PRODUCTS

MAGNOLIA BARK EXTRACT

CAS Number: 947686-05-7
EC Number: 943-705-7
Chem/IUPAC Name: Magnolia Officinalis Bark Extract
INCI: Magnolia Officinalis Bark Extract

SYNONYMS:
Magnolia Bark Extract, Magnolia officinalis Extract, Houpu Extract, Saiboku-to Extract, Magnolia Cortex Extract, Cortex Magnoliae Officinalis Extract, Magnolol Extract, Honokiol Extract, MAGNOLIA OFFICINALIS BARK EXTRACT, EXTRACT OF MAGNOLIA OFFICINALIS BARK, Magnolia Officinalis Bark, Houpo, Houpu, Extract of the bark of magnolia officinalis, magnoliaceae

Magnolia Bark Extract is a traditional chinese medicine known for its neuroprotective and relaxing properties, being used to treat depression and anxiety as well as acting as a slight sedative.
Magnolia Bark Extract may also possess anti-cancer effects in higher doses.

Magnolia Bark Extract pharmacologically active components magnolol and honokiol.
Magnolia Bark Extract has a very good effect against bacteria, yeasts and fungi even at very low dosages.
Magnolia Bark Extract works particularly well in combination with Pentylene Glycol natural and Glyceryl Caprylate (GMCY).

Magnolia Bark Extract is hydroscopic and should be protected against moisture.
As you might have gathered from its name, Magnolia Bark Extract refers to the bark of the magnolia tree — a native of East and Southeast Asia.
This tree belongs to the Magnoliaceae family and can grow to a mature height from 16 ft up to 80 ft.

You can easily identify the magnolia tree from its large and fragrant flowers that often reach 8 inches in diameter.
Along with the bark, sometimes these flowers and leaves are also used for making medicine.
The scientific name of Magnolia Bark Extract is Magnolia officinalis.

The Chinese also call this herb "Houpu" — referring to the thick (hou) bark that comes from the unadorned (pu) part of the tree.
Its other names are magnolia cortex, cucumber tree, honoki, and swamp sassafras.
Those who practice traditional Chinese medicine (TCM) often harvest the bark in April and June.

They do it by peeling or cutting the bark from the roots, stems, and branches of the tree.
While the stem barks are decocted to a slight extent in boiling water, the branch and root barks are dried in the shade.
All these barks are then stacked up in a wet area.

Once their inner surface turns dark brown or purplish brown, the TCM practitioners steam, roll, and dry them.
This dried bark — known for Magnolia Bark Extract's sharp smell and bitter taste — is then soaked in a traditional medicine tincture for oral use.
Today, you can also find this herb in the medical stores sold as bundles of 4 inches long magnolia bark strips.

Magnolia Bark Extract is an extract of the bark of Magnolia officinalis.
Magnolia Bark Extract is an extract derived from the bark of the magnolia tree and has long been employed in traditional Chinese medicine.
Magnolol and honokiol are the two major components of this natural ingredient, demonstrating significant antioxidative, anti-inflammatory, and anti-bacterial capabilities.

Magnolia Bark Extract has a number of benefits for skin health, particularly due to its anti-inflammatory compounds.
Magnolia Bark Extract can assist with reducing flare-ups, relieving redness, and calming irritation, making it ideal for those with sensitive or acne-prone skin.

Additionally, Magnolia Bark Extract is rich in antioxidants, helping to protect the skin from environmental free radical damage and thereby reducing the appearance of wrinkles and fine lines.
Another benefit of Magnolia Bark Extract is its calming properties that may help to reduce skin inflammation associated with rosacea and eczema.

Additionally, Magnolia Bark Extract's antimicrobial activity can help to reduce the growth of bacteria on the skin, which may reduce the risk of breakouts and infections.
In fats and oils, Magnolia Bark Extract helps as a booster - similar to vitamin C palmitate - to extend the effect of mixed tocopherols and thus the shelf life of the fat/oil.

Magnolia Bark Extract works particularly well in combination with Pentylene Glycol natural and Glyceryl Caprylate (GMCY).
Magnolia Bark Extract (commonly called houpu magnolia or magnolia-bark) is a species of Magnolia native to the mountains and valleys of China at altitudes of 300–1500 m.

Magnolia Bark Extract, also known as Magnolia Officinalis, is a natural compound used in traditional Chinese practices and known for its ability to support healthy sleep habits and its relaxation properties.
Magnolia Bark Extract is a plant from the Magnolia species of plants that share similar compounds.

