PRODUCTS

METHANE SULFONIC ACID 70%

MSA (Methane Sulfonic Acid 70% - CAS 75-75-2) is a strong acid widely used as a catalyst (esterification, alkylation, etc.) thanks to its performances, it is an interesting substitute for organic and inorganic strong acids in various applications.

CAS No.: 75-75-2
EC No.: 200-898-6

Synonyms:
METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit %70; methane sulfonic acid; METHANESULFONIC ACID; 75-75-2; Methylsulfonic acid; Methanesulphonic acid; Mesylate; Methanesulfonicacid; Kyselina methansulfonova; Mesylic acid; Methansulfonsaeure; NSC 3718; CCRIS 2783; UNII-12EH9M7279; Kyselina methansulfonova [Czech]; HSDB 5004; EINECS 200-898-6; CH3SO3H; MFCD00007518; BRN 1446024; METHANE SULFONIC ACID; Sulfomethane; AI3-28532; CHEBI:27376; 22515-76-0; Methanesulfonic acid, ammonium salt (1:1); 12EH9M7279; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; Methanesulfonic acid, 98%; Methanesulfonic acid, 99%, extra pure; Methanesulfonic acid, ammonium salt; Methanesulfonic acid, pure, 70% solution in water; Mesic acid; metanesulfonic acid; methansulfonic acid; MsOH; methansulphonic acid; methylsulphonic acid; 03S; methyl sulfonic acid; methyl-sulfonic acid; methane-sulfonic acid; MeSO3H; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; methane sulphonic acid; methanesulphonic-acid-; NSC 166292; PubChem2058; PubChem11149; LACTIC ACID(DL); AI3-62914; ammonium methanesulphonate; CH3SO2OH; H3CSO3H; DSSTox_CID_6422; WLN: WSQ1; EC 200-898-6; DSSTox_RID_78109; Methane Sulfonic Acid 99%; DSSTox_GSID_26422; 4-04-00-00010 (Beilstein Handbook Reference); METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; KSC377E0F; Methanesulfonic acid, 99.5%; Methanesulfonic acid, anhydrous; $l^{1}-oxidanylsulfonylmethane; CHEMBL3039600; DL-MALICACIDMONOSODIUMSALT; DTXSID4026422; CTK2H7202; KS-00000WAQ; Methanesulfonic acid, HPLC grade; NSC3718; Methanesulfonic acid, >=99.0%; [C]S(O)(=O)=O; NSC-3718; Tox21_201073; ANW-42735; STL264182; Methane Sulfonic Acid, 70% Solution; AKOS009146947; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; MCULE-6572487779; CAS-75-75-2; NCGC00248914-01; NCGC00258626-01; BP-12823; LS-90299; DB-075013; FT-0628287; M0093; M2059; C11145; Methanesulfonic acid, >=99.0%, ReagentPlus(R); Methanesulfonic acid, for HPLC, >=99.5% (T); Methanesulfonic acid solution, 70 wt. % in H2O; Q414168; J-521696; Methanesulfonic acid, Vetec(TM) reagent grade, 98%; F1908-0093; Z940713430; Methanesulfonic acid solution, 4 M (with 0.2% (w/v) tryptamine); Methanesulfonic acid concentrate, 0.1 M CH3SO3H in water (0.1N), eluent concentrate for IC; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; Methanesulfonic acid, PharmaGrade, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production; methylsulfonic acid; methanesulphonic acid; methanesulfonicacid; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; kyselina methansulfonova; methansulfonsaeure; ccris 2783; kyselina methansulfonova czech; ch3so3h; methane sulfonic acid; sulfomethane; Alkanesulfonic acid; METHANESULFONIC ACID; METHANESULPHONIC ACID; METHYLSULFONATE, POLYMER-BOUND; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHYLSULFONIC ACID; MSA; SULFOMETHANE; acidemethanesulfonique; Kyselina methansulfonova; kyselinamethansulfonova; Methylsulphonicacid; Sulphonethane; Mesic acid; Methanesulfonicacidaqsoln; METHANE SULFONIC ACID ANHYDROUS; METHANESULFONIC ACID, >=99.5%; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANESULFONIC ACID,70WT.