LOBELIA INTIATA EXTRACT

Lobelia Intiata Extract is a species of lobelia long utilized for medicinal purposes. 
Lobelia Intiata Extract's main active compound, lobeline, may help fight asthma, depression, and memory issues.

CAS Number: 84929-15-1
EC Number: Not specifically assigned
Scientific Name(s): Lobelia inflate
Binomial name: Lobelia inflata

SYNONYMS:
Lobelia inflata Extract, Indian Tobacco Extract, Asthma Weed Extract, Bladderpod Extract, Gagroot Extract, Pukeweed Extract, Wild Tobacco Extract, Lobeline Extract, Lobelia Intiata Extract, Lobelia chinensis extract, Lobelia Intiata Herb Extract, Asthma weed, Bladderpod, Eyebright, Gagroot, Indian tobacco, Indian weed, Pukeweed, Vomitwort, Asthma Weed, Bladderpod, Emetic Herb, Gagroot, Herbe à Asthme, Indian Tobacco, Lobelia inflata, Lobélie, Lobélie Brûlante, Lobélie Enflée, Lobélie Gonflée, Pukeweed, Tabac Indien, Vomit Wort, Wild Tobacco, Lobelia Intiata Extract is also known as Indian tobacco, Indian weed, pukeweed, asthma weed, gagroot, vomitwort, bladderpod, and eyebright

Lobelia Intiata Extract (Indian tobacco) contains lobeline and other pyridine alkaloids. 
Lobelia Intiata Extract, also known as Indian tobacco or puke weed, is a species of Lobelia native to eastern North America, from southeastern Canada (Nova Scotia to southeast Ontario) south through the eastern United States to Alabama and west to Kansas.

Lobelia Intiata is an annual or biennial herbaceous plant growing to 15–100 cm (5.9–39.4 in) tall, with stems covered in tiny hairs. 
Lobelia Intiata's leaves are usually about 8 cm (3.1 in) long, and are ovate and toothed. 
They are alternately arranged. 

Lobelia Intiata has violet-colored flowers that are tinted yellow on the inside, and usually appear in mid-summer and continue to bloom into fall.
The seedcases are small, brown, dehiscent, and papery.

Lobelia Intiata Extract, also known as urgent solution to cable, and half of the flower, small Spartina Guaren grass, long caterpillar fungus, snake tongue grass, Campanulaceae perennial herb about 10cm. 
The whole plant medicine with diuretic swelling, heat and detoxification, can be used for the treatment of large abdominal edema, swelling of the face enough, carbuncles boils Snake bites. 

Born in the ditch beside the paddy field edge, roadside and other wet at. 
Lobelia is a group of flowering plants native to North America.
Hundreds of species exist, including Lobelia Intiata Extract, which has tall green stems, long leaves, and tiny violet flowers.

Native Americans in the New England region of the United States used Lobelia Intiata Extract for medicinal and ceremonial purposes for centuries. 
Lobelia Intiata Extract was smoked and burned to induce vomiting or treat asthma and muscular disorders.
This variety of applications of Lobelia Intiata Extract earned the plant the nicknames Indian tobacco and puke weed.

Lobelia Intiata Extract continues to be used for medical purposes today. 
Studies indicate that lobeline, Lobelia Intiata Extract's main active compound, may protect against depression, help treat drug addiction, and improve memory and concentration.

Lobelia is available loose and dried for making into tea, as well as in capsules, tablets, and liquid extracts. 
The flowers, leaves, and seeds are used in various preparations.
Lobelia Intiata Extract is a species of lobelia long utilized for medicinal purposes. 

Lobelia Intiata Extract's main active compound, lobeline, may help fight asthma, depression, and memory issues.
Lobelia Intiata Extract is a potentially toxic herb. 
Lobelia Intiata Extract can be safely used in small doses (particularly homeopathic doses), but moderate-to-large doses may cause side effects ranging from dry mouth and nausea to convulsions and even coma. 

You should use Lobelia Intiata Extract only under the supervision of your health care provider.
Lobelia Intiata Extract, also known as Indian tobacco, is an annual or biennial herbaceous plant growing to 15–100 cm tall, with stems covered in tiny hairs. 

Its leaves are usually about 8 cm long, and are ovate and toothed. 
The fruit is a box. 
Seeds are small, yellowish-brown, and numerous with a small germ and abundant fleshy endosperm. It blooms in June-August, bears fruit in August.

