MEKO (METHYLETHYL KETONE OXIME)

Synonyms:
MEKO;  2-BUTANONE OXIME; Methyl ethyl ketoxime; 96-29-7; 2-Butanone, oxime; Butanone oxime; Ethyl methyl ketoxime; Troykyd anti-skin B; Ethyl methyl ketone oxime; (E)-butan-2-one oxime; DSSTox_CID_1821; USAF AM-3; DSSTox_RID_76348; DSSTox_GSID_21821; 2-Butoxime; Methylethylketoxime; NSC 442; Pentan-2-one,oxime; Butan-2-one, oxime; Skino No. 2; CAS-96-29-7; Aron M 1; SKINO 2; 2-Butanone, oxime, (E)-; MEK oxime; ethylmethyl-ketoxime; methylethyl ketoxime; methylethylketone oxime; ACMC-1BQBU; 2-Butanone, oxime, (Z)-; MEKO;  2-BUTANONE OXIME; Methyl ethyl ketoxime; 96-29-7; 2-Butanone, oxime; Butanone oxime; Ethyl methyl ketoxime; Troykyd anti-skin B; Ethyl methyl ketone oxime; (E)-butan-2-one oxime; DSSTox_CID_1821; USAF AM-3; DSSTox_RID_76348; DSSTox_GSID_21821; 2-Butoxime; Methylethylketoxime; NSC 442; Pentan-2-one,oxime; Butan-2-one, oxime; Skino No. 2; CAS-96-29-7; Aron M 1; SKINO 2; 2-Butanone, oxime, (E)-; MEK oxime; ethylmethyl-ketoxime; methylethyl ketoxime; methylethylketone oxime; ACMC-1BQBU; 2-Butanone, oxime, (Z)-; Methylethyl ketone oxime; Methyl ethyl ketone oxime; Methylethyl ketone oxim; Methyl ethyl ketone oxim; Methilethyl ketone oxime; Metiletil ketone oxime; meko; Meko; MEKO;  2-BUTANONE OXIME; METHYL ETHYL KETOXİME; 96-29-7; 2-BUTANONE, OXİME; BUTANONE OXİME; ETHYL METHYL KETOXİME; TROYKYD ANTİ-SKİN B; ETHYL METHYL KETONE OXİME; (E)-BUTAN-2-ONE OXİME; DSSTOX_CID_1821; USAF AM-3; DSSTOX_RID_76348; DSSTOX_GSID_21821; 2-BUTOXİME; METHYLETHYLKETOXİME; NSC 442; PENTAN-2-ONE,OXİME; BUTAN-2-ONE, OXİME; SKİNO NO. 2; CAS-96-29-7; ARON M 1; SKINO 2; 2-BUTANONE, OXİME, (E)-; MEK OXİME; ETHYLMETHYL-KETOXİME; METHYLETHYL KETOXİME; METHYLETHYLKETONE OXİME; ACMC-1BQBU; 2-BUTANONE, OXİME, (Z)-; METHYLETHYL KETONE OXİME; METHYL ETHYL KETONE OXİME; METHYLETHYL KETONE OXİM; METHYL ETHYL KETONE OXİM; METHİLETHYL KETONE OXİME; METİLETİL KETONE OXİME; MEKO; MEKO; MEKO;  2-BUTANONE OXIME; methyl ethyl ketoxime; 96-29-7; 2-butanone, oxime; butanone oxime; ethyl methyl ketoxime; troykyd anti-skin b; ethyl methyl ketone oxime; (e)-butan-2-one oxime; dsstox_cıd_1821; usaf am-3; dsstox_rıd_76348; dsstox_gsıd_21821; 2-butoxime; Methylethyl ketone oxime; Methyl ethyl ketone oxime; Methylethyl ketone oxim; Methyl ethyl ketone oxim; Methilethyl ketone oxime; Metiletil ketone oxime; meko; Meko; MEKO;  2-BUTANONE OXIME; METHYL ETHYL KETOXİME; 96-29-7; 2-BUTANONE, OXİME; BUTANONE OXİME; ETHYL METHYL KETOXİME; TROYKYD ANTİ-SKİN B; ETHYL METHYL KETONE OXİME; (E)-BUTAN-2-ONE OXİME; DSSTOX_CID_1821; USAF AM-3; DSSTOX_RID_76348; DSSTOX_GSID_21821; 2-BUTOXİME; METHYLETHYLKETOXİME; NSC 442; PENTAN-2-ONE,OXİME; BUTAN-2-ONE, OXİME; SKİNO NO. 2; CAS-96-29-7; ARON M 1; SKINO 2; 2-BUTANONE, OXİME, (E)-; MEK OXİME; ETHYLMETHYL-KETOXİME; METHYLETHYL KETOXİME; METHYLETHYLKETONE OXİME; ACMC-1BQBU; 2-BUTANONE, OXİME, (Z)-; METHYLETHYL KETONE OXİME; METHYL ETHYL KETONE OXİME; METHYLETHYL KETONE OXİM; METHYL ETHYL KETONE OXİM; METHİLETHYL KETONE OXİME; METİLETİL KETONE OXİME; MEKO; MEKO; MEKO;  2-BUTANONE OXIME; methyl ethyl ketoxime; 96-29-7; 2-butanone, oxime; butanone oxime; ethyl methyl ketoxime; troykyd anti-skin b; ethyl methyl ketone oxime; (e)-butan-2-one oxime; dsstox_cıd_1821; usaf am-3; dsstox_rıd_76348; dsstox_gsıd_21821; 2-butoxime; methylethylketoxime; nsc 442; pentan-2-one,oxime; butan-2-one, oxime; skino no. 2; cas-96-29-7; aron m 1; skıno 2; 2-butanone, oxime, (e)-; mek oxime; ethylmethyl-ketoxime; methylethyl ketoxime; methylethylketone oxime; acmc-1bqbu; 2-butanone, oxime, (z)-; methylethyl ketone oxime; methyl ethyl ketone oxime; methylethyl ketone oxim; methyl ethyl ketone oxim; methilethyl ketone oxime; metiletil ketone oxime; meko; Meko; metil etil keton oksim;  metiletil keton oksim;  Metil etil keton oksim;  Metil Etil keton oksim; metiletil ketonoksim ; Metiletil keton oksim