%SOLUTION IN H; METHANESULFONIC ACID 70 WT. % SOLUTION&; METHANESULFONIC ACID, TECH., 70%; METHANESULFONIC ACID, ELECTR GR(MSA 70%; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANESULFONIC ACID; 75-75-2; Methylsulfonic acid; Methanesulphonic acid; Mesylate; Methanesulfonicacid; Kyselina methansulfonova; Mesylic acid; Methansulfonsaeure; NSC 3718; CCRIS 2783; UNII-12EH9M7279; Kyselina methansulfonova [Czech]; HSDB 5004; EINECS 200-898-6; CH3SO3H; MFCD00007518; BRN 1446024; METHANE SULFONIC ACID; Sulfomethane; AI3-28532; CHEBI:27376; 22515-76-0; Methanesulfonic acid, ammonium salt (1:1); 12EH9M7279; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; Methanesulfonic acid, 98%; Methanesulfonic acid, 99%, extra pure; Methanesulfonic acid, ammonium salt; Methanesulfonic acid, pure, 70% solution in water; Mesic acid; metanesulfonic acid; methansulfonic acid; MsOH; methansulphonic acid; methylsulphonic acid; 03S; methyl sulfonic acid; methyl-sulfonic acid; methane-sulfonic acid; MeSO3H; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; methane sulphonic acid; methanesulphonic-acid-; NSC 166292; PubChem2058; PubChem11149; LACTIC ACID(DL); AI3-62914; ammonium methanesulphonate; CH3SO2OH; H3CSO3H; DSSTox_CID_6422; WLN: WSQ1; EC 200-898-6; DSSTox_RID_78109; Methane Sulfonic Acid 99%; DSSTox_GSID_26422; 4-04-00-00010 (Beilstein Handbook Reference); METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; KSC377E0F; Methanesulfonic acid, 99.5%; Methanesulfonic acid, anhydrous; $l^{1}-oxidanylsulfonylmethane; CHEMBL3039600; DL-MALICACIDMONOSODIUMSALT; DTXSID4026422; CTK2H7202; KS-00000WAQ; Methanesulfonic acid, HPLC grade; NSC3718; Methanesulfonic acid, >=99.0%; [C]S(O)(=O)=O; NSC-3718; Tox21_201073; ANW-42735; STL264182; Methane Sulfonic Acid, 70% Solution; AKOS009146947; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; MCULE-6572487779; CAS-75-75-2; NCGC00248914-01; NCGC00258626-01; BP-12823; LS-90299; DB-075013; FT-0628287; M0093; M2059; C11145; Methanesulfonic acid, >=99.0%, ReagentPlus(R); Methanesulfonic acid, for HPLC, >=99.5% (T); Methanesulfonic acid solution, 70 wt. % in H2O; Q414168; J-521696; Methanesulfonic acid, Vetec(TM) reagent grade, 98%; F1908-0093; Z940713430; Methanesulfonic acid solution, 4 M (with 0.2% (w/v) tryptamine); Methanesulfonic acid concentrate, 0.1 M CH3SO3H in water (0.1N), eluent concentrate for IC; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; Methanesulfonic acid, PharmaGrade, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production; methylsulfonic acid; methanesulphonic acid; methanesulfonicacid; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; kyselina methansulfonova; methansulfonsaeure; ccris 2783; kyselina methansulfonova czech; ch3so3h; methane sulfonic acid; sulfomethane; Alkanesulfonic acid; METHANESULFONIC ACID; METHANESULPHONIC ACID; METHYLSULFONATE, POLYMER-BOUND; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHYLSULFONIC ACID; MSA; SULFOMETHANE; acidemethanesulfonique; Kyselina methansulfonova; kyselinamethansulfonova; Methylsulphonicacid; Sulphonethane; Mesic acid; Methanesulfonicacidaqsoln; METHANE SULFONIC ACID ANHYDROUS; METHANESULFONIC ACID, >=99.5%; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid; METHANESULFONIC ACID,70WT.%SOLUTION IN H; METHANESULFONIC ACID 70 WT. % SOLUTION&; METHANESULFONIC ACID, TECH., 70%; METHANESULFONIC ACID, ELECTR GR(MSA 70%; METHANE SULFONIC ACID 70%; METAN SÜLFONİK ASİT %70; metan sülfonik asit%70; methane sulfonic acid

