MAGNESIUM TRISILICATE

Magnesium Trisilicate acts as a filler, coating agent, or glidant in pharmaceutical tablet manufacturing.
Magnesium Trisilicate is applied in cosmetics and ceramics or as a technical adsorbent due to its porous nature and high surface area.
Magnesium trisilicate provides symptomatic relief from acid‑related gastrointestinal discomfort.

CAS Number: 14987-04-3  
39365-87-2 (monohydrate) 
EC Number: 239-076-7
Chemical formula: Mg2O8Si3
Molar mass: 260.857 g·mol−1

SYNONYMS:
Dimagnesium dioxido-bis[(oxido-oxosilyl)oxy]silane, Magnesium trisilicate, 14987-04-3, FML8G1U0Y3, Magnesium trisilicate anhydrous, Magnesium silicate (Mg2Si3O8), DTXSID50904706, Magnesium silicates magnesium trisilicate, SILICIC ACID (H4SI3O8), MAGNESIUM SALT (1:2), Mag trisil co, RefChem:55540, VIRUS BLOCKER CL-40, DTXCID601353925, 239-076-7, C2E1CI501T, Dicarbocalm, Magnesium mesotrisilicate, Magnesium trisilicate USP, Magnosil, Parasepiolite, Petimin, Silicic acid, magnesium salt (1:2), Trisilicalm, Magnesium silicon oxide (Mg2Si3O8), dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane, MFCD00016203, Magnesii trisilicas, di-Magnesium trisilicate, Mg2O8Si3, orb2942251, CHEMBL2096633, SCHEMBL29389841, GXGAKHNRMVGRPK-UHFFFAOYSA-N, PAA98704, AKOS015904142, MAGNESIUM TRISILICATE [WHO-DD], DB09281, HY-W115757, CS-0198008, MAGNESIUM TRISILICATE ANHYDROUS [HSDB], Q836952, MAGNESIUM SILICATES MAGNESIUM TRISILICATE [MI], Magnesium trisilicate, dimagnesium trisilicon octaoxide, magnesium silicate, magnesium silicate oxide, magnesium trisilicate hydrate, magnesium silicon oxide, magnesiummesotrisilicate, meerschaum (mineral form), dicarbocalm, trisilicalm, petimin, Sanguisuanmei, magnesium orthosilicate

Magnesium is a naturally occurring mineral, and is essential for the diet.
Magnesium Trisilicate is an odorless, white powder.
Magnesium Trisilicate is important for many systems in the body, especially the muscles and nerves.

Magnesium is present in fruits, vegetables, grains, milk, meat and fish and the natural content of these foods is the major source of the current dietary intake.
Magnesium trisilicate is an over-the-counter antacid that has been used by humans for more than 40 years with only minimal apparent deleterious effects reported.

Magnesium Trisilicate is a gelling agent that is used in pharmaceuticals to reduce paraquat-induced gastric mucosal injury and increase viscosity of gastric contents, slowing gastric emptying.
However, when used alone, magnesium trisilicate is not a very effective antacid.

Magnesium Trisilicate is an inorganic compound.
Magnesium trisilicate is a compound frequently employed in the medical field as an antacid to alleviate symptoms associated with conditions like acid reflux, heartburn, and indigestion.

Numerous research institutions and pharmaceutical companies have evaluated its efficacy, further establishing Magnesium Trisilicate's role in treating mild gastrointestinal disorders.
The drug type, Magnesium Trisilicate, is primarily classified as an antacid, and it is indicated for the neutralization of stomach acid, thereby providing symptomatic relief.

Research has shown that magnesium trisilicate is effective in managing symptoms of hyperacidity and related conditions, although it is not a permanent cure for underlying issues such as GERD or peptic ulcers.
Magnesium trisilicate comprises magnesium oxide, silica, and water, which together form a compound that helps to neutralize stomach acid.

When ingested, magnesium trisilicate reacts with gastric hydrochloric acid to produce magnesium chloride and silicon dioxide.
This reaction raises the pH level in the stomach, making Magnesium Trisilicate less acidic.
The elevated pH level reduces irritation in the esophagus and stomach lining, providing symptomatic relief from conditions like heartburn and indigestion.

In addition, the silicon dioxide formed acts as a protective coating for the stomach lining, further mitigating irritation and inflammation.
This dual action makes magnesium trisilicate both an effective antacid and a gastric mucosal protector.
Magnesium trisilicate is an inorganic compound that is used as a food additive.

Magnesium trisilicate is an inorganic compound that is used as an antacid in the treatment of peptic ulcers.
Magnesium Trisilicate is a small molecule drug with a maximum clinical trial phase of IV that was first approved in 1983.
Magnesium trisilicate relieves the pain and discomfort of indigestion and heartburn.

The recommended adult dose of Magnesium Trisilicate is one to two tablets three times a day between meals, and at bedtime.
If you are taking other medicines, do not take magnesium trisilicate within two hours (before or after) of your other medicines.
Magnesium trisilicate is a compound frequently employed in the medical field as an antacid to alleviate symptoms associated with conditions like acid reflux, heartburn, and indigestion.