Two of the compounds, Magnolol and Honokiol are the two primary active ingredients found in the bark.
Honokiol and Magnolol are two biphenolic structural isomers called neolignans.
They were first found in plants in the Magnolia family and historically used to support stress and respiratory health.

As a result, metabolic rate and colonic temperature were notably reduced.
Research determined that Magnolia Bark extract seems to interact with the serotonin transporter but so far has not discovered how it interacts with the serotonin transporter.

However, Magnolia Bark Extract is able to regulate serotonin release from neurons.
The neolignans found in Magnolia Bark extract (Honokiol and Magnolol) have been found to interact with GABAA receptors in both in vitro and in vivo studies.
Relaxation effects were noted with Magnolol in isolation and seems to promote healthy sleep patterns when taken orally.

In addition, GABAA agonists will augment the effects.
Clinical studies have found that the neolignans (Magnolol and Honokiol) in Magnolia Bark Extract seem to have a positive impact on modulating muscarinic acetylcholine receptors in a similar fashion to how they impact GABAA receptors.

The neolignans in Magnolia Bark Extract seem to increase the binding affinity of muscarine to the muscarinic acetylcholine receptors.
This is due to Magnolia Bark Extract's ability to allosterically modify low binding receptors to a higher binding capacity and therefore causing a larger amount of overall binding.

Magnolia Bark Extract contains rich bio-active ingredients , magnolol and Honokiol are mostly researched.
Magnolia Bark Extract is off-white powder crystal.
Magnolia Bark Extract is soluble in benzene, ether, chloroform, acetone, insoluble in water, easily soluble in dilute alkali solution to obtain sodium salt.

Magnolia Bark Extract proves a special, long-lasting muscle relaxation effect and strong antibacterial effect, which can inhibit platelet aggregation.
Clinically, Magnolia Bark Extract is mainly used as an antibacterial and antifungal drug.
Magnolia Bark Extract is a traditional oriental medicinal plant.

Magnolia Bark Extract is a light yellow to white powder which is extracted by supercritical CO2 extraction from the bark of Magnolia officinalis.
Magnolia Bark Extract is an ingredient in formulas used for treating coughs and asthma.
The Magic Anti-Inflammatory Ingredient, Magnolia Bark Extract:

With age, our immune system slowly becomes less effective and inflammation can increase.
Inflammation is an important process that our body goes through when it has to fight off infection or repair damaged tissue.
However, this same protective process contributes to the aging process.

Magnolia Bark Extract is an adaptogenic supplement.
Magnolia Bark Extract reduces anxiety and stress without causing drowsiness.
Magnolia Bark Extract helps normalize and protect cerebral function.

Magnolia Bark Extract is standardized to contain 90% honokiol and magnolol, two powerful antioxidants.
Magnolia Bark Extract is a potent antioxidant and anti-inflammatory compound used widely in the beauty industry.
Magnolia Bark Extract effectively neutralizes free radicals, protecting the skin from oxidative stress and premature aging.

Magnolia Bark Extract works wonders for irritated or sensitive skin as it reduces inflammation and redness.
Further, Magnolia Bark Extract is also a great antimicrobial ingredient that helps manage acne and other skin infections.
In its raw form, Magnolia Bark Extract appears as a brown to dark brown liquid or powder with a woody and earthy aroma.

Being natural, Magnolia Bark Extract is not only good for the skin and hair but also for the environment.
Magnolia Officinalis Bark Extract Description
Magnolia Bark Extract is a plant-derived skin care ingredient that comes from the bark of the flowering magnolia tree (_Magnolia officinalis_).

Magnolia Bark Extract is native to Asia and is a staple in traditional Chinese and Japanese medicine.
Magnolia Bark Extract contains soothing polyphenolic neolignans, magnolol and honokiol, that help calm while simultaneously assisting in mitigating the pro-aging damage that outside aggressors, like UV rays and pollution, can have on skin.

Magnolia Bark Extract also helps to contribute to a plump skin appearance.
When fermented with the fungus Aspergillus niger, Magnolia Bark Extract demonstrated greater antioxidant benefits and exhibited the ability to help even skin tone and reduce the appearance of dark spots.

Magnolia Bark Extract can also serve as part of a natural preservative blend due to its ability to help thwart the growth of microorganisms in skin care products.
A report noted that Magnolia Bark Extract can cause skin sensitization on some when applied topically in percentages between 0.05 and 0.5%, however the exact reason why is not currently known.

On balance, Magnolia Bark Extract has far more benefits than risks for skin.
Suppliers recommend using a 0.2% concentration of Magnolia Bark Extract for preservation purposes in combination with other preservatives and a 0.05% concentration for anti-aging purposes.

