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Methanesulfonyl Chloride is an organosulfur compound used as an intermediate in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, dyes, and specialty chemicals.
Methanesulfonyl Chloride is valued for its ability to act as a sulfonylating agent, introducing the methanesulfonyl (mesyl) group into a wide variety of molecules.
Methanesulfonyl Chloride is also widely known as a precursor to methanesulfonates and other sulfonyl derivatives.
CAS Number: 124-63-0
EC Number: 204-709-8
Molecular Formula: CH3SO2Cl
Molecular Weight: 114.55 g/mol
Synonyms: Methanesulfonyl Chloride, Mesyl Chloride, Methylsulfonyl Chloride, Methylsulphonic Acid Chloride, Chloromethanesulfonyl, Methanesulphonyl Chloride, Mesyl Halide, CH3SO2Cl, Methanesulfonyl Halide, Methyl Sulfonic Acid Chloride, Methyl Sulphonyl Chloride, Mesyl Reagent, Methanesulfonic Acid Chloride, Methanesulfonyl Chloride Intermediate, Methylsulfonic Chloride
APPLICATIONS
Methanesulfonyl Chloride is widely used as a sulfonylating agent in organic synthesis.
Methanesulfonyl Chloride is employed in the preparation of methanesulfonate esters for use in pharmaceutical intermediates.
Methanesulfonyl Chloride is used to protect hydroxyl groups during multistep organic reactions.
Methanesulfonyl Chloride is applied in the synthesis of sulfonamide drugs.
Methanesulfonyl Chloride reacts with amines to form methanesulfonamides, important in medicinal chemistry.
Methanesulfonyl Chloride derivatives are used in antibacterial and antiviral compounds.
Methanesulfonyl Chloride is incorporated into agrochemical formulations.
Methanesulfonyl Chloride is used to synthesize herbicides and fungicides.
Methanesulfonyl Chloride provides chemical stability to active ingredients.
Methanesulfonyl Chloride is used in the dye industry.
Methanesulfonyl Chloride introduces sulfonyl groups into chromophores to enhance solubility and binding.
Methanesulfonyl Chloride derivatives improve dye fastness properties.
Methanesulfonyl Chloride is used in polymer chemistry.
Methanesulfonyl Chloride functions as a reactive intermediate for grafting and functionalizing polymers.
Methanesulfonyl Chloride improves adhesion and chemical resistance in coatings.
Methanesulfonyl Chloride is used in specialty chemical production.
Methanesulfonyl Chloride is a key reagent in the manufacture of ionic liquids.
Methanesulfonyl Chloride is applied in photoresist materials for microelectronics.
Methanesulfonyl Chloride is used in peptide synthesis.
Methanesulfonyl Chloride helps in modifying amino acid side chains.
Methanesulfonyl Chloride protects functional groups during peptide assembly.
Methanesulfonyl Chloride is utilized in laboratory research.
Methanesulfonyl Chloride acts as a versatile electrophile in chemical transformations.
Methanesulfonyl Chloride serves as a catalyst modifier in certain organic reactions.
Methanesulfonyl Chloride is employed in fragrance and flavor chemistry.
Methanesulfonyl Chloride is used to introduce sulfonyl groups that alter volatility and stability.
Methanesulfonyl Chloride improves aroma compound durability.
Methanesulfonyl Chloride is used as an intermediate in the synthesis of pharmaceuticals such as antibiotics, cardiovascular drugs, and antiviral agents.
Methanesulfonyl Chloride is incorporated into the preparation of active pharmaceutical ingredients through sulfonation reactions.
Methanesulfonyl Chloride is applied in the synthesis of prodrugs to improve bioavailability.
Methanesulfonyl Chloride is used in agrochemical manufacturing for the production of herbicides, fungicides, and insecticides.
Methanesulfonyl Chloride is incorporated into sulfonamide-based pesticides to enhance biological activity.
Methanesulfonyl Chloride is applied in the formulation of plant growth regulators.
Methanesulfonyl Chloride is used in polymer chemistry to introduce sulfonyl functional groups for improved chemical resistance.
Methanesulfonyl Chloride is incorporated into specialty polymer synthesis for membrane and ion-exchange applications.
Methanesulfonyl Chloride is applied in the modification of engineering plastics for enhanced durability.
Methanesulfonyl Chloride is used as a sulfonylating agent in organic synthesis for the preparation of sulfonates and sulfonamides.
Methanesulfonyl Chloride is incorporated into esterification processes to form methanesulfonate esters.
Methanesulfonyl Chloride is applied in the synthesis of sulfone-containing pharmaceuticals.
Methanesulfonyl Chloride is used in the electronics industry for the functionalization of semiconductor materials.
Methanesulfonyl Chloride is incorporated into photoresist formulations for microelectronics manufacturing.
Methanesulfonyl Chloride is applied in surface modification for improved adhesion and wettability.
Methanesulfonyl Chloride is used as a catalyst precursor in polymerization reactions.