Marketed under various trade names such as "Gaviscon" and "Gelusil," Magnesium Trisilicate has become a staple in over-the-counter remedies for gastrointestinal discomfort.
Numerous research institutions and pharmaceutical companies have evaluated its efficacy, further establishing Magnesium Trisilicate's role in treating mild gastrointestinal disorders.

The drug type is primarily classified as an antacid, and it is indicated for the neutralization of stomach acid, thereby providing symptomatic relief.
Research has shown that magnesium trisilicate is effective in managing symptoms of hyperacidity and related conditions, although it is not a permanent cure for underlying issues such as GERD or peptic ulcers.

Magnesium trisilicate is a compound commonly used for its antacid properties.
Magnesium Trisilicate is known for its ability to neutralize stomach acid and is often included in formulations to treat gastric hyperacidity and related conditions.

Magnesium trisilicate is widely recognized for its antacid properties.
However, Magnesium Trisilicate's effectiveness in neutralizing stomach acid has been a subject of debate.
Some studies have shown that magnesium trisilicate has a slower rate of reaction with hydrochloric acid, which may limit its immediate neutralizing action.

Despite this, Magnesium Trisilicate has been noted for providing a prolonged neutralizing effect compared to other alkalies, making it a satisfactory substitute for controlling gastric hyperacidity.
Research comparing different magnesium trisilicate products has revealed significant variations in their antacid responses.

These differences are attributed to the crystal structure and density of the magnesium trisilicate used.
Magnesium trisilicate is an inorganic chemical compound commonly used in pharmaceuticals as an antacid to neutralize excess stomach acid, and in various industrial applications such as absorbent, decolorizing agent, and odor control.

Magnesium Trisilicate is typically a white, odorless powder and is often formulated in antacid preparations either alone or with other active ingredients.

USES and APPLICATIONS of MAGNESIUM TRISILICATE:
Magnesium trisilicate is used as an antacid to relieve heartburn, indigestion, acid reflux, and mild gastro‑oesophageal reflux symptoms by neutralizing stomach acid.
Magnesium Trisilicate is included in formulations for peptic ulcer and dyspepsia management.

Magnesium Trisilicate is often combined with other antacid ingredients, such as aluminum hydroxide and simethicone, to balance effects and mitigate side effects.
In the food industry, magnesium trisilicate is employed as an absorbent and anticaking agent in food production, often to purify used frying oils by absorbing fatty acids and impurities.

In industrial and other uses, magnesium trisilicate is used as an odor absorbent, decolorizing agent, and antioxidant.
Magnesium Trisilicate acts as a filler, coating agent, or glidant in pharmaceutical tablet manufacturing.
Magnesium Trisilicate is applied in cosmetics and ceramics or as a technical adsorbent due to its porous nature and high surface area.

When ingested, magnesium trisilicate neutralizes gastric hydrochloric acid.
The reaction forms magnesium chloride and colloidal silicon dioxide, which can coat the gastric mucosa, reduce acidity, and provide symptomatic relief.

Magnesium trisilicate provides symptomatic relief from acid‑related gastrointestinal discomfort.
Magnesium Trisilicate does not produce gas during neutralization, which may help reduce bloating.
Colloidal silica formed may help protect gastric mucosa.

Magnesium trisilicate has functional and industrial characteristics, including acting as an adsorbent and filter aid useful in food and industrial oil processing.
Magnesium Trisilicate is an absorbent and deodorizer, removing odors and impurities from environments and media.

Magnesium trisilicate (Mg2O8Si3) is used in preparations as an antacid for heartburn to lessen stomach acid.
Magnesium Trisilicate is a compound of magnesium oxide and silicon dioxide with varying proportions of water.
Magnesium Trisilicate occurs in nature as meerschaum, pararepiolite, and repiolite.

Magnesium Trisilicate is used as a gastric antacid.
Magnesium Trisilicate is frequently used by fast food chains to absorb fatty acids and extract impurities formed while frying edible oils.
Magnesium Trisilicate has good acid-neutralizing properties, but the reaction appears too slow to serve as an effective non-prescription antacid.

Magnesium trisilicate is an antacid used for the symptomatic treatment of peptic ulcers.
Magnesium trisilicate comprises magnesium oxide, silica, and water, which together form a compound that helps to neutralize stomach acid.
When ingested, magnesium trisilicate reacts with gastric hydrochloric acid to produce magnesium chloride and silicon dioxide.

This reaction raises the pH level in the stomach, making Magnesium Trisilicate less acidic.
The elevated pH level reduces irritation in the esophagus and stomach lining, providing symptomatic relief from conditions like heartburn and indigestion.

In addition, the silicon dioxide formed acts as a protective coating for the stomach lining, further mitigating irritation and inflammation.
This dual action makes magnesium trisilicate both an effective antacid and a gastric mucosal protector.
For optimal efficacy, magnesium trisilicate is typically administered orally in tablet or liquid suspension form.