The aromatic bark of Magnolia Bark Extract has natural antimicrobial properties, and has been used in traditional Chinese medicine for many centuries, where it is known as ‘Houpu’.
Magnolia Bark Extract is a species of Magnolia native to China.

These deciduous trees grow to around 20 meters tall, with broad oval leaves and large white fragrant flowers.
The bark is harvested during spring months, softened with steam, then rolled and dried.
Magnolia Bark Extract has a bitter taste, and contains many components with useful pharmacological properties.

Magnolia Bark Extract may have a number of medical uses, more studies are needed to determine whether it can measurably improve sleep.
We discuss the current state of research and how Magnolia Bark Extract may be used as a treatment for insomnia and other conditions.
Magnolia Bark Extract is a medicinal plant and is sometimes referred to by its botanical name, Magnolia officinalis, as well as its traditional names, Houpo or Hou Po.

In biomedical research, the primary active compounds in Magnolia Bark Extract are called magnolol and honokiol.
Magnolia Bark Extract is available in the form of tablets or powders containing bark extract.

When used medicinally, Magnolia Bark Extract is often combined with other substances.
In fact, much of the research done so far has studied the effects of Magnolia Bark Extract in combination with other things, like calcium, magnesium, zinc, and phellodendron.

USES and APPLICATIONS of MAGNOLIA BARK EXTRACT:
Magnolia Bark Extract has a strong antimicrobial, antibacterial and anti-inflammatory effect.
Used in acne treatment, Magnolia Bark Extract is very effective against acne-causing germs without irritating the skin.
As it has a much higher antioxidant effect than alpha-tocopherol, Magnolia Bark Extract is perfect for sun protection products.

Oxidation products are neutralised and resulting skin damage is prevented.
In fats and oils Magnolia Bark Extract helps as a booster - similar to vitamin C palmitate - to extend the effect of mixed tocopherols and thus the shelf life of the fat/oil.

The highly aromatic bark is stripped from the stems, branches, and roots and used in traditional Chinese medicine, where it is known as hou po (厚朴; thus the common name).
The traditional use indications are to eliminate damp and phlegm, and relieve distension.

Today, the bulk of bark, Magnolia Bark Extract, used for commercial and domestic use is supplied by plants in cultivation.
Currently, Magnolia Bark Extract is widely used in food supplements and beauty products.
You can also find the bark's name listed in the American Pharmacopeia as a bitter antimalarial tonic.

Magnolia Bark Extract is an extract derived from the bark of the magnolia tree and has long been employed in traditional Chinese medicine.
Common Uses of Magnolia Bark Extract: Skincare formulations
Magnolia Bark Extract should be added to a formulation at the recommended usage rate.

Magnolia Bark Extract is a plant from the Magnolia species of plants that share similar compounds.
Two of the compounds, Magnolol and Honokiol are the two primary active ingredients found in the bark.
Honokiol and Magnolol are two biphenolic structural isomers called neolignans.

They were first found in plants in the Magnolia family and historically used to support stress and respiratory health.
Most literature sources are from Japanese and Chinese foreign-language publications, clinical studies are on the efficacy of Magnolia Bark Extract (MBE) are limited.

Documentation on the materials and extracts for several studies is also limited.
Magnolia Bark Extract is a plant found in parts of Asia and North and South America.
The bark and flowers are used in Traditional Chinese Medicine.

Magnolia Bark Extract seems to have anxiety-reducing effects.
Chemicals in Magnolia Bark Extract might kill bacteria in the mouth which might help prevent cavities or reduce gum swelling.
In Traditional Chinese Medicine, Magnolia Bark Extract is used to treat the "stagnation of qi" as well as for depression and anxiety.

People also use Magnolia Bark Extract for obesity, stress, gingivitis, plaque, and other conditions, but there is no good scientific evidence to support most of these uses.
Magnolia Bark Extract's scent bark (obtained from the stems, branches, and roots) has been used folklorically to treat anxiety, nervousness, and dermatitis.

Containing high amounts of the bioactive molecules Magnolol, Honokiol, and Magnone A and B-lignans, Magnolia Bark Extract has numerous beneficial effects on the skin.
An herbal remedy, Magnolia Bark Extract is best known for its power to preserve skin elasticity and combat sagging skin.

The soothing extract also calms redness and irritation, guards against free radical damage, and diminishes the look of lines and wrinkles.
Magnolia Bark Extract lessens the stinging discomfort of sensitive skin or product-related causes.
This natural antioxidant, Magnolia Bark Extract, is an ideal ingredient for anti-aging and sun-care products.

