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Melatonin is an indoleamine compound used in dietary supplements, pharmaceutical preparations, cosmetic formulations, and research applications, and Melatonin is valued for its role in regulating sleep-wake rhythm and supporting circadian timing.
Melatonin is commonly used in sleep-support supplements, jet-lag products, controlled-release tablets, oral sprays, gummies, capsules, and topical products where antioxidant positioning and biological rhythm support are required.
Melatonin is typically supplied as a white to off-white crystalline powder, and Melatonin performance depends on purity, particle size, formulation type, dosage form, release profile, stability, packaging, and regulatory status in the target market.
CAS Number: 73-31-4
EC Number: 200-797-7
Molecular Formula: C13H16N2O2
Molecular Weight: 232.28 g/mol
Synonyms: Melatonin, N-Acetyl-5-Methoxytryptamine, 5-Methoxy-N-Acetyltryptamine, N-Acetylmethoxytryptamine, Circadin-Type Active, Sleep Support Ingredient, Melatonin Powder, Melatonin USP, Melatonin Pharmaceutical Grade, Melatonin Supplement Grade, Melatonin Nutraceutical Ingredient, Melatonin Active Ingredient, Melatonin, N-Acetyl-5-methoxytryptamine, 5-Methoxy-N-acetyltryptamine, N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide, 5-Methoxytryptamine N-Acetate, Acetyl-5-Methoxytryptamine, Melatonine, Melatonina, Melatoninum, Pineal Hormone Melatonin, Sleep Hormone Melatonin, Circadin, Regulin, N-Acetylmethoxytryptamine, 5-Methoxy-N-acetyl-3-indoleethylamine, 3-(2-Acetamidoethyl)-5-methoxyindole, Acetamide N-[2-(5-methoxyindol-3-yl)ethyl], 5-Methoxyindole-3-ethylacetamide, N-Acetyl-5-methoxyindoleethylamine, Melatonin USP, Melatonin EP, Melatonin BP, Melatonin Pharmaceutical Grade, Melatonin Supplement Grade, Melatonin Nutritional Grade, Melatonin Food Grade, Melatonin Technical Grade, Melatonin Reagent Grade, Melatonin Laboratory Grade, Melatonin Analytical Grade, High Purity Melatonin, Synthetic Melatonin, Natural Melatonin, Melatonin Powder, Melatonin Crystals, Melatonin Granules, Melatonin Active Ingredient, Melatonin API, Melatonin Intermediate, Sleep Aid Melatonin, Chronobiotic Melatonin
APPLICATIONS
Melatonin is used in dietary supplements to support normal sleep timing and sleep-wake rhythm.
Melatonin is incorporated into capsules and tablets for evening-use sleep-support products.
Melatonin is used in controlled-release tablets where gradual release is desired during the night.
Melatonin is used in gummies, chewable tablets, and oral sprays for convenient consumer dosage forms.
Melatonin is incorporated into fast-dissolving products where rapid onset positioning is desired.
Melatonin is used in liquid drops and syrup formulations in selected markets where permitted by regulation.
Melatonin is used in jet-lag support products to help align sleep timing after travel across time zones.
Melatonin is incorporated into travel wellness formulations where circadian rhythm support is a key claim.
Melatonin is used in shift-work-related sleep-support products in selected markets under appropriate regulatory conditions.
Melatonin is used in pharmaceutical preparations in markets where Melatonin is regulated as a medicine.
Melatonin is incorporated into prescription or over-the-counter products depending on national regulatory classification.
Melatonin is used in modified-release dosage forms where controlled plasma exposure is required.
Melatonin is used in cosmetic and personal care formulations in selected applications for antioxidant and skin-conditioning positioning.
Melatonin is incorporated into creams, serums, and night-care products where nighttime repair and antioxidant marketing concepts are desired.
Melatonin is valued because Melatonin provides a well-known biological rhythm active with supplement, pharmaceutical, cosmetic, and research relevance.