Ludwigshafen, Germany – December 20, 2018 – BASF intends to expand the production capacity for methane sulfonic acid (MSA) at its Ludwigshafen site by around 65 percent and increase the global capacity to 50,000 metric tons per year. With the investment the company further strengthens its position as the leading global producer of MSA. The volumes from the additional capacity are expected to be available late in 2021 for customers in all regions.

“The demand for MSA increased strongly across industries. This expansion will allow us to support the rapid growth of our customers, especially in Asia. Beyond the increase in Ludwigshafen, we evaluate investment options outside of Europe to continuously expand our MSA capacities,” says Martin Widmann, Global Strategic Marketing and Development, Care Chemicals division at BASF. “We focus our extensive know-how and highly efficient manufacturing processes on our customers’ needs to enhance their applications’ performance, sustainability and efficacy."

Sustainable alternative to conventional acids

Methane sulfonic acid is a strong organic acid used in numerous applications ranging from chemical and biofuel synthesis to industrial cleaning and metal surface treatment in the electronics industry. The expansion is in line with the trend for top-performance and at the same time environmentally friendly technologies in various industries. BASF’s proprietary process enables the production of Lutropur® MSA – a high-purity methane sulfonic acid. Lutropur MSA is a sustainable alternative to other acids such as sulfuric, phosphoric or acetic acid. As part of the natural sulfur cycle MSA is readily biodegradable. Further benefits in practical applications come, for example, from its nonoxidizing nature, the high solubility of its salts and the absence of color and odor.

As already announced at the end of 2018, BASF will proceed with expanding global capacities for methane sulfonic acid (MSA) to 50,000 metric tons per year. This involves a higher double-digit million euro investment in constructing a new methane sulfonic acid plant at the Ludwigshafen site. The construction works started recently. The volumes from the additional capacity are expected to be available from the end of 2021 and are dedicated to mainly serve European customers as well as the rapidly growing Asian market.

“We want to meet our customers' growing demand for high-quality, sustainable and high-performance technologies in the best possible way now and in future. To achieve that, we continuously invest in expanding our capacities and production technologies. To this end, we acquired an innovative process approach for producing MSA from Grillo-Werke AG in mid 2019 to strengthen our own R&D activities and to accelerate the development of a new manufacturing process for methane sulfonic acid. In doing so, we support as reliable partner the growth of our customers across the world,” said Ralph Schweens, President Care Chemicals, BASF.

Sustainable alternative to conventional acids

Methane sulfonic acid is a strong organic acid used in numerous applications ranging from chemical and biofuel synthesis to industrial cleaning and metal surface treatment in the electronics industry. BASF's high-purity methane sulfonic acid – sold under the brand name Lutropur® MSA – is a sustainable alternative to other acids such as sulfuric, phosphoric or acetic acid. As part of the natural sulfur cycle, Lutropur MSA is readily biodegradable. Further benefits of using methane sulfonic acid come from its non-oxidizing character, the high solubility of its salts and the absence of color and odor.

Product overview
MSA (Methane Sulfonic Acid 70% - CAS 75-75-2) is a strong acid widely used as a catalyst (esterification, alkylation, etc.) thanks to its performances, it is an interesting substitute for organic and inorganic strong acids in various applications.

