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The median particle size of LIGAMED MF-2-V is 8-11μm.
LIGAMED MF-2-V is developed for highly complex pharmaceutical applications (e.g. inhalation medicine).
LIGAMED MF-2-V has a high quality specification with additional tests for the fatty acid profile, particle size characterization and microbial count.
CAS: 557-04-0
MF: C36H70MgO4
MW: 591.24
EINECS: 209-150-3
Synonyms:
stearatedemagnesium;MAGNESIUM STEARATE;MAGNESIUM OCTADECANOATE;MAGENSIUM STEARATE;STEARIC ACID MAGNESIUM SALT;OCTADECONIC ACID MAGNESIUM SALT;OCTADECANOIC ACID MAGNESIUM SALT;Magnesium Stearate Bp
LIGAMED MF-2-V-MB is a premium grade magnesium stearate powder used in the pharmaceutical industry.
LIGAMED MF-2-V-MB magnesium stearate provides excellent flow and lubrication properties.
As a lubricant excipient, LIGAMED MF-2-V-MB helps in tablet manufacturing by reducing friction during compression and preventing the adhesion of tablet material to the machine surfaces.
LIGAMED MF-2-V-MB meets stringent requirements of pharmacopeial standards and is suitable for direct compression as well as wet and dry granulation processes.
LIGAMED MF-2-V is manufactured in a GMP compliant facility ensuring consistent high quality.
LIGAMED MF-2-V is the magnesium salt of stearic acid.
LIGAMED MF-2-V's anhydrate, dihydrate and trihydrate forms have been prepared.
The tabletting of the blends of LIGAMED MF-2-V and lactose granules has been described.
The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined.
LIGAMED MF-2-V is widely used lubricant in pharmaceutical industry.
LIGAMED MF-2-V also plays a role in delaying the process of dissolution.
LIGAMED MF-2-V's detection in tablets by laser-induced breakdown spectroscopy has been proposed.
Chemical Properties
LIGAMED MF-2-V is a fatty acid, salt-type anionic surfactant with its appearance being white powder with a creamy feeling.
LIGAMED MF-2-V is a compound of magnesium with a mixture of solid organic acids obtained from edible sources and consists chiefly of variable proportions of magnesium stearate and magnesium palmitate.
LIGAMED MF-2-V appears as bright white soft powder with the industrial products containing a small amount of oleic acid and 7% magnesium oxide and is odorless and tasteless.
LIGAMED MF-2-V is slightly soluble in water and soluble in hot ethanol.
LIGAMED MF-2-V is a compound of magnesium with a mixture of solid organic acids obtained from edible sources and consists chiefly of variable proportions of magnesium stearate and magnesium palmitate.
LIGAMED MF-2-V occurs as a fine, white, bulky powder having a faint, characteristic odor.
LIGAMED MF-2-V is unctuous and is free from grittiness.
LIGAMED MF-2-V is insoluble in water, in alcohol, and in ether.
LIGAMED MF-2-V conforms to the regulations of the U.S. Food and Drug Administration pertaining to specifications for salts of fatty acids derived from edible fat sources.
LIGAMED MF-2-V is a very fine, light white, precipitated or milled, impalpable powder of low bulk density, having a faint odor of stearic acid and a characteristic taste.
The powder is greasy to the touch and readily adheres to the skin.
nonflammable used in baby dusting powder(s) and as tablet lubricant.
Uses
LIGAMED MF-2-V has been widely used for many decades in the food industry as an emulsifier, binder and thickener, as well as an anticaking, lubricant, release, and antifoaming agent.
LIGAMED MF-2-V is present in many food supplements, confectionery, chewing gum, herbs and spices, and baking ingredients.
LIGAMED MF-2-V is also commonly used as an inactive ingredient in the production of pharmaceutical tablets, capsules and powders.
The main reason for its good lubricating properties is its hydrophobic nature and an ability to reduce friction between tablets and die wall during the ejection process.
LIGAMED MF-2-V can be regarded as being non-toxic, the United States, Germany and Japan allow it to be applied to products being contact with food.
However, LIGAMED MF-2-V doesn’t have wide application to be applied as PVC heat stabilizers.
In China and some other countries Pharmacopoeia, there are always records of this specie.
The pharmacopeia has also made provisions on the magnesium content, moisture, heavy metals, iron, sulfate and chloride content.
LIGAMED MF-2-V is often used as a anti-adherent in the manufacture of medical tablets, capsules and powders.
In this regard, LIGAMED MF-2-V is also useful, because it has lubricating properties, preventing ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets; magnesium stearate is the most commonly used lubricant for tablets.
Studies have shown that LIGAMED MF-2-V may affect the release time of the active ingredients in tablets, etc., but not that it reduces the overall bioavailability of those ingredients.
As a food additive or pharmaceutical excipient, LIGAMED MF-2-V's E number is E470b.
LIGAMED MF-2-V is also used to bind sugar in hard candies like mints, and is a common ingredient in baby formulas.
In pure powder form, LIGAMED MF-2-V can be a dust explosion hazard, although this issue is effectively insignificant beyond the manufacturing plants using it.
LIGAMED MF-2-V is manufactured from both animal and vegetable oils.
Some nutritional supplements specify that the magnesium stearate used is sourced from vegetables.
LIGAMED MF-2-V is a major component of "bathtub rings."
When produced by soap and hard water, LIGAMED MF-2-V and calcium stearate both form a white solid insoluble in water, and are collectively known as "soap scum.".
LIGAMED MF-2-V is the magnesium salt of stearic acid which functions as a lubricant, binder, emulsifier, and anticaking agent. it is a white powder that is insoluble in water.
LIGAMED MF-2-V is used as a lubricant or die release in tableting pressed candies and is also used in sugar- less gum and mints.
Pharmaceutical Applications
LIGAMED MF-2-V is the magnesium salt of stearic acid that possess lubricating properties and hence prevents ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets.
LIGAMED MF-2-V has been used as a tablet and capsule lubricant.
LIGAMED MF-2-V has also been used for preparing microcapsules.
Dry coating of drugs with magnesium stearate leads to flow improvement, flow-aid and lubrication effects, tabletability as well as non-inhibited dissolution rate.
LIGAMED MF-2-V is widely used in cosmetics, foods, and pharmaceutical formulations.
LIGAMED MF-2-V is primarily used as a lubricant in capsule and tablet manufacture at concentrations between 0.25% and 5.0% w/w.
LIGAMED MF-2-V is also used in barrier creams.
Production Methods
LIGAMED MF-2-V is prepared either by the interaction of aqueous solutions of magnesium chloride with sodium stearate or by the interaction of magnesium oxide, hydroxide, or carbonate with stearic acid at elevated temperatures.