Melatonine is used in dietary supplement formulations. Melatonine is used to support normal sleep patterns. Melatonine is applied in sleep-aid tablets. Melatonine helps promote sleep onset in selected supplement products.
Melatonine is used in capsules for nighttime wellness support. Melatonine is applied in chewable supplement formats. Melatonine is used in gummy supplement formulations. Melatonine helps provide convenient sleep-support dosage forms.
Melatonine is used in liquid supplement preparations. Melatonine is applied in oral spray formulations. Melatonine is used in sublingual tablets. Melatonine supports fast-dissolving sleep-support products.
Melatonine is used in controlled-release supplement tablets. Melatonine helps provide gradual release during the night. Melatonine is applied in sustained-release wellness formulations. Melatonine supports products designed for sleep maintenance.
Melatonine is used in combination sleep-support formulas. Melatonine is combined with magnesium in selected supplement products. Melatonine is combined with herbal extracts in nighttime formulations. Melatonine supports multi-ingredient relaxation products.
Melatonine is used in travel-related sleep products. Melatonine helps support adjustment to changing sleep schedules. Melatonine is applied in jet-lag support supplements. Melatonine supports circadian rhythm wellness formulations.
Melatonine is used in nutraceutical products. Melatonine is applied in functional health formulations. Melatonine is used in wellness products for occasional sleeplessness. Melatonine helps support relaxation-oriented supplement lines.
Melatonine is used in pharmaceutical research. Melatonine is studied for circadian rhythm regulation. Melatonine is used in sleep science studies. Melatonine helps researchers evaluate sleep-wake cycle mechanisms.
Melatonine is used in chronobiology research. Melatonine is applied in studies of biological clock function. Melatonine is used in endocrine research. Melatonine helps investigate hormone signaling pathways.
Melatonine is used in antioxidant research. Melatonine is studied for free-radical scavenging properties. Melatonine is applied in cellular protection studies. Melatonine supports research on oxidative stress mechanisms.
Melatonine is used in cosmetic research. Melatonine is evaluated in skin-care formulations for antioxidant support. Melatonine is applied in anti-aging product development. Melatonine helps support concepts related to skin protection.
Melatonine is used in topical cosmetic formulations under suitable regulatory conditions. Melatonine is applied in night creams. Melatonine is used in serums designed for nighttime skin care. Melatonine supports antioxidant-focused cosmetic claims.
Melatonine is used in laboratory reagent applications. Melatonine is applied in biochemical assay development. Melatonine is used as a reference compound in analytical testing. Melatonine supports quality-control methods for finished supplement products.
Melatonine is used in stability testing programs. Melatonine helps evaluate degradation behavior in dosage forms.
DESCRIPTION
Melatonin is N-acetyl-5-methoxytryptamine, an indoleamine naturally produced mainly by the pineal gland in response to darkness.
Melatonin participates in circadian rhythm signaling, and Melatonin levels normally rise at night and decrease with light exposure.
Melatonin is used in supplements and pharmaceutical products because exogenous Melatonin can influence sleep timing and circadian phase in suitable use conditions.
Melatonin formulation performance depends on release profile, because immediate-release Melatonin and controlled-release Melatonin can behave differently in finished products.
Melatonin is sensitive to light, oxidation, and unsuitable storage conditions, so protective packaging and controlled processing are important.
Melatonin dosage and permitted claims vary by country, and Melatonin should be used according to applicable supplement, pharmaceutical, food, cosmetic, or research regulations for the target market.
Melatonin should not be positioned as a general cure or treatment without appropriate regulatory approval.
Melatonin raw material should be tested for assay, impurities, residual solvents, particle size, and microbiological quality depending on intended use.
Melatonin should be stored in tightly closed containers in a cool, dry, light-protected area to maintain potency and stability.
Melatonine is an indoleamine compound. Melatonine is naturally associated with sleep-wake cycle regulation. Melatonine is commonly supplied as a white to off-white crystalline powder. Melatonine is generally odorless or nearly odorless.