Ester quality, easy recyclability and "green" effluent are part of the major methane sulfonic acid 70% advantage is in esterification.

Methane sulfonic acid 70%
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Methane sulfonic acid 70%
Structural formula of Methane sulfonic acid 70%
Ball-and-stick model of Methane sulfonic acid 70%
Names
IUPAC name
Methane sulfonic acid 70%
Other names
Methylsulfonic acid, MSA
Identifiers
CAS Number
75-75-2 check
3D model (JSmol)
Interactive image
ChEBI
CHEBI:27376 check
ChemSpider
6155 check
ECHA InfoCard   100.000.817 Edit this at Wikidata
EC Number
200-898-6
PubChem CID
6395
UNII
12EH9M7279 check
CompTox Dashboard (EPA)
DTXSID4026422 Edit this at Wikidata
InChI[show]
SMILES[show]
Properties
Chemical formula   CH4O3S
Molar mass   96.10 g·mol−1
Appearance   Clear, colourless liquid
Density   1.48 g/cm3
Melting point   17 to 19 °C (63 to 66 °F; 290 to 292 K)
Boiling point   167 °C (333 °F; 440 K) at 10 mmHg, 122 °C/1 mmHg
Solubility in water   miscible
Solubility   Miscible with methanol, diethyl ether.
Immiscible with hexane
log P   -2.424[1]
Acidity (pKa)   −1.9[2]
Hazards
Safety data sheet   Oxford MSDS
EU classification (DSD) (outdated)   Harmful (Xn), Corrosive (C)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Methane sulfonic acid 70% (MsOH) or methanesulphonic acid (in British English) is a colorless liquid with the chemical formula CH3SO3H. It is the simplest of the alkylsulfonic acids. Salts and esters of Methane sulfonic acid 70% are known as mesylates (or methanesulfonates, as in ethyl methanesulfonate). It is hygroscopic in its concentrated form. Methane sulfonic acid 70% may be considered an intermediate compound between sulfuric acid (H2SO4), and methylsulfonylmethane ((CH3)2SO2), effectively replacing an –OH group with a –CH3 group at each step. This pattern can extend no further in either direction without breaking down the –SO2– group. Methane sulfonic acid 70% can dissolve a wide range of metal salts, many of them in significantly higher concentrations than in hydrochloric or sulfuric acid.[3]

Contents
1   Applications
1.1   Electroplating
2   See also
3   References
Applications
Methane sulfonic acid 70% is used as an acid catalyst in organic reactions because it is a non-volatile, strong acid that is soluble in organic solvents. It is convenient for industrial applications because it is liquid at ambient temperature, while the closely related p-toluenesulfonic acid (PTSA) is solid. However, in a laboratory setting, solid PTSA is more convenient.

Methane sulfonic acid 70% can be used in the generation of borane (BH3) by reacting Methane sulfonic acid 70% with NaBH4 in an aprotic solvent such as THF or DMS, the complex of BH3 and the solvent is formed.[4]

Electroplating
Solutions of Methane sulfonic acid 70% are used for the electroplating of tin and tin-lead solders. It is displacing the use of fluoroboric acid, which releases corrosive and volatile hydrogen fluoride.[5]

Methane sulfonic acid 70% is also a primary ingredient in rust and scale removers.[6] It is used to clean off surface rust from ceramic, tiles and porcelain which are usually susceptible to acid attack.