Magnolia Bark Extract is used internally in the treatment of abdominal distension, loss of appetite, gastro-enteritis, vomiting, diarrhoea, asthma and coughs with acute phlegm.
The bark and flower buds of Magnolia Bark Extract have been used to treat coughs and colds and intestinal problems.

Magnolia Bark Extract has been used for centuries in traditional Chinese medicine to treat an array of conditions including depression, anxiety, and sleep issues like insomnia.
Magnolia Bark Extract continues to be used in dietary supplements today, marketed for potential benefits like reducing stress, decreasing inflammation, and as a natural sleep aid.

-Traditional Medicine uses of Magnolia Bark Extract:
*Anti-inflammatory and Antioxidant:Magnolia Bark Extract is widely used in traditional Chinese medicine to reduce inflammation and provide antioxidant protection.

*Anxiolytic and Relaxant: Magnolia Bark Extractelps in reducing anxiety, stress, and promoting relaxation.
*Digestive Health: Magnolia Bark Extract is used to relieve digestive issues such as bloating and indigestion.

-Cosmetics and Skincare uses of Magnolia Bark Extract:
*Anti-aging: Due to its antioxidant properties, Magnolia Bark Extract is used in formulations for anti-aging creams to fight free radicals.
*Anti-inflammatory: Magnolia Bark Extract helps in soothing irritated or inflamed skin.
*Skin Brightening: Magnolia Bark Extract is known to promote even skin tone and reduce pigmentation.

-Pharmaceuticals uses of Magnolia Bark Extract:
*Cognitive Health: Magnolia Bark Extract is studied for potential neuroprotective effects in preventing neurodegenerative diseases.
*Antimicrobial Properties: Magnolia Bark Extract is used for its ability to fight bacteria, including oral bacteria, helping in dental care formulations.

-Dietary Supplements uses of Magnolia Bark Extract:
*Stress Reduction: Taken in supplement form to alleviate symptoms of stress and promote mental calmness.
*Weight Management: Sometimes included in weight management supplements due to Magnolia Bark Extract's potential impact on metabolism and cortisol levels.

-Active Compounds of Magnolia Bark Extract:
Magnolol: A polyphenol with strong antioxidant and anti-inflammatory properties, often studied for Magnolia Bark Extract's health benefits.
Honokiol: A compound known for Magnolia Bark Extract's anxiolytic, antimicrobial, and anti-inflammatory effects.

WHAT IS MAGNOLIA BARK EXTRACT USED FOR?
There are many potential health benefits of Magnolia Bark Extract offered by two key micronutrients — magnolol and honokiol — present in it.
You can easily find Magnolia Bark Extract in pill form in most medical and drug stores.

These are some of the more common conditions that people have used Magnolia Bark Extract for:
*Stress and anxiety.
More human research is needed.

*Sleep problems.
Many use Magnolia Bark Extract for getting better sleep at night or as a remedy for insomnia.

*Weight loss.
Early research shows that Magnolia Bark Extract could help those who have a habit of overeating when stressed to lose weight.
This is due to its stress-relieving properties.

*As an aid digestion.
Magnolia Bark Extract can improve the health of your digestive system.
Studies done on Magnolia Bark Extract’s active constituents, magnolol and honokiol, also show that they can help food move more easily through the digestive tract.

*Cancer prevention.
Some lab studies suggest Magnolia Bark Extract has anticancer properties, but more research is needed.

*Antioxidant properties.
The two active ingredients in Magnolia Bark Extract have antioxidant properties.
Antioxidants can help reduce inflammation in the body which may be helpful for conditions such as diabetes, Alzheimer's, and heart disease.
More research is needed.

MAGNOLIA BARK EXTRACT BENEFITS AND USES:
Magnolia Bark Extract may help support healthy cellular function
Magnolia Bark Extract may help promote feelings of well being
Magnolia Bark Extract may help support healthy stress levels
Magnolia Bark Extract may help promote healthy sleeping habits
Magnolia Bark for Sleep

HOW WAS MAGNOLIA BARK EXTRACT USED HISTORICALLY IN TRADITIONAL MEDICINE?
The extract of the Magnolia Bark Extract has been used for thousands of years in traditional Chinese and Japanese medicine.
During the 7th century, monks in the Chinese Buddhist temples grew these trees in their gardens for use in treating conditions like depression, asthma, muscle pain, and headache.

Magnolia Bark Extract was also valued in TCM for its ability to reduce inflammation, anxiety, and bloating.
Within Kampo or traditional Japanese medicine, Magnolia Bark Extract's main role was that of a digestive supplement.
Magnolia Bark Extract was also used in Native American medicine as an antimalarial herb.

