on the heart of the disease or arrhythmia caused by cardiac glycoside, but on the supraventricular tachycardia is poor.
Lidocaine hydrochloride is fast and oral ineffective, with short duration, and often used as intravenous administration.

This pharmaceutical secondary standard can also be used as follows:
Sensitive determination of Lidocaine hydrochloride and cetylpyridinium chloride in their binary mixtures in different pharmaceutical formulations by three spectrophotometric-based methods
Simultaneous analysis of aminoacridine hydrochloride and Lidocaine hydrochloride in bulk powder and pharmaceutical formulation by high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC)-densitometric methods

Quantification of ceftriaxone sodium and lidocaine HCl in human plasma samples by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS)
Quantitative analysis of Lidocaine hydrochloride and miramistin in a wound healing gel sample by high-performance liquid chromatography (HPLC) combined with UV detection

Development of a method based on liquid–liquid extraction of nifedipine and Lidocaine hydrochloride from human plasma samples for their subsequent analysis by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
Dispersive liquid-liquid microextraction (DLLME) followed by attenuated total reflectance-Fourier transform infrared measurement of dry films for the determination of Lidocaine hydrochloride in human urine sample

Physical and Chemical Properties of Lidocaine Hydrochloride:
Lidocaine hydrochloride is white and odorless crystal with bitter and numb taste.
Lidocaine hydrochloride is easily soluble in water, ethanol and organic solvents, but insoluble in ether.
Aqueous solution in the case of acid and alkali do not break down, repeated autoclave rarely go bad.

Stability and Reactivity of Lidocaine Hydrochloride:

Chemical Stability:
Stable under recommended storage and handling conditions.

Reactivity:
May react with strong oxidizing agents, strong acids, strong bases, and other incompatible chemicals.

Conditions to Avoid:
Excessive heat, direct light, moisture, dust formation, and incompatible materials.

Incompatible Materials:
Strong oxidizing agents, strong acids, and strong alkalis.

Handling and Storage of Lidocaine Hydrochloride:

Safe Handling:
Avoid inhalation, ingestion, and contact with skin or eyes and minimize dust generation.

Storage Conditions:
Store tightly closed in a cool, dry, well-ventilated place protected from light, moisture, and incompatible substances.

First Aid Measures of Lidocaine Hydrochloride:

Inhalation:
Move the affected person to fresh air and seek medical attention if symptoms occur.

Skin Contact:
Wash thoroughly with soap and plenty of water and remove contaminated clothing.

Eye Contact:
Rinse cautiously with plenty of water for several minutes and obtain medical attention if irritation persists.

Ingestion:
Rinse mouth and seek prompt medical advice if a significant amount has been swallowed.

Firefighting Measures of Lidocaine Hydrochloride:

Suitable Extinguishing Media:
Use water spray, foam, dry chemical, or carbon dioxide as appropriate for the surrounding fire.

Specific Hazards:
Thermal decomposition may produce carbon oxides, nitrogen oxides, hydrogen chloride, and irritating fumes.

Protective Equipment:
Firefighters should wear suitable protective clothing and self-contained breathing apparatus.

Accidental Release Measures of Lidocaine Hydrochloride:

Personal Precautions:
Avoid dust formation, inhalation, and direct contact and use appropriate protective equipment.

Cleanup Methods:
Carefully collect spilled material into a suitable closed container and clean the affected area while minimizing dust.

Environmental Precautions:
Prevent significant quantities from entering drains, soil, or surface waters.

Exposure Controls/Personal Protection of Lidocaine Hydrochloride:

Engineering Controls:
Provide adequate general or local exhaust ventilation and suitable washing facilities.

Eye Protection:
Wear chemical safety goggles.

Hand Protection:
Wear suitable chemical-resistant gloves.

Skin Protection:
Wear appropriate protective clothing.

Respiratory Protection:
Use suitable particulate respiratory protection where ventilation is inadequate or airborne dust may be generated.

Identifiers of Lidocaine Hydrochloride:
Chemical Name: Lidocaine hydrochloride
Common Name: Lidocaine HCl
CAS Number: 73-78-9
EC Number: 200-803-8
Molecular Formula: C14H23ClN2O
Molecular Weight: 270.80 g/mol
IUPAC Name: 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride

Empirical Formula (Hill Notation): C14H22N2O · HCl · H2O
CAS Number: 6108-05-0
Molecular Weight: 288.81
NACRES: NA.24
PubChem Substance ID: 329823258
UNSPSC Code: 41116107
EC Number: 200-803-8
MDL number: MFCD00150329

CAS No.: 73-78-9
Chemical Name: Lidocaine hydrochloride
CBNumber: CB4117973
Molecular Formula: C14H23ClN2O
Molecular Weight: 270.8
MDL Number: MFCD00034865

Properties of Lidocaine Hydrochloride:
Appearance: White or almost white crystalline powder
Odor: Odorless or nearly odorless
Physical Form: Crystalline solid
Molecular Weight: 270.80 g/mol

Quality Segment: 300
grade: certified reference material, pharmaceutical secondary standard
agency: traceable to BP 214, traceable to Ph. Eur. L0600000, traceable to USP 1366013
API family: lidocaine
CofA: current certificate can be downloaded
technique(s): HPLC: suitable, gas chromatography (GC): suitable
application(s): pharmaceutical (small molecule)
format: neat
storage temp.: 2-30°C
SMILES string: Cl[H].[H]O[H].CCN(CC)CC(=O)Nc1c(C)cccc1C
InChI: 1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2
InChI key: YECIFGHRMFEPJK-UHFFFAOYSA-N
Gene Information: human SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Melting point: 80-82°C
storage temp.: Inert atmosphere,2-8°C
form: Solid
color: White to off-white
Water Solubility: Water : ≥ 36 mg/mL (132.94 mM)
InChI: InChI=1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H
InChIKey: IYBQHJMYDGVZRY-UHFFFAOYSA-N
SMILES: C(NC1=C(C)C=CC=C1C)(=O)CN(CC)CC.[H]Cl
LogP: 2.359 (est)
CAS DataBase Reference: 73-78-9(CAS DataBase Reference)
FDA 21 CFR: 310.545

Physical State: Solid
Solubility: Soluble in Chloroform
Storage: Store at 4° C

Molecular Weight: 270.80 g/mol
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 5
Exact Mass: 270.1498911 Da
Monoisotopic Mass: 270.1498911 Da
Topological Polar Surface Area: 32.3 Ų
Heavy Atom Count: 18
Complexity: 228
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Computed by PubChem
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Molecular Weight: 270.798
Formula: C14H23ClN2O
Cas No.: 73-78-9
Smiles: Cl.CCN(CC)CC(=O)Nc1c(C)cccc1C
Relative Density.: no data available