Methanesulfonyl Chloride is incorporated into catalyst systems for fine chemical synthesis.
Methanesulfonyl Chloride is applied in controlled radical polymerization processes.
Methanesulfonyl Chloride is used in dye and pigment manufacturing to improve fastness and stability.
Methanesulfonyl Chloride is incorporated into reactive dye synthesis for textile applications.
Methanesulfonyl Chloride is applied in pigment dispersant production.
Methanesulfonyl Chloride is used in fragrance chemical synthesis to introduce sulfonyl groups for enhanced stability.
Methanesulfonyl Chloride is incorporated into aroma chemical intermediates.
Methanesulfonyl Chloride is applied in the production of long-lasting fragrance compounds.
Methanesulfonyl Chloride is used in lubricants and additive manufacturing to improve extreme-pressure performance.
Methanesulfonyl Chloride is incorporated into synthetic lubricant base stocks for enhanced oxidation stability.
Methanesulfonyl Chloride is applied in specialty grease formulations.
Methanesulfonyl Chloride is used in photographic chemicals for film processing agents.
Methanesulfonyl Chloride is incorporated into stabilizers for photographic emulsions.
Methanesulfonyl Chloride is applied in specialty developers for improved image contrast.
DESCRIPTION
Methanesulfonyl Chloride is a colorless to pale yellow liquid with a pungent, irritating odor.
Methanesulfonyl Chloride is an organosulfur compound with the chemical formula CH₃SO₂Cl.
Methanesulfonyl Chloride is highly reactive due to the presence of the sulfonyl chloride functional group.
Methanesulfonyl Chloride is soluble in many organic solvents such as dichloromethane, chloroform, and toluene.
Methanesulfonyl Chloride hydrolyzes readily in the presence of water to produce methanesulfonic acid and hydrogen chloride gas.
Methanesulfonyl Chloride is typically produced by the chlorination of methanesulfonic acid or its salts.
Methanesulfonyl Chloride is stable under dry storage conditions but must be kept away from moisture.
Methanesulfonyl Chloride is a strong irritant to skin, eyes, and respiratory tract, requiring careful handling.
Methanesulfonyl Chloride is used in small to large-scale manufacturing across multiple industries.
Methanesulfonyl Chloride is shipped in sealed containers under inert gas to prevent degradation.
Methanesulfonyl Chloride is a colorless to pale yellow liquid with a sharp, irritating odor.
It is moisture-sensitive and hydrolyzes rapidly in water to release methanesulfonic acid and hydrogen chloride.
Methanesulfonyl Chloride is soluble in most organic solvents such as dichloromethane, chloroform, and benzene.
The compound is highly reactive toward nucleophiles, making it valuable for sulfonylation reactions.
Methanesulfonyl Chloride must be handled under dry conditions to avoid hydrolysis.
It is a corrosive and lachrymatory substance, requiring careful handling in laboratories and industrial facilities.
Methanesulfonyl Chloride is typically produced by the reaction of methanesulfonic acid or its salts with thionyl chloride or phosphorus pentachloride.
It is available in various purity grades depending on application requirements.
PROPERTIES
Chemical Formula: CH3SO2Cl
Molecular Weight: 114.55 g/mol
Common Name: Methanesulfonyl Chloride
Appearance: Colorless to pale yellow liquid
Odor: Sharp, pungent
Density: ~1.48 g/cm³
Melting Point: -32°C
Boiling Point: ~161°C
Solubility: Insoluble in water; soluble in organic solvents
pH: Acidic when hydrolyzed
Reactivity: Reacts violently with water, alcohols, amines, and bases
Chemical Stability: Stable under dry, inert storage conditions
Storage Temperature: Store in a cool, dry place under inert atmosphere
FIRST AID
Inhalation:
Move the exposed person to fresh air immediately.
Seek medical attention if respiratory irritation or difficulty occurs.
Skin Contact:
Immediately flush with plenty of water for at least 15 minutes.
Remove contaminated clothing.
Seek immediate medical attention for burns or irritation.
Eye Contact:
Rinse cautiously with water for at least 15 minutes, holding eyelids open.
Seek immediate medical attention.
Ingestion:
Do not induce vomiting.
Rinse mouth thoroughly with water.
Seek immediate medical assistance.
Note to Physicians:
Provide symptomatic and supportive treatment.
HANDLING AND STORAGE
Handling:
Wear chemical-resistant gloves, goggles, and protective clothing.
Use only in well-ventilated areas or fume hoods.
Avoid inhalation of vapors and direct skin contact.
Storage:
Store in tightly closed containers under dry inert gas such as nitrogen.
Keep away from water, alcohols, amines, and strong bases.
Protect from heat, sparks, and open flames.
Spill and Leak Procedures:
Evacuate area and ventilate.
Contain spill with inert absorbent material such as vermiculite.
Neutralize carefully and dispose of according to local regulations.