The first recorded mention of the herb was made in the ancient Chinese herb guide "Shennong Bencao Jing" around 100 A.D.
Magnolia Bark Extract was said to treat "fright qi" — a condition caused by emotional distress due to fear and anxiety.
Later, Magnolia Bark Extract was described in many famous Chinese medical texts such as the "Jingui Yaolue" and the "Shanghan Lun".

Today, Magnolia Bark Extract is still used in these two traditional medicinal formulas:
*Banxia Houpo Tang:
This Chinese formula is said to move stagnant qi in the solar plexus, head, and throat area.

*Saiboku-To:
This Japanese formula has anti-inflammatory properties that can help to reduce asthma symptoms.
In the western world, the magnolia tree was first seen in North Carolina during the 16th century.
Later, it was carried to England.
The tree got its scientific name from the name of Pierre Magnol, a well-known French physician and botanist of the 17th century.

DOSING OF MAGNOLIA BARK EXTRACT:
Magnolia Bark Extract is commercially available in the United States and throughout Europe.
Dosage varies depending on the condition treated, with weight loss products containing Magnolia Bark Extract available mostly in powder form.

Several strengths are available for Relora, a patented blend marketed as "a natural stress management supplement" that includes Magnolia Bark Extract.
Dosing recommendations include taking a 300 mg capsule of Relora 2 to 3 times per day.
One small, randomized, controlled study treated patients with one 60 mg tablet of Magnolia Bark Extract daily to help relieve menopausal symptoms.

MAGNOLIA BARK EXTRACT BENEFITS FOR THE SKIN:
Magnolia bark extract is one of the most potent anti-wrinkle ingredients.
Magnolia Bark Extract is obtained from the bark of the Magnolia officinalis plant and it contains high amounts of organic compounds magnolol and honokiol, which are said to be up to 1000 times more potent in antioxidants than vitamin E.

The anti-inflammatory properties of magnolol and honokiol also effectively help to fight and inhibit the activation of NF-KB, a key facilitator in the aging and chronic inflammation processes.

*Anti-Oxidant and Anti-Bacterial
Magnolia Bark Extract also has anti-oxidant and anti-bacterial properties, which helps to neutralise free radicals and decelerate the aging process.
Normally, the body can handle free radicals, but if antioxidants are unavailable, or if too many free radicals have been produced they can damage our cells.

*Soft and Even Complexion
Magnolia Bark Extract is also used in skin care products to help fade dark spots and pigmentation, and to give the appearance of a soft and even complexion.

WHAT BENEFITS DOES MAGNOLIA BARK EXTRACT HAVE?
Inflammation has negative effects as Magnolia Bark Extract’s associated with the consistent production of free radicals in the skin.
These are known to be instrumental in the development of wrinkles, smaller fine lines, sagging skin, blotchiness and skin redness.

Magnolia bark extract has been used for centuries for its anti-inflammatory purposes in Traditional Chinese Medicine.
Celebrated as a herbal remedy for treating the stagnation of qi (energy), for digestive disorders, anxiety and allergic diseases, Magnolia bark extract can also help to prevent the loss of skin elasticity and reduce reddening of the skin.

FUNCTIONS OF MAGNOLIA BARK EXTRACT:
*Antiseptic
*Firming
*Antioxidant
*Smoothing
*Soothing
*Skin conditioning

WHAT ARE THE NUTRIENTS IN MAGNOLIA BARK EXTRACT?
To date, scientists have found over 250 chemical compounds in the bark, flowers, cones, and leaves of the genus Magnolia.
Among them, magnolol and honokiol are the main nutrients in Magnolia Bark Extract thought to have the most medicinal value.
These two compounds come under the category of polyphenols — plant micronutrients that offer health benefits like defense against UV radiation and microbial infection.

Research suggests that both magnolol and honokiol are, by nature:
*Anti-inflammatory: able to reduce inflammation in the body
*Antimicrobial: able to kill or slow the spread of bacteria, viruses, and fungi
*Antioxidant: able to protect cells against damage by free radicals
*Neuroprotective: able to protect brain cells against damage
*Antidiabetic: able to control blood sugar and prevent diabetes
*Antidepressant: able to reduce the symptoms of depression
*Antixiolytic: able to reduce anxiety
*Antiangiogenic: able to keep new blood vessels from forming and prevent tumor growth, but more research is needed to back up all of these claims.

COLLECTION OF MAGNOLIA BARK EXTRACT:
*Magnolia Bark Extract For Skin:
Magnolia Bark Extract is a natural ingredient with numerous benefits for the skin.
Magnolia Bark Extract is derived from the bark of the magnolia tree and has been used for centuries in traditional Chinese medicine.