MEKO

Methylethyl ketone oxime
MEKOstr'.png
Names
IUPAC name of MEKO:
(2E)-N-Hydroxy-2-butanimine
Other names of MEKO:
MEKO, 2-Butanone oxime
Identifiers of MEKO:
CAS Number of MEKO:    
96-29-7 ☑
3D model (JSmol)    
Interactive image
ChemSpider of MEKO:    
4481809 ☒
ECHA InfoCard of MEKO:    100.002.270
EC Number of MEKO:    
202-496-6
PubChem CID of MEKO:    
5324275
UNII     of MEKO:
51YGE935U9 ☑
CompTox Dashboard of MEKO: (EPA)    
DTXSID1021821 
InChI[show] of MEKO:
SMILES[show] of MEKO:
Properties of MEKO:
Chemical formula of MEKO:    C4H9NO
Appearance of MEKO:    colourless liquid
Density     of MEKO:0.923 g/cm3
Melting point of MEKO:    −15 °C (5 °F; 258 K)
Boiling point of MEKO:    152 °C (306 °F; 425 K)

Methylethyl ketone oxime MEKO is the organic compound with the formula C2H5C(NOH)CH3. This colourless liquid is the oxime derivative of methyl ethyl ketone. MEKO, as it is called in the paint industry, is used to suppress "skinning" of paints: the formation of a skin on paint before it is used. MEKO functions by binding the drying agents, metal salts that catalyze the oxidative crosslinking of drying oils. Once the paint is applied to a surface, MEKO evaporates, thereby allowing the drying process to proceed. Other antiskinning agents have been used, including phenol-based antioxidants, but these tend to yellow the paint.[1] Butanone oxime is also used in some types of RTV silicones.

Methyl Ethyl Ketoxime (MEKO)
Product Stewardship Summary December 2007
Chemical Name: Methyl ethyl ketoxime
Synonyms: 2-Butoxime; 2-Butanonoxim; Methyl ethyl ketone oxime; Ethyl methyl
ketoxime; MEK-oxime; MEKO
CAS Number: 96-29-7
CAS Name: 2-Butanone oxime
EC (EINECS) Number: 202-496-6
• Methyl ethyl ketoxime (MEKO) is an essential chemical used as an anti-skinning agent in paints
and lacquers, as a blocking-agent for isocyanate in polyurethanes, and in the manufacture of
oxime silanes (that are used as crosslinkers for silicone sealants).
• MEKO is a High Production Volume (HPV) chemical produced at over 1,000,000 pounds
annually. Honeywell, as a member of a consortium, has sponsored MEKO under EPA’s HPV
Challenge program and the Organisation for Economic Co-operation and Development’s HPV
Programme.
• Honeywell has established a provisional occupational exposure limit of 3 ppm (10 mg/m3
) for
an 8-hour time-weighted average and a short-term exposure limit of 10 ppm for use in worksite
safety programs.
• MEKO is a clear, colorless combustible liquid.
• MEKO is severely irritating to eyes. If it gets into the eyes, immediately flush with plenty of
water and seek medical attention to avoid serious damage. MEKO is moderately toxic in the
unlikely event of ingestion. Ingesting or breathing high concentrations may cause harmful, but
reversible, effects on the blood (anemia) and inhalation can irritate nasal passages. MEKO is
slightly irritating to skin, and can be absorbed through the skin to cause harmful effects on the
blood and nervous system. Getting MEKO on the skin may cause an allergic response in
certain individuals.
• MEKO is rapidly metabolized and eliminated from the body. MEKO does not cause harmful
effects on reproduction or development.
• Male rodents developed liver tumors when repeatedly exposed during their lifetime to high
concentrations of MEKO. These tumors developed late in life and did not affect survival.
MEKO is not genotoxic, pointing to a threshold mechanism for cancer development (i.e., a
“safe level” below which cancer will not occur, a level well above typical exposures).
Therefore the human risk of cancer is low. 
MEKO has low toxicity to aquatic organisms, upon either single or repeated exposure.
• MEKO has minimal potential to accumulate in the bodies of humans or animals. It is readily
biodegradable and will not persist in the environment.