Melatonine has limited solubility in water. Melatonine is more soluble in selected organic solvents. Melatonine contains an indole ring structure. Melatonine has functional groups that influence its biological activity.
Melatonine is sensitive to light and should be protected during storage. Melatonine should be stored in tightly closed containers. Melatonine should be kept in a cool and dry place. Melatonine should be protected from heat and moisture.
Melatonine is used at low levels in many finished formulations. Melatonine dosage form performance depends on particle size, excipients, and release design. Melatonine can be formulated into tablets, capsules, gummies, liquids, and sprays. Melatonine requires careful quality control in supplement and pharmaceutical products.
Melatonine is valued for its role in circadian rhythm support. Melatonine is widely used in sleep-related wellness products. Melatonine is studied for antioxidant and biological signaling properties. Melatonine is important in research related to sleep, hormones, and cellular protection.
Melatonine should be handled according to applicable safety data sheet instructions. Melatonine should be used according to relevant regulatory requirements in finished products. Melatonine purity and grade selection depend on the intended application. Melatonine stability depends on storage conditions and formulation design.
Melatonine is an important active ingredient for sleep-support supplements and chronobiology research.
PROPERTIES
Chemical Formula: C13H16N2O2
Molecular Weight: 232.28 g/mol
Common Name: Melatonin
Chemical Type: Indoleamine; sleep-support active; nutraceutical or pharmaceutical ingredient
Appearance: White to off-white crystalline powder
Odor: Odorless or nearly odorless
Taste: Slightly bitter, grade dependent
Solubility: Slightly soluble in water; soluble in alcohol and selected organic solvents
Melting Point: Approximately 116–118°C
Light Sensitivity: Protect from light
Oxidation Sensitivity: Protect from oxidizing conditions and unsuitable storage
Stability: Stable under recommended dry, cool, light-protected storage
Storage Temperature: 15–25°C, tightly closed, dry, protect from light
Shelf Life: Typically 24–36 months in original sealed packaging, supplier dependent
FIRST AID
Inhalation:
Move to fresh air if dust is inhaled.
Seek medical attention if respiratory irritation, coughing, or discomfort persists.
Avoid breathing dust during powder handling and blending operations.
Skin Contact:
Wash skin with soap and water after contact.
Remove contaminated clothing if necessary and wash before reuse.
Seek medical advice if irritation develops or persists.
Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek medical attention if irritation persists.
Ingestion:
Rinse mouth with water.
Seek medical attention if discomfort, excessive drowsiness, dizziness, or unusual symptoms occur.
Never give anything by mouth to an unconscious person.
Note to Physicians:
Treat symptomatically.
Monitor for drowsiness, dizziness, gastrointestinal discomfort, or interaction concerns after significant exposure.
Provide supportive care as needed.
HANDLING AND STORAGE
Handling:
Use appropriate PPE including gloves, safety glasses, and dust protection for bulk powder handling.
Avoid generating dust during weighing, sieving, blending, granulation, and tableting operations.
Use clean, dry equipment to prevent contamination in pharmaceutical, nutraceutical, or cosmetic applications.
Ventilation:
Use general ventilation for normal handling.
Use local exhaust ventilation where dust may be generated.
Control airborne particulate exposure in enclosed processing areas.
Storage:
Store in tightly closed containers in a cool, dry, well-ventilated area.
Protect from light, heat, moisture, and oxidizing conditions to maintain potency.
Keep away from strong oxidizers and sources of contamination.
Spill and Leak Procedures:
Sweep or vacuum spilled powder while avoiding dust generation.
Collect into suitable containers for reuse or disposal according to local regulations and facility procedures.
Clean remaining residues carefully to prevent dust accumulation and cross-contamination.
Handling Precautions:
Control light exposure because Melatonin can lose potency when exposed to unsuitable light and storage conditions.
Select the appropriate regulatory grade because supplement, pharmaceutical, cosmetic, and research uses require different quality specifications.
Rotate stock using FIFO practices to maintain consistent assay, purity, and finished product performance.