Magnolia Bark Extract contains two main compounds, magnolol, and honokiol, which have been shown to have antioxidant, anti-inflammatory, and antimicrobial properties.
One of the main benefits of Magnolia Bark Extract for the skin is its ability to reduce inflammation.

Magnolia Bark Extract contains compounds that can help to reduce redness, swelling, and irritation, making it an excellent choice for those with sensitive or acne-prone skin.
Magnolia Bark Extract can also help to reduce the appearance of fine lines and wrinkles, as it contains antioxidants that help to protect the skin from free radicals.

Another benefit of Magnolia Bark Extract is its ability to soothe and calm the skin.
Magnolia Bark Extract contains anti-inflammatory properties that can help to alleviate skin conditions such as rosacea and eczema.
Magnolia Bark Extract also has antimicrobial properties that can help to prevent the growth of bacteria on the skin, reducing the risk of breakouts and infections

SHELF LIFE OF MAGNOLIA BARK EXTRACT:
12 months, properly stored, in a sealed container.

FORMULATION NOTES OF MAGNOLIA BARK EXTRACT:
Most extracts should be added to the cool-down phase of the formulation.
For maximal anti-bacterial outcomes, it is necessary to dissolve Magnolia Bark Extract (Magnolol) in a solubilizer, then incorporate the solution into the oil phase before emulsifying.

WHAT IS MAGNOLIA BARK EXTRACT USED FOR?
Magnolia Bark Extract is a versatile ingredient in cosmetics, offering several benefits.
Magnolia Bark Extract provides antioxidant protection, helping to guard the skin against oxidative damage and signs of aging.
Magnolia Bark Extract's anti-inflammatory qualities soothe and calm irritated or sensitive skin, reducing redness and swelling.

Magnolia Bark Extract also has antimicrobial properties that aid in controlling acne by targeting acne-causing bacteria.
Commonly included in serums, creams, and moisturizers, Magnolia Bark Extract enhances overall skin health by improving resilience and promoting a more balanced, clear complexion.

In hair care, Magnolia Bark Extract can enhance scalp health by reducing inflammation and combating dandruff.
Magnolia Bark Extract also helps maintain healthy hair growth and manage scalp irritation.

ORIGIN OF MAGNOLIA BARK EXTRACT:
Magnolia Bark Extract is made by first harvesting the bark from the Magnolia officinalis tree.
The bark is then dried and ground into a coarse powder.
To extract the active compounds, Magnolia Bark Extract, the powdered bark is subjected to solvent extraction using ethanol or water.
The solution is filtered to remove impurities, and Magnolia Bark Extract is concentrated through evaporation.

WHAT DOES MAGNOLIA BARK EXTRACT DO IN A FORMULATION?
*Antidandruff
*Antioxidant
*Hair conditioning
*Moisturising
*Skin conditioning
*Skin protecting
*Soothing

SAFETY PROFILE OF MAGNOLIA BARK EXTRACT:
Magnolia Bark Extract is a safe ingredient, rarely causing any side effects.
Magnolia Bark Extract is non-comedogenic and well tolerated by most skin types.
However, a patch test should be performed before using any new product containing Magnolia Bark Extract.
Further, Magnolia Bark Extract is safe for the environment and is considered vegan and halal.

ALTERNATIVES OF MAGNOLIA BARK EXTRACT:
*CAMELLIA SINENSIS LEAF EXTRACT,
*CHAMOMILLA RECUTITA FLOWER EXTRACT,
*GLYCYRRHIZA GLABRA ROOT

PROCESSING TIP OF MAGNOLIA BARK EXTRACT:
If you want to use Magnolia Bark Extract for its antimicrobial properties and thus for product protection, you must use a solubiliser such as Pentylene Glycol Natural.
Only then can it show its full antimicrobial potential.
Dissolve Magnolia Bark Extract in Pentylene Glycol Natural and add it to the oil phase before emulsifying.

USE CONCENTRATION OF MAGNOLIA BARK EXTRACT:
0.05% as an active ingredient against acne
0.2 - 0.3% as an antimicrobial enhancer

PHARMACEUTICAL POTENTIAL OF MAGNOLIA BARK EXTRACT:
The bark contains magnolol and honokiol, two polyphenolic compounds that have been demonstrated as peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists and GABAA modulators

CAN MAGNOLIA BARK EXTRACT HELP YOU SLEEP?
Magnolia Bark Extract has long been used in traditional Chinese medicine to help with sleep.
However, there is not yet enough scientific evidence to determine whether Magnolia Bark Extract’s effective for this purpose in humans.

