MCC 102

MCC 102 is a versatile excipient designed to improve powder flow, tablet strength, and manufacturing efficiency.
MCC 102's balanced particle size makes it especially suitable for direct compression and high-speed tableting processes.
MCC 102 provides reliable filling, binding, and processing performance across pharmaceutical, nutraceutical, and supplement formulations.

CAS Number: 9004-34-6
EC Number: 232-674-9
Molecular Formula: (C6H10O5)n

Synonyms: Microcrystalline cellulose 102, AVICEL PH-102, CELLULOSE, MICROCRYSTALLINE 102, CELLULOSE, MICROCRYSTALLINE PH102, CELLULOSE, MICROCRYSTALLINE PH102 (II), CELLULOSE, MICROCRYSTALLINE PH102 [II], MICROCRYSTALLINE CELLULOSE 102 IS INCLUDED IN FDA INACTIVE INGREDIENTS AS MICROCRYSTALLINE CELLULOSE, PNR0YF693Y, RefChem:818831, VIVAPUR MCC SPHERES-GRADE 100

MCC 102 is natural polymers of plant origin.
MCC 102 is a white, odorless, fine powder used primarily as a preservative and bulking agent in the pharmaceutical, food, and cosmetic industries.

MCC 102 is obtained through the controlled breakdown of cellulose and is known by the food additive code E460.
Due to its high compressibility, MCC 102 is one of the complementary raw materials used in pharmaceutical production.

MCC 102 is a technical auxiliary raw material derived from plant-derived cellulose, used as a filler, binder, and structural support in tablet, capsule, and powder formulations.
MCC 102 is preferred as a standard quality component in the production of pharmaceuticals, supplements, and functional products.

Thanks to its particle size and fluidity properties, MCC 102 ensures homogeneous mixing in production lines, facilitates compression processes, and contributes to product form stability.
MCC 102 increases process efficiency in industrial production processes.

MCC 102 is a purified, partially depolymerized cellulose widely used as a functional excipient in pharmaceutical, nutraceutical, food, and industrial formulations.
MCC 102 is typically supplied as a white or almost white, odorless, free-flowing powder with a larger average particle size than MCC PH 101.

MCC 102 is particularly valued for its excellent flowability, compressibility, binding performance, and compatibility with direct-compression manufacturing processes.
Compared with finer MCC grades, MCC 102 generally provides improved powder flow while maintaining strong tablet-forming characteristics.

MCC 102 is commonly used as a binder, filler, diluent, disintegrant, bulking agent, and processing aid in tablets, capsules, nutritional supplements, and other solid dosage formulations.

MCC 102 is a white crystalline powder or granules made from natural cellulose through acid hydrolysis, purification, and drying.
MCC 102 exhibits high chemical inertness, good dispersibility, excellent flowability, and compression moldability, making it widely used in the pharmaceutical, food, cosmetic, and industrial sectors.

In the pharmaceutical industry, MCC 102 is an ideal tablet filler, disintegrant, and diluent; in the food industry.
MCC 102 can be used as a dietary fiber supplement, thickener, and anti-caking agent; and in cosmetics, it serves as a stabilizer and adsorbent.

MCC 102 is a premium excipient produced from purified plant cellulose, offering excellent compressibility, flowability, and stability for a wide range of nutraceutical and pharmaceutical formulations.
With a slightly larger particle size than MCC 101, this grade provides enhanced flow properties ideal for high-speed tablet compression and capsule filling applications.

The bulk-dried format ensures low moisture content and improved functional performance, delivering uniform blend behavior, consistent tablet hardness, and low friability.
MCC 102 is widely used as a binder, filler, and flow aid, supporting efficient production processes and high-quality finished dosage forms.

Chemically inert and non-reactive, MCC is suitable for vegan, vegetarian, allergen-free, and clean-label applications.
MCC 102 is compatible with vitamins, minerals, botanical extracts, enzymes, amino acids, and a wide range of active ingredients commonly used in tablet and capsule formulations.

MCC 102 is a white, free flowing, dietary fiber with a neutral taste and odor.
MCC 102 is indigestible and serves as a separating agent, or carrier material, consisting of high chemical and microbial purity.
Composed of 99.5% dietary fiber content, the product is used as a technological aid for dairy based drinks, cheese, spreads, and confectionery.

MCC 102 compacts more effectively than any other excipient making Pharmacel® 102 the ideal choice for direct compression.
MCC 102's versatility in direct compression extends to very high-dose actives, where compatibility is at a premium.