See also
TrifluoroMethane sulfonic acid 70% - the more acidic trifluoro analogue

4.3.3.2.1 Methane sulfonic acid 70% system
Methane sulfonic acid 70% with high acidity is not only the catalyst in the process of chitin acylation, but also is a good solvent for partially acylated chitin. Thus homogeneous acylation of chitin can be achieved in the Methane sulfonic acid 70% system. Norio et al. [75] mixed chitin, Methane sulfonic acid 70%, and glacial acetic acid according to different molar ratios, and reacted it at 0°C overnight to obtain acetylated chitin with different DS. In this experiment, a homogeneous phase is gradually formed as the reaction proceeds, which contributes to further acylation. This reaction should be kept at a low temperature to prevent degradation of chitin in acidic conditions. The acylating agent is not limited to carboxylic acid but also acid chloride. Furthermore, Kaifu et al. [78] mixed the chitin, Methane sulfonic acid 70%, and acid chloride first, then the mixture was reacted at 0°C for 2 h, followed by an overnight reaction at –20°C to obtain acylated chitin. By changing the kind and molar amount of acid chloride, hexanoylation, oxime acylation, and dodecyl acylation of chitin with different DS can be obtained, of which DS can be up to 1.9. In this process, the crystallinity of chitin can be effectively destroyed by further acylation by reacting at –20°C overnight. In general, the acylation ability of the acid chloride is higher than that of the carboxylic acid. The larger the acylation group, the greater the damage to the crystalline region of chitin.

c. Dilute Methane sulfonic acid 70% in Dioxane–Dichloromethane
This diluted Methane sulfonic acid 70% (MSA) system, which uses 0.5 M MSA in 1:9 (v/v) dioxane–CH2Cl2 (Kiso et al., 1992b), is primarily used in SPPS. The advantages are as follows: (i) elimination of side-chain protecting groups is reduced compared to the conventional 45% TFA/CH2Cl2 method, and (ii) pyroglutamyl formation from glutamine-containing peptides is similarly decreased relative to the use of 4 N HCl/dioxane. Using the MSA deprotection system, Kiso et al. (1990a) developed an efficient method for SPPS consisting of in situ neutralization and the rapid coupling reaction using BOP or BOI reagent activation (Kiso et al., 1990a) (Fig. 7). Porcine brain natriuretic peptide (pBNP) was synthesized successfully using this method (Kiso et al., 1992b).

10.14.10.6 DMSO and Methane sulfonic acid 70%
DMSO and Methane sulfonic acid 70% are two of the most important organic oxidation products of DMS. It is not entirely clear how Methane sulfonic acid 70%, CH3S(O)(O)(OH), forms, but methanesulfinic acid, CH3S(O)(OH)CH3, has been reported during oxidation in OH–DMS systems. Further addition of OH to methanesulfinic acid, followed by reaction with oxygen, can yield Methane sulfonic acid 70%. At lower temperatures found in the Arctic, there are a wide variety of oxidation products of DMS that include the MSA, DMS, and dimethylsulfone, CH3S(O)(O)CH3.

WHAT IS METHANE SULPHONIC ACID 70%
Methane sulphonic acid 70%, also known as methane sulfonic acid 70% or mesylic acid. It is widely used as an acid catalyst and solvent in organic reactions in biological and agricultural industry. It is also a key ingredient in plating various metals to print circuit board manufacture in electric industry. Besides, Methane sulphonic acid 70% is popularly used in textile treatment, and the production of plastics and polymers.

Synonyms: Methane sulfonic acid 70%, Methane sulphonic acid 70%, Mesylate, Methylsulfonate, Methane sulfonic acid 70%, MSA
INCI: Methane Sulphonic Acid
Chemical Formula: CH3SO3H
CAS Number: CAS 75-75-2

Sustainable alternative to conventional acids

Methane sulfonic acid is a strong organic acid used in numerous applications ranging from chemical and biofuel synthesis to industrial cleaning and metal surface treatment in the electronics industry. BASF's high-purity methane sulfonic acid – sold under the brand name Lutropur® MSA – is a sustainable alternative to other acids such as sulfuric, phosphoric or acetic acid. As part of the natural sulfur cycle, Lutropur MSA is readily biodegradable. Further benefits of using methane sulfonic acid come from its non-oxidizing character, the high solubility of its salts and the absence of color and odor.

Ester quality, easy recyclability and "green" effluent are part of the major methane sulfonic acid 70% advantage is in esterification.

See also
TrifluoroMethane sulfonic acid 70% - the more acidic trifluoro analogue