While suggest that extracts from Magnolia Bark Extract may shorten the time it takes to fall asleep, it has not been extensively studied in humans.
Though in one human study, Magnolia Bark Extract combined with the mineral magnesium was shown to reduce sleep disturbances.

MAGNOLIA BARK EXTRACT STANDARDIZATION:
This Magnolia Bark Extract is standardized to Magnolol + Honokiol minimum content 80% by UPLC

MAGNOLIA BARK EXTRACT AT A GLANCE:
*Plant extract taken from the bark of the Magnolia officinalis tree
*Magnolia Bark Extract contains unique soothing compounds
*Magnolia Bark Extract helps mitigate environmental damage, including discolorations
*Magnolia Bark Extract can be used as a part of a natural cosmetics preservative blend

IDENTIFICATION OF MAGNOLIA BARK EXTRACT:
It is a deciduous tree growing to 20 m in height.
The bark is thick and brown, but does not fissure.
The leaves are broad, ovate, 20–40 cm long, and 11–20 cm broad.
The flowers are fragrant and 10–15 cm wide, with 9–12 (rarely to 17) white tepals, and appear from May to June.

The two varieties are:
Magnolia Bark Extract has leaves with an acute apex.
Magnolia officinalis var. biloba has leaves with a notch at the apex.

This variety does not appear in the wild, and is only known in cultivation.
It is possibly not a true variety at all, but actually a cultigen instead, though this has yet to be determined.

M. officinalis differs very little from Magnolia obovata; the only difference consistently observed between the two is that the fruit aggregate of M. officinalis has a rounded base, while that of M. obovata has an acute base.
Further research may or may not eventually determine if M. officinalis should be treated as a subspecies of M. obovata.

6 POTENTIAL HEALTH BENEFITS OF MAGNOLIA BARK EXTRACT:
1. May reduce stress and anxiety
Magnolia Bark Extract has been shown to reduce stress and anxiety.

In a 2022 study, a supplement containing Magnolia Bark Extract and phellodendron bark (Phellodendron amurense) was used in 56 people who were moderately stressed.
Salivary cortisol, a stress indicator, was decreased by 18% by the herb combination compared with a placebo.
The combination also improved the mood of people who took the supplement.

In another study, the same Magnolia Bark Extract/philodendron mixture was proven to lower anxiety in premenopausal female adults.
Although anxiety was temporarily reduced, there was no lasting effect after participants stopped using the blend.
Magnolia Bark Extract was able to control brain protein levels that are an indication of anxious behavior.

2. May improve sleep
Magnolia Bark Extract may help improve sleep quality by reducing anxiety.
In a different study on the effects of magnolol, researchers observed similar results.
The effectiveness of Magnolia Bark Extract for promoting sleep needs to be confirmed by human clinical trials.

3. May support gut health
Magnolia Bark Extract promotes digestion and gut health.
Although Magnolia Bark Extract may support healthy gut flora, large-scale human studies are needed to confirm these effects in humans.

4. May improve weight loss
Magnolia Bark Extract may promote weight loss by reducing stress.
In a clinical experiment, Magnolia Bark Extract exerted a weight loss effect on healthy, overweight, premenopausal women who had a tendency to overeat when stressed.
Researchers discovered that Magnolia Bark Extract reduced evening cortisol levels, a stress indicator, which resulted in a reduction in nighttime snacking.

Another study reported that people who experienced moderate stress consumed fewer calories as a result of taking a supplement that contains Magnolia Bark Extract.
Participants who took 500 mg per day (250 mg in the morning and 250 mg in the evening) experienced better weight loss.

5. May have anticancer properties
In higher doses, Magnolia Bark Extract may have anticancer properties, although studies to prove this benefit are lacking.
Honokiol was successful in preventing the growth of skin cancer.
According to researchers, the anticancer properties of Magnolia Bark Extract were caused by its capacity to activate specific proteins.

Laboratory tests have also demonstrated the antitumor effects of active Magnolia Bark Extract components.
In one study, the combination of honokiol and tumor radiotherapy reduced lung tumors by 78%

In vitro and in vivo studies have reported that honokiol may prevent the growth of breast cancer cells and enhance the effects of other breast cancer treatments.
Another in vitro experiment that used honokiol on oral cancer cells had positive outcomes.
Honokiol was able to inhibit cell proliferation while inducing cancer cell death.

Although initial lab research suggests that Magnolia Bark Extract components, particularly honokiol, may aid in the prevention of cancer, more extensive research is needed to confirm whether Magnolia Bark Extract is beneficial in preventing cancer.