The dosage and frequency of Magnesium Trisilicate depend on the severity of symptoms and the specific product being used.
Commonly, Magnesium Trisilicate is recommended to take the medication 30 minutes to one hour after meals and at bedtime.
The onset of action is relatively quick; patients usually experience relief within 15 to 30 minutes after ingestion.

Liquid formulations of Magnesium Trisilicate  may offer faster relief compared to tablets, as they do not require dissolution in the stomach.
It is crucial to follow the dosage instructions provided by healthcare professionals or Magnesium Trisilicate labeling to avoid potential side effects or interactions.

Magnesium Trisilicate is known for its ability to neutralize stomach acid and is often included in formulations to treat gastric hyperacidity and related conditions.
Magnesium trisilicate is widely recognized for its antacid properties.

Magnesium trisilicate also exhibits notable adsorptive properties.
Magnesium Trisilicate has been shown to adsorb various substances, including toxic compounds and drugs.
For instance, Magnesium Trisilicate has a high adsorptive capacity for nitrofurantoin, which can significantly reduce the drug's absorption and efficacy when co-administered.

Similarly, it can adsorb mebeverine hydrochloride, affecting the dissolution and antacid efficacy of Magnesium Trisilicate.
Innovative applications of magnesium trisilicate include its use in nanomedicine.
Coating magnetic nanoparticles with magnesium trisilicate has been explored for the efficient removal of lactic acid, potentially preventing exercise-induced fatigue.

These nanoparticles demonstrate prompt and efficient lactic acid adsorption, highlighting Magnesium Trisilicate's versatility beyond traditional antacid use.
Magnesium trisilicate is an inorganic chemical compound commonly used in pharmaceuticals as an antacid to neutralize excess stomach acid, and in various industrial applications such as absorbent, decolorizing agent, and odor control.

Magnesium Trisilicate is typically a white, odorless powder and is often formulated in antacid preparations either alone or with other active ingredients.
Magnesium trisilicate contains magnesium, silicon, and oxygen in silicate lattice, and may include bound water (hydrate) in its structure.
Magnesium Trisilicate reacts with gastric acid to form magnesium chloride and colloidal silicon dioxide, raising stomach pH and protecting mucosa.

PHYSICAL and CHEMICAL PROPERTIES of MAGNESIUM TRISILICATE:
Chemical formula: Mg2O8Si3
Molar mass: 260.857 g·mol−1
Appearance: White crystals
Odor: Odourless
CAS Number: 14987-04-3
39365-87-2 (monohydrate)
EC Number: 239-076-7
Molecular Weight: 260.86 g/mol
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 8

Rotatable Bond Count: 2
Exact Mass: 259.8601799 Da
Monoisotopic Mass: 259.8601799 Da
Topological Polar Surface Area: 145 Ų
Heavy Atom Count: 13
Formal Charge: 0
Complexity: 141
Isotope Atom Count: 0

Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes
CAS: 14987-04-3
IUPAC Name: dimagnesium(2+) spiro[3.3]trisiloxane-2,2,6,6-tetrakis(olate) hydrate

Molecular Formula: H2Mg2O9Si3
InChI Key: DGVMNQYBHPSIJS-UHFFFAOYSA-N
SMILES: O.[Mg++].[Mg++].[O-][Si]1([O-])O[Si]2(O1)OSi
([O-])O2
Molecular Weight (g/mol): 278.87
Synonym: magnesium trisilicate
Chemical Name: Magnesium trisilicate
CAS Number: 14987-04-3 (anhydrous)
Other CAS (hydrate): 39365-87-2 (hydrate form)

EC / EINECS Number: 239-076-7
PubChem CID: 5311266
ChemSpider ID: 4470779
DrugBank: DB09281
UNII: FML8G1U0Y3
Chemical Formula: Mg₂Si₃O₈ · xH₂O (variable depending on hydration)
Approximate Molecular Weight: ~260.86 g/mol (anhydrous)
Appearance: Fine white, odorless powder
State: Solid
Color: White
Odor: Odorless

Density: ~2.70 g/mL (approx.)
Melting Point: ~1557 °C (reported; may vary with composition)
Solubility: Practically insoluble in water and ethanol
Hygroscopicity: Slightly hygroscopic depending on formulation
Chemical Stability: Stable under normal conditions; decomposes with strong mineral acids
CAS Number: 14987-04-3 (anhydrous)
Other CAS: 39365-87-2 (hydrate)
EC / EINECS: 239-076-7
PubChem CID: 5311266
ChemSpider ID: 4470779
DrugBank: DB09281

FIRST AID MEASURES of MAGNESIUM TRISILICATE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of MAGNESIUM TRISILICATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of MAGNESIUM TRISILICATE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of MAGNESIUM TRISILICATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of MAGNESIUM TRISILICATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of MAGNESIUM TRISILICATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available