MCC 102 is a pure partially depolymerized cellulose synthesized from α-cellulose precursor (type Iβ), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization.
The MCC can be synthesized by different processes such as reactive extrusion, enzyme-mediated, steam explosion, and acid hydrolysis.

MCC 102 is commonly manufactured by spray-drying the neutralized aqueous slurry of hydrolyzed cellulose.
The MCC is a valuable additive in pharmaceutical, food, cosmetics, and other industries.

MMC obtained from different sources will differ considerably in chemical composition, structural organization, and physicochemical properties (crystallinity, moisture content, surface area and porous structure, molecular weight, etc.).
The high demand for MCC 102 used in pharmaceutical industries has led to the utilization of locally and naturally occurring materials in the production of MCC 102.

MCC 101 is a fine, white, free-flowing powder obtained from purified cellulose.
MCC 102 is extensively used in pharmaceutical formulations because of its superior binding characteristics and compactibility.
MCC 102 is especially suitable for formulations that require enhanced tablet strength and stability during production.

The MCC 101 particle size is comparatively smaller, which allows better surface area contact between particles during compression.
Because of this property, pharmaceutical manufacturers commonly use this grade in immediate-release formulations where hardness and fast disintegration are both important.

Applications of MCC 102:
MCC 102 is used as an emulsifier in creams produced in the cosmetics industry.
MCC 102 is used in the pharmaceutical industry.

MCC 102 is used in tablet and capsule production as a binding agent, bulking agent, and anti-caking agent due to its lack of nutritional value.
MCC 102 is used to form white opaque gels in water dispersions. In dietary supplements.

MCC 102 is used as a bulking agent due to its lack of nutritional value.
MCC 102 is used in tablet production.

MCC 102 ensures the formation of harder and more easily dispersed tablets.
MCC 102 can also act as a matrix to keep active ingredients together.

MCC 102 is used in the food industry, MCC is used to hold suspended matter in liquid products.
Compared to many dilution agents, MCC has the highest potential in tablets and capsules.

Pharmaceutical Industry:
MCC 102 is used as a tablet and capsule filler and disintegrant to improve tablet hardness and disintegration performance

Food Industry:
MCC 102 is used as a dietary fiber, emulsion stabilizer, thickener, and anti-caking agent

Cosmetics:
MCC 102 is used to improve texture and stability in products such as facial masks, pressed powder, and toothpaste

Industrial Uses:
MCC 102 is used as a coating thickener, plastic reinforcing filler, and rubber reinforcing agent

Uses of MCC 102:
MCC 102 is widely used as a binder and diluent in tablet and capsule formulations.
MCC 102 is particularly suitable for direct-compression processes because of its good flowability and compressibility.

MCC 102 is used as a filler and bulking agent in pharmaceutical and nutraceutical products.
MCC 102 can support tablet disintegration by promoting water penetration into compressed formulations.

MCC 102 is used in vitamin, mineral, and dietary supplement tablets to improve processing and tablet strength.
MCC 102 may also be applied in food and industrial formulations as a stabilizing, texturizing, or carrier material.

Pharmaceutical Industry:

Tablet Binder:
MCC 102 is a key binder in tablet formulations, helping to hold the ingredients together and maintain the tablet’s integrity.
MCC 102 also plays a role in disintegration, which is important for the release of active ingredients in the body.

Excipient:
MCC 102 is widely used as a filler and bulking agent in both tablets and capsules.

Controlled Release Formulations:
Because MCC 102 can help in the controlled release of drugs.
MCC 102 is used in formulations where a slow release of the active ingredient is desired.

Food Industry:

Texturizing Agent:
In food products, MCC 102 is used as a fat replacer or bulking agent in low-calorie or reduced-fat formulations.
MCC 102 helps create the desired texture in products like low-fat or sugar-free baked goods, frozen desserts, and snack foods.

Stabilizer and Emulsifier:
MCC 102 stabilizes emulsions and suspensions, improving the texture and consistency of processed foods like salad dressings and sauces.

Cosmetics:

Thickening and Stabilizing Agent:
MCC 102 is used in creams, lotions, and gels to enhance texture and improve the overall feel of the product.
MCC 102 helps stabilize emulsions, making it ideal for formulations like moisturizing creams, foundations, and sunscreens.

Controlled Release:
Similar to its use in pharmaceuticals, MCC 102 is sometimes used in cosmetic formulations to control the release of active ingredients.