6. Anti-inflammatory and antioxidant properties
Researchers discovered that both magnolol and honokiol induced anti-inflammatory and antioxidant effects.
At concentrations of 1 and 10 g/mL, the bark extract of Magnolia Bark Extract proved effective in lowering the release of inflammatory chemicals, and magnolignan B had the strongest antioxidative potential.

OTHER BENEFITS OF MAGNOLIA BARK EXTRACT:
A number of uses of Magnolia Bark Extract have been investigated.

*Treating inflammation:
Magnolia Bark Extract’s active compounds, magnolol and honokiol, are strong antioxidants.
Laboratory studies have also shown an anti-inflammatory effect.

*Lowering blood sugar:
The active compounds in Magnolia Bark Extract improved insulin sensitivity and lowered blood sugar in both laboratory research.

*Treating infection:
Laboratory research has shown that Magnolia Bark Extract can work against bacteria that cause some infections.

*Preventing cancer:
Laboratory research suggests that Magnolia Bark Extract may help prevent cancer, but human research is needed to test this potential use.

*Easing depression:
Research conducted in a lab suggests that Magnolia Bark Extract may be able to help normalize brain chemicals that affect depression.
Human research suggests that Magnolia Bark Extract may help improve mood.

*Managing weight:
While more research is needed, that one of Magnolia Bark Extract’s active compounds, honokiol, helps improve fat metabolism and insulin resistance.
A small human study suggested that Magnolia Bark Extract may help reduce stress-related eating.

*Improving digestion:
Magnolia Bark Extract may help ease digestive problems and protect against ulcers.

*Maintaining brain health:
One of the active compounds in Magnolia Bark Extract, may prevent the death of brain cells and stop the buildup of harmful proteins that are linked to Alzheimer’s disease.

HOW DOES MAGNOLIA BARK EXTRACT WORK?
There are two biologically active compounds in Magnolia Bark Extract that scientists believe are responsible for its beneficial effects.

*Magnolol: One effect of magnolol is to act upon neurochemical receptors in the brain.
Researchers believe that magnolol could help restore the normal function of chemicals in the brain, which could help with anxiety, depression, and insomnia.

*Honokiol:
After a long history of use in Asian medicine, honokiol is being studied for Magnolia Bark Extract's potential uses for anxiety, pain, diseases affecting the blood vessels, seizures, and Alzheimer’s disease.

Research has shown that magnolol and honokiol interact with brain chemistry in a way that promotes relaxation and sleep.
Specifically, these compounds – especially honokiol – interact with a brain chemical called GABA in a way that is similar to sedative drugs like benzodiazepines.

Lab studies have also shown that magnolol and honokiol also interact with cannabinoid receptors in the brain.
Cannabinoid receptors are sites on nerve cells that are concentrated in the parts of the brain that influence pleasure, perception, and coordination.
Interactions between magnolol and honokiol and cannabinoid receptors may help reduce pain, improve mood, and lower inflammation.

PHYSICAL and CHEMICAL PROPERTIES of MAGNOLIA BARK EXTRACT:
CAS Number: 947686-05-7
Chem/IUPAC Name: Magnolia Officinalis Bark Extract
EINECS/ELINCS No: 943-705-7
COSING REF No: 57597
Appearance: Brown or light yellow powder
Solubility: Soluble in ethanol, slightly soluble in water
Active Components: Magnolol, Honokiol (primary bioactive compounds)
Melting Point: Not applicable for the extract
Boiling Point: Not applicable
Flash Point: Not applicable
pH: Neutral to slightly acidic when dissolved in water
INCI Nomenclature: Magnolia Officinalis Bark Extract

Appearance: White to light yellow powder
Solubility: Oil Soluble
Suggested Use Levels: 0.05-0.3%
Storage: Protected from direct light and humidity at a temperature of 50°-77°F (10°-25°C)
Family: Magnoliaceae
Genus: Magnolia
Subgenus: Magnolia subg. Magnolia
Section: Magnolia sect. Rhytidospermum
Subsection: Magnolia subsect. Rhytidospermum
Species: M. officinalis
Binomial Name: Magnolia officinalis
pH: 4.5-7.0
Solubility: Soluble in water
Viscosity: Medium

FIRST AID MEASURES of MAGNOLIA BARK EXTRACT:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of MAGNOLIA BARK EXTRACT:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of MAGNOLIA BARK EXTRACT:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of MAGNOLIA BARK EXTRACT:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of MAGNOLIA BARK EXTRACT:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of MAGNOLIA BARK EXTRACT:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available