PRODUCTS

MEMANTINE HCl

Memantine HCL is used primarily to treat moderate to severe Alzheimer’s disease.
Memantine HCl blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction.

CAS Number: 41100-52-1
EC Number: 255-219-6
Molecular Formula: C12H22ClN
Molecular Weight: 215.76 g/mol

SYNONYMS:
MEMANTINE HYDROCHLORIDE, 41100-52-1, Memantine HCL, 3,5-dimethyladamantan-1-amine hydrochloride, 3,5-Dimethyl-1-adamantanamine hydrochloride, Akatinol, Namenda XR, Memary, Memantine Mylan, Memantine Merz, Memantine Accord, Memantine LEK, 1-Amino-3,5-dimethyladamantane Hydrochloride, Acrescent, Balaxur, Auxura, Memantine ratiopharm, JY0WD0UA60, CHEBI:64323, SUN-Y7017, NSC-102290, MARIXINO, FP-01, DTXSID90961439, NSC102290, 3,5-Dimethyltricyclo(3.3.1.13,7)decan-1-amine hydrochloride, 3,5-dimethyltricyclo[3.3.1.13,7]decan-1-amine hydrochloride, NAMZARIC COMPONENT MEMANTINE HYDROCHLORIDE, Ebixia, Valios, Memantine Hydrochloride Oral, Memantine Hydrochloride Tablets, DTXCID501389266, 255-219-6, Namenda, Ebixa, memantine.HCl, Memantine (hydrochloride), UNII-JY0WD0UA60, 3,5-dimethyladamantan-1-amine;hydrochloride, Memantine hydrochloride [USAN], Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-, hydrochloride, 3,5-dimethyladamantan-1-aminium chloride, MLS001332605, 3,5-Dimethyl-1-aminoadamantane hydrochloride, (3,5-Dimethyl-1-adamantyl)amine hydrochloride, 3,5-dimethyltricyclo(3.3.1.1(3,7))decan-1-amine hydrochloride, MFCD00214336, 1,3-Dimethyl-5-adamantanamine HCl, 41100-52-1 (HCl), Mantine, Ebixza, 3,5-Dimethyltricyclo(3.3.1.1(sup 3,7))decan-1-amine hydrochloride, 3,5-dimethyladamantanylamine, chloride, Tricyclo(3.3.1.1(sup 3,7))decan-1-amine, 3,5-dimethyl-, hydrochloride, 3,5-Dimethyl-1-adamantylamine, SMR000875213, SR-01000075458, SUN Y7017, EINECS 255-219-6, Namenda (TN), Memary (TN), NSC 102290, SCHEMBL3053, CHEMBL1699, MLS001332606, SPECTRUM1501121, Rac-(3S,5S)-3,5-Bis(trideuteriomethyl)adamantan-1-amine hydrochloride, HY-B0365A, MSK10370A, Memantine hydrochloride (Namenda), NMI-131, HMS1571C17, HMS1921H03, HMS5080J19, Pharmakon1600-01501121, Memantine hydrochloride (JAN/USP), PXB71318, 3,5-Dimethylamantadine hydrochloride, MEMANTINE HYDROCHLORIDE [MI], Tox21_500861, AC-559, CCG-39018, HB0407, MEMANTINE HYDROCHLORIDE [JAN], MRZ-2/145, NSC757843, s2043, SBB003390, AKOS015889460, BCP9000253, FM05692, LP00861, MEMANTINE HYDROCHLORIDE [MART.], NC00680, MEMANTINE HYDROCHLORIDE [USP-RS], MEMANTINE HYDROCHLORIDE [WHO-DD], NCGC00094186-01, NCGC00094186-02, NCGC00094186-03, NCGC00261546-01, AS-13331, BM164662, MEMANTINE HYDROCHLORIDE [EMA EPAR], ST088119, 3,5-dimethyladamantan-1-aminehydrochloride, D3608, EU-0100861, Memantine hydrochloride - Bio-X trade mark, MEMANTINE HYDROCHLORIDE [ORANGE BOOK], NS00088181, SW060653-4, 1-amino-3,5-dimethyl-adamantane hydrochloride, 3,5-dimethyladamantan-1-amine hy-drochloride, D04905, EN300-123026, M 9292, MEMANTINE HYDROCHLORIDE [USP MONOGRAPH], SR-01000075458-1, SR-01000075458-3, SR-01000075458-8, Q27133218, Z1551429722, Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, hydrochloride, Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-, hydrochloride (1:1) (CA INDEX NAME), 1-Amino-3,5-dimethyladamantane . HCl, 3,5-Dimethyl-1-aminoadamantane . HCl, Memantine . hydrochloride, 1-Amino-3,5-dimethyladamantane hydrochloride, 3,5-Dimethyltricyclo[3.3.1.13.7]decan-1-amine hydrochloride, 3,5-Dimethyl-1-adamantanamine hydrochloride, Memantine HCl, 3,5-Dimethyl-1-adamantanamine hydrochloride, 3,5-Dimethyl-amantadine hydrochloride, 3,5-Dimethyltricyclo[3.3.1.1³,⁷]decan-1-amine hydrochloride, 1-Amino-3,5-dimethyladamantane hydrochloride, Memantine Hydrochloride, 3,5-Dimethyl-1-adamantanamine hydrochloride