Other Industrial Uses:

Film Forming:
MCC 102 is sometimes used in the production of films for controlled release in various industrial applications.
For example, it’s used in the manufacture of biodegradable plastics or in applications requiring high mechanical strength.

Anti-Caking Agent:
MCC 102 also serves as an anti-caking agent in powdered products, helping to keep them free-flowing and easy to use.

Advantages of MCC 102:
High purity (α-cellulose ≥99%), strong chemical inertness
Customizable particle size to suit different application requirements
Excellent flowability and compression molding properties
Meets USP, EP, JP, and other pharmacopoeia quality standards
Factory-direct supply, significant price advantage

Stability and Reactivity of MCC 102:

Chemical Stability:
Stable under recommended storage and handling conditions.

Reactivity:
Generally low reactivity under normal conditions.

Conditions to Avoid:
Excessive heat, open flames, moisture, and unnecessary dust generation.

Incompatible Materials:
Strong oxidizing agents and other highly reactive chemicals.

Handling and Storage of MCC 102:

Safe Handling:
Avoid inhalation of dust and minimize airborne powder formation during handling.

Storage Conditions:
Store tightly closed in a cool, dry, well-ventilated area protected from moisture and contamination.

First Aid Measures of MCC 102:

Inhalation:
Move the affected person to fresh air and seek medical attention if irritation or discomfort persists.

Skin Contact:
Wash with soap and water if irritation occurs.

Eye Contact:
Rinse cautiously with plenty of water for several minutes and obtain medical attention if irritation continues.

Ingestion:
Rinse mouth and seek medical advice if a large quantity has been swallowed or symptoms occur.

Firefighting Measures of MCC 102:

Suitable Extinguishing Media:
Use water spray, foam, dry chemical, or carbon dioxide according to the surrounding fire.

Specific Hazards:
Fine cellulose dust may form combustible dust mixtures in air and combustion may produce carbon oxides.

Protective Equipment:
Firefighters should wear suitable protective equipment and self-contained breathing apparatus where necessary.

Accidental Release Measures of MCC 102:

Personal Precautions:
Avoid dust formation and inhalation and ensure adequate ventilation.

Cleanup Methods:
Carefully sweep or vacuum spilled material using equipment suitable for combustible dust and place it in a suitable container.

Environmental Precautions:
Prevent excessive release into drains or surface waters.

Exposure Controls/Personal Protection of MCC 102:

Engineering Controls:
Provide adequate ventilation and dust extraction where airborne powder may be generated.

Eye Protection:
Wear safety glasses or chemical goggles where dust exposure is possible.

Hand Protection:
Wear suitable protective gloves during prolonged handling.

Skin Protection:
Wear appropriate work clothing.

Respiratory Protection:
Use suitable particulate respiratory protection where dust concentrations cannot be adequately controlled.

Identifiers of MCC 102:
Chemical Name: Microcrystalline Cellulose
Common Name: MCC 102
Grade Name: Microcrystalline Cellulose PH 102
CAS Number: 9004-34-6
EC Number: 232-674-9
Molecular Formula: (C6H10O5)n
Molecular Weight: Variable polymeric molecular weight
IUPAC Name: Cellulose

CAS Number: 9004-34-6
Molecular Formula: C12H22O11
Molecular Weight: 342.30 g/mol
Density: 1.5 g/cm³

Product Name: Microcrystalline Cellulose (MCC)
CAS Number: 9004-34-6
Molecular Formula: (C6H10O5)n
Appearance: White, odorless, tasteless crystalline powder
Particle Size: 20 – 200 μm (customizable)
Bulk Density: 0.26 – 0.31 g/cm³
Loss on Drying: ≤ 5.0%
pH (10% suspension): 5.0 – 7.5
Solubility: Insoluble in water and most organic solvents
Purity (α-cellulose): ≥ 99%
Shelf Life: 24 months

Properties of MCC 102:
Appearance: White or almost white free-flowing powder
Odor: Odorless
Physical Form: Fine to moderately coarse powder

Appearance: White, odorless powder
Chemical Formula: C14H26O11
Molecular Weight: 370.35 g/mol
Density: 1.5 g/cm³
pH Value: 5.0 – 7.5
Flash Point: 164 °C
Melting Point: 76–78 °C
Boiling Point: 667.9 °C
Solubility: Insoluble in water, ethanol and ether; soluble in sodium hydroxide solution