According to a popular historical herbal text, Lobelia Intiata Extract acts on the uterus, but not in a way that would contraindicate its use during pregnancy, as a parturifacient. 
The text notes that Lobelia Intiata Extract promotes normal uterine contraction after the cervical os is dilated, and it relaxes perineal muscles.

Lobelia is a genus of perennial flowering plants that have been used in folk medicine for centuries. 
Although there are over 300 species of lobelia, the most commonly used herb is Lobelia Intiata Extract, which is native to the Northeastern United States.
Lobelia Intiata Extract has pale colored flowers, compared to its cousin species, and it belongs to the Lobeliaceae plant family.

Native Americans understood the potential medicinal value of this powerful herb and tribes used the herb for a wide variety of purposes. 
This is why the herb is sometimes called “Indian tobacco.”
The most important compound in the plant is lobeline, which has been studied for its ability to improve neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease, as well as ADHD and neuropsychiatric disease.

Lobelia Intiata Extract, also called Indian tobacco, has a long history of use as an herbal remedy for respiratory conditions such as asthma, bronchitis, pneumonia, and cough. 
Historically, Native Americans smoked Lobelia Intiata Extract as a treatment for asthma. 

In the 19th century, American physicians prescribed Lobelia Intiata Extract to induce vomiting in order remove toxins from the body. 
Because of this, Lobelia Intiata Extract earned the name "puke weed." 
Today, Lobelia Intiata Extract is sometimes suggested to help clear mucus from the respiratory tract, including the throat, lungs, and bronchial tubes. 

Although few studies have evaluated the safety and effectiveness of Lobelia Intiata Extract, some herbalists today use lobelia as part of a comprehensive treatment plan for asthma.
Lobelia Intiata Extract is a perennial herb found in the eastern half of the United States and parts of Canada. 

The base of the violet-pinkish flowers "inflates" to form the seed capsule, which is the source of the name "inflata."
Scientists think an active ingredient in the lobelia plant, lobeline, has similar effects to nicotine. 
For this reason, Lobelia Intiata Extract was once used as a nicotine substitute in many antismoking products and preparations designed to break the smoking habit. 

In 1993, the U.S. Food and Drug Administration (FDA) prohibited the sale of smoking products containing lobeline. 
The FDA reported that such products were not effective in helping people quit or reduce smoking.
Researchers now think that Lobelia Intiata Extract may actually reduce the effects of nicotine in the body, particularly the release of dopamine. 

Dopamine is a brain chemical that plays a number of important roles in the brain. 
It is also involved in drug addiction, so researchers think that lobeline may have some potential in treating addiction. 
So far, however, there have been no studies to determine whether lobeline is effective.

Lobelia Intiata Extract is a potentially toxic herb. 
Lobelia Intiata Extract can be safely used in small doses (particularly homeopathic doses), but moderate-to-large doses may cause side effects ranging from dry mouth and nausea to convulsions and even coma. 
You should use Lobelia Intiata Extract only under the supervision of your health care provider.

USES and APPLICATIONS of LOBELIA INTIATA EXTRACT:
Lobelia Intiata Extract has been used as an emetic, antidepressant, respiratory stimulant, an aid to smoking cessation, and a treatment for metamfetamine abuse
Lobelia Intiata Extract is applied in pharmaceutical field

Lobelia Intiata Extract is applied in Medicine and health products
Lobelia Intiata Extract may provide health benefits
Lobelia Intiata Extract contains several different alkaloids, or compounds that provide therapeutic or medicinal effects. 

Well-known alkaloids include caffeine, nicotine, and morphine.
The most prominent alkaloid in Lobelia Intiata Extract is lobeline, which may protect against the following ailments — though more research is needed.
Lobelia Intiata Extract is also used to relieve pneumonia and bronchitis, two types of lung infections that cause coughing and difficulty breathing, among other symptoms.

Attention deficit hyperactivity disorder (ADHD):
Lobelia Intiata Extract may help manage attention deficit hyperactivity disorder (ADHD).
Lobeline, the active compound in Lobelia Intiata Extract, may help treat asthma, depression, ADHD, and drug abuse, but human research is limited.

Compounds like lobinaline in other types of lobelia may have antioxidant effects.
Lobelia Intiata Extract, also called Indian tobacco, has a long history of use as an herbal remedy for respiratory conditions such as asthma, bronchitis, pneumonia, and cough. 

Historically, Native Americans smoked Lobelia Intiata Extract as a treatment for asthma. 
In the 19th century, American physicians prescribed Lobelia Intiata Extract to induce vomiting in order remove toxins from the body. 
Because of this, it earned the name "puke weed." 

Today, Lobelia Intiata Extract is sometimes suggested to help clear mucus from the respiratory tract, including the throat, lungs, and bronchial tubes. 
Although few studies have evaluated the safety and effectiveness of lobelia, some herbalists today use Lobelia Intiata Extract as part of a comprehensive treatment plan for asthma.

Scientists think an active ingredient in the Lobelia Intiata Extract plant, lobeline, has similar effects to nicotine. 
For this reason, lobeline was once used as a nicotine substitute in many antismoking products and preparations designed to break the smoking habit. 
In 1993, the U.S. Food and Drug Administration (FDA) prohibited the sale of smoking products containing lobeline. 

The FDA reported that such products were not effective in helping people quit or reduce smoking.
Lobelia Intiata Extract and its major alkaloid, lobeline, have been used in smoking cessation programs and proposed for treatment of other drug dependencies. 

The sale of over-the-counter (OTC) lobeline products for smoking cessation was prohibited by the US Food and Drug Administration (FDA) in 1993. 
Lobeline has traditionally been used to treat asthma and bronchitis. 
However, clinical trial data are lacking to recommend use for any indication.

Lobelia Intiata Extract has been used in smoking cessation programs and has been proposed for treatment of other drug dependencies; however, clinical evidence is limited.

-Medicinal Uses and Indications
Few studies have examined at the effect of Lobelia Intiata Extract in either animals or people. 
It is sometimes suggested (usually in combination with other herbs) for the treatment of the following respiratory problems:

*Asthma
*Bronchitis
*Cough
In homeopathy, Lobelia Intiata Extract is also used alone or with other products for smoking cessation, muscle relaxation, nausea, vomiting, skin infections (bites, bruises, poison ivy, and ringworm), and various respiratory illnesses.

-Asthma and other respiratory disorders: 
Lobelia Intiata Extract is sometimes used alongside conventional medications to help treat symptoms of asthma attacks, such as wheezing, uncontrollable coughing, and chest tightness.
This is because lobeline may relax your airways, stimulate breathing, and clear mucus from your lungs.

-Depression
Compounds found in Lobelia Intiata Extract may also help protect against mood disorders, including depression.
Specifically, Lobelia Intiata Extract may block certain receptors in the brain that play a role in the development of depression.

-Drug abuse
Lobelia Intiata Extract has been studied as a potential treatment for drug abuse.
Since lobeline has similar effects on your body as nicotine, it has long been considered a possible tool to help people quit smoking.

-Antioxidant capacity: 
Compounds in other types of lobelia, especially the alkaloid lobinaline found in Lobelia cardinalis, have been shown to act as antioxidants.
Antioxidants are compounds that fight free radicals. 
These are reactive molecules that can damage cells in your body and increase your risk for illnesses, such as cancer and heart disease.
Thus, Lobelia Intiata Extract may play a beneficial role in diseases that stem from free radical damage and affect the brain, such as Parkinson’s disease. 

TRADITIONAL USES AND ADVERSE EFFECTS OF LOBELIA INTIATA EXTRACT:
Lobelia Intiata Extract has a long use as a medicinal plant as an entheogenic, emetic, and skin or respiratory aid.
Native Americans used Lobelia Intiata Extract for respiratory and muscle disorders, as a purgative, and as a ceremonial medicine.
The leaves were chewed and smoked.

The plant was used as a traditional medicinal plant by the Cherokee, Iroquois, Penobscot, and other indigenous peoples.
The foliage was burned by the Cherokee as a natural insecticide, to smoke out gnats.
Although Lobelia Intiata Extract may be used medicinally, consuming lobelia causes adverse effects, which may include sweating, nausea, vomiting, diarrhea, tremors, rapid heartbeat, mental confusion, convulsions, hypothermia, coma, or possibly death.

CHEMICAL CONSTITUENTS OF LOBELIA INTIATA EXTRACT:
Lobelia Intiata Extract contains multiple alkaloid compounds, including lobeline, norlobelanine, lobelanidine, and radicamine, among other compounds, such as flavonoids, terpenes, alkynes, and coumarins.
Lobelia Intiata Extract concentration is highest in the seeds.

POTENTIAL BENEFITS OF LOBELIA INTIATA EXTRACT:
1. Reduces Inflammation
Lobelia Intiata Extract has anti-inflammatory effects and is able to decrease pro-inflammatory cytokines.

2. Improves Asthma Symptoms
Lobelia Intiata Extract is commonly used to improve asthma symptoms because of its ability to ease coughing and improve breathing. 
Research demonstrates that the herb is an antispasmodic that relaxes the bronchial tubes. 
Lobelia Intiata Extract also works as an expectorant that loosens phlegm and makes it easier to breathe.

In addition to improving asthma symptoms, Lobelia Intiata Extract is also used to alleviate symptoms related to allergies, bronchitis and other conditions affecting the respiratory system.
Although this is a well-known Lobelia Intiata Extract benefit, there are no human studies examining its efficacy for asthma and respiratory health.

3. May Promote Cognitive Health
Research indicates that lobeline, a piperidine alkaloid that’s often isolated from Lobelia Intiata Extract, exhibits neuroprotective effects.

4. Used for Smoking Cessation
Lobelia Intiata Extract acts as a partial nicotine agonist, which means that it can mimic the actions of nicotine stimulation. 
For this reason, Lobelia Intiata Extract is commonly used to support smoking cessation.

There’s very limited evidence on the efficacy of Lobelia Intiata Extract or lobeline on smoking cessation. 
However, clinical trials and many years of use suggest that the herb may have effects similar to nicotine on cognition and, therefore, supports people trying to quit smoking.

5. May Improve Depression
Lobelia Intiata Extract has become known as an antidepressant, relaxant and euphoriant agent.
A 1993 study published in Life Sciences displays that a compound in Lobelia Intiata Extract called beta-amyrin palmitate may have antidepressant activity.
Like most research on Lobelia Intiata Extract, there isn’t enough human evidence on its efficacy for depression. 

MAIN FUNCTION OF LOBELIA INTIATA EXTRACT:
1. Diuretic effect;Antiulcer effect
2. Choleretic effect;Anti-snake venom effect
3. Lobelia Herb effects on the nervous system similar to nicotine, but strength only 1/5-1/20 of nicotine
4. Central system inhibition;Respiratory exciting role
5. Role in the cardiovascular system
6. Light diarrhoea function, inhibit appetite
7. Hemostasis function;Anticarcinogenic function

BENEFITS OF LOBELIA INTIATA EXTRACT:
• A powerful relaxant for smooth muscles and the nervous system.
• Provides pain relief and eases spasms.
• Stimulates the respiratory system, relaxes and opens the lungs.
• Eases allergy and asthma symptoms and congestion.
• Lobelia Intiata Extract is highly effective in fighting the shingles virus.
• Promotes perspiration, helping to relieve fevers by cooling the skin and rids the body of toxins, while contributing to healthy blood circulation.
• Lobelia Intiata Extract acts as a diaphoretic – useful in treating liver and kidney disorders.

PLANT DESCRIPTION OF LOBELIA INTIATA EXTRACT:
Lobelia is an attractive annual or sometimes biennial (reseeding every year or 2) herb that grows to a height of 3 feet. 
Its upright, hairy stem is angular, branching at the top, usually green with a tinge of violet. 
The pale green or yellowish leaves have a sharp taste and a slightly irritating odor. 
The sparse flowers are pale violet blue outside and pale yellow inside.

PARTS USED OF LOBELIA INTIATA EXTRACT:
The above-ground portions of the lobelia plant (namely the leaves and seeds) are used for medicinal purposes.

MEDICINAL USES AND INDICATIONS OF LOBELIA INTIATA EXTRACT:
Few studies have examined at the effect of Lobelia Intiata Extract in either animals or people. 
Lobelia Intiata Extract is sometimes suggested (usually in combination with other herbs) for the treatment of the following respiratory problems:
*Asthma
*Bronchitis
*Cough
In homeopathy, Lobelia Intiata Extract is also used alone or with other products for smoking cessation, muscle relaxation, nausea, vomiting, skin infections (bites, bruises, poison ivy, and ringworm), and various respiratory illnesses.

AVAILABLE FORMS OF LOBELIA INTIATA EXTRACT:
Lobelia Intiata Extract is available in liquid extracts, tinctures, and as a dried herb in capsules and for teas. 
Lobelia Intiata Extract may also be put on the skin in the form of ointments, lotions, and plastics.

HOW TO TAKE LOBELIA INTIATA EXTRACT:
Begin with low dosages and increase gradually, depending on response. 
Remember that even moderate doses can be toxic; herbal Lobelia Intiata Extract should only be taken under the guidance of a knowledgeable herbal prescriber.

Pediatric
There are no studies evaluating whether Lobelia Intiata Extract is safe to give Lobelia Intiata Extract to a child. 

Adult
Lobelia Intiata Extract comes in dried form to be used as a tea, liquid extract, tincture, and even vinegar tincture. 
Speak to a knowledgeable provider to find the right dose for you.

PROPAGATION OF LOBELIA INTIATA EXTRACT:
Propagation is usually accomplished by cuttings or seed. 
Seeds are sown in containers in mid spring or mid fall. 
The seeds take about 2 weeks to germinate.

WHAT IS LOBELIA INTIATA EXTRACT USED FOR?
Traditional/Ethnobotanical uses:
American Indians smoked the leaves as tobacco and used them medicinally for respiratory illnesses. Lobelia Intiata Extract was introduced into New England medical practice in the 18th century to produce vomiting. 
Lobelia Intiata Extract was also used in treating colic, rheumatism, fever, and asthma. 

By the 19th century, Lobelia Intiata Extract was considered an important medicinal plant used in many conditions (eg, abscess, insomnia, tetanus, shock); however, deaths were recorded due to dosing inconsistencies. 
In 1993, the sale of Lobelia Intiata Extract over-the-counter (OTC) products for smoking cessation was prohibited by the US Food and Drug Administration (FDA).

DOSING OF LOBELIA INTIATA EXTRACT:
Clinical trials are lacking to support the use of Lobelia Intiata Extract or provide dosing recommendations. 
Traditional use of the leaf (ie, as an expectorant) suggests 100 mg of dry herb up to 3 times a day. 

MECHANISM OF ACTION OF LOBELIA INTIATA EXTRACT:
The leaves and seed pods are the most commonly used medicinal parts of Lobelia. 
They have been shown to have antiasthmatic, antispasmodic, emetic, expectorant, and respiratory stimulant effects.
α-Lobeline is the most biologically active and frequently investigated alkaloid in Lobelia, out of the more than 20 piperidine alkaloids that have been identified. 

α-Lobeline has been shown to be a partial nicotine agonist with effects on the CNS, neuromuscular system, and peripheral circulation. 
It is known as a strong respiratory stimulant, activating the carotid and aortic body chemoreceptors.
α-Lobeline relaxes lung tissue and aids in expectoration. 
Small amounts stimulate respiration and have expectorant activity. 

Larger amounts have emetic, purgative, and diuretic effects.
α-Lobeline initially causes CNS stimulation and then causes CNS and respiratory depression. 
Lobelia has been used with success in an array of respiratory conditions including asthma, chronic pneumonia, bronchitis, and laryngitis.

EVIDENCED-BASED RESEARCH OF LOBELIA INTIATA EXTRACT:
A study on horses tested the respiratory effects α-lobeline. 
The results revealed a transitory hyperpnea (increased depth and rate of breathing) with an increase in tidal volume and respiratory rate. 
This increase in respiratory ventilation lasted for about 90 seconds and was accompanied by a sharp rise in the respiratory peak airflows, especially the expiratory flows.

LOBELIA INTIATA EXTRACT CONTAINS:
In addition to the lobeline present in lobelia, the herb also contains:
*lobelanine
*alkaloids
*vitamin C
*calcium
*magnesium
*potassium
This medicinal herb is used for its ability to support respiratory health, reduce inflammation and possibly help people to quit smoking.

PHYSICAL and CHEMICAL PROPERTIES of LOBELIA INTIATA EXTRACT:
CAS Number: 84929-15-1
Appearance: Brown to greenish-brown powder or liquid
Solubility: Soluble in water, alcohol, and glycerin
Molecular Weight: Varies depending on the specific alkaloids present (e.g., lobeline)
Melting Point: Not applicable for the extract
Boiling Point: Not applicable
Flash Point: Not applicable
pH: Neutral to slightly alkaline when dissolved in water
CAS Number: 84929-15-1
EC Number: Not specifically assigned
Scientific Name(s): Lobelia inflate
Family: Campanulaceae
Genus: Lobelia
Species: L. inflata
Binomial name: Lobelia inflata

FIRST AID MEASURES of LOBELIA INTIATA EXTRACT:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of LOBELIA INTIATA EXTRACT:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of LOBELIA INTIATA EXTRACT:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of LOBELIA INTIATA EXTRACT:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of LOBELIA INTIATA EXTRACT:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of LOBELIA INTIATA EXTRACT:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available