Memantine HCl is an NMDA receptor antagonist that works by regulating the activity of glutamate, a neurotransmitter involved in learning and memory.
Memantine HCl helps improve cognitive function and daily living activities in individuals suffering from Alzheimer’s, making it easier for them to engage in everyday tasks.

USES and APPLICATIONS of MEMANTINE HCl:
Memantine HCl blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction.
Memantine HCl is under investigation for the treatment of Alzheimer's disease, but there has been no clinical support for the prevention or slowing of disease progression.
Memantine HCl is a prescription medicine used for the treatment of moderate to severe dementia in people with Alzheimer’s disease.

MECHANISM, THERAPEUTIC USES & BENEFITS
Mode of Action:
Memantine HCl is an NMDA receptor (glutamate receptor) antagonist—blocks ion channel pore

Medical Use of Memantine HCl:
FDA-approved for treatment of moderate-to-severe Alzheimer’s disease; also under research for other neuropsychiatric conditions

Pharmacokinetics:
Oral bioavailability ~100%
Minimal metabolism; excreted mainly via urine (57–82% unchanged)
Elimination half-life: ~60–80 hours

HOW SHOULD I TAKE MEMANTINE HCl?
Take Memantine HCL Tablets exactly as prescribed by your doctor.
The dosage usually starts low and is gradually increased to minimize the risk of side effects.
It is crucial to take Memantine HCl at the same time each day to maintain consistent levels in the body.
Do not stop taking Memantine HCl suddenly without consulting your healthcare provider, as this may worsen your condition.

HOW SHOULD I TAKE MEMANTINE HCl?
Your doctor will tell you how much Memantine HCl to take and when to take it.
Your doctor may change your dose if needed.
Memantine HCl can be taken with food or without food.

Do not use any tablets of Memantine HCl that are damaged or show signs of tampering.
If you forget to take one dose of Memantine HCl, do not double up on the next dose.

You should take only the next dose as scheduled.
If you have forgotten to take Memantine HCl for several days, you should not take the next dose until you talk to your doctor.

HOW TO USE MEMANTINE HCl:
Memantine HCL should be used as directed by your healthcare provider.
Memantine HCl is typically taken once or twice daily, with or without food.

It is important to follow the prescribed dosage of Memantine HCl and not to deviate from the treatment plan.
Swallow the tablet whole with water; do not crush or chew Memantine HCl.

HOW DOES MEMANTINE HCl WORK?
Memantine HCl works by blocking NMDA receptors in the brain, which are involved in the transmission of nerve signals related to memory and learning.

In Alzheimer’s disease, excessive glutamate activity can lead to overstimulation of these receptors, causing neuronal damage.
By inhibiting this overstimulation, Memantine HCl helps protect neurons, thereby improving cognitive function and slowing the progression of symptoms.

WHAT SHOULD I TELL MY DOCTOR BEFORE TAKING MEMANTINE HCl?
Before you take Memantine HCl, tell your doctor if you:
*have or have had seizures
*have or have had problems passing urine
*have or have had bladder or kidney problems
*have liver problems
*have any other medical conditions
*are pregnant or plan to become pregnant.

It is not known if Memantine HCl will harm your unborn baby.
It is not known if Memantine HCl passes into your breast milk.

You and your doctor should decide if you will take Memantine HCl or breastfeed.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Taking Memantine HCl with certain other medicines may affect each other.
Taking Memantine HCl with other medicines can cause serious side effects.

Especially tell your doctor if you take:
other NMDA antagonists such as amantadine, ketamine, and dextromethorphan
medicines that make your urine alkaline such as carbonic anhydrase inhibitors and sodium bicarbonate

Ask your doctor or pharmacist for a list of these medicines, if you are not sure.
Know the medicines you take.
Keep a list of them to show your doctor and pharmacist when you get a new medicine.

WHO SHOULD NOT TAKE MEMANTINE HCl?
Do not take Memantine HCl if you are allergic to memantine or any of the ingredients in Memantine HCl.

PHYSICAL and CHEMICAL PROPERTIES of MEMANTINE HCl:
Molecular Weight: 215.76 g/mol
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 0
Exact Mass: 215.1440774 Da
Monoisotopic Mass: 215.1440774 Da
Topological Polar Surface Area: 26 Å²
Heavy Atom Count: 14
Formal Charge: 0

Complexity: 240
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 2
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes
CAS Number: 41100-52-1
EC / EINECS Number: 255-219-6

PubChem CID: 181458
Chemical Formula: C12H21N·HCl
Molecular Weight: ~215.76 g/mol
Appearance: White crystalline powder or solid
Solubility: Soluble in water; e.g., up to 100 mg/mL
Stability & Incompatibilities: Avoid oxidizing agents;
decomposition may produce CO, CO₂, NOₓ, and HCl
CAS / EC Numbers: 41100-52-1 / 255-219-6
Formula / Mol. Wt.: C12H21N·HCl / ~215.76 g/mol

Appearance: White crystalline powder
Solubility: Water-soluble (e.g., 100 mg/mL)
Stability: Stable; avoid oxidizers; dust explosion risk
Mechanism: NMDA receptor antagonist
Use: Alzheimer’s therapy
Pharmacokinetics: Oral bioavailability 100%; long half-life
Handling: Store properly; use PPE; avoid dust and oxidizers

Physical State: Solid
Color: White
Odor: No data available
Melting Point/Freezing Point: No data available
Initial Boiling Point and Boiling Range: No data available
Flammability (solid, gas): No data available
Upper/Lower Flammability or Explosive Limits: No data available
Flash Point: No data available

Autoignition Temperature: No data available
Decomposition Temperature: No data available
pH: No data available
Viscosity, Kinematic: No data available
Viscosity, Dynamic: No data available
Water Solubility: 1 g/L
Partition Coefficient n-octanol/water: No data available
Vapor Pressure: No data available

Density: No data available
Relative Density: No data available
Relative Vapor Density: No data available
Particle Characteristics: No data available
Explosive Properties: No data available
Oxidizing Properties: No data available
Other Safety Information: No data available

FIRST AID MEASURES of MEMANTINE HCl:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of MEMANTINE HCl:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of MEMANTINE HCl:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of MEMANTINE HCl:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of MEMANTINE HCl:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of MEMANTINE